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zadetkov: 12
1.
  • Leveraging the replication ... Leveraging the replication stress response to optimize cancer therapy
    Cybulla, Emily; Vindigni, Alessandro Nature reviews. Cancer, 01/2023, Letnik: 23, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    High-fidelity DNA replication is critical for the faithful transmission of genetic information to daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways are activated ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK, ZAGLJ
2.
  • A Cell-Intrinsic Interferon... A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin
    Kreienkamp, Ray; Graziano, Simona; Coll-Bonfill, Nuria ... Cell reports, 02/2018, Letnik: 22, Številka: 8
    Journal Article
    Recenzirano
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    Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS patient-derived fibroblasts ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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3.
  • To skip or not to skip: cho... To skip or not to skip: choosing repriming to tolerate DNA damage
    Quinet, Annabel; Tirman, Stephanie; Cybulla, Emily ... Molecular cell, 02/2021, Letnik: 81, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    Accurate DNA replication is constantly threatened by DNA lesions arising from endogenous and exogenous sources. Specialized DNA replication stress response pathways ensure replication fork ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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4.
  • Temporally distinct post-re... Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
    Tirman, Stephanie; Quinet, Annabel; Wood, Matthew ... Molecular cell, 10/2021, Letnik: 81, Številka: 19
    Journal Article
    Recenzirano
    Odprti dostop

    PRIMPOL repriming allows DNA replication to skip DNA lesions, leading to ssDNA gaps. These gaps must be filled to preserve genome stability. Using a DNA fiber approach to directly monitor gap ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
5.
  • PRIMPOL ready, set, reprime PRIMPOL ready, set, reprime
    Tirman, Stephanie; Cybulla, Emily; Quinet, Annabel ... Critical reviews in biochemistry and molecular biology, 01/2021, Letnik: 56, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    DNA replication forks are constantly challenged by DNA lesions induced by endogenous and exogenous sources. DNA damage tolerance mechanisms ensure that DNA replication continues with minimal effects ...
Celotno besedilo
Dostopno za: BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK

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6.
  • PRIMPOL-Mediated Adaptive R... PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
    Quinet, Annabel; Tirman, Stephanie; Jackson, Jessica ... Molecular cell, 02/2020, Letnik: 77, Številka: 3
    Journal Article
    Recenzirano
    Odprti dostop

    Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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7.
  • Mechanisms of Replication S... Mechanisms of Replication Stress Response in BRCA-Deficient Cancers
    Cybulla, Emily 01/2022
    Dissertation

    DNA replication is essential for cell survival, and cancer cells employ diverse DNA damage tolerance mechanisms to cope with replication stress, including Translesion DNA Synthesis (TLS), Template ...
Celotno besedilo
8.
  • A RAD18–UBC13–PALB2–RNF168 ... A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells
    Cybulla, Emily; Wallace, Sierra; Meroni, Alice ... Nucleic acids research, 06/2024
    Journal Article
    Recenzirano
    Odprti dostop

    Abstract BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA breaks through homologous recombination and by protecting stalled replication forks from nucleolytic ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
9.
  • Entinostat, a selective HDA... Entinostat, a selective HDAC1/2 inhibitor, potentiates the effects of olaparib in homologous recombination proficient ovarian cancer
    Gupta, Vijayalaxmi G.; Hirst, Jeff; Petersen, Shariska ... Gynecologic oncology, 07/2021, Letnik: 162, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Poly ADP ribose polymerase inhibitors (PARPi) are most effective in BRCA1/2 mutated ovarian tumors. Better treatments are needed for homologous recombination HR-proficient cancer, including CCNE1 ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
10.
  • GAS6/AXL Inhibition Enhance... GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress
    Mullen, Mary M; Lomonosova, Elena; Toboni, Michael D ... Molecular cancer research, 02/2022, Letnik: 20, Številka: 2
    Journal Article
    Recenzirano
    Odprti dostop

    Over 80% of women with high-grade serous ovarian cancer (HGSOC) develop tumor resistance to chemotherapy and die of their disease. There are currently no FDA-approved agents to improve sensitivity to ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
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zadetkov: 12

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