A BSTRACT Objective: To study the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association of with microvascular complications and ventricular dysfunction in patients with type 2 ...diabetes mellitus (T2DM). Methods: In this cross-sectional study, 100 T2DM patients were screened randomly for detection of fatty liver in ultrasonography. Patients with fatty liver (NAFLD group, n = 36) were compared with subjects without fatty liver (non-NAFLD group, n = 64). Detailed clinical, biochemical, and imaging parameters like lipid profile, LFT, fasting plasma glucose, 2-hour post-prandial plasma glucose, HbA1C, fasting insulin, spot urinary albumin/creatinine ratio, and 2-D ECHO (M-mode) were performed. Results: The prevalence of NAFLD was found to be 36%. NAFLD group had significantly higher BMI, WHR, blood pressure, glycemic profile, and lipid parameters compared to non-NAFLD group. HOMA IR was elevated significantly in NAFLD group (3.16 ± 1.96) compared to non-NAFLD group (1.73 ± 1.59). There was significantly higher prevalence of all the diabetes-related microvascular complications and LV diastolic dysfunction in NAFLD patients with higher odds for the occurrence of neuropathy (OR = 4.74; P = 0.001), nephropathy (OR = 3.92; P = 0.003), retinopathy (OR = 5.95; P = 0.002), and LV diastolic dysfunction (OR = 1.84; P = 0.043). Conclusions: NAFLD is significantly associated with various diabetes-related microvascular complications as well as LV diastolic dysfunction in T2DM patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Diaphragm disease (DD) is a rare condition that is associated with the use of nonsteroidal anti-inflammatory drugs. It is characterized by multiple diaphragm-like septa that cause a narrowing of the ...small bowel lumen. The diagnosis of this disorder can be challenging due to its rarity and its non-specific symptoms, which often suggest other, more probable diseases. We report the case of a 16-year-old boy who presented with iron-deficiency anemia that did not respond to iron supplementation. Despite undergoing endoscopy and computed tomography (CT) enterography, the cause of his condition could not be identified. Capsule endoscopy was attempted, but due to technical difficulties, images could not be obtained. Two years later, the patient's symptoms persisted, prompting further investigation. CT enterography revealed a foreign body in the distal ileum, which was identified as the previously administered capsule. Diagnostic laparoscopy with intraoperative endoscopy was performed to retrieve the capsule. This procedure also revealed multiple short-segment strictures causing luminal narrowing and ulcerations. These were confirmed by histopathology to be lesions associated with DD.
Bronchobiliary fistula is a very rare entity that presents with bilioptysis. We present a noteworthy case involving a patient with portal cavernoma cholangiopathy complicated by cholangitis and ...bronchobiliary fistula. The diagnosis was established through high-resolution computed tomography of the thorax and bronchoscopic evaluation. Subsequently, the patient underwent endoscopic retrograde cholangiopancreatography with stenting of the common bile duct. Remarkably, the bronchobiliary fistula resolved 1 month after the procedure.
A case of tofacitinib induced mania Dalai, Dr Motij Kumar; Ingle, Dr Meghraj; Singh, Dr Gaurav ...
Psychiatry Research Case Reports,
June 2023, Letnik:
2, Številka:
1
Journal Article
Odprti dostop
Adverse drug reactions (ADRs) complicate the management of many diseases especially chronic conditions. Inflammatory bowel disease (IBD) frequently requires chronic immunosuppressive treatment and ...active involvement from patients during treatment decision making. Tofacitinib is a new drug used for induction and remission of moderate to severe ulcerative colitis. Common side effects associated with Tofacitinib are nasopharyngitis,reactivation of latent infection especially herpes zoster and hyperlipidemia. We report a rare case of acute mania after initiation of tofacitinib in a case of acute severe ulcerative colitis who was initially induced with intravenous steroid and was later switched to tofacitinib in view of no response to steroids. He developed behavioural abnormalities and mood swings affecting his day to day life. Literature in the field of affective disorder with use of tofacitinib is limited. Tough this relation of mania and use of tofacitinib is causal, adequate research in the field of psychiatric adverse drug reactions with tofacitinib needs to be done regarding its underlying mechanism and its temporal association as regards to dose and duration of use. Also,clinicians using JAK inhibitors should be aware of the possible neuropsychiatric side-effects which can lead to unnecessary workup.
