Context.
The dissipation of tidal inertial waves in planetary and stellar convective regions is one of the key mechanisms that drive the evolution of star–planet and planet–moon systems. This ...dissipation is particularly efficient for young low-mass stars and gaseous giant planets, which are rapid rotators. In this context, the interaction between tidal inertial waves and turbulent convective flows must be modelled in a realistic and robust way. In the state-of-the-art simulations, the friction applied by convection on tidal waves is commonly modeled as an effective eddy viscosity. This approach may be valid when the characteristic length scales of convective eddies are smaller than those of the tidal waves. However, it becomes highly questionable in the case where tidal waves interact with potentially stable large-scale vortices such as those observed at the poles of Jupiter and Saturn. The large-scale vortices are potentially triggered by convection in rapidly-rotating bodies in which the Coriolis acceleration forms the flow in columnar vortical structures along the direction of the rotation axis.
Aims.
We investigate the complex interactions between a tidal inertial wave and a columnar convective vortex.
Methods.
We used a quasi-geostrophic semi-analytical model of a convective columnar vortex, which is validated by numerical simulations. First, we carried out linear stability analysis using both numerical and asymptotic Wentzel–Kramers–Brillouin–Jeffreys (WKBJ) methods. We then conducted linear numerical simulations of the interactions between a convective columnar vortex and an incoming tidal inertial wave.
Results.
The vortex we consider is found to be centrifugally stable in the range –Ω
p
≤ Ω
0
≤ 3.62Ω
p
and unstable outside this range, where Ω
0
is the local rotation rate of the vortex at its center and Ω
p
is the global planetary (stellar) rotation rate. From the linear stability analysis, we find that this vortex is prone to centrifugal instability with perturbations with azimuthal wavenumbers
m
= {0,1, 2}, which potentially correspond to eccentricity, obliquity, and asynchronous tides, respectively. The modes with
m
> 2 are found to be neutral or stable. The WKBJ analysis provides analytic expressions of the dispersion relations for neutral and unstable modes when the axial (vertical) wavenumber is sufficiently large. We verify that in the unstable regime, an incoming tidal inertial wave triggers the growth of the most unstable mode of the vortex. This would lead to turbulent dissipation. For stable convective columns, the wave-vortex interaction leads to the mixing of momentum for tidal inertial waves while it creates a low-velocity region around the vortex core and a new wave-like perturbation in the form of a progressive wave radiating in the far field. The emission of this secondary wave is the strongest when the wavelength of the incoming wave is close to the characteristic size (radius) of the vortex. Incoming tidal waves can also experience complex angular momentum exchanges locally at critical layers of stable vortices.
Conclusions.
The interaction between tidal inertial waves and large-scale coherent convective vortices in rapidly-rotating planets (stars) leads to turbulent dissipation in the unstable regime and complex behaviors such as mixing of momentum and radiation of new waves in the far field or wave-vortex angular momentum exchanges in the stable regime. These phenomena cannot be modeled using a simple effective eddy viscosity.
Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning ...of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
3.
Feebly-interacting particles Carenza, Pierluca; Milstead, David A.; Wallisch, Benjamin
The European physical journal. C, Particles and fields,
12/2023, Letnik:
83, Številka:
12
Journal Article
Recenzirano
Odprti dostop
Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning ...of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning ...of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.
Prior studies suggest increased cytomegalovirus (CMV) infection after haploidentical donor transplantation with posttransplant cyclophosphamide (HaploCy). The role of allograft source and ...posttransplant cyclophosphamide (PTCy) in CMV infection is unclear. We analyzed the effect of graft source and PTCy on incidence of CMV infection, and effects of serostatus and CMV infection on transplant outcomes. We examined patients reported to the Center for International Blood and Marrow Transplantation Research between 2012 and 2017 who had received HaploCy (n = 757), matched related (Sib) with PTCy (SibCy, n = 403), or Sib with calcineurin inhibitor-based prophylaxis (SibCNI, n = 1605). Cumulative incidences of CMV infection by day 180 were 42%, 37%, and 23%, respectively (P < .001). CMV disease was statistically comparable. CMV infection risk was highest for CMV-seropositive recipients (R+), but significantly higher in PTCy recipients regardless of donor (HaploCy n = 545: hazard ratio HR, 50.3; SibCy n = 279: HR, 47.7; SibCNI n = 1065: HR, 24.4; P < .001). D+/R− patients also had increased risk for CMV infection. Among R+ or those developing CMV infection, HaploCy had worse overall survival and nonrelapse mortality. Relapse was unaffected by CMV infection or serostatus. PTCy was associated with lower chronic graft-versus-host disease (GVHD) overall, but CMV infection in PTCy recipients was associated with higher chronic GVHD (P = .006). PTCy, regardless of donor, is associated with higher incidence of CMV infection, augmenting the risk of seropositivity. Additionally, CMV infection may negate the chronic GVHD protection of PTCy. This study supports aggressive prevention strategies in all receiving PTCy.
•PTCy increased the risk of CMV infection in seropositive Haplo and Sib HCT recipients relative to Sib HCT with conventional GVHD prophylaxis.•CMV infection was associated with higher chronic GVHD in PTCy recipients, potentially negating the protective effect of PTCy.
Display omitted
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of hematopoietic cell transplantation (HCT) associated with significant morbidity and ...mortality. However, TA-TMA is a clinical diagnosis, and multiple criteria have been proposed without universal application. Although some patients have a self-resolving disease, others progress to multiorgan failure and/or death. Poor prognostic features also are not uniformly accepted. The lack of harmonization of diagnostic and prognostic markers has precluded multi-institutional studies to better understand incidence and outcomes. Even current interventional trials use different criteria, making it challenging to interpret the data. To address this urgent need, the American Society for Transplantation and Cellular Therapy, Center for International Bone Marrow Transplant Research, Asia-Pacific Blood and Marrow Transplantation, and European Society for Blood and Marrow Transplantation nominated representatives for an expert panel tasked with reaching consensus on diagnostic and prognostic criteria. The panel reviewed literature, generated consensus statements regarding diagnostic and prognostic features of TA-TMA using the Delphi method, and identified future directions of investigation. Consensus was reached on 4 key concepts: (1) TA-TMA can be diagnosed using clinical and laboratory criteria or tissue biopsy of kidney or gastrointestinal tissue; however, biopsy is not required; (2) consensus diagnostic criteria are proposed using the modified Jodele criteria with additional definitions of anemia and thrombocytopenia. TA-TMA is diagnosed when ≥4 of the following 7 features occur twice within 14 days: anemia, defined as failure to achieve transfusion independence despite neutrophil engraftment; hemoglobin decline by ≥1 g/dL or new-onset transfusion dependence; thrombocytopenia, defined as failure to achieve platelet engraftment, higher-than-expected transfusion needs, refractory to platelet transfusions, or ≥50% reduction in baseline platelet count after full platelet engraftment; lactate dehydrogenase (LDH) exceeding the upper limit of normal (ULN); schistocytes; hypertension; soluble C5b-9 (sC5b-9) exceeding the ULN; and proteinuria (≥1 mg/mg random urine protein-to-creatinine ratio rUPCR); (3) patients with any of the following features are at increased risk of nonrelapse mortality and should be stratified as high-risk TA-TMA: elevated sC5b-9, LDH ≥2 times the ULN, rUPCR ≥1 mg/mg, multiorgan dysfunction, concurrent grade II-IV acute graft-versus-host disease (GVHD), or infection (bacterial or viral); and (4) all allogeneic and pediatric autologous HCT recipients with neuroblastoma should be screened weekly for TA-TMA during the first 100 days post-HCT. Patients diagnosed with TA-TMA should be risk-stratified, and those with high-risk disease should be offered participation in a clinical trial for TA-TMA-directed therapy if available. We propose that these criteria and risk stratification features be used in data registries, prospective studies, and clinical practice across international settings. This harmonization will facilitate the investigation of TA-TMA across populations diverse in race, ethnicity, age, disease indications, and transplantation characteristics. As these criteria are widely used, we expect continued refinement as necessary. Efforts to identify more specific diagnostic and prognostic biomarkers are a top priority of the field. Finally, an investigation of the impact of TA-TMA-directed treatment, particularly in the setting of concurrent highly morbid complications, such as steroid-refractory GVHD and infection, is critically needed.
Display omitted
•A consensus panel of transplantation-associated thrombotic microangiopathy (TA-TMA) experts was convened by international hematopoietic cell transplantation societies.•Modified Jodele diagnostic criteria with definitions of cytopenia were agreed upon as standard.•TA-TMA should be stratified using high-risk features associated with death.•Elevated sC5b-9, lactate dehydrogenase, proteinuria, multiorgan dysfunction, and concurrent acute graft-versus-host disease/infection are high-risk features.
