The solar analogues 16 Cyg A and B are excellent asteroseismic targets in the Kepler field of view and together with a red dwarf and a Jovian planet form an interesting system. For these more evolved ...Sun-like stars we cannot detect surface rotation with the current Kepler data but instead use the technique of asteroseimology to determine rotational properties of both 16 Cyg A and B. We find the rotation periods to be ... and ..., and the angles of inclination to be ... and ..., for A and B, respectively. Together with these results we use the published mass and age to suggest that, under the assumption of a solar-like rotation profile, 16 Cyg A could be used when calibrating gyrochronology relations. In addition, we discuss the known 16 Cyg B star-planet eccentricity and measured low obliquity which is consistent with Kozai cycling and tidal theory. (ProQuest: ... denotes formulae/symbols omitted.)
In this study the origin, behaviour and fate of anthropogenic Pb in sandy roadside soils were assessed by measuring soil characteristics, Pb isotope composition and content. In 1991 and 2003 samples ...were taken at different depth intervals at approximately 8 and 75m from two highways in The Netherlands. The Pb isotope composition of the litter layer (206Pb/207Pb=1.12–1.14) differs from the deeper soil samples (206Pb/207Pb=1.20–1.21). Based on a mixing model it is concluded that the samples contain two Pb sources: natural Pb and anthropogenic Pb, the latter mainly derived from gasoline.
206Pb/207Pb ratios demonstrate that the roadside soils were polluted to a depth of ~15cm. Within this depth interval, anthropogenic Pb content is associated with organic matter. Although Pb pollution only reached a depth of ~15cm, this does not mean that the topsoils retain all anthropogenic Pb. Due to the low pH and negligible binding capacity of soils at depths >15cm, anthropogenic Pb migrated towards groundwater after reaching depths of >15cm. The Pb isotope composition of the groundwater (206Pb/207Pb=1.135–1.185) establishes that groundwater is polluted with anthropogenic Pb. The contribution of anthropogenic Pb to the groundwater varies between ~30 and 100%.
Based on the difference in soil Pb content and Pb isotope compositions over a period of 12years, downward Pb migration is calculated to vary from 72±95 to 324±279mgm−2y−1. Assuming that the downward Pb flux is constant over time, it is calculated that 35–90% of the atmospherically delivered Pb has migrated to the groundwater.
•Lead isotope composition of litter and topsoil differs from the deeper soil samples.•Litter and topsoil contain anthropogenic Pb, with gasoline Pb as main source.•Anthropogenic Pb is strongly associated with organic matter in litter and topsoil.•Approximately 35–90% of atmospherically derived Pb migrated to groundwater.•Migration is caused by low soil pH and lack of reactive phases in subsoil.
Context. We still do not understand which physical mechanisms are responsible for the transport of angular momentum inside stars. The recent detection of mixed modes that contain the clear signature ...of rotation in the spectra of Kepler subgiants and red giants gives us the opportunity to make progress on this question. Aims. Our aim is to probe the radial dependence of the rotation profiles for a sample of Kepler targets. For this purpose, subgiants and early red giants are particularly interesting targets because their rotational splittings are more sensitive to the rotation outside the deeper core than is the case for their more evolved counterparts. Methods. We first extracted the rotational splittings and frequencies of the modes for six young Kepler red giants. We then performed a seismic modeling of these stars using the evolutionary codes Cesam2k and astec. By using the observed splittings and the rotational kernels of the optimal models, we inverted the internal rotation profiles of the six stars. Results. We obtain estimates of the core rotation rates for these stars, and upper limits to the rotation in their convective envelope. We show that the rotation contrast between the core and the envelope increases during the subgiant branch. Our results also suggest that the core of subgiants spins up with time, while their envelope spins down. For two of the stars, we show that a discontinuous rotation profile with a deep discontinuity reproduces the observed splittings significantly better than a smooth rotation profile. Interestingly, the depths that are found to be most probable for the discontinuities roughly coincide with the location of the H-burning shell, which separates the layers that contract from those that expand. Conclusions. We characterized the differential rotation pattern of six young giants with a range of metallicities, and with both radiative and convective cores on the main sequence. This will bring observational constraints to the scenarios of angular momentum transport in stars. Moreover, if the existence of sharp gradients in the rotation profiles of young red giants is confirmed, it is expected to help in distinguishing between the physical processes that could transport angular momentum in the subgiant and red giant branches.
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug ...targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13355/full. G protein‐coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC‐IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR‐DB and GRAC and provides a permanent, citable, point‐in‐time record that will survive database updates.
RAVE stars in K2 Valentini, M; Chiappini, C; Davies, G R ...
Astronomy and astrophysics (Berlin),
4/2017, Letnik:
600
Journal Article
Recenzirano
Odprti dostop
We present a set of 87 RAVE stars with detected solar like oscillations, observed during Campaign 1 of the K2 mission (RAVE K2-C1 sample). This data set provides a useful benchmark for testing the ...gravities provided in RAVE data release 4 (DR4), and is key for the calibration of the RAVE data release 5 (DR5). The RAVE survey collected medium-resolution spectra (R= 7500) centred in the Ca II triplet(8600 A) wavelength interval, which although being very useful for determining radial velocity and metallicity, even at low S/N, is known be affected by a log(g)-T sub(eff) degeneracy. This degeneracy is the cause of the large spread in the RAVE DR4 gravities for giants. The understanding of the trends and offsets that affects RAVE atmospheric parameters, and in particular log(g), is a crucial step in obtaining not only improved abundance measurements, but also improved distances and ages. In the present work, we use two different pipelines, GAUFRE and Sp_Ace, to determine atmospheric parameters and abundances by fixing log(g) to the seismic one. Our strategy ensures highly consistent values among all stellar parameters, leading to more accurate chemical abundances. A comparison of the chemical abundances obtained here with and without the use of seismic log(g) information has shown that an underestimated (overestimated) gravity leads to an underestimated (overestimated) elemental abundance (e.g. Mg/H is underestimated by ~0.25 dex when the gravity is underestimated by 0.5 dex). We then perform a comparison between the seismic gravities and the spectroscopic gravities presented in the RAVE DR4 catalogue, extracting a calibration for log(g) of RAVE giants in the colour interval 0.50 < (J-K sub(S)) < 0.85. Finally, we show a comparison of the distances, temperatures, extinctions (and ages) derived here for our RAVE K2-C1 sample with those derived in RAVE DR4 and DR5. DR5 performs better than DR4 thanks to the seismic calibration, although discrepancies can still be important for objects for which the difference between DR4/DR5 and seismic gravities differ by more than ~0.5 dex. The method illustrated in this work will be used for analysing RAVE targets present in the other K2 campaigns, in the framework of Galactic Archaeology investigations.
Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell ...transplantation.
Oral cyclophosphamide, thalidomide, and dexamethasone was compared with infusional cyclophosphamide, vincristine, doxorubicin, and dexamethasone in patients with newly diagnosed multiple myeloma.
The post-induction overall response rate (≥ partial response) for the intent-to-treat population was significantly higher with cyclophosphamide-thalidomide-dexamethasone (n=555) versus cyclophosphamide-vincristine-doxorubicin-dexamethasone (n=556); 82.5% versus 71.2%; odds ratio 1.91; 95% confidence interval 1.44-2.55; P<0.0001. The complete response rates were 13.0% with cyclophosphamide-thalidomide-dexamethasone and 8.1% with cyclophos-phamide-vincristine-doxorubicin-dexamethasone (P=0.0083), with this differential response being maintained in patients who received autologous stem-cell transplantation (post-transplant complete response 50.0% versus 37.2%, respectively; P=0.00052). Cyclophosphamide-thalidomide-dexamethasone was non-inferior to cyclophosphamide-vincristine-doxorubicin-dexamethasone for progression-free and overall survival, and there was a trend toward a late survival benefit with cyclophosphamide-thalidomide-dexamethasone in responders. A trend toward an overall survival advantage for cyclophosphamide-thalidomide-dexamethasone over cyclophosphamide-vincristine-doxorubicin-dexamethasone was also observed in a subgroup of patients with favorable interphase fluorescence in situ hybridization. Compared with cyclophosphamide-vincristine-doxorubicin-dexamethasone, cyclophosphamide-thalidomide-dexamethasone was associated with more constipation and somnolence, but a lower incidence of cytopenias.
The cyclophosphamide-thalidomide-dexamethasone regimen showed improved response rates and was not inferior in terms of survival outcomes to the standard infusional regimen of cyclophosphamide-vincristine-doxorubicin-dexamethasone. Based on its oral administration and the reduced incidence of infection and cytopenia, cyclophosphamide-thalidomide-dexa-methasone may be considered an effective induction therapy option for patients with newly diagnosed multiple myeloma. (ISRCTN: 68454111).
ABSTRACT We study the dynamics of the stellar interior of the early red-giant star KIC 4448777 by asteroseismic inversion of 14 splittings of the dipole mixed modes obtained from Kepler observations. ...In order to overcome the complexity of the oscillation pattern typical of red-giant stars, we present a procedure to extract the rotational splittings from the power spectrum. We find not only that the core rotates from a minimum of 8 to a maximum of 17 times faster than the surface, confirming previous inversion results generated for other red giants (Deheuvels et al.), but we also estimate the variation of the angular velocity within the helium core with a spatial resolution of 0.001R and verify the hypothesis of a sharp discontinuity in the inner stellar rotation. The results show that the entire core rotates rigidly and provide evidence for an angular velocity gradient around the base of the hydrogen-burning shell; however, we do not succeed in characterizing the rotational slope, due to the intrinsic limits of the applied techniques. The angular velocity, from the edge of the core, appears to decrease with increasing distance from the center, reaching an average value in the convective envelope of 68 22 nHz. We conclude that a set of data that includes only dipolar modes is sufficient to infer quite accurately the rotation of a red giant not only in the dense core but also, with a lower level of confidence, in part of the radiative region and in the convective envelope.
Rotation is expected to have an important influence on the structure and the evolution of stars. However, the mechanisms of angular momentum transport in stars remain theoretically uncertain and very ...complex to take into account in stellar models. To achieve a better understanding of these processes, we desperately need observational constraints on the internal rotation of stars, which until very recently was restricted to the Sun. In this paper, we report the detection of mixed modes-i.e., modes that behave both as g modes in the core and as p modes in the envelope-in the spectrum of the early red giant KIC 7341231, which was observed during one year with the Kepler spacecraft. By performing an analysis of the oscillation spectrum of the star, we show that its non-radial modes are clearly split by stellar rotation and we are able to determine precisely the rotational splittings of 18 modes. We then find a stellar model that reproduces very well the observed atmospheric and seismic properties of the star. We use this model to perform inversions of the internal rotation profile of the star, which enables us to show that the core of the star is rotating at least five times faster than the envelope. This will shed new light on the processes of transport of angular momentum in stars. In particular, this result can be used to place constraints on the angular momentum coupling between the core and the envelope of early red giants, which could help us discriminate between the theories that have been proposed over the last few decades.
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug ...targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13350/full. Voltage‐gated ion channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ligand‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC‐IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR‐DB and GRAC and provides a permanent, citable, point‐in‐time record that will survive database updates.
ABSTRACT Data Release 5 (DR5) of the Radial Velocity Experiment (RAVE) is the fifth data release from a magnitude-limited ( ) survey of stars randomly selected in the Southern Hemisphere. The RAVE ...medium-resolution spectra ( ) covering the Ca-triplet region (8410-8795 ) span the complete time frame from the start of RAVE observations in 2003 to their completion in 2013. Radial velocities from 520,781 spectra of 457,588 unique stars are presented, of which 255,922 stellar observations have parallaxes and proper motions from the Tycho-Gaia astrometric solution in Gaia DR1. For our main DR5 catalog, stellar parameters (effective temperature, surface gravity, and overall metallicity) are computed using the RAVE DR4 stellar pipeline, but calibrated using recent K2 Campaign 1 seismic gravities and Gaia benchmark stars, as well as results obtained from high-resolution studies. Also included are temperatures from the Infrared Flux Method, and we provide a catalog of red giant stars in the dereddened color interval (0.50, 0.85) for which the gravities were calibrated based only on seismology. Further data products for subsamples of the RAVE stars include individual abundances for Mg, Al, Si, Ca, Ti, Fe, and Ni, and distances found using isochrones. Each RAVE spectrum is complemented by an error spectrum, which has been used to determine uncertainties on the parameters. The data can be accessed via the RAVE Web site or the VizieR database.
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