Dementia associated with the Alzheimer's disease is thought to be correlated with the conversion of the β - Amyloid (Aβ) peptides from soluble monomers to aggregated oligomers and insoluble fibrils. ...We present a discrete-time mathematical model for the aggregation of Aβ monomers into oligomers using concepts from chemical kinetics and population dynamics. Conditions for the stability and instability of the equilibria of the model are established. A formula for the number of monomers that is required for producing oligomers is also given. This may provide compound designers a mechanism to inhibit the Aβ aggregation.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
We examine the production of energetic neutral atoms (ENAs) in solar flares and coronal mass ejection (CME)-driven shocks and their subsequent propagation to 1 au. Time profiles and fluence ...spectra of solar ENAs at 1 au are computed for two scenarios: (1) ENAs are produced downstream at CME-driven shocks, and (2) ENAs are produced at large-scale post-flare loops in solar flares. Both the time profiles and fluence spectra for these two scenarios are vastly different. Our calculations indicate that we can use solar ENAs as a new probe to examine the underlying acceleration process of solar energetic particles (SEPs) and to differentiate the two acceleration sites: large loops in solar flares and downstream of CME-driven shocks, in large SEP events.
Abstract
Extreme-ultraviolet (EUV) images of the Sun are becoming an integral part of space weather prediction tasks. However, having different surveys requires the development of instrument-specific ...prediction algorithms. As an alternative, it is possible to combine multiple surveys to create a homogeneous data set. In this study, we utilize the temporal overlap of Solar and Heliospheric Observatory Extreme ultraviolet Imaging Telescope and Solar Dynamics Observatory Atmospheric Imaging Assembly 171 Å surveys to train an ensemble of deep-learning models for creating a single homogeneous survey of EUV images for two solar cycles. Prior applications of deep learning have focused on validating the homogeneity of the output while overlooking the systematic estimation of uncertainty. We use an approach called “approximate Bayesian ensembling” to generate an ensemble of models whose uncertainty mimics that of a fully Bayesian neural network at a fraction of the cost. We find that ensemble uncertainty goes down as the training set size increases. Additionally, we show that the model ensemble adds immense value to the prediction by showing higher uncertainty in test data that are not well represented in the training data.
Abstract
We report on the annual variation of quiet-time suprathermal ion composition for C through Fe using Advanced Composition Explorer (ACE)/Ultra-Low Energy Isotope Spectrometer data over the ...energy range 0.3–1.28 MeV nuc
−1
from 1998 through 2019, covering solar cycle 23's rising phase through Solar Cycle 24's declining phase. Our findings are: (1) quiet-time suprathermal abundances resemble CIR-associated particles during solar minima; (2) quiet-time suprathermals are M/Q fractionated in a manner that is consistent with M/Q fractionation in large gradual solar energetic particle events (GSEP) during solar maxima; and (3) variability within the quiet-time suprathermal pool increases as a function of M/Q and is consistent with the analogous variability in GSEP events. From these observations, we infer that quiet-time suprathermal ions are remnants of CIRs in solar minima and GSEP events in solar maxima. Coincident with these results, we also unexpectedly show that S behaves like a low FIP ion in the suprathermal regime, and is therefore drawn from low FIP solar sources.
An outstanding problem in heliospheric physics is understanding the acceleration of solar energetic particles (SEPs) in coronal mass ejections (CMEs) and flares. A fundamental question is whether the ...acceleration occurs in interplanetary space or near the Sun. Recent work has shown that CME-driven shocks may produce SEPs while still below five solar radii. In this work we explore SEP acceleration during the onset of CMEs and shocks even lower in the corona, using realistic suprathermal spectra, for a selection of events. We have calculated quiet-time, pre-event suprathermal particle spectra from 1 au observations, and scaled them back to the low corona to serve as seed spectra. For each event, AIA observations and the CASHeW framework were used to model the compressive/shock wave kinematics and its interaction with the corona. The proton acceleration was then modeled using an analytic diffusive shock acceleration model as the shock waves propagate between ∼1.05 and ∼1.3 solar radii. We demonstrate the capability of low coronal shock-related extreme ultraviolet waves to accelerate protons to multi-MeV energies in a matter of minutes, in the very early stages of the associated solar eruptions. We find that strong proton energization occurs for high values of the density jump, Alfvén Mach number, and shock speed. In future work the results of this early-stage shock acceleration will be used to model the continued acceleration higher in the corona.
Abstract We report on the annual variation of quiet-time suprathermal heavy ion spectral indices for C through Fe in the energy range 0.3–1.28 MeV nuc −1 during Solar Cycle 23's rising phase through ...Solar Cycle 24's declining phase. These Advanced Composition Explorer/Ultra-Low Energy Isotope Spectrometer measurements cover 1998–2019. We show that the average quiet-time suprathermal spectral index across species is γ = 2.5 ± 0.3. Such observations may imply that quiet-time suprathermals are the result of a superposition of various underlying acceleration and transport processes that accelerate suprathermal ions. As such, they may be remnants of particles from discrete events like large and impulsive solar energetic particle events along with corotating interaction regions that have decayed in intensity.
The densities of three ion species in the Martian upper atmosphere were compared during the MY33 and MY34 Martian regional and global dust storms (RDS 2016 and GDS 2018, respectively) using data from ...the neutral gas and ion mass spectrometer of the Mars atmosphere and volatile evolution mission. The trends of the ion species and their relative abundances in altitudes compared to some neutral species were examined from 10 September–4 October 2016 and 27 May–18 June 2018, at altitudes of 160–240 km. Both RDS 2016 and GDS 2018 caused variations in the ion species abundance of the upper atmosphere at their onsets in 18–21 September 2016 and 5–8 June 2018 respectively. The densities of O2+, CO2+, and O+ increased during RDS 2016. Meanwhile, O2+ and O+ densities decreased and CO2+ density increased during GDS 2018. Ion species’ relative abundances indicate that during RDS 2016, the increase in O2+ density may be caused by the increase of CO2+ or O+ densities rather than the increase of O or CO2 densities. Meanwhile, the decrease in O2+ density during GDS 2018 may be caused by the decrease of O or O+ densities rather than the decrease in CO2+ or CO2 densities.
Astronauts will encounter extended exposure to galactic cosmic radiation (GCR) during deep space exploration, which could impair brain function. Here, we report that in male mice, acute or chronic ...GCR exposure did not modify reward sensitivity but did adversely affect attentional processes and increased reaction times. Potassium (K+)-stimulation in the prefrontal cortex (PFC) elevated dopamine (DA) but abolished temporal DA responsiveness after acute and chronic GCR exposure. Unlike acute GCR, chronic GCR increased levels of all other neurotransmitters, with differences evident between groups after higher K+-stimulation. Correlational and machine learning analysis showed that acute and chronic GCR exposure differentially reorganized the connection strength and causation of DA and other PFC neurotransmitter networks compared to controls which may explain space radiation-induced neurocognitive deficits.
Abstract
Measuring energetic neutral atoms (ENAs) allows for the remote observation of ion populations from the frontiers of our heliosphere. In this study, we compare the ENAs observed with the ...IBEX-Lo instrument onboard the Interstellar Boundary Explorer with ENA predictions from two heliosphere models. In contrast to previous studies, this paper presents model-data comparisons for the energy range 50 eV–2 keV over one full solar cycle not only in the upwind direction (Voyager 1 and Voyager 2 sky directions), but also for the north pole, south pole, port tail lobe, and downwind directions. The two heliosphere models produce the same basic result: there is a large gap (1 to 2 orders of magnitude in ENA intensity at 100 eV) between ENA data and model predictions between 100 and 500 eV for all sky directions. The reason for this gap is not understood yet. While some explanations are plausible and will be investigated in future studies, other explanations are excluded.
It has been noted that in large solar energetic particle (SEP) events, the peak intensities show an East-West asymmetry with respect to the source flare locations. Using the 2D improved Particle ...Acceleration and Transport in the Heliosphere (iPATH) model, we investigate the origin of this longitudinal trend. We consider multiple cases with different solar wind speeds and eruption speeds of the coronal mass ejections (CMEs) and fit the longitudinal distributions of time-averaged fluence by symmetric/asymmetric Gaussian functions with three time intervals of 8, 24 and 48 hr after the flare onset time respectively. The simulation results are compared with a statistical study of three-spacecraft events. We suggest that the East-West asymmetry of SEP fluence and peak intensity can be primarily caused the combined effect of an extended shock acceleration process and the evolution of magnetic field connection to the shock front. Our simulations show that the solar wind speed and the CME speed are important factors determining the East-West fluence asymmetry.
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