Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts Safatle, Angélica M.V.(Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de Cirurgia); Hvenegaard, Ana Paula(Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de Cirurgia); Otsuki, Denise(USP Faculdade de Medicina) ...
Pesquisa Veterinária Brasileira,
12/2010, Letnik:
30, Številka:
12
Journal Article
Recenzirano
Odprti dostop
Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the ...electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs.
Catarata madura e hipermadura, alteração frequentemente observada em cães, impossibilita a visibilização do fundo do olho e provável diagnóstico de degenerações retinianas. Objetivou-se comparar as respostas retiniana de cães diabéticos e não diabéticos, ambos portadores de catarata madura ou hipermadura, com auxílio do eletrorretinograma de campo total, utilizando o protocolo da International Society for Clinical Electrophysiology of Vision. Sessenta e seis cães, com idades variando entre 6 a 15 anos de idade foram divididos em dois grupos: (1) CG, cães não diabéticos com catarata madura ou hipermadura e (2) DG, cães diabéticos com catarata madura ou hipermadura. Mensurou-se amplitude pico a pico (microvolts) e tempo de culminação da onda-b (milisegundos) para as cinco respostas do ERG (resposta de bastonetes, máxima resposta, potencial oscilatório, resposta de cones e flicker a 30Hz). Avaliando-se as respostas obtidas com o exame, o grupo de cães diabéticos apresentou menor amplitude e maior tempo de culminação da onda-b em todas as respostas. O aumento do tempo de culminação da onda-b em DG foi estatisticamente significante (p<0.05) no flicker a 30 Hz (24.0ms versus 22.4ms). ERG de campo total é capaz de registrar alterações em respostas sensíveis como o tempo de culminação da onda-b do flicker, podendo ser útil para investigar retinopatias em cães diabéticos.
The DFT method has become a promising alternative in the support of traditional NMR experimental techniques, comparing experimental data with theoretical data, thereby achieving accurate and ...satisfactory results. In the present study, the experimental data of two diterpenes were compared to the theoretical data obtained by the GIAO method, applying DFT at the B3LYP/cc-pVDZ and B3PW91/DGDZVP levels to verify the degree of correlation, significance and predictability of the models obtained with the purpose of proving which of the computational methods is the most efficient for this class of substances. The theoretical NMR values obtained at B3LYP/cc-pVDZ were the more satisfactory, showing better linear correlations, presenting greater degrees of adjustments, significance and predictability compared to the B3PW91/DGDZVP method. Thus, these values were used to define H? and H? 1, 2, 3, 6 and 7 for diterpene 1 and 1, 2, 3, 6 and 7 for diterpene 2, which was not possible using experimental data. This showed that the quantum method used could help in the structural elucidation of natural products.
nema
With the crescent rates of HIV infection within female population in reproductive age, we may observe a correspondent increase in congenital infections. Thus, the obstetric nurse must be updated to ...participate and to develop programs of pre-natal care for HIV pregnant women. The purpose of this study was to review the pre-natal follow-up of this population regarding nursing care. Authors did not intend to approach all aspects of this subject, especially considering that investigations extend the great improvements already achieved since the acknowledge of the disease.
The present work shows an antinociceptive and dose-dependent effect of shark cartilage hydrosoluble fraction (HF) on writhing and formalin tests in mice. The effect was not altered by thalidomide, a ...known inhibitor of tumor necrosis factor-alfa (TNF-alfa) synthesis. Similarly, the antinosiceptive effect did not change in the presence of naloxone, indicating that the opioid system is not involved. However, the effect observed was blocked by L-arginine, a NO synthesis substrate, and it was potentiated by L-NAME, suggesting a role of the NO system in the shark cartilage antinociceptive effect. Effects similar to those seen with the HF were detected with peak II from gel filtration chromatography. The increase in vascular permeability induced by serotonin in rats was significantly abolished by the HF at the dose of 2 mg/kg, p.o., and again it was not potentiated by thalidomide. The observed blockade in the vascular permeability increase induced by histamine was detected only with a higher dose (10 mg/kg, p.o.).
Estudios previos han sugerido que el tejido adiposo epicárdico (TAE) podría ejercer un efecto paracrino en el miocardio. Sin embargo, pocos estudios han evaluado su papel en el riesgo de recurrencia ...de la fibrilación auricular (FA). El objetivo de ese estudio fue evaluar la asociación entre el volumen de TAE y su atenuación con el riesgo de recurrencia de FA tras la ablación de FA.
Se incluyó un total de 350 pacientes consecutivos sometidos a ablación de FA - mediana de edad 57 años RIC 48-65, 21% FA persistente. La grasa epicárdica se cuantificó mediante tomografía computarizada multidetector utilizando el software Syngo.via Frontier-Cardiac Risk Assessment, midiendo el volumen tejido adiposo pericárdico (VTAP), el volumen de TAE y la atenuación de TAE posterior a la aurícula izquierda. La recurrencia de FA se definió como cualquier episodio documentado de FA, aleteo auricular, o taquicardia auricular más de 3 meses después del procedimiento.
Tras una mediana de seguimiento de 34 meses rango de 12 a 57 meses, 114 pacientes (33%) tuvieron recurrencia de FA. La regresión de Cox univariable mostró que los pacientes con un volumen de TAE ≥ 80ml tenían un mayor riesgo de recurrencia de FA (HR=1,65; IC95%, 1,14-2,39; p=0,007). Sin embargo, después del ajuste multivariable, el volumen de TAE no fue un predictor independiente de recurrencia de FA (HR=1,24; IC95%, 0,83-1,87; p=0,3). Se observaron resultados similares con VTAP. Los pacientes con menor atenuación de TAE no tenían un mayor riesgo de recurrencia de FA (prueba de rango logarítmico p=0,75).
Los parámetros de TAE, incluida la evaluación del volumen de TAE, VTAP y la atenuación de TAE, no fueron predictores independientes de recurrencia de FA después de la ablación con catéter.
Previous studies have suggested that epicardial adipose tissue (EAT) could exert a paracrine effect in the myocardium. However, few studies have assessed its role in the risk of atrial fibrillation (AF) recurrence. This study aimed to evaluate the association between EAT volume, and its attenuation, with the risk of AF recurrence after AF ablation.
A total of 350 consecutive patients who underwent AF ablation were included. The median age was 57 IQR 48-65 years and 21% had persistent AF. Epicardial fat was quantified by multidetector computed tomography using Syngo.via Frontier-Cardiac Risk Assessment software, measuring pericardial fat volume (PATV), EAT volume, and attenuation of EAT posterior to the left atrium. AF recurrence was defined as any documented episode of AF, atrial flutter, or atrial tachycardia more than 3 months after the procedure.
After a median follow-up of 34 range, 12-57 months, 114 patients (33%) had AF recurrence. Univariable Cox regression showed that patients with an EAT volume ≥ 80mL had an increased risk of AF recurrence (HR, 1.65; 95%CI, 1.14-2.39; P=.007). However, after multivariable adjustment, EAT volume did not remain an independent predictor of AF recurrence (HR, 1.24; 95%CI, 0.83-1.87; P=.3). Similar results were observed with PATV. Patients with lower attenuation of EAT did not have a higher risk of AF recurrence (log-rank test, P=.75).
EAT parameters including the evaluation of EAT volume, PATV and EAT attenuation were not independent predictors of AF recurrence after catheter ablation.
55 Cnc e is a transiting super-Earth (radius \(1.88\rm\,R_\oplus\) and mass \(8\rm\, M_\oplus\)) orbiting a G8V host star on a 17-hour orbit. Spitzer observations of the planet's phase curve at 4.5 ...\(\mu\)m revealed a time-varying occultation depth, and MOST optical observations are consistent with a time-varying phase curve amplitude and phase offset of maximum light. Both broadband and high-resolution spectroscopic analyses are consistent with either a high mean molecular weight atmosphere or no atmosphere for planet e. A long term photometric monitoring campaign on an independent optical telescope is needed to probe the variability in this system. We seek to measure the phase variations of 55 Cnc e with a broadband optical filter with the 30 cm effective aperture space telescope CHEOPS and explore how the precision photometry narrows down the range of possible scenarios. We observed 55 Cnc for 1.6 orbital phases in March of 2020. We designed a phase curve detrending toolkit for CHEOPS photometry which allows us to study the underlying flux variations of the 55 Cnc system. We detected a phase variation with a full-amplitude of \(72 \pm 7\) ppm but do not detect a significant secondary eclipse of the planet. The shape of the phase variation resembles that of a piecewise-Lambertian, however the non-detection of the planetary secondary eclipse, and the large amplitude of the variations exclude reflection from the planetary surface as a possible origin of the observed phase variations. They are also likely incompatible with magnetospheric interactions between the star and planet but may imply that circumplanetary or circumstellar material modulate the flux of the system. Further precision photometry of 55 Cnc from CHEOPS will measure variations in the phase curve amplitude and shape over time this year.
Liver biopsy in ragwort poisoning Lombardo de Barros, C S; Castilhos, L M; Dos Santos, M N
Veterinary record,
10/1987, Letnik:
121, Številka:
16
Journal Article
Measuring entrance exposures to diagnostic or therapeutic radiology patients is valuable to infer dose distributions within their bodies in order to minimize unnecessary exposures. For this purpose, ...we investigated the development of dosimeters consisting of waterproof, transparent, and flexible films containing OSL microcrystals. In our method, films are produced by casting solutions, followed by solvent evaporation. Non-aggressive chemicals are used, which allows the production of films containing large quantities of crystals without altering their structure. In this proof of principle study, we chose polyvinyl chloride (PVC) as a polymer matrix due to its high transparency and its waterproof nature and we produced films loaded with microcrystals of CaF2:Ce. A mixture of acetone:benzene (40:60 wt%) was selected as the best solvent for producing PVC films loaded with CaF2:Ce crystals. This solvent offers ease of handling, low toxicity, low cost, and does not affect the crystal structure nor its OSL emission. The PVC films can be loaded with any luminescent material. For proof of concept we chose to load them with CaF2:Ce micron sized particles because they emit an intense OSL signal for a low beta dose of 100 mGy, showing very good sensitivity for dosimetric applications. Our results indicate that films loaded with OSL crystals may be suitable for the production of a novel OSL dosimeter, which adheres closely to the body and could be used during a radiological procedure to estimate the entrance dose. As OSL materials are sensitive to light, somehow the films would have to be shielded from light for dosimetric purposes.
•PVC films loaded with OSL crystals may be suitable for the production of novel 2D-OSL dosimeter.•Waterproof, transparent, and flexible films containing OSL microcrystals were developed.•Dosimetric films are produced by casting solutions, followed by solvent evaporation.
We report on precise Doppler measurements of L231-32 (TOI-270), a nearby M dwarf (\(d=22\) pc, \(M_\star = 0.39\) M\(_\odot\), \(R_\star = 0.38\) R\(_\odot\)), which hosts three transiting planets ...that were recently discovered using data from the Transiting Exoplanet Survey Satellite (TESS). The three planets are 1.2, 2.4, and 2.1 times the size of Earth and have orbital periods of 3.4, 5.7, and 11.4 days. We obtained 29 high-resolution optical spectra with the newly commissioned Echelle Spectrograph for Rocky Exoplanet and Stable Spectroscopic Observations (ESPRESSO) and 58 spectra using the High Accuracy Radial velocity Planet Searcher (HARPS). From these observations, we find the masses of the planets to be \(1.58 \pm 0.26\), \(6.15 \pm 0.37\), and \(4.78 \pm 0.43\) M\(_\oplus\), respectively. The combination of radius and mass measurements suggests that the innermost planet has a rocky composition similar to that of Earth, while the outer two planets have lower densities. Thus, the inner planet and the outer planets are on opposite sides of the `radius valley' -- a region in the radius-period diagram with relatively few members, which has been interpreted as a consequence of atmospheric photo-evaporation. We place these findings into the context of other small close-in planets orbiting M dwarf stars, and use support vector machines to determine the location and slope of the M dwarf (\(T_\mathrm{eff} < 4000\) K) radius valley as a function of orbital period. We compare the location of the M dwarf radius valley to the radius valley observed for FGK stars, and find that its location is a good match to photo-evaporation and core-powered mass loss models. Finally, we show that planets below the M dwarf radius valley have compositions consistent with stripped rocky cores, whereas most planets above have a lower density consistent with the presence of a H-He atmosphere.
We use a sample of 149 spectroscopically confirmed UV-selected galaxies at \(z\sim 2\) to investigate the relative dust attenuation of the stellar continuum and the nebular emission lines. For each ...galaxy in the sample, at least one rest-frame optical emission line (H\(\alpha\)/NII\(\lambda6583\) or OIII\(\lambda5007\)) measurement has been taken from the litterature, and 41 galaxies have additional Spitzer/MIPS 24\(\mu\)m observations that are used to infer infrared luminosities. We use a spectral energy distribution (SED) fitting code that predicts nebular line strengths when fitting the stellar populations of galaxies in our sample, and we perform comparisons between the predictions of our models and the observed/derived physical quantities. We find that on average our code is able to reproduce all the physical quantities (e.g., UV \(\beta\) slopes, infrared luminosities, emission line fluxes), but we need to apply a higher dust correction to the nebular emission compared to the stellar emission for the largest SFR (\(\log\mathrm{(SFR/M}_\odot\mathrm{yr}^{-1})>1.87\), Salpeter IMF). We find a correlation between SFR and the difference in nebular and stellar color excesses, which could resolve the discrepant results regarding nebular dust correction at \(z\sim2\) from previous results.
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