Abstract
Aims
Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in ...associations between various heart disease subtypes and in-hospital mortality.
Methods and results
We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66–75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%; n = 1545 vs. 15.9%; n = 1797). However, following multivariable adjustment, this difference was not significant adjusted risk ratio (aRR) 1.08, 95% confidence interval (CI) 1.02–1.15; P = 0.12 (corrected for multiple testing). Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure (aRR 1.19, 95% CI 1.10–1.30; P < 0.018) particularly for severe (New York Heart Association class III/IV) heart failure (aRR 1.41, 95% CI 1.20–1.64; P < 0.018). None of the other heart disease subtypes, including ischaemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in <1% of patients.
Conclusion
Considerable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare during hospitalization.
Graphical Abstract
Graphical Abstract
After multivariable adjustment, the strongest association was found for heart failure and in-hospital mortality (aRR 1.19, 95% CI 1.10–1.30; P < 0.018 and in particular for severe (NYHA class III/IV) heart failure (aRR 1.41, 95% CI 1.20–1.64; P < 0.018). For the other heart disease subtypes, including ischaemic heart disease, no significant associations with in-hospital mortality were found after correction for multiple testing. BMI = body mass index; NYHA = New York Heart Association; PAD = peripheral arterial disease. *Significant after correcting for multiple testing.
Neutral pion and Formula omitted meson invariant differential yields were measured in non-single diffractive p-Pb collisions at Formula omitted = 5.02 TeV with the ALICE experiment at the CERN LHC. ...The analysis combines results from three complementary photon measurements, utilizing the PHOS and EMCal calorimeters and the Photon Conversion Method. The invariant differential yields of Formula omitted and Formula omitted meson inclusive production are measured near mid-rapidity in a broad transverse momentum range of Formula omitted and Formula omitted, respectively. The measured Formula omitted ratio increases with Formula omitted and saturates for Formula omitted > 4 Formula omitted at Formula omitted. A deviation from Formula omitted scaling is observed for Formula omitted 2 Formula omitted. The measured Formula omitted ratio is consistent with previous measurements from proton-nucleus and pp collisions over the full Formula omitted range. The measured Formula omitted ratio at high Formula omitted also agrees within uncertainties with measurements from nucleus-nucleus collisions. The Formula omitted and Formula omitted yields in p-Pb relative to the scaled pp interpolated reference, Formula omitted, are presented for Formula omitted 20 Formula omitted and Formula omitted 20 Formula omitted, respectively. The results are compared with theoretical model calculations. The values of Formula omitted are consistent with unity for transverse momenta above 2 Formula omitted. These results support the interpretation that the suppressed yield of neutral mesons measured in Pb-Pb collisions at LHC energies is due to parton energy loss in the hot QCD medium.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We report on the measurement of the inclusive J/ Formula omitted polarization parameters in pp collisions at a center of mass energy Formula omitted TeV with the ALICE detector at the LHC. The ...analysis is based on a data sample corresponding to an integrated luminosity of 1.23 pb Formula omitted. J/ Formula omitted resonances are reconstructed in their di-muon decay channel in the rapidity interval Formula omitted and over the transverse-momentum interval Formula omitted Formula omitted. The three polarization parameters ( Formula omitted, Formula omitted, Formula omitted) are measured as a function of Formula omitted both in the helicity and Collins-Soper reference frames. The measured J/ Formula omitted polarization parameters are found to be compatible with zero within uncertainties, contrary to expectations from all available predictions. The results are compared with the measurement in pp collisions at Formula omitted TeV.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Formula omitted meson measurements provide insight into strangeness production, which is one of the key observables for the hot medium formed in high-energy heavy-ion collisions. ALICE measured ...Formula omitted production through its decay in muon pairs in Pb-Pb collisions at Formula omitted TeV in the intermediate transverse momentum range Formula omitted GeV/c and in the rapidity interval Formula omitted. The Formula omitted yield was measured as a function of the transverse momentum and collision centrality. The nuclear modification factor was obtained as a function of the average number of participating nucleons. Results were compared with the ones obtained via the kaon decay channel in the same Formula omitted range at midrapidity. The values of the nuclear modification factor in the two rapidity regions are in agreement within uncertainties.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A measurement of beauty hadron production at mid-rapidity in proton-lead collisions at a nucleon–nucleon centre-of-mass energy sNN=5.02 TeV is presented. The semi-inclusive decay channel of beauty ...hadrons into J/ψ is considered, where the J/ψ mesons are reconstructed in the dielectron decay channel at mid-rapidity down to transverse momenta of 1.3 GeV/c. The bb¯ production cross section at mid-rapidity, dσbb¯/dy, and the total cross section extrapolated over full phase space, σbb¯, are obtained. This measurement is combined with results on inclusive J/ψ production to determine the prompt J/ψ cross sections. The results in p–Pb collisions are then scaled to expectations from pp collisions at the same centre-of-mass energy to derive the nuclear modification factor RpPb, and compared to models to study possible nuclear modifications of the production induced by cold nuclear matter effects. RpPb is found to be smaller than unity at low pT for both J/ψ coming from beauty hadron decays and prompt J/ψ.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We present results on transverse momentum (Formula: see text) and rapidity (Formula: see text) differential production cross sections, mean transverse momentum and mean transverse momentum square of ...inclusive Formula: see text and Formula: see text at forward rapidity (Formula: see text) as well as Formula: see text-to-Formula: see text cross section ratios. These quantities are measured in pp collisions at center of mass energies Formula: see text and 13 TeV with the ALICE detector. Both charmonium states are reconstructed in the dimuon decay channel, using the muon spectrometer. A comprehensive comparison to inclusive charmonium cross sections measured at Formula: see text, 7 and 8 TeV is performed. A comparison to non-relativistic quantum chromodynamics and fixed-order next-to-leading logarithm calculations, which describe prompt and non-prompt charmonium production respectively, is also presented. A good description of the data is obtained over the full Formula: see text range, provided that both contributions are summed. In particular, it is found that for Formula: see text GeV/
the non-prompt contribution reaches up to 50% of the total charmonium yield.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Two-particle angular correlations were measured in pp collisions at Formula omitted TeV for pions, kaons, protons, and lambdas, for all particle/anti-particle combinations in the pair. Data for ...mesons exhibit an expected peak dominated by effects associated with mini-jets and are well reproduced by general purpose Monte Carlo generators. However, for baryon-baryon and anti-baryon-anti-baryon pairs, where both particles have the same baryon number, a near-side anti-correlation structure is observed instead of a peak. This effect is interpreted in the context of baryon production mechanisms in the fragmentation process. It currently presents a challenge to Monte Carlo models and its origin remains an open question.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The invariant differential cross sections for inclusive Formula: see text and Formula: see text mesons at midrapidity were measured in pp collisions at Formula: see text TeV for transverse momenta ...Formula: see text GeV/
and Formula: see text GeV/
, respectively, using the ALICE detector. This large range in Formula: see text was achieved by combining various analysis techniques and different triggers involving the electromagnetic calorimeter (EMCal). In particular, a new single-cluster, shower-shape based method was developed for the identification of high-Formula: see text neutral pions, which exploits that the showers originating from their decay photons overlap in the EMCal. Above 4 GeV/Formula: see text, the measured cross sections are found to exhibit a similar power-law behavior with an exponent of about 6.3. Next-to-leading-order perturbative QCD calculations differ from the measured cross sections by about 30% for the Formula: see text, and between 30-50% for the Formula: see text meson, while generator-level simulations with PYTHIA 8.2 describe the data to better than 10-30%, except at Formula: see text GeV/Formula: see text. The new data can therefore be used to further improve the theoretical description of Formula: see text and Formula: see text meson production.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The transverse momentum distributions of the strange and double-strange hyperon resonances (Σ(1385)±, Ξ(1530)0) produced in p–Pb collisions at sNN=5.02 TeV were measured in the rapidity range ...-0.5<yCMS<0 for event classes corresponding to different charged-particle multiplicity densities, ⟨dNch/dηlab⟩. The mean transverse momentum values are presented as a function of ⟨dNch/dηlab⟩, as well as a function of the particle masses and compared with previous results on hyperon production. The integrated yield ratios of excited to ground-state hyperons are constant as a function of ⟨dNch/dηlab⟩. The equivalent ratios to pions exhibit an increase with ⟨dNch/dηlab⟩, depending on their strangeness content.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF