Prospects of poisoning - a multi facet study Mishra, Pradeep K; Kulkarni, Rashmi; Sane, Mandar R ...
Archiwum medycyny sądowej i krjminologii,
2016, Letnik:
66, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Aim of the study is to find out demographic profile, clinical characteristics and analysis of poison in clinical set up. The study carried out in Sri Aurobindo Medical College and PG Institute ...Indore, Madhya Pradesh. Total 75 cases of poisoning were studied for demographic profile, vitals (BP, pulse, heart rate, pupils, etc.), clinical features (such as vomiting, salivation, consciousness, etc.), type of poison and its analysis. Results: Poisoning was more common in cases between 15 and 25 years of age, in males than in females and in Hindu religion. Poisoning cases were predominantly from rural areas and in married people. Majority of cases were discharged after proper treatment and counseling. Altered vitals and clinical features were found in most of the cases. Organophosphate and aluminum phosphide compound were evaluated in most of the cases. Conclusions: Preventive measures should be applied through educating people, proper counseling, promoting poison information centers, and introducing separate toxicological units in hospitals.
In this letter, a comprehensive dc and RF model of heterostructure interband tunnel diodes (HITDs) is extracted. Active antennas incorporating tunnel diodes are analyzed in the time domain using this ...tunnel diode model. The simulated and measured results are in good agreement in terms of oscillation frequencies of the active antennas. Phase noise of -114.67 dBc/Hz @1.0 MHz offset is achieved for injection-locked active antennas. The simulated injection locking range of a Ka band active antenna array is investigated.
Tunnel Diodes have a unique property: Negative Differential Resistance (NDR). The integration of tunnel diodes with other electronic devices create novel, quantum functional devices and circuits. The ...enhanced functionality of these devices enables design of both digital and analog circuits with reduced complexity, size and better performance. In this paper we investigate the applications of a non-linear, large signal model of the tunnel diode. This model is used to analyze tunnel diode characteristics under external conditions such as input RF signal and termination resistance. We also discuss the application of the model to simulate quantum-MMIC circuits. VCO's, and active antennas designed using tunnel diodes show power outputs in the range of -4 to -10 dBm in the 1-2GHz band. The DC to RF conversion efficiency is about 8% in VCO's and 16% in the antennas.
Abstract
The Protein Data Bank (PDB) is the single global archive of experimentally determined three-dimensional (3D) structure data of biological macromolecules. Since 2003, the PDB has been managed ...by the Worldwide Protein Data Bank (wwPDB; wwpdb.org), an international consortium that collaboratively oversees deposition, validation, biocuration, and open access dissemination of 3D macromolecular structure data. The PDB Core Archive houses 3D atomic coordinates of more than 144 000 structural models of proteins, DNA/RNA, and their complexes with metals and small molecules and related experimental data and metadata. Structure and experimental data/metadata are also stored in the PDB Core Archive using the readily extensible wwPDB PDBx/mmCIF master data format, which will continue to evolve as data/metadata from new experimental techniques and structure determination methods are incorporated by the wwPDB. Impacts of the recently developed universal wwPDB OneDep deposition/validation/biocuration system and various methods-specific wwPDB Validation Task Forces on improving the quality of structures and data housed in the PDB Core Archive are described together with current challenges and future plans.
The Protein Data Bank in Europe (http://pdbe.org) accepts and annotates depositions of macromolecular structure data in the PDB and EMDB archives and enriches, integrates and disseminates structural ...information in a variety of ways. The PDBe website has been redesigned based on an analysis of user requirements, and now offers intuitive access to improved and value-added macromolecular structure information. Unique value-added information includes lists of reviews and research articles that cite or mention PDB entries as well as access to figures and legends from full-text open-access publications that describe PDB entries. A powerful new query system not only shows all the PDB entries that match a given query, but also shows the 'best structures' for a given macromolecule, ligand complex or sequence family using data-quality information from the wwPDB validation reports. A PDBe RESTful API has been developed to provide unified access to macromolecular structure data available in the PDB and EMDB archives as well as value-added annotations, e.g. regarding structure quality and up-to-date cross-reference information from the SIFTS resource. Taken together, these new developments facilitate unified access to macromolecular structure data in an intuitive way for non-expert users and support expert users in analysing macromolecular structure data.
Abstract
The Protein Data Bank in Europe (PDBe), a founding member of the Worldwide Protein Data Bank (wwPDB), actively participates in the deposition, curation, validation, archiving and ...dissemination of macromolecular structure data. PDBe supports diverse research communities in their use of macromolecular structures by enriching the PDB data and by providing advanced tools and services for effective data access, visualization and analysis. This paper details the enrichment of data at PDBe, including mapping of RNA structures to Rfam, and identification of molecules that act as cofactors. PDBe has developed an advanced search facility with ∼100 data categories and sequence searches. New features have been included in the LiteMol viewer at PDBe, with updated visualization of carbohydrates and nucleic acids. Small molecules are now mapped more extensively to external databases and their visual representation has been enhanced. These advances help users to more easily find and interpret macromolecular structure data in order to solve scientific problems.
Display omitted
•M. pollinis was evaluated for the first time on sugarcane juice and molasses.•Lysate prepared from Moniliella cell biomass was used as sole source of nutrients.•An erythritol titre ...of 94 g/L & yield of 0.38 g/g was achieved using sugarcane juice.•Ethanol utilization during fermentation led to enhancement of erythritol yield.•Downstream processing resulted into 96 % pure erythritol crystals.
Biotechnological production of erythritol from industrial substrates such as sugarcane juice and molasses may provide an alternative route for the production of this important platform chemical. In the present study, pure erythritol crystals were produced from sugarcane juice using basidiomycetous fungi Moniliella pollinis in batch and fed batch fermentation. Moniliella cells recovered from the fermentation broth were boiled and the resulting cell lysate was used as the sole source of nitrogen as well as other essential nutrients, including several macro and micronutrients, for erythritol fermentation. In sugarcane juice, Moniliella cells lysate based media resulted in a two-fold increase in erythritol yield and productivity when compared to yeast extract based medium. Maximum of 94.9 g/L erythritol titre with 0.38 g/g yield of total sugar was achieved in fed batch fermentation with sugarcane juice. Downstream processing of fermentation broth resulted in 96 % pure erythritol crystals. Use of Monililella cells lysate based media allowed ethanol to erythritol conversion, resulting in higher overall yield. It is proposed that M. pollinis utilizes ethanol by converting into acetic acid which is subsequently metabolized via TCA cycle. This study demonstrated the potential of sugarcane juice as an industrial feedstock for erythritol production using wild type M. pollinis.
Presence of methanotrophs in diverse environmental habitats helps to reduce emissions of greenhouse gas like methane. Isolation and culture of undiscovered wealth of methanotrophic organisms can help ...in exploitation of these organisms in value added products. The present study focuses on the enrichment of methanotroph dominated mixed microbial community by use of three stage strategy of revival, proliferation, and segregation. During the enrichment process amplicon sequencing of 16 s rRNA V3-V4 region showed relative abundance of mixed culture comprising single methanotrophic species of Methylocystis genus (88.92%) along with only three other species. Methylocystis dominant mixed culture (MMI-11) was observed to produce polyhydroxyalkanoates (PHA). During studies to identify favourable culture conditions, nitrate was found to be preferred nitrogen source for growth and PHA production. Cell growth ability to produce PHA was also evaluated at 14 L fermentor by supplying gas using continuous bubbling and through pressurization in the headspace. The mixed methanotrophic culture was found to accumulate maximum of 22.20% polyhydroxybutyrate (PHB) under nitrate limited condition. The molecular weight of PHB was found to be 2.221 × 105 g mol−1 with polydispersity of 1.82.
•Methanotroph enrichment using revival, proliferation and segregation strategy.•Mixed methanotrophic culture from rice field with Methylocystis as dominant genus.•PHA production using methane as feedstock.
PDF
