QCD in 0+1 dimensions is numerically solved via thimble regularization. In the context of this toy model, a general formalism is presented for SU(N) theories. The sign problem that the theory ...displays is a genuine one, stemming from a (quark) chemical potential. Three stationary points are present in the original (real) domain of integration, so that contributions from all the thimbles associated to them are to be taken into account: we show how semiclassical computations can provide hints on the regions of parameter space where this is absolutely crucial. Known analytical results for the chiral condensate and the Polyakov loop are correctly reproduced: this is in particular trivial at high values of the number of flavors Nf. In this regime we notice that the single thimble dominance scenario takes place (the dominant thimble is the one associated to the identity). At low values of Nf computations can be more difficult. It is important to stress that this is not at all a consequence of the original sign problem (not even via the residual phase). The latter is always under control, while accidental, delicate cancelations of contributions coming from different thimbles can be in place in (restricted) regions of the parameter space.
Numerical Stochastic Perturbation Theory (NSPT) allows for perturbative computations in quantum field theory. We present an implementation of NSPT that yields results for high orders in the ...perturbative expansion of lattice gauge theories coupled to fermions. The zero-momentum mode is removed by imposing twisted boundary conditions; in turn, twisted boundary conditions require us to introduce a smell degree of freedom in order to include fermions in the fundamental representation. As a first application, we compute the critical mass of two flavours of Wilson fermions up to order
O
(
β
-
7
)
in a
SU
(
3
)
gauge theory. We also implement, for the first time, staggered fermions in NSPT. The residual chiral symmetry of staggered fermions protects the theory from an additive mass renormalisation. We compute the perturbative expansion of the plaquette with two flavours of massless staggered fermions up to order
O
(
β
-
35
)
in a
SU
(
3
)
gauge theory, and investigate the renormalon behaviour of such series. We are able to subtract the power divergence in the Operator Product Expansion (OPE) for the plaquette and estimate the gluon condensate in massless QCD. Our results confirm that NSPT provides a viable way to probe systematically the asymptotic behaviour of perturbative series in QCD and, eventually, gauge theories with fermions in higher representations.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Thimble regularization is a possible solution to the sign problem, which is evaded by formulating quantum field theories on manifolds where the imaginary part of the action stays constant (Lefschetz ...thimbles). A major obstacle is due to the fact that one in general needs to collect contributions coming from more than one thimble. Here we explore the idea of performing Taylor expansions on Lefschetz thimbles. We show that in some cases we can compute expansions in regions where only the dominant thimble contributes to the result in such a way that these (different, disjoint) regions can be bridged. This can most effectively be done via Padé approximants. In this way multi-thimble simulations can be circumvented. The approach can be trusted provided we can show that the analytic continuation we are performing is a legitimate one, which thing we can indeed show. We briefly discuss two prototypal computations, for which we obtained a very good control on the analytical structure (and singularities) of the results. All in all, the main strategy that we adopt is supposed to be valuable not only in the thimble approach, which thing we finally discuss.
Abstract
Data from ground-based gravitational-wave detectors contains numerous short-duration instrumental artifacts, called ‘glitches’. The high rate of these artifacts in turn results in a ...significant fraction of gravitational-wave signals from compact binary coalescences overlapping glitches. In LIGO-Virgo’s third observing run, ≈20% of gravitational-wave source candidates required some form of mitigation due to glitches. This was the first observing run where glitch subtraction was included as a part of LIGO-Virgo-KAGRA data analysis methods for a large fraction of detected gravitational-wave events. This work describes the methods to identify glitches, the decision process for deciding if mitigation was necessary, and the two algorithms,
BayesWave
and
gwsubtract
, that were used to model and subtract glitches. Through case studies of two events, GW190424_180648 and GW200129_065458, we evaluate the effectiveness of the glitch subtraction, compare the statistical uncertainties in the relevant glitch models, and identify potential limitations in these glitch subtraction methods. We finally outline the lessons learned from this first-of-its-kind effort for future observing runs.
Due to its endocrine disruptive activity, the plastic additive Bisphenol A (BPA) is classified as substance of very high concern (EU ECHA 2017). A correlation between environmental exposure to BPA ...and congenital defects has been described in humans and in experimental species including the amphibian Xenopus laevis, where severe branchial defects were associated to lethality. The exposure of X. laevis embryos to the BPA analogue bisphenol B (BPB) was recently linked to similar teratogenic effects, with BPB having relative potency about 3 times higher than BPA. The combined BPA-BPB exposure is realistic as both BPA and BPB are detected in human samples and environment. Limited experimental data are available on the combined developmental toxicity of BPA and BPB. The aim of the present work is to evaluate the effects of BPA and BPB mixture in the X. laevis development model, using R-FETAX procedure. The exposure was limited to the first day of development (corresponding to the phylotypic developmental period, common to all vertebrates). Samples were monitored for lethal effects during the full six-day test period and the external morphology was evaluated at the end of the test. Mixture effects were described by modelling, using the PROAST software package. Overall data modelling showed that dose-addiction could not be rejected, suggesting a health concern for co-exposure.
•Data modelling showed dose-addiction not rejected.•Need for re-evaluating impacts of bisphenols when mixtures occur.•R-FETAX: alternative predictive model for human abnormalities induced by BPs.
The aim of the present work is to propose a new quantitative assessment method (FETAX-score) for determining the degree of Xenopus laevis embryo development intended for use in embryotoxicity ...studies. Inspired by a similar scoring system used to evaluate developmental delays (young-for-age phenotypes) in rat embryos cultured in vitro, the FETAX-score was established by considering seven morphological features (head, naris, mouth, lower jaw, tentacles, intestine, anus) that are easily evaluable in tadpoles during the late stages of development at the conclusion of the test. Given that X. laevis development is temperature-dependent and that temperatures below 14°C and above 26°C are teratogenic, the FETAX-score was tested in embryos maintained at 17, 20, 23 and 26°C. No abnormalities were observed in any group, while the total score was temperature-related, suggesting that the FETAX-score is sensitive to moderate distress that does not influence general morphology. Intestine and anus were the least sensitive structures to temperature variations. To assess the applicability of the FETAX-score in developmental toxicological studies, we evaluated FETAX-score in tadpoles exposed during the morphogenetic period to Ethanol (Eth) at concentrations of 0, 0.25, 0.5, 1, 1.5, and 2% v/v. Gross malformations were observed only in tadpoles from the Eth 2% group. By contrast, data analysis of the other Eth groups showed dose-related reductions in the FETAX-score. Tentacles were the most sensitive structures to Eth-related delays. These results support the use of the FETAX-score to quantitatively assess developmental deviations in FETAX embryotoxicity studies.
•quantitative measurement for developmental degree of Xenopus laevis•fine morphological description of key features of X. laevis tadpole•description of Eth related young for age phenotype
Bisphenol A (BPA) is a plastic additive with endocrine disruptive activity, classified in 2017 by EU ECHA as substance of very high concern. A correlation between environmental exposure to BPA and ...congenital defects has been described in humans and in experimental species, including the amphibian Xenopus laevis. Among BPA analogues, bisphenol B (BPB) is used as alternative in different not-EU countries, including US, but seems to share with BPA its endocrine disruptor properties. Aim of the present work is the evaluation of the effects of BPB versus BPA exposure in a X. laevis developmental model. A windowed exposure (R-FETAX method) was applied covering the developmental phylotypic period (teratogenicity window), or the late tailbud stages (neuro-behavioural toxicity window, corresponding to the spontaneous swimming acquisition period). Samples were monitored for lethal effects during the full test period. External morphology evaluation and deglutition functional test were applied in any group. Abnormal tadpoles were also processed for cartilage staining. In groups exposed during neuro-behavioural toxicity window the swimming test was also applied. Lethality and malformations were obtained only in samples exposed during the teratogenicity window; these data were modelled using PROAST software and BPB relative potency resulted about 3 times higher than BPA. The day-by-day evaluation revealed that lethality was correlated to embryonic abnormal development of gills and apoptosis in gill primordia. Teratogenicity was never detected in groups exposed during the neuro-behavioural toxicity window, where some significant neuro-behavioural deficits were detected in tadpoles exposed to the highest tested concentrations of BPA and BPB.
Peritoneal metastases are the leading cause of morbidity and mortality in ovarian cancer. Cancer cells float in peritoneal fluid, named ascites, together with a definitely higher number of non ...neo-neoplastic cells, as single cells or multicellular aggregates. The aim of this work is to uncover the features that make these aggregates the metastasizing units. Immunofluorescence revealed that aggregates are made almost exclusively of ovarian cancer cells expressing the specific nuclear PAX8 protein. The same cells expressed epithelial and mesenchymal markers, such as EPCAM and αSMA, respectively. Expression of fibronectin further supported a hybrid epithelia-mesenchymal phenotype, that is maintained when aggregates are cultivated and proliferate. Hematopoietic cells as well as macrophages are negligible in the aggregates, while abundant in the ascitic fluid confirming their prominent role in establishing an eco-system necessary for the survival of ovarian cancer cells. Using ovarian cancer cell lines, we show that cells forming 3D structures neo-expressed thoroughly fibronectin and αSMA. Functional assays showed that αSMA and fibronectin are necessary for the compaction and survival of 3D structures. Altogether these data show that metastasizing units display a hybrid phenotype that allows maintenance of the 3D structures and the plasticity necessary for implant and seeding into peritoneal lining.
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