Oligohydramnios is defined as amniotic fluid index in ultrasonographic measurement is less than 5 percentile according to gestational age, the amniotic fluid volume is ≤ 5 cm, or if the single ...deepest dial is < 2 cm. The condition of oligohydramnios that not with fetal structural/chromosomal abnormalities, intrauterine growth retardation, intrauterine infection and maternal disease is described as isolated oligohydramnios (IO). The aim of this study is to examine whether oxidative stress and reactive oxygen species (ROS) have a place in the pathophysiology of IO.
In this prospective case–control study, a total of 126 participants were included. The patient group consisted of 65 patients who were diagnosed IO, and the control group consisted of 61 healthy normal pregnants. Native thiol (-SH), total thiol (-SH + -SS), dynamic disulfide (-SS), IMA values from maternal serum were measured and compared between groups.
Maternal serum -SH and -SH + -SS values were significantly lower in the IO group than in the control group (409.47 ± 55.36 μmol/L vs. 437.40 ± 48.68 μmol/L, p = 0.03 and 457.40 ± 63.01 μmol/L vs. 484.59 ± 52.75 μmol/L, p = 0.01). In the IO group when -SS/-SH and -SS/-SH + -SS ratio was found to be statistically significantly higher than control group (5.84 ± 1.1 vs 5.41 ± 0.71, p = 0.01 and 5.2 ± 0.88 vs 4.8 ± 0.58, p = 0.01), -SH/-SH + -SS ratio was significantly lower (89.56 ± 1.7 vs 90.24 ± 1.16, p = 0.01). There was no significant difference in terms of -SS value (p = 0.66). IMA value was significantly higher in the IO group than control group (0.76 ± 0.10 ABSU vs 0.68 ± 0.06, p < 0.01). It is seen as a result of ROC analysis that -SH, -SH + -SS, -SS/-SH, -SS/-SH + -SS, -SH/-SH + -SS and IMA values have a diagnostic value for IO (p < 0.05).
The thiol/disulfide balance shifted towards oxidative stress in IO compared to control group. So oxidative stress and ROS have a place in the pathophysiology of IO.
Vaginal length (VL), size and width may show individual differences among women. Hysterectomy causes VL shortening in patients, and this shortening varies according to the type of hysterectomy ...performed. Some studies in literature have shown that the shortened VL after hysterectomy may cause dyspareunia and have a negative effect on female sexuality. The aim of this study is to compare preoperative and postoperative vaginal lengths, vaginal shortening rate (VSR) not used before in the literature, and postoperative sexual functions according to hysterectomy types.
In the study, which included 136 55 Total Abdominal Hysterectomy (TAH), 33 Vaginal Hysterectomy (VH), 48 Total Laparoscopic Hysterectomy (TLH) sexually active patients under the age of 60 who underwent hysterectomy, the patients were divided into three groups according to the type of hysterectomy performed. Groups were compared in terms of demographic variables, preoperative/postop and control VL, vaginal shortening rate and The Female Sexual Function Index (FSFI) scores.
Vaginal lengths measured after TLH was longer and vaginal lengths measured after VAH was shorter, the difference was significant (p < 0.01). VSRs were 15.9% in TAH group, 10.9% in VH group and 8.3% in TLH group (p < 0.05). Total FSFI score was higher in TLH group than TAH and VH group (p < 0.01). Group of VSR>15% had statistically significantly lower FSFI scores in lubrication, orgasm, pain and total score than both the VSR<10% group and the VSR 10–15% group (p < 0.05).
Calculating the VSR after hysterectomy instead of postoperative VL measurement will allow us to obtain more individual and accurate results in predicting postoperative sexual functions. We found that TLH is the best hysterectomy method in terms of preserving sexual functions due to less loss of vaginal tissue in the postoperative period from these three techniques that are frequently.
The aim of our study was to investigate the protective effect of taxifolin on ovarian damage and reproductive dysfunction created by cisplatin administration.
A total of 36 albino Wistar female adult ...rats were equally divided into 3 groups as cisplatin administered only (CIS), taxifolin+cisplatin (T+C) and healthy control group (HG). Taxifolin 50 mg/kg was administered orally by gavage in the T+C (n=12) group. In the HG (n=12) and CIS (n=12) groups, the same volume of distilled water as a solvent was orally administered. One hour after administration of taxifolin or distilled water, animals in the T+C and CIS groups were injected with cisplatin at a dose of 2.5 mg/kg intraperitoneally. This procedure was repeated once a day for 14 days. Six animals from each group were sacrificed on day 15, and their ovaries were removed for histopathological and biochemical analysis. Ovarian tissue malondialdehyde (MDA), total Glutathione (tGSH), Nuclear Factor-Kappa B (NF-kB), Tumor Necrosis Factor-α (TNF-α), Interleukin 1 beta (IL-1β), and Interleukin-6 (IL-6) levels were measured. The remaining animals (n=6 in each group) were kept in the laboratory with mature male rats for two months to breed.
CIS administration led to an increase in inflammatory molecules and membrane lipid peroxidation products, and decreased the synthesis of antioxidant molecules. Compared to the CIS group, the ovarian tissue MDA, NF-kB, TNF-α, IL-1β and IL-6 levels were found to be significantly decreased in the T+C group (p<0.001 for all comparisons). On the other hand, the tGSH levels of the T+C group were significantly higher than the CIS group (p<0.001). Milder ovarian necrosis, fibrosis and follicle damage were detected in animals which were given taxifolin. Four out of the six rats (67%) treated with taxifolin gave birth within 27 days.
We demonstrated, for the first time, that taxifolin ameliorates cisplatin-induced ovarian injury by decreasing MDA and proinflammatory cytokines and increasing the antioxidant enzyme. The fact that more than half of the animals receiving taxifolin became pregnant suggests that the cytoprotective effect of taxifolin is strong enough to preserve fertility.
The aim of this study was to determine the effect of desflurane on reproductive capacity in female rats through a study of biochemical evaluations.
After experimental procedure, the blood samples of ...female rats were collected, and the malondialdehyde, interleukin‑1‑beta, total glutathione and superoxide dismutase levels were measured to evaluate oxidative stress. In addition to biochemical evaluations, the reproductive performance of the experimental groups was also examined.
The results of our study demonstrated that in blood samples of desflurane‑treated groups of rats, the parameters indicating oxidative stress and inflammation increased, and antioxidant parameters decreased (p < 0.05). It was also proven that repeated desflurane doses caused infertility in female rats, prolonged the gestation period and reduced the number of offspring.
This study showed that recurrent desflurane application can cause infertility problems through oxidative stress in female rats (Tab. 3, Fig. 1, Ref. 25).
An in situ steady-state fluorescence (SSF) technique was applied in order to study the dissolution process of polystyrene (PS) latex films. The effect of the molecular weight
M
w
of the PS on the ...dissolution rate was investigated. The PS chains were copolymerized with (1-pyrene)methyl methacrylate in order to make use of pyrene (P) as a fluorescent probe to monitor the dissolution process. Seven different films were prepared from P-labeled PS latex dispersions with different molecular weights at room temperature. These films were then annealed at 200 °C for 15 min to complete the film formation process before dissolution. The dissolution of PS films in a toluene (70 %)–cyclohexane (30 %) mixture was monitored in real time by watching the change in the fluorescence intensity of P,
I
P
. We used a model that included both case I and case II diffusion kinetics to interpret the results of the dissolution experiments. The relaxation constants
k
0
and the dissolution coefficients
D
d
of the polymer chains were measured. Two different dissolution coefficients were obtained, which were attributed to the small and long polymer chains in the film, considering the high polydispersity of the polymer. It was also found that both of the
D
d
values scaled with
M
w
according to the law
D
d
≈
M
−
n
.
Cation exchange is an emerging synthetic route for modifying the secondary building units (SBUs) of metal-organic frameworks (MOFs). This technique has been used extensively to enhance the properties ...of nanocrystals and molecules, but the extent of its applications for MOFs is still expanding. To harness cation exchange as a rational tool, we need to elucidate its governing factors. Not nearly enough experimental observations exist for drawing these conclusions, so we provide a conceptual framework for approaching this task. We address which SBUs undergo exchange, why certain ions replace others, how the framework influences the process, the role of the solvent, and current applications. Using these guidelines, certain trends emerge from the available data and missing experiments become obvious. If future studies follow this framework, then a more comprehensive body of observations will furnish a deeper understanding of cation exchange and inspire future applications.
This review examines the governing factors of cation exchange at the secondary building units of MOFs and reviews its applications.
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•Electrocoagulation/ electroflotation methods allow for the simultaneous removal of surfactants, color, and turbidity.•The anode dissolution rate is a function of quantity of ...electricity and the water temperature.•Current density, pH, and treatment time have a significant effect on the wastewater cleaning.•The process under study appeared to be cost-effective for the laundry wastewater purification and reuse.•The study showed that economic effect of EC and EF processes is due to low electrical energy consumption.
The purpose of this work is to purify wastewater from industrial laundries and return them to the washing process. By means of the methods of electrocoagulation and electroflotation, laboratory and pilot studies on the wastewater treatment were carried out using aluminium electrodes. The process of wastewater treatment has been studied in dependence on treatment time, temperature, pH and current density. The effectiveness of the cleaning process under different values of operating parameters of the reactor was estimated as the percentage of color, turbidity and surfactant removal from the wastewater. As a result of laboratory studies, the optimum values of the operating parameters of the reactor at 90% removal of contamination were the following: current density value as 5.26 mA/cm2, pH as 5.5 and 5 min processing time. The consumption of electrical energy in this case amounted to 1.25 kW h/ m3. The quality control of the purified water was carried out according to such additional parameters as total suspended solids, chemical oxygen demand, total organic carbon, and the content of metal ions and phosphate and nitrate anions in the water. The study of the wastewater treatment in a pilot plant with laboratory values of operating parameters showed the reproducibility of the purification results for the controlled parameters of water quality and suitability of the water for reuse. The washing performed with purified water was estimated by the whiteness index for bed linen and was not inferior to the traditional washing with water from a source of water supply.
It is almost impossible to prepare representative cores of rock masses including discontinuities patterns for laboratory studies. To overcome these difficulties, researchers have focused on ...developing empirical equations for estimating of the stress–strain behavior of a rock mass, including measurements of the discontinuity patterns. As can be seen in the literature, the uniaxial compressive strength value of rock mass (
UCS
RM
) can be estimated by reducing the uniaxial compressive strength of intact rock material (
UCS
i
) based on the quality of a rock mass, represented by variables such as Rock Mass Rating (
RMR), Geological Strength Index (
GSI) and
Q value. For this reason, a unique reducing curve form empirical equation has limited application and generally, cannot be applied to all kind of rock masses from particularly soft to hard rock masses. In this study, a new general empirical approach is constructed to estimate the strength of rock masses of varying hardness. The new empirical equations have been calibrated using data from five slope failures and four sets of uniaxial compressive strength data of rock masses. In the new empirical equations, the
UCS
i
is considered not only to be a scale parameter used in the strength reduction but also used to adjust the degree of strength reduction in conjunction with elastic modulus of the rock material (
E
i
). The disturbance factor on the rock mass is taken into consideration by two separate reduction factors applied to the Structure Rating (
SR) to capture increasing joint density, and to the
s and
m
b
parameters of the Hoek–Brown criterion, to decrease the degree of interlocking. Hence, non-interlocked (cohesionless under zero normal stress) rock masses such as spoil piles can also be modeled in the new empirical approach.
Reaction of 2,3,6,7,10,11-hexaaminotriphenylene with Ni2+ in aqueous NH3 solution under aerobic conditions produces Ni3(HITP)2 (HITP = 2,3,6,7,10,11-hexaiminotriphenylene), a new ...two-dimensional metal–organic framework (MOF). The new material can be isolated as a highly conductive black powder or dark blue-violet films. Two-probe and van der Pauw electrical measurements reveal bulk (pellet) and surface (film) conductivity values of 2 and 40 S·cm–1, respectively, both records for MOFs and among the best for any coordination polymer.
Background
Globally, 88% of deaths are caused by noncommunicable diseases (NCD) and they are increasing in our country as in many parts of the world. Effective control, prevention and treatment of ...NCD, can begin from knowing the disease incidence by age, sex and regions.
Methods
This study aimed to determine the incidence of chronic diseases (coronary heart disease, stroke, diabetes, hypertension and cancer) by record linkage of the data from the Turkey Chronic Diseases and Risk Factors Prevalence Study 2011 (TCD-RFS) with health service databases, which are Family Medicine Information System, Medulla- E-Pulse and Death Notification System. The cohort (18.477 people above age 15) from TCD-RFS is followed up to determine the incidence of coronary heart disease, hypertension, diabetes, stroke and cancer, from the electronic health record systems for the period between 2012 and 2017 (6 years). Cumulative incidences were calculated, age and sex standardized incidences were given with 95% CI.
Results
The age and sex standardized cumulative incidences are, 5939 (95% CI 5933-5945) for CHD 1378 (95%CI:1369-1388) for stroke, 2254 (95% CI 2 253 -2 255) for cancer, 4200 (95% CI 4194-4204) for diabetes and 20788 (95% CI 1369-1388) for hypertension (per 100,000). The annual incidences are approximately 990 for CHD, 229 for stroke, 375 for cancer, 700 for diabetes and 3464 for hypertension (per 100,000). CHD and cancer incidences are higher in men, while diabetes, hypertension and stroke incidences are higher in women.
Conclusions
Regardless of the difficulties in comparing incidence of NCD with other countries, we think our results show that hypertension, diabetes, stroke and CHD have higher incidence than Western European countries. We also showed that these metrics can be obtained through data linkage of National Health Records for the first time in Turkey.
Key messages
The NCDs needs to be monitored by surveillance using the current data sources for health services.
This data can provide very useful information regularly to monitor and control NCDs if necessary actions are taken to adjust data management.
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