This Letter reports on a cavity haloscope search for dark matter axions in the Galactic halo in the mass range 2.81-3.31 μeV. This search utilizes the combination of a low-noise Josephson parametric ...amplifier and a large-cavity haloscope to achieve unprecedented sensitivity across this mass range. This search excludes the full range of axion-photon coupling values predicted in benchmark models of the invisible axion that solve the strong CP problem of quantum chromodynamics.
We report the results from a haloscope search for axion dark matter in the 3.3-4.2 μeV mass range. This search excludes the axion-photon coupling predicted by one of the benchmark models of ..."invisible" axion dark matter, the Kim-Shifman-Vainshtein-Zakharov model. This sensitivity is achieved using a large-volume cavity, a superconducting magnet, an ultra low noise Josephson parametric amplifier, and sub-Kelvin temperatures. The validity of our detection procedure is ensured by injecting and detecting blind synthetic axion signals.
The μeV axion is a well-motivated extension to the standard model. The Axion Dark Matter eXperiment (ADMX) collaboration seeks to discover this particle by looking for the resonant conversion of ...dark-matter axions to microwave photons in a strong magnetic field. In this Letter, we report results from a pathfinder experiment, the ADMX "Sidecar," which is designed to pave the way for future, higher mass, searches. This testbed experiment lives inside of and operates in tandem with the main ADMX experiment. The Sidecar experiment excludes masses in three widely spaced frequency ranges (4202-4249, 5086-5799, and 7173-7203 MHz). In addition, Sidecar demonstrates the successful use of a piezoelectric actuator for cavity tuning. Finally, this publication is the first to report data measured using both the TM_{010} and TM_{020} modes.
Searching for axion dark matter, the ADMX Collaboration acquired data from January to October 2018, over the mass range 2.81–3.31 μeV, corresponding to the frequency range 680–790 MHz. Using an ...axion haloscope consisting of a microwave cavity in a strong magnetic field, the ADMX experiment excluded Dine-Fischler-Srednicki-Zhitnisky (DFSZ) axions at 90% confidence level and 100% dark matter density over this entire frequency range, except for a few gaps due to mode crossings. This paper explains the full ADMX analysis for run 1B, motivating analysis choices informed by details specific to this run.
Reservoir inflow is a major component of the reservoir operations management system. It becomes highly essential to predict the accurate reservoir inflow. The lumped models and semi-distributed or ...fully distributed model implemented to solve a range of specific problems in the prediction of reservoir inflow. The findings in this paper compare a conceptual semi distributed Hydrologic Engineering Centre Hydrologic Modelling System (HEC-HMS) model and an ANN (Artificial Neural Network) based model for the prediction of inflow in the Koyna reservoir catchment, Maharashtra. The performance of the models is assessed using different statistical indicators such as Nash–Sutcliffe Efficiency (NSE), Root Mean Square Error (RMSE), Correlation Coefficient (r) and Mean Absolute Error (MAE). The results confirmed the ability of the semi distributed (r
HEC-HMS
= 0.92, RMSE
HEC-HMS
= 129.37 m
3
/s, MAE
HEC-HMS
= 21.66 m
3
/s, NSE
HEC-HMS
= 0.82 and RSR
HEC-HMS
= 0.42) and ANN model (r
ANN
= 0.85, RMSE
ANN
= 176.29 m
3
/s, MAE
ANN
= 14.62 m
3
/s, NSE
ANN
= 0.69 and RSR
ANN
= 0.55) to capture the effect of the complex hydrological phenomenon, variations of land use and soils of watershed. The study illustrates that the semi distributed HEC-HMS model shows moderately better results compared to ANN model. It may be noted that the ANN predicts the reservoir inflow using only one input i.e., rainfall, whereas the HEC-HMS requires exogenous input parameters and plenty of time for model building compared to ANN. This work will have a significant contribution for planning of reservoir operations within the catchment of Koyna reservoir.
Ni-Mo low alloy steel exhibits an admirable amalgamation of high strength and toughness at subzero temperature and show resistance to brittle fracture with good weldability. This steel has been ...established to fulfill the needs of specific applications, such as the construction of ships and submarines. To develop a companionable wire for welding of Ni-Mo low alloy steel, the amount of the alloying elements in a wire is increased to toughen of weld metal, the wire itself has high strength so that the wire is hardened at the wire drawing, making the wire production difficult. In order to avoid the problems related to the solid wires, various flux cored wires have been developed. In this work, the effect of flux basicity index and heat input on chemical composition, oxygen-nitrogen analysis, mechanical properties and microstructure of Ni-Mo low alloy steel welded by SAW welding using flux cored wires are presented along with the effect of flux cored wire and basicity index on deposition rate.
The Axion Dark Matter eXperiment (ADMX) has previously excluded Dine-Fischler-Srednicki- Zhitnisky (DFSZ) axions between 680-790 MHz under the assumption that the dark matter is described by the ...isothermal halo model. However, the precise nature of the velocity distribution of dark matter is still unknown, and alternative models have been proposed. Here, we report the results of a non-virialized axion search over the mass range 2.81–3.31 µeV, corresponding to the frequency range 680–800 MHz. This analysis marks the most sensitive search for non-virialized axions sensitive to Doppler effects in the Milky Way Halo to date. Accounting for frequency shifts due to the detector’s motion through the Galaxy, we exclude cold flow relic axions with a velocity dispersion of $\mathscr{O}$(10-7)c with 95% confidence.
We report here the synthesis, antibacterial and antitubercular evaluation of 61 novel pyrrolyl derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties. Molecular docking was carried ...out on enoyl ACP reductase from Mycobacterium tuberculsosis using Surflex-Dock, which is one of the key enzymes involved in type II fatty acid biosynthetic pathway of Mycobacterium tuberculosis, an attractive target for designing novel antitubercular agents. Docking analysis of the crystal structure of ENR performed using Surflex-Dock in Sybyl-X 2.0 software indicates the occupation of substituted pyrrolyl derivatives into hydrophobic pocket of InhA enzyme. Compounds 9b and 9d exhibited the highest antitubercular activity almost close to isoniazid (0.4 μg/mL) with a MIC value of 0.8 μg/mL. All other compounds showed the good activity with a MIC value of 6.25–100 μg/mL. The compounds were further tested for mammalian cell toxicity using human lung cancer cell-line (A549) and were nontoxic. Some compounds exhibited inhibition activities against InhA.
Antitubercular activity of novel series of pyrrolyl chalcone, pyrazline, isoxazole and phenyl urea derivatives was analyzed. Molecular modeling constructed using Surflex-Dock study using enoyl ACP reductase from Mycobacterium tuberculosis. Display omitted
•Inhibitors of mycobacterial Enoyl ACP reductase were designed using in silico approach.•Synthesis of a range of these pyrrolyl chalcones, pyrazoles, isoxazoles and phenyl thiourea derivatives is described.•Surflex docking studies were carried out to understand the binding affinity of the compounds.•Inhibitors were active against Mycobacterium tuberculosis, Staphylococcus aureus, Eschrichia coli, Cell-line (A549) and InhA.
Purpose
Children are often afraid to visit a dentist. Dental anxiety is a worldwide issue and a barrier to successful treatment outcome. Pet therapy, especially through dogs, has been demonstrated to ...be beneficial in reducing anxiety. In today’s generation, where dopamine is prevalent, attention is hijacked, and children are tethered to screens—this research on animal-assisted therapy outlines the impact on children undergoing simple dental procedures, and to evaluate its use in long-term behavior management, and child and parental acceptance of this technique.
Methods
One hundred and two children between five and 10 years of age and requiring simple dental procedures were selected randomly and divided into two groups. In Group A, dental treatment was carried out in the presence of a therapy dog, and in Group B (the control group), dental treatment was carried out in a regular dental setup. Anxiety levels were evaluated by pulse rate and anxiety rating scale. Prior to exiting the room, the parents were asked to rate the child’s interaction with therapy dogs.
Results
According to an independent
t
test, reduction in anxiety was highly significant (
p
< 0.001).
Conclusion
Animal-assisted therapy is an effective behavior management strategy.
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