Chemical doping is an important strategy to alter the charge-transport properties of both molecular and polymeric organic semiconductors that find widespread application in organic electronic ...devices. We report on the use of a new class of Co(III) complexes as p-type dopants for triarylamine-based hole conductors such as spiro-MeOTAD and their application in solid-state dye-sensitized solar cells (ssDSCs). We show that the proposed compounds fulfill the requirements for this application and that the discussed strategy is promising for tuning the conductivity of spiro-MeOTAD in ssDSCs, without having to rely on the commonly employed photo-doping. By using a recently developed high molar extinction coefficient organic D-π-A sensitizer and p-doped spiro-MeOTAD as hole conductor, we achieved a record power conversion efficiency of 7.2%, measured under standard solar conditions (AM1.5G, 100 mW cm–2). We expect these promising new dopants to find widespread applications in organic electronics in general and photovoltaics in particular.
A heat shield called the thermal protection system (TPS) is an important structure in hypersonic vehicles as it prevents hot air from entering vehicles and potential impacts from space debris. With ...the increase in demand for low-cost reusable launch vehicles as well as for searching and exploration of new planets in both unmanned and manned missions, the need for developing an effective TPS has increased across many countries. The structural design of TPSs has become more prominent in the early stage of hypersonic vehicle development. Sandwich structures that have the advantages of low density and high performance are integrated into the structural design of an effective TPS. This paper provides a comprehensive review of recent research efforts on sandwich structures for TPSs. The topics discussed in this paper include aspects of structural and material design, mechanical and thermomechanical performances, and manufacturing methods. In particular, we review and discuss the structural design as well as the material design of sandwich structures for different TPS types with various configurations, including corrugated cores, lattice cores, multilayer cores, foams, honeycomb cores, bio-inspired cores. The materials used for the sandwich structures, such as various types of laminated composite, ceramic matrix composite, and metals, are included. We also discuss the performance of the TPS sandwich structures in terms of temperature gradients, deformation limits, and mechanical strengths and provide a discussion on the manufacturing methods of TPS sandwich structures for hypersonic vehicles. Finally, further research directions and challenges of sandwich structures for TPSs are presented.
It is widely known that the availability of lightweight structures with excellent energy absorption capacity is essential for numerous engineering applications. Inspired by many biological structures ...in nature, bio-inspired structures have been proved to exhibit a significant improvement over conventional structures in energy absorption capacity. Therefore, use of the biomimetic approach for designing novel lightweight structures with excellent energy absorption capacity has been increasing in engineering fields in recent years. This paper provides a comprehensive overview of recent advances in the development of bio-inspired structures for energy absorption applications. In particular, we describe the unique features and remarkable mechanical properties of biological structures such as plants and animals, which can be mimicked to design efficient energy absorbers. Next, we review and discuss the structural designs as well as the energy absorption characteristics of current bio-inspired structures with different configurations and structures, including multi-cell tubes, frusta, sandwich panels, composite plates, honeycombs, foams, building structures and lattices. These materials have been used for bio-inspired structures, including but not limited to metals, polymers, fibre-reinforced composites, concrete and glass. We also discussed the manufacturing techniques of bio-inspired structures based on conventional methods, and adaptive manufacturing (3D printing). Finally, contemporary challenges and future directions for bio-inspired structures are presented. This synopsis provides a useful platform for researchers and engineers to create novel designs of bio-inspired structures for energy absorption applications.
A paradox of tumor immunology is that tumor-infiltrating lymphocytes are dysfunctional in situ, yet are capable of stem cell-like behavior including self-renewal, expansion, and multipotency, ...resulting in the eradication of large metastatic tumors. We find that the overabundance of potassium in the tumor microenvironment underlies this dichotomy, triggering suppression of T cell effector function while preserving stemness. High levels of extracellular potassium constrain T cell effector programs by limiting nutrient uptake, thereby inducing autophagy and reduction of histone acetylation at effector and exhaustion loci, which in turn produces CD8
T cells with improved in vivo persistence, multipotency, and tumor clearance. This mechanistic knowledge advances our understanding of T cell dysfunction and may lead to novel approaches that enable the development of enhanced T cell strategies for cancer immunotherapy.
In this study, a novel bio-inspired honeycomb sandwich panel (BHSP) based on the microstructure of a woodpecker’s beak is proposed. Unlike a conventional honeycomb, the walls of the bio-inspired ...honeycomb (BH), which is used as the core of a sandwich panel, are made wavy. Finite element simulation shows that under dynamic crushing the proposed BHSPs exhibit superior energy absorption capability compared with the conventional honeycomb sandwich panel (CHSP). In particular, the specific energy absorption (SEA) of the BHSP increases by 125% and 63.7%, respectively, compared with that of the honeycomb sandwich panel with the same thickness core or the same volume core. In addition, a parametric study of the BHSPs is carried out to investigate the influences of the wave amplitude, wave number and core thickness on the energy absorption performance of the BHSPs. It is found that the BH core with a larger wave number and amplitude shows higher SEA. Furthermore, an increase in core thickness can improve the SEA. These results provide guidelines in the design of a lightweight sandwich panel for high-energy absorption capability.
Our objectives were to describe Human Papillomavirus vaccination coverage rates (HPV-VCR), policies, and practical steps for programme implementation that may be linked to high uptake in the ...population targeted by routine programmes across 30 European Union/European Economic Area Member States and Switzerland.
Information from institutional websites and from articles indexed in Medline between 01/2006 and 01/2017 was reviewed and extracted using a standardised form. In 12/2017, a cross-sectional survey was administered to national experts, in order to update the compiled information.
Data were available in 31 countries, and validated by national experts in 28 of them. National vaccination programmes targeted girls 9–15 years of age in 30 countries and boys in 11 countries. HPV-VCR in girls was monitored in 25 countries: VCR was reported ≥71%(high) in ten countries, 51–70% in seven, 31–50% in four, and ≤30%(very low) in four. In high VCR countries, HPV vaccination was mainly delivered through school health services, and invitation and reminders to attend for vaccination were used. In areas with very low VCR, vaccination tended to be opportunistic and no reminders were used.
According to our findings, school delivery within structured vaccination programmes and the use of reminders tended to be associated with highest HPV-VCR.
Tumour heterogeneity poses a substantial problem for the clinical management of cancer. Somatic evolution of the cancer genome results in genetically distinct subclones in the primary tumour with ...different biological properties and therapeutic sensitivities. The problem of heterogeneity is compounded in metastatic disease owing to the complexity of the metastatic process and the multiple biological hurdles that the tumour cell must overcome to establish a clinically overt metastatic lesion. New advances in sequencing technology and clinical sample acquisition are providing insights into the phylogenetic relationship of metastases and primary tumours at the level of somatic tumour genetics while also illuminating fundamental mechanisms of the metastatic process. In addition to somatically acquired genetic heterogeneity in the tumour cells, inherited population-based genetic heterogeneity can profoundly modify metastatic biology and further complicate the development of effective, broadly applicable antimetastatic therapies. Here, we examine how genetic heterogeneity impacts metastatic disease and the implications of current knowledge for future research endeavours and therapeutic interventions.
This study proposes novel bio-inspired fractal multi-cell circular (BFMC) tubes for energy absorption. The inner structures of the proposed BFMC tubes were constructed based on the fractal tree-like ...forms found in many biological structures such as giant water lily and dragon blood tree. The crashworthiness performances of the proposed structures with different fractal orders and mass were numerically investigated. The numerical results indicated that the specific energy absorption (SEA) increased with the fractal order and the SEA of the 2nd-order BFMC tube was 35.43% higher than that of the conventional multi-cell circular tube. Furthermore, the complex proportional assessment (COPRAS) method was adopted to optimize the performance of the BFMC. The results demonstrated that the proposed structure with four number of tree-like branches and 2nd-order fractal provided the best performance. Finally, a theoretical derivation of the mean crushing force (MCF) was developed for the proposed tubes based on the simplified super folding element theory. The theoretical results of MCF agreed well with the numerical results. The findings of this study provide an effective guide for using the biomimetic approach with the fractal tree-like forms for the design of a multi-cell energy absorber with high energy absorption efficiency.
•The novel bio-inspired fractal multi-cell circular (BFMC) tubes were proposed.•The SEA of the 2nd order BFMC tube was 35.43% higher than that of the conventional tube.•The IPCF remained unchanged with the order of fractal.•The COPRAS method was used to rank the performance of the BFMC tubes.•The theoretical predictions of MCF agreed well with the numerical results.
A series of mesoporous WO3 catalysts were facilely synthesized by a hydrothermal method using mesoporous silica KIT-6 as a hard template and silicotungstic acid as a precursor. All the catalysts ...possess a well-defined mesoporous structure with interconnected networks. Oxygen-deficient mesoporous WO3 (m-WO3-x) was prepared by hydrogenation treatment at different temperatures with improved photothermal coupling performance. Moreover, the as-prepared catalysts exhibit selectivity toward CH4 evolution under visible-light only irradiation. Then, under photothermal conditions, the results show that the concentration of oxygen vacancies of m-WO3 has a great influence on its catalytic performance. The CH4 evolution rate reached 25.77 mu mol g (1), which is about 22 times that of mesoporous WO3 (1.17 mu mol g(-1)) under the same conditions, and a moderate concentration of oxygen vacancies is necessary to achieve selectivity for the conversion of CO2 into CH4. A mechanism of the catalytic reduction of CO2 over m-WO3-x is proposed, in which the initial oxygen vacancies function as an excellent electron transfer mediator and decompose CO2 into its elements (C/CO). These findings may further broaden the scope for photothermal chemical conversion and provide new insights into the oxygen nonstoichiometry strategy for the development of CO2 reduction.
Head and neck cancers (HNCs), primarily head and neck squamous cell carcinoma (HNSCC), are associated with high‐risk human papillomavirus (HR HPV), notably HPV16 and HPV18. HPV status guides ...treatment and predicts outcomes, with distinct molecular pathways in HPV‐driven HNSCC influencing survival rates. HNC incidence is rising globally, with regional variations reflecting diverse risk factors, including tobacco, alcohol, and HPV infection. Oropharyngeal cancers attributed to HPV have significantly increased, particularly in regions like the United States. The HPV16 genome, characterized by oncoproteins E6 and E7, disrupts crucial cell cycle regulators, including tumor protein p53 (TP53) and retinoblastoma (Rb), contributing to HNSCC pathogenesis. P16 immunohistochemistry (IHC) is a reliable surrogate marker for HPV16 positivity, while in situ hybridization and polymerase chain reaction (PCR) techniques, notably reverse transcription‐quantitative PCR (RT‐qPCR), offer sensitive HPV detection. Liquid‐based RT‐qPCR, especially in saliva, shows promise for noninvasive HPV detection, offering simplicity, cost‐effectiveness, and patient compliance. These molecular advancements enhance diagnostic accuracy, guide treatment decisions, and improve patient outcomes in HNC management. In conclusion, advances in HPV detection and molecular understanding have significant clinical management implications. Integrating these advancements into routine practice could ultimately improve patient outcomes.
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