A new series of diphosphorylated amidophosphates was obtained as a result of the reaction of
meta
-phenylenediamine with dialkyl phosphites in the presence of CCl
4
and triethylamine (Atherton–Todd ...reaction) under microwave irradiation. Structure of all the obtained amidophosphates was established on the basis of
31
P,
1
H,
13
C NMR, IR spectroscopy and mass spectrometry methods, as well as single crystal X-ray diffraction and elemental analysis data.
The method for the synthesis of complex alkaloid-like aza-heterocycles has been developed through the Povarov reaction of
in situ
generated 2-oxoimidazolium cations. The reaction lead to the ...formation of 2 C-N, 2 C-C bonds and three stereocentres, and features excellent regio- and diastereoselectivity. Based on the controlled experiments and quantum chemistry data, the mechanism of the reaction cyclization was proposed and diastereoselectivity origins were rationalized. Additionally, a straightforward synthesis of hardly accessible 4,4′-bi(imidazol-2-one) derivatives has been achieved using the same methodology.
A rapid diastereoselective construction of the polycyclic quinoline scaffold has been developed through the triflic-acid catalysed tandem intramolecular cyclization/Povarov reaction of (2,2-dialkoxyethyl)ureas.
1D coordination silver(I) polymer L
2
AgONO
2
n
has been obtained via the reaction of 10-(4-ethoxyphenyl)phenoxarsine with silver(I) nitrate (metal : ligand molar ratio 1 : 2) in ethanol. The ...complex has been identified and characterized by a set of physicochemical methods of analysis (mass spectrometry,
1
H NMR spectroscopy, elemental analysis, and X-ray diffraction analysis). The ligand and its Ag(I) complex have been evaluated for cytotoxicity against the cancer cell lines M-HeLa and HuTu 80 and the normal cell line Chang liver; antimicrobial activity of the complex against a series of Gram-positive and Gram-negative bacteria has been investigated.
The reactions of pyridoxal imidazolidines with diphenylchlorophosphine oxide, depending on the substituents nature in the imidazolidine ring, resulted in the formation of new salt-like tricyclic ...structures or a bisalt structure based on
N
,
N
′-dibenzylethylenediamine and diphenylphosphinic acid. The benzoylation of pyridoxal imidazolidines also led to decomposition of the imidazolidine fragment with the formation of dibenzoylated
N
,
N
′-dimethylethylenediamine.
Chiral 1,9-diaza-3,7,11,15-tetraphosphacyclohexadecanes were stereoselectively synthesized as pure RPSPSPRP isomers via a one-pot Mannich-type condensation reaction of 1,3-bis(arylphosphino)propane, ...formaldehyde and optically active, as well as racemic, primary amines. An unprecedented intermolecular exchange of endocyclic amino fragments of 1,9-diaza-3,7,11,15-tetraphosphacyclohexadecanes was observed. The lability of the P–CH2–N fragment in macrocyclic aminomethylphosphines is the reason of the stereoisomerization, formation of products with medium-sized cycles as well as the exchange of endocyclic amino fragments. The mechanism of these transformations involving the formation of a methylenephosphonium intermediate and further intra- and intermolecular nucleophilic substitution is discussed.
Dinuclear complexes with stoichiometry Cu
2
I
2
L
4
are obtained by reaction of 10-(m-(R)-phenyl)phenoxarsine ligands with copper iodide in acetonitrile in a 1: 2 stoichiometry.
The electrochemical properties of Co(Ph
2
PCH
2
P(Ph)
2
PPPPP(Ph)
2
CH
2
PPh
2
)BF
4
complex have been studied by the method of cyclic voltammetry. The electrochemical methylation of this complex ...have been cunducted in the presence of iodomethane which has led to the formation of phosphonium salt—methylene bis(methyldiphenylphosphonium) diiodide as final product. It was found, that this reaction proceeds with the breakage of the P–P bonds in polyphosphorus ligand and with the formation of new P–C bonds.
A series of dimeric gold(I) complexes L
2
Au
2
Cl
2
has been synthesized by the reaction of equimolar amounts of 10-(aryl)phenoxarsine ligands with chloro(tetrahydrothiophene)gold(I). The structure ...of complexes
4
–
6
has been confirmed by a combination of physicochemical methods. The crystal structure of complex
4
has been determined by single-crystal X-ray diffraction. The Tolman angles have been calculated for the known tertiary arsine ligands and the ligands in the synthesized gold complexes. It has been shown that the dimeric structure of the complexes is formed through the aurophilic interaction between two monomers. The Tolman angle of the phenoxarsine ligand plays a significant role in this interaction; in the dimeric complexes, this angle is on average 147°.
The reaction of 4,6-di-
tert
-butyl-3-(methoxymethyl)benzene-1,2-diol with 1-methyl-3-phenyl-1,3-dihydro-2
H
-imidazol-2-one led to the formation of a new imidazocoumarin derivative. Structure and ...composition of the obtained compound was proven by NMR (1H,
13
C,
15
N, COSY,
1
H–
13
C HSQC,
1
H–
13
C HMBC,
1
H–
15
N HMBC, NOESY), X-ray diffraction and elemental analysis data.
The possibility of spontaneous reduction of benzofuroxans to benzofurazans in course of time due to reactions with diamines was shown for the first time. A possible mechanism of the reaction of ...4,6-dichloro-5-nitrobenzofuroxan with diamines and related amines was analyzed by the quantum-chemical method. The results of research fully confirm the obtained experimental data and explain the impossibility of the subsequent reduction of amino-containing benzofuroxans due to a high activation barrier.
![Chiral [16]-ane P4N2 macroc...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1477-9226/small "Chiral [16]-ane P4N2 macrocycles: stereoselective synthesis and unexpected intermolecular exchange of endocyclic fragments")
