This article discusses the ideas about gender contained in the Enseñanzas Sufíes Para Los Tiempos Actuales, a text by Abdul Rauf Felpete, the leader of the Naqshbandiyya Haqqaniyya in Latin America, ...probably the largest Sufi group in the continent. I analyse these ideas against the backdrop context in which they were produced: on the one hand, a conservative Sufi Islamic frame inspired by Nazim al-Haqqani’s ideas, and on the other, an Argentinian society that was incurring profound gender-related societal changes at the time when the shaykh delivered the sermons contained in the book. This historical moment was characterised by a growing feminist and LGTBQ+ activism and the arrival of a progressive government in Argentina, which over time, positioned this Latin American country in the vanguard of gender and sexual equality rights in the Spanish speaking world. In this context, Rauf Felpete proposes a gender model inspired in a Haqqani form of Islamic conservatism as a remedy to address what he perceives as the threat of civilizational decadence brought about by these changes. I discuss Rauf Felpete’s family ideology, a set of moral norms based on gender determinism and pronatalism, articulated through two key concepts, first, domesticity, understood as a way to regulate female behaviour and, second, motherhood, viewed as a Godly ordained natural instinct. In order to put into practice these gender norms, the devout Haqqani is called to move to the countryside; rural communes are presented as the only possible way of living a pious and authentically Islamic life, a mode of living that implies profound reconfigurations of gender (and of lifestyle, more generally) for his Latin American followers.
Machine learning is a growing field of research with many applications. It provides a series of techniques able to solve complex nonlinear problems, and that has promoted their application for ...statistical downscaling. Intercomparison exercises with other classical methods have so far shown promising results. Nevertheless, many evaluation studies of statistical downscaling methods neglect the analysis of their extrapolation capability. In this study, we aim to make a wakeup call to the community about the potential risks of using machine learning for statistical downscaling of climate change projections. We present a set of three toy experiments, applying three commonly used machine learning algorithms, two different implementations of artificial neural networks and a support vector machine, to downscale daily maximum temperature, and comparing them with the classical multiple linear regression. We have tested the four methods in and out of their calibration range, and have found how the three machine learning techniques can perform poorly under extrapolation. Additionally, we have analysed the impact of this extrapolation issue depending on the degree of overlapping between the training and testing datasets, and we have found very different sensitivities for each method and specific implementation.
Standardised T850 versus observed (grey) downscaled maximum temperature (°C) by multiple linear regression (blue), artificial neural network with relu activation function (orange) artificial neural network with logistic activation function (red) and support vector regression (green). Pink background indicates extrapolation beyond the calibration range.
Total synthesis and structural confirmation of homo- and heterodimeric bispyrrolidinoindoline dioxopiperazine alkaloids isolated from fungi and bacteria, namely, ditryptoleucine A, ditryptoleucine B ...(11), the N,N′-bis-demethylated analogue (+)-12, (−)-dibrevianamide F (13), (−)-SF-5280-451 (14), tetratryptomycin A (15), (−)-tryprophenaline (17), and (−)-SF-5280-415 (18), has been carried out starting from the corresponding bispyrrolidinoindolines derived from tryptophan. Our efforts to synthesize all possible diastereomers of the natural ditryptoleucine isolates uncovered structural factors that determine the rate and efficiency of dioxopiperazine ring formation, leading in some cases to mixtures of diastereomers by concomitant epimerization, to the formation of their putative monomeric dioxopiperazine dipeptide biogenetic precursors, and to the alternative formation of a dimer with a fused 1,3,5-triazepan-6-one heterocycle.
There is broad consensus regarding the fact that street art is a form of social, political and cultural protest and critique. However, rather than one single form, street art consists of a wide range ...of complex and contradictory styles featuring a diversity of interests, derivations and conflicts with underlying factors of both a structural and contextual nature. Taking as examples the cases of Pinacoteca a
Cel Obert and Pinta Malasaña, in Barcelona and Madrid respectively, this article explores the production of urban art and notes how, as part of plans to revitalize neighborhoods, it assumes different versions in harmony with the characteristics and circumstances of the surrounding areas. Using a qualitative methodology, it explores the conception, development and results of both projects, revealing the heterogeneity of explanatory factors, the complexity of their implementation, and the role, which is not exempt from conflict and rivalry, of street artists in the urban space.
ObjectiveExtravasation is a potential complication resulting from parenteral administration of drugs. The purpose of this study was to characterise the physicochemical properties of ...non-antineoplastic parenterally administered drugs and determine their potential to cause a toxic effect on tissue.MethodsA list of drugs administered by intermittent or continuous intravenous (IV) infusion was prepared. A database was also established to collect information from the literature. Each active substance was classified according to its risk to cause tissue damage using the following criteria: (1) High risk: active substances presenting with any of the following characteristics: osmolarity of the IV solution form >500 mOsm/L; vasoconstriction; vesication; cellular toxicity; very common, common or uncommon adverse events such as phlebitis, necrosis or pain at the site of administration according to the Summary of Product Characteristics. (2) Moderate risk: active substances where the pH range was <3 or >11 or where adverse events at the site of administration occurred rarely, very rarely or with unknown frequency. (3) Low risk: active substances where the osmolarity of the IV solution was <500 mOsm/L and the pH ranged between 3 and 11. These active substances did not cause vasoconstriction, neither were they classified as vesicant or cytotoxic or presented with adverse events at the site of administration.ResultsThe risk classification list included 138 active substances, of which 86 were classified as ‘high risk’, 18 as ‘moderate risk’ and 34 as ‘low risk’.ConclusionThe classification of intravenously administered drugs according to their risk profile is useful to ensure their safe use, as it can be used to implement the necessary safety measures to prevent adverse events.
Infection (either community acquired or nosocomial) is a major cause of morbidity and mortality in critical care medicine. Sepsis is present in up to 30% of all ICU patients. A large fraction of ...sepsis cases is driven by severe community acquired pneumonia (sCAP), which incidence has dramatically increased during COVID-19 pandemics. A frequent complication of ICU patients is ventilator associated pneumonia (VAP), which affects 10-25% of all ventilated patients, and bloodstream infections (BSIs), affecting about 10% of patients. Management of these severe infections poses several challenges, including early diagnosis, severity stratification, prognosis assessment or treatment guidance. Digital PCR (dPCR) is a next-generation PCR method that offers a number of technical advantages to face these challenges: it is less affected than real time PCR by the presence of PCR inhibitors leading to higher sensitivity. In addition, dPCR offers high reproducibility, and provides absolute quantification without the need for a standard curve. In this article we reviewed the existing evidence on the applications of dPCR to the management of infection in critical care medicine. We included thirty-two articles involving critically ill patients. Twenty-three articles focused on the amplification of microbial genes: (1) four articles approached bacterial identification in blood or plasma; (2) one article used dPCR for fungal identification in blood; (3) another article focused on bacterial and fungal identification in other clinical samples; (4) three articles used dPCR for viral identification; (5) twelve articles quantified microbial burden by dPCR to assess severity, prognosis and treatment guidance; (6) two articles used dPCR to determine microbial ecology in ICU patients. The remaining nine articles used dPCR to profile host responses to infection, two of them for severity stratification in sepsis, four focused to improve diagnosis of this disease, one for detecting sCAP, one for detecting VAP, and finally one aimed to predict progression of COVID-19. This review evidences the potential of dPCR as a useful tool that could contribute to improve the detection and clinical management of infection in critical care medicine.
A variety of anatomical alterations have been reported in the hippocampal formation of patients with Alzheimer's Disease (AD) and these alterations have been correlated with cognitive symptoms in the ...early stages of the disease. Major hallmarks in AD are the presence of paired helical filaments of tau protein (PHF
) within neurons, also known as neurofibrillary tangles (NFTs), and aggregates of amyloid-β protein (Aβ) which form plaques in the extracellular space. Nevertheless, how the density of plaques and NFTs relate to the severity of cell loss and cognitive decline is not yet clear. The aim of the present study was to further examine the possible relationship of both Aβ plaques and NFTs with neuronal loss in several hippocampal fields (DG, CA3, CA1, and subiculum) of 11 demented AD patients. For this purpose, using stereological techniques, we compared neuronal densities (Nissl-stained, and immunoreactive neurons for NeuN) with: (i) numbers of neurons immunostained for two isoforms of PHF
(PHF
and PHF
); and (ii) number of Aβ plaques. We found that CA1 showed the highest number of NFTs and Aβ plaques, whereas DG and CA3 displayed the lowest number of these markers. Furthermore, AD patients showed a variable neuronal loss in CA1 due to tangle-related cell death, which seems to correlate with the presence of extracellular tangles.
•This is a prospective analysis of 1047 patients with A (H3N2) laboratory-confirmed infection.•The analysis of the cycle threshold value by quantitative reverse transcription-polymerase chain ...reaction was used as a marker of viral load.•Infants, children, and the elderly present the highest viral load.•Outpatients showed higher viral loads than hospitalized patients.•Age and care setting are important for viral load evaluation.
The aim of this study was to analyze the viral load (VL) using cycle threshold (Ct) in patients infected with influenza A (H3N2).
This prospective study was conducted during the 2022-2023 influenza season in sentinel, non-sentinel, and hospitalized patients of Castilla y León (Spain). Respiratory samples were obtained from nasopharyngeal swabs and analyzed by quantitative reverse transcription-polymerase chain reaction specific for influenza A (H3N2) to obtain the Ct value.
A total of 1047 individuals were enrolled (174 16.6% sentinel, 200 19.1% non-sentinel, 673 64.3% hospitalized). The mean Ct value was lower in infants, young children, and in the elderly, with a sharp increase in the last from 65 years until 90 years. In addition, the lower Ct values were observed in non-sentinel patients and then in hospitalized patients, probably because non-sentinel are outpatients in the acute phase of the influenza infection.
A higher VL (lower Ct value) is related to the extreme ages of life: children and the elderly. Furthermore, a higher VL is related with the care setting, being probably higher in outpatients because they are in the acute phase of the disease and slightly lower in hospitalized patients because they are attended during the post-acute phase.
This study was performed aimed at comparing multidirectional bilateral and unilateral jump performance and passive range of motion (ROM) of lower limbs between soccer and basketball young players and ...evaluating associations between inter-limb ROM asymmetry and bilateral jump performance. A total of 67 young male athletes participated in this study, who were classified as soccer (n = 40; 15.55 ± 1.5 y; 1.76 ± 0.12 m; 58.15 ± 10.82 kg; 19.84 ± 2.98 kg·m2) and basketball (n = 27; 15.7 ± 1.66 y; 1.76 ± 0.12 m; 62.33 ± 16.57 kg; 19.84 ± 2.98 kg·m2) players. Participants were asked to perform bilateral and unilateral multidirectional jumps, and passive ROM of hip (flexion, extension and abduction), knee (flexion) and ankle (dorsiflexion) joints was also assessed. Significant between-group differences were observed for hip extension with flexed knee ROM in dominant (soccer: 142.43 ± 7.74°; basketball: 148.63 ± 8.10°) and non-dominant (soccer: 144.38 ± 8.36°; basketball: 148.63 ± 6.45°) legs; hip flexion with flexed knee ROM in dominant (soccer: 13.26 ± 4.71°; basketball: 9.96 ± 3.42°) and non-dominant (soccer: 12.86 ± 4.55°; basketball: 9.70 ± 3.62°) legs; and for the ratio of hip abduction (soccer: 1.02 ± 0.08; basketball: 0.97 ± 0.11). However, no significant between-group differences were observed for bilateral and unilateral jump capacity, or for inter-limb asymmetries (dominant vs. non-dominant leg). Finally, no associations were observed between ROM ratio (dominant vs. non-dominant leg) and bilateral jump performance. These findings lead to the suggestion that differences on passive ROM values in young male athletes may be sport-specific. Additionally, there seems to be need for the implementation of training strategies specifically aimed at improving bilateral or unilateral jump ability, or at diminishing inter limb passive ROM differences in order to improve multidirectional jump performance for neither soccer nor basketball youth male players.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The central aim of this article is to describe the state of art of the impact of globalisation on Barcelona and Madrid (Spain). It especially focuses on the transformations of their historic centres, ...the most accessible and highly contested spaces, and the reactions of their citizen movements and city councils. It begins by analysing the gentrification process. It then shows how these cities were even more intensively transformed by commercial gentrification, touristification and studentification, all within a general framework of financialisation. Consequently, both cities act like businesses, seeking high profits, and ignoring many of their citizens. Within this context, public policies have undergone a slight change of orientation. In this tense context, this article presents a series of reflections and suggestions for future action.
PDF
