RESUMEN Introducción: el síndrome antifosfolípido es una enfermedad trombofílica, autoinmune, rara, todavía poco conocida por todos los profesionales de la salud, lo cual implica demora en el ...diagnóstico y en el tratamiento oportuno. Objetivo: exponer los factores de impacto social del síndrome antifosfolípido por su incidencia en la calidad de vida de los pacientes. Métodos: se realizó la revisión de la bibliografía a través del motor de búsqueda Google Académico con los descriptores: síndrome antifosfolípido, morbimortalidad, daño, impacto social, calidad de vida, en las bases de datos SciELO, Medline-Pubmed, Hinari. Resultados: la revisión se centra en cuatro subtemas: Ocurrencia del síndrome antifosfolípido en la morbimortalidad trombótica y obstétrica, La recurrencia de los eventos trombóticos y el daño crónico acumulado, El deterioro de la calidad de vida de los pacientes con síndrome antifosfolípido, e Importancia de la labor educativa en el impacto social del síndrome antifosfolípido. Los cambios en los estilos de vida para la corrección de los factores de riesgo que deben enfrentar estos pacientes, añaden restricciones a su vida diaria y el temor a las recurrencias y a la muerte, provocan alteraciones psicológicas adicionales que motivan atención especializada. Conclusiones: se hace necesario diseñar estrategias de salud a gran escala para la atención integral y multidisciplinaria de los pacientes con síndrome antifosfolípido, que incluyan capacitar a los profesionales de la salud y aplicar acciones educativas que involucren a las familias.
Resumen: En las últimas décadas, se ha venido observando en las ciudades occidentales una tendencia generalizada a un uso cada vez menor de los espacios públicos por parte de la infancia. Si bien, ...desde una perspectiva psicológica, sus consecuencias negativas sobre los y las niñas son ampliamente conocidas, en el plano sociológico, sus efectos sobre la ciudad han sido mucho menos explorados. Sin embargo, si partimos de los planteamientos que evalúan el éxito o fracaso de la ciudad a partir de su capacidad de incluir la diversidad social, el uso del espacio público por parte de la infancia puede considerarse un indicador afinado de su buen o mal funcionamiento. Partiendo de esta hipótesis y por medio de un estudio comparativo de dos espacios públicos del centro de Madrid, se hace una reflexión sobre las causas del problema y las respuestas necesarias para avanzar hacia ciudades más sostenibles e inclusivas, proponiendo recuperar el concepto de “los ojos de la calle” de Jane Jacobs como herramienta para la evaluación y diseño de los espacios públicos desde una perspectiva infantil.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
One unidentified, Gram-stain-positive, catalase-negative coccus-shaped organism was recovered from a subcutaneous abscess of the udder of a sheep and subjected to a polyphasic taxonomic analysis. ...Based on cellular morphology and biochemical criteria, the isolate was tentatively assigned to the genus Streptococcus, although the organism did not appear to match any recognized species. 16S rRNA gene sequence comparison studies confirmed its identification as a member of the genus Streptococcus and showed that the nearest phylogenetic relatives of the unknown coccus corresponded to Streptococcus moroccensis and Streptococcus cameli (95.9 % 16S rRNA gene sequence similarity). The sodA sequence analysis showed less than 89.3 % sequence similarity with the currently recognized species of the genus Streptococcus. The novel bacterial isolate was distinguished from close relatives of the genus Streptococcusby using biochemical tests. A mass spectrometry profile was also obtained for the novel isolate using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Based on both phenotypic and phylogenetic findings, it is proposed that the unknown bacterium be classified as a representative of a novel species of the genus Streptococcus, Streptococcus ovuberis sp. nov. The type strain of Streptococcus ovuberissp. nov. is VB15-00779
(=CECT 9179
=CCUG 69612
).
Staphylococcus aureus encompasses 2 subspecies (aureus and anaerobius) with significant differences in their epidemiology and pathogenicity. We evaluated the suitability of matrix-assisted laser ...desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the rapid identification of both subspecies using a panel of 52 S. aureus isolates (30 subsp. anaerobius and 22 subsp. aureus) recovered from different origins, countries, and years. The on-board library identification system correctly identified 42 of 52 (81%) S. aureus isolates at the species level with score values >2.0. Limited performance was observed for differentiation of S. aureus subspecies (particularly subsp. anaerobius). Visual inspection of MALDI-TOF MS profiles identified 5 subspecies-specific mass peaks (m/z 3430 and 6861 in S. aureus subsp. anaerobius, and m/z 4046, 6890, and 8093 in S. aureus subsp. aureus) with 100% sensitivity and specificity values, which is potentially useful for differentiating these subspecies. The suitability of 3 models, Genetic Analysis (GA), Quick Classifier (QC), and Supervised Neural Network, for automatic identification of both subspecies was evaluated using the Recognition Capability (RC) and Cross Validation (CV) values provided by the on-board ClinProTools software. The GA and QC models reached RC and CV values of 100%. Both models were externally validated using a panel of 26 S. aureus isolates of both subspecies, with both models correctly classifying all isolates of both subspecies. MALDI-TOF MS coupled with ClinProTools software represents a rapid and simple approach for S. aureus subspecies discrimination.
En este artículo se analiza la importancia de los mercados de abastos como espacios turísticos en el planteamiento promocional de la ciudad y sus consecuencias sobre ésta. Los casos de Barcelona y ...Madrid nos sirven para ilustrar esta realidad. Concretamente, los mercados de La Boquería, Santa Caterina, Barceloneta, La Princesa y Sant Antoni (para Barcelona); San Miguel, San Antón, La Cebada, Barceló, San Fernando, Antón Martín y Los Mostenses (en Madrid). Y en éstos, lo que presenciamos es que los mercados de abastos presentan diversas fisonomías en función del grado de turistificación que puede constatarse en ellos. Así pues, nos planteamos establecer una tipología de mercados, a partir de diferentes variables que determinan la actual evolución de estos espacios desde ser equipamientos y servicios públicos a ser equipamientos propiamente de comercio y consumo, y las consecuencias que reportan para la ciudad cada uno de ellos.
Staphylococcus are widespread bacteria that cause superficial and invasive infections in several species. The species Staphylococcus delphini is a Gram-positive bacterium belonging to the ...Staphylococcus intermedius group, being a mucosa colonizer and an opportunistic pathogen in some animals, including delphinids. The first isolation was from two aquarium dolphins suffering from multifocal purulent skin lesions. S. delphini has subsequently been isolated from other mammals and avian species. Recently, the zoonotic potential of S. delphini has been recognized. Here, Romani-Cremaschi et al present the diagnosis and successful treatment of S. delphini-caused cutaneous lesions on a common bottlenose dolphin (Tursiops truncatus) under human care.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
In elderly patients with non-ST elevation acute coronary syndrome (NSTEACS), while routine invasive management is established in high-risk NSTEACS patients, there is still uncertainty regarding the ...optimal timing of the procedure.
This study analyzes the association of early coronary angiography with all-cause mortality, cardiovascular mortality, heart failure (HF) hospitalization, and major adverse cardiovascular events (MACE) in patients older than 75 years old with NSTEACS.
This retrospective observational study included 7811 consecutive NSTEACS patients who were examined between the years 2003 and 2017 at two Spanish university hospitals. There were 2290 patients older than 75 years old. We compared their baseline characteristics according to the early invasive strategy used (coronarography ≤24 h vs. coronarography >24 h) after the diagnosis of NSTEACS.
Among the study participants, 1566 patients (68.38%) underwent early invasive coronary intervention. The mean follow-up period was 46 months (interquartile range 18–71 months).
This association was also maintained after propensity score matching: early invasive strategy was significantly related to lower all-cause mortality HR 0.61 (95% CI 0.51–0.71), cardiovascular mortality HR 0.52 (95% CI 0.43–0.63), and MACE HR 0.62 (CI 95% 0.54–0.71).
In a contemporary real-world registry of elderly NSTEACS patients, early invasive management significantly reduced all-cause mortality, cardiovascular mortality, and MACE during long-term follow-up.
In this real-world retrospective observational study that included 2451 patients older than 75 years old, 1566 patients (68.38%) underwent early invasive coronary intervention. After performing a propensity score matching, the early invasive strategy was still associated with lower all-cause mortality HR (hazard ratio) 0.61, 95% CI (95% confidence interval) (0.51–0.71), cardiovascular mortality HR 0.52 (95%CI 0.43–0.63), and MACE HR 0.62 (95%CI 0.54–0.71) during long-term follow-up.
Leishmaniasis is one of the most important neglected zoonosis and remains endemic in at least 88 developing countries in the world. In addition, anthropogenic environmental changes in urban areas are ...leading to its emergency world wide. Zoonotic leishmaniasis control might only be achieved by an integrated approach targeting both the human host and the animal reservoirs, which in certain sylvatic cycles are yet to be identified. Recently, hares have been pointed out as competent reservoirs of Leishmania infantum in Spain, but the role of other lagomorphs has not been clarified. Here, 69 rabbits (Oryctolagus cuniculus) from a natural area in Madrid in which a high density was present were analyzed using indirect (immunofluorescence antibody test, IFAT) and direct (PCR, culture) techniques. Fifty-seven (82.6%) of the animals were positive to at least one technique, with IFAT yielding the highest proportion of positive samples. L. infantum was isolated in 13% animals demonstrating the occurrence of infection in this setting. Our results suggest that rabbits could play a role of competent reservoir of L. infantum and demonstrate that the prevalence of infection is high in the analyzed area.
The aim of this article is to highlight the importance of urban food markets as tourist icons in the current competitive race to create attractive cities. Food markets attract a large number of ...consumers, both local and tourists. However, their impact on the city and its dynamics should be treated to establish measures to ensure sustainable (compatible) uses for both kinds of users. This calls for the establishment of a system of indicators to determine what level of sustainability food markets are at and facilitate decision-making for the agents involved in their management.
Se examina la relevancia de los arraigos y las proximidades espaciales en las grandes ciudades iberoamericanas, analizando su protagonismo en los arreglos cotidianos que posibilitan los cuidados y la ...provisión de bienestar, y con los que se hace frente a situaciones de vulnerabilidad. La perspectiva que se adopta permite atender a estos arraigos locales, que han quedado en un lugar subordinado en la literatura sobre la globalización. Se presta atención tanto a su dimensión material como simbólica y representacional, incorporando, al mismo tiempo, sus transformaciones en el contexto global desde una aproximación multiescalar. El foco de atención son las ciudades de Barcelona, Buenos Aires y Madrid, especialmente sus barrios vulnerables.
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