•Viaduct redesign using Fiber Reinforced Concrete (FRC) as resisting material.•Case study on the replacement of reinforced concrete by FRC.•FRC replaces conventional reinforcement in transversally ...prestressed viaducts.•Serviceability reinforcement due to light-train loads is fully eliminated with FRC.•FRC improves crack opening for large concrete covers while using ULS reinforcement.
An assessment concerning the structural applicability and performance of fiber reinforced concrete (FRC) is presented for different bridge elements and within a design framework. FRC as the main bearing material in structural members has evolved from low-demand applications to increasingly ones, where bending and shear are the main internal forces. In actual applications, this was reflected with initial slab-on-grade cases, through tunnels, and later moving towards elevated slabs. Past experiences show that FRC has notable features regarding ultimate capacity and serviceability performance (i.e., enhanced crack control). These capabilities allowed for optimizations such as material savings, reduction of intensive labor during construction, or extended durability. Considering FRC's enhancements from previous applications, a case study based on the Metrorrey Line 2 light-train viaduct (Mexico) is developed. The case study aims to assess the structural performance that FRC can deliver within bridge geometries, loads, and specific conditions. Two numerical models considering different transversal post-tensioning configurations are developed based on the reference structure. The use of these two numerical models aims to broaden the applicability of this study to most U-shaped light-train viaducts. The design is based on current and future standards and recommendations, being prEN1992-1-1:2021, EN1992-1-1:2004, and fib Model Code 2010. After the numerical models and structural analysis, different sectional analyses at ultimate and serviceability levels are carried out, considering both conventional and fiber reinforced concretes. From the sectional results, FRC can provide reductions to reinforcement quantities at ultimate load levels, which are tied to the initially required reinforcement ratio (in other words, linked to the internal forces existing in the element). When higher reinforcement ratios are necessary, FRC optimizations point toward serviceability limit states, especially on the crack width reduction and the potential to reduce or suppress any additional reinforcement due to crack limitations.
The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in 11Craclopride studies in rats. The final aim was to determine ...if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of 11Craclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Purpose
11
C-GSK931145 is a novel radioligand suitable for imaging the glycine transporter 1 (GlyT-1) in brain. In the present study, human dosimetry is estimated from baboon and human ...biodistribution data.
Procedures
Three baboons and eight healthy human volunteers underwent whole-body positron emission tomography (PET) scans. Human dosimetry was estimated using three different region-of-interest (ROI) delineation methods that ranged in their complexity and execution time: ROIs drawn on anterior-posterior compressed PET images, on subsamples of the organs, and covering the whole-organ. Residence times for each organ were calculated as the area under the time-activity curves divided by the injected activity. Radiation dose estimates were calculated from organ residence times using the OLINDA/EXM software package.
Results
The overall distribution of activity was similar in baboons and humans. Early scans presented high activity in the liver, and moderate activity in the lungs and kidneys. The principal route of clearance was intestinal and no urinary excretion was observed. The limiting organ with the highest radiation-absorbed dose was the liver. The mean effective dose in humans was 4.02 μSv/MBq (male phantom) and 4.95 μSv/MBq (female phantom) (ROIs drawn on subsamples of the organs). The human effective dose estimated from baboon data was ~15% larger than the effective dose estimated from human data.
Conclusion
Human PET imaging of the glycine transporter-1 with
11
C-GSK931145 results in a moderate effective human radiation dose, which allows for multiple PET examinations in the same individual. Among the three methods compared to delineate ROIs, the organ subsampling method shows the best balance between quantitative accuracy and practical application.
^sup 11^C-GSK931145 is a novel radioligand suitable for imaging the glycine transporter 1 (GlyT-1) in brain. In the present study, human dosimetry is estimated from baboon and human biodistribution ...data. Three baboons and eight healthy human volunteers underwent whole-body positron emission tomography (PET) scans. Human dosimetry was estimated using three different region-of-interest (ROI) delineation methods that ranged in their complexity and execution time: ROIs drawn on anterior-posterior compressed PET images, on subsamples of the organs, and covering the whole-organ. Residence times for each organ were calculated as the area under the time-activity curves divided by the injected activity. Radiation dose estimates were calculated from organ residence times using the OLINDA/EXM software package. The overall distribution of activity was similar in baboons and humans. Early scans presented high activity in the liver, and moderate activity in the lungs and kidneys. The principal route of clearance was intestinal and no urinary excretion was observed. The limiting organ with the highest radiation-absorbed dose was the liver. The mean effective dose in humans was 4.02 μSv/MBq (male phantom) and 4.95 μSv/MBq (female phantom) (ROIs drawn on subsamples of the organs). The human effective dose estimated from baboon data was ~15% larger than the effective dose estimated from human data. Human PET imaging of the glycine transporter-1 with ^sup 11^C-GSK931145 results in a moderate effective human radiation dose, which allows for multiple PET examinations in the same individual. Among the three methods compared to delineate ROIs, the organ subsampling method shows the best balance between quantitative accuracy and practical application.PUBLICATION ABSTRACT
The new Information Society context entails new risks of social exclusion due to the digital exclusion even when it generates new possibilities for inclusion thanks to accessible Information and ...Communication Technologies (ICT) and universal design 15. In this context, we see that e-learning provides a powerful tool towards social inclusion. Yet, we have seen that compliance with accessibility and e-learning standards together with the usage of adequate devices does not guarantee a satisfactory experience for those with a disability 9. As a result, our project specifically tackles the design of educational technical applications specifically developed for the visually impaired, following a user-centered design perspective.
Purpose: super(11)C-GSK931145 is a novel radioligand suitable for imaging the glycine transporter 1 (GlyT-1) in brain. In the present study, human dosimetry is estimated from baboon and human ...biodistribution data. Procedures: Three baboons and eight healthy human volunteers underwent whole-body positron emission tomography (PET) scans. Human dosimetry was estimated using three different region-of-interest (ROI) delineation methods that ranged in their complexity and execution time: ROIs drawn on anterior-posterior compressed PET images, on subsamples of the organs, and covering the whole-organ. Residence times for each organ were calculated as the area under the time-activity curves divided by the injected activity. Radiation dose estimates were calculated from organ residence times using the OLINDA/EXM software package. Results: The overall distribution of activity was similar in baboons and humans. Early scans presented high activity in the liver, and moderate activity in the lungs and kidneys. The principal route of clearance was intestinal and no urinary excretion was observed. The limiting organ with the highest radiation-absorbed dose was the liver. The mean effective dose in humans was 4.02 mu Sv/MBq (male phantom) and 4.95 mu Sv/MBq (female phantom) (ROIs drawn on subsamples of the organs). The human effective dose estimated from baboon data was ~15% larger than the effective dose estimated from human data. Conclusion: Human PET imaging of the glycine transporter-1 with super(11)C-GSK931145 results in a moderate effective human radiation dose, which allows for multiple PET examinations in the same individual. Among the three methods compared to delineate ROIs, the organ subsampling method shows the best balance between quantitative accuracy and practical application.
The User-centered design (UCD) game is a tool for human-computer interaction practitioners to demonstrate the key user-centered design methods and how they interrelate in the design process in an ...interactive and participatory manner. The target audiences are departments and institutions unfamiliar with UCD but whose work is related to the definition, creation, and update of a product or service.
User-centered design gymkhana Garreta-Domingo, Muriel; Almirall-Hill, Magí; Mor, Enric
CHI '07 Extended Abstracts on Human Factors in Computing Systems,
04/2007
Conference Proceeding
Odprti dostop
The User-centered design (UCD) Gymkhana is a tool for human-computer interaction practitioners to demonstrate through a game the key user-centered design methods and how they interrelate in the ...design process. The target audiences are other organizational departments unfamiliar with UCD but whose work is related to the definition, creation, and update of a product or service.
The User-centered design (UCD) game is a tool for
human-computer interaction practitioners to demonstrate the key user-centered design methods
and how they interrelate in the design process in an ...interactive and participatory manner. The target audiences are departments and institutions unfamiliar with UCD but whose work is related to the definition, creation, and update of a product or service.
![Optimization of [11C]Raclop...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1536-0121/small "Optimization of [11C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification")
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