Highly sensitive and efficient biosensors play a crucial role in clinical, environmental, industrial, and agricultural applications, and tremendous efforts have been dedicated to advanced electrode ...materials with superior electrochemical activities and low cost. Here, we report a three-dimensional binder-free Cu foam-supported Cu2O nanothorn array electrode developed via facile electrochemistry. The nanothorns growing in situ along the specific direction of have single crystalline features and a mesoporous surface. When being used as a potential biosensor for nonenzyme glucose detection, the hybrid electrode exhibits multistage linear detection ranges with ultrahigh sensitivities (maximum of 97.9 mA mM–1 cm–2) and an ultralow detection limit of 5 nM. Furthermore, the electrode presents outstanding selectivity and stability toward glucose detection. The distinguished performances endow this novel electrode with powerful reliability for analyzing human serum samples. These unprecedented sensing characteristics could be ascribed to the synergistic action of superior electrochemical catalytic activity of nanothorn arrays with dramatically enhanced surface area and intimate contact between the active material (Cu2O) and current collector (Cu foam), concurrently supplying good conductivity for electron/ion transport during glucose biosensing. Significantly, our findings could guide the fabrication of new metal oxide nanostructures with well-organized morphologies and unique properties as well as low materials cost.
Purpose
To analyze how family resilience mediates the relationship between childhood trauma and psychological resilience in undergraduate nursing students.
Design and Methods
A cross‐sectional survey ...design was used to investigate 698 nursing undergraduate students (mean age: 18.77 ± 0.86 years) using the Childhood Trauma Questionnaire, Family Resilience Assessment Scale, and Connor–Davidson Resilience Scale. The mediating effect of family resilience was estimated using structural equation modeling and the bootstrap method.
Findings
Both childhood trauma and family resilience were associated with psychological resilience. Family resilience showed a partial mediating effect between childhood trauma and psychological resilience, accounting for 21.5% of the total effect.
Practice Implication
Our findings may help inform family interventions to improve the psychological resilience of nursing students, especially for those with childhood trauma experience.
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Recently, hyaluronic acid (HA) hydrogels have been extensively researched for delivering cells and drugs to repair damaged tissues, particularly articular cartilage. However, the in ...vivo degradation of HA is fast, thus limiting the clinical translation of HA hydrogels. Furthermore, HA cannot bind proteins with high affinity because of the lack of negatively charged sulfate groups. In this study, we conjugated tunable amount of sulfate groups to HA. The sulfated HA exhibits significantly slower degradation by hyaluronidase compared to the wild type HA. We hypothesize that the sulfation reduces the available HA octasaccharide substrate needed for the effective catalytic action of hyaluronidase. Moreover, the sulfated HA hydrogels significantly improve the protein sequestration, thereby effectively extending the availability of the proteinaceous drugs in the hydrogels. In the following in vitro study, we demonstrate that the HA hydrogel sulfation exerts no negative effect on the viability of encapsulated human mesenchymal stem cells (hMSCs). Furthermore, the sulfated HA hydrogels promote the chondrogenesis and suppresses the hypertrophy of encapsulated hMSCs both in vitro and in vivo. Moreover, intra-articular injections of the sulfated HA hydrogels avert the cartilage abrasion and hypertrophy in the animal osteoarthritic joints. Collectively, our findings demonstrate that the sulfated HA is a promising biomaterial for the delivery of therapeutic agents to aid the regeneration of injured or diseased tissues and organs.
In this paper, we conjugated sulfate groups to hyaluronic acid (HA) and demonstrated the slow degradation and growth factor delivery of sulfated HA. Furthermore, the in vitro and in vivo culture of hMSCs laden HA hydrogels proved that the sulfation of HA hydrogels not only promotes the chondrogenesis of hMSCs but also suppresses hypertrophic differentiation of the chondrogenically induced hMSCs. The animal OA model study showed that the injected sulfated HA hydrogels significantly reduced the cartilage abrasion and hypertrophy in the animal OA joints. We believe that this study will provide important insights into the design and optimization of the HA-based hydrogels as the scaffold materials for cartilage regeneration and OA treatment in clinical setting.
•Binary metal hydroxides with vertically nanosheets were prepared•The NiCo(OH)2 electrode revealed enhanced supercapacitor properties•Excellent performance linked to high electrical conductivity and ...abundant active sites
Electrode materials are crucial for the electrochemical performance of supercapacitors. Thus, it is urgent to develop a satisfactory electrode material with excellent energy storage properties. Binary metal hydroxides are competitive candidates for supercapacitors. Herein, we prepared honeycomb-like NiCo(OH)2 nanosheet arrays grown on nickel foam by a facile one-step solvothermal method. The electrochemical performance of as-prepared honeycomb-like NiCo(OH)2 nanosheet arrays as electrode materials for supercapacitor have been evaluated. The NiCo(OH)2 electrode exhibits higher areal capacity (267 mF cm−2) compared with Ni(OH)2 (31.2 mF cm−2) and Co(OH)2 (87.73 mF cm−2) at the current density of 20 mA cm−2. The capacity retention can up to 83.8% after 5000 cycles. Such intriguing electrochemical performance enables it to be a potential electrode material for supercapacitors.
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Hydrogels are appealing biomaterials for applications in regenerative medicine due to their tunable physical and bioactive properties. Meanwhile, therapeutic metal ions, such as ...magnesium ion (Mg2+), not only regulate the cellular behaviors but also stimulate local bone formation and healing. However, the effective delivery and tailored release of Mg2+ remains a challenge, with few reports on hydrogels being used for Mg2+ delivery. Bisphosphonate exhibits a variety of specific bioactivities and excellent binding affinity to multivalent cations such as Mg2+. Herein, we describe a nanocomposite hydrogel based on hyaluronic acid and self-assembled bisphosphonate-magnesium (BP-Mg) nanoparticles. These nanoparticles bearing acrylate groups on the surface not only function as effective multivalent crosslinkers to strengthen the hydrogel network structure, but also promote the mineralization of hydrogels and mediate sustained release of Mg2+. The released Mg2+ ions facilitate stem cell adhesion and spreading on the hydrogel substrates in the absence of cell adhesion ligands, and promote osteogenesis of the seeded hMSCs in vitro. Furthermore, the acellular porous hydrogels alone can support in situ bone regeneration without using exogenous cells and inductive agents, thereby greatly simplifying the approaches of bone regeneration therapy.
In this study, we developed a novel bioactive nanocomposite hydrogel based on hyaluronic acid and self-assembled bisphosphonate-magnesium (BP-Mg) nanoparticles. Such hydrogels are stabilized by the multivalent crosslinking domains formed by the aggregation of Ac-BP-Mg NPs, and therefore show enhanced mechanical properties, improved capacity for mineralization, and controlled release kinetics of Mg2+. Moreover, the released Mg2+ can enhance cell adhesion and spreading, and further promote the osteogenic differentiation of hMSCs. Owing to these unique properties, these acellular hydrogels alone can well facilitate the in vivo bone regeneration at the intended sites. We believe that the strategy reported in this work opens up a new route to develop biopolymer-based nanocomposite hydrogels with enhanced physical and biological functionalities for regenerative medicine.
This study proposes a novel type of tube with helical dimples. Turbulent heat transfer and flow resistance in a heat exchanger tube with helical dimples were numerically investigated. Furthermore, ...the effects of the geometric parameters, including spiral pitch, transverse length, number of starts, depth, and radius on the performance were investigated. The results demonstrated that the longitudinal swirling flow and vortex generated behind the helical dimples result in adequate fluid mixing between the mainstream and near-wall regions. Therefore, the thermal performance of the tube with helical dimples was enhanced by 120–270% in comparison with the plain tube. Both Nu/Nu0 and f/f0 increased with increasing dimple starts, depth, and radius and decreasing spiral pitch and transverse length. Additionally, a maximum PEC = 1.93 was obtained by employing the geometric model with P = 30 mm, L = 6.9 mm, N = 4, D = 2 mm, and R = 2 mm in all cases.
Abstract
Neural network has made remarkable achievements in the field of image classification, but they are threatened by adversarial examples in the process of application, making the robustness of ...neural network classifiers face danger. Programs or software based on neural network image classifiers need to undergo rigorous robustness testing before use and promotion, in order to effectively reduce losses and security risks. To comprehensively test the robustness of neural network image classifiers and standardize the test process, starting from the two aspects of generated content and interference intensity, a variety of robustness test sets are constructed, and a robustness testing framework suitable for neural network classifiers is proposed. And the feasibility and effectiveness of the test framework and method are verified by testing LENET-5 and the model reinforced by the adversavial training.
BACKGROUNDThe urgency of ensuring adequate professional competence in clinical nursing practice is evident. However, there is little formal professional competence framework for the education of ...master's degree students in nursing specialist programs in China. OBJECTIVETo develop a professional competence framework for the Master of Nursing Specialist (MNS) degree program in China. DESIGNA modified Delphi study. PARTICIPANTSAn expert panel discussion was held with 12 experts, and Delphi rounds were conducted with 24 experts. METHODSA literature review and an expert panel discussion were conducted to develop an initial competence framework. A two-round Delphi survey was employed to obtain a consensus on the framework through either an online or paper questionnaire. Descriptive statistics were used to analyze the data. The consensus threshold was set according to the mean (≥ 4.0), coefficient of variation (< 0.25), and consensus level of agreement (≥70 %). RESULTSA consensus on seven domains and 54 items of the professional framework for the MNS degree program was achieved. The framework domains included clinical practice (12 items), professional attitude (8 items), collaboration and communication (5 items), professional development (8 items), research (7 items), education (7 items), and administration (7 items). CONCLUSIONThe professional competence framework offers guidelines for MNS degree programs in China. Future research should focus on imbedding these competences in MNS degree programs to prepare qualified advanced practice nurses.
Abstract Aims This study explored the relationships between family resilience, dyadic coping and psychological adjustment among adolescents with chronic illnesses and their parents. The actor–partner ...interdependence mediation model was used to validate the mediating role of dyadic coping in the relationship between family resilience and psychological adjustment. Design This is a cross‐sectional study. Methods A total of 318 parent–adolescents dyads were recruited from three paediatric hospitals in Wenzhou, Hangzhou, Shanghai city, China, between June 2022 and August 2023. The parents had a mean age of 41.62 years, and the adolescents had a mean age of 12.66 years. Participants independently completed a self‐report questionnaire assessed family resilience, dyadic coping and psychological adjustment. Data analysis was conducted using the actor–partner interdependence mediation model. Results The findings suggest that in the actor effects, family resilience directly influenced psychological adjustment, and family resilience is related to psychological adjustment through positive dyadic coping. In the partner effect, parents' family resilience influenced adolescents' psychological adjustment through the parents' positive dyadic coping. Similarly, adolescents' family resilience influenced parents' psychological adjustment through both parents' positive dyadic coping and adolescents' negative dyadic coping. Additionally, there was a partner effect between parents' family resilience and adolescents' psychological adjustment. Conclusion This study demonstrated the importance of developing effective dyadic interventions based on family resilience or positive dyadic coping strategies to improve the mental health of adolescents with chronic illnesses and their parents. Impact The mediating role of dyadic coping in the relationship between family resilience and psychological adjustment among adolescents with chronic illnesses and their parents was demonstrated. Future psychosocial interventions should focus on increasing parents' positive dyadic coping strategies and improving adolescents' negative dyadic coping strategies. Patient or Public Contribution No patient or public contribution.
This inquiry probes the suicide resilience experiences in suicide attempts by self-poisoning among Chinese youth. The study's goal is to provide healthcare professionals with critical insights to ...develop effective interventions that enhance suicide prevention measures and diminish the likelihood of subsequent attempts.
Utilizing a qualitative phenomenological approach, we conducted semi-structured interviews with 12 youths (Mean age = 21.1 ± 2.8 years; n = 7 females) who survived suicide attempts by self-poisoning. Data analysis was performed using Colaizzi's seven-step method, a rigorous method entailing iterative reading for the extraction of key statements and the distillation of thematic essence.
Four primary themes with ten sub-themes were extracted: (1) New understanding of life (cherish life, and meaning of life), (2) Self-Reconciliation (self-acceptance, self-understanding, and self-openness), (3) Personal empowerment (increased self-reliance, increased responsibility, and increased emotional regulation), and (4) Life redesigning (faith in the future, and plan for the future).
The findings reveal a potential for psychological growth and beneficial transformation in youth following suicide attempts by self-poisoning. These insights advocate for the integration of positive psychology principles in therapeutic interventions for this demographic.
•Incorporating a strength-based perspective in youth suicide prevention research is essential.•This study examines how Chinese youths rebound after self-poisoning, offering insights into suicide resilience in suicidal crises.•Surviving youths can develop suicide resilience, making it crucial for nurses to enhance their supportive role in this transformation.
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