The role of autotransplantation in end-stage hepatic alveolar echinococcosis (AE) is unclear. We aimed to present our 15-case experience and propose selection criteria for autotransplantation. All ...patients were considered to have unresectable hepatic AE by conventional resection due to critical invasion to retrohepatic vena cava, hepatocaval region along with three hepatic veins, and the tertiary portal and arterial branches. All patients successfully underwent ex vivo extended right hepatectomy and autotransplantation without intraoperative mortality. The median autograft weight was 706 g (380–1000 g); operative time was 15.5 hours (11.5–20.5 hours); and anhepatic time was 283.8 minutes (180–435 min). Postoperative hospital stay was 32.3 days (12–60 days). Postoperative complication Clavien–Dindo grade IIIa or higher occurred in three patients including one death that occurred 12 days after the surgery due to acute liver failure. One patient was lost to follow-up after the sixth month. Thirteen patients were followed for a median of 21.6 months with no relapse. This is the largest reported series of patients with end-stage hepatic AE treated with liver autotransplantation. The technique requires neither organ donor nor postoperative immunosuppressant. The early postoperative mortality was low with acceptable morbidity. Preoperative precise assessment and strict patient selection are of utmost importance.
We calculate the two-photon exchange corrections to electron-proton scattering with nucleon and Delta intermediate states. The results show a dependence on the elastic nucleon and nucleon- Delta ...-transition form factors used as input which leads to significant changes compared to previous calculations. We discuss the relevance of these corrections and apply them to the most recent and precise data set and world data from electron-proton scattering. Using this, we show how the form factor extraction from these data is influenced by the subsequent inclusion of physical constraints. The determination of the proton charge radius from scattering data is shown to be dominated by the enforcement of a realistic spectral function. Additionally, the third Zemach moment from the resulting form factors is calculated. The obtained radius and Zemach moment are shown to be consistent with Lamb shift measurements in muonic hydrogen.
A novel sandwich-like heterotrinuclear Zn(II)
2
Mn(III) complex, {Zn(L)Cl}
2
MnCl, has been constructed successfully from a bicompartmental 3-MeOSalphen ligand (H
2
L), ...N,N′-bis(3-methoxy-salicylidene)phenylene-1,2-diamine. The chemically obained structure was determined through single crystal X-ray diffraction and spectrochemical (IR and UV-Vis) analyses. The structural studies revealed that characteristic inner N
2
O
2
compartment of H
2
L is occupied by Zn(II) atom and outer O
2
O
2
compartment is coordinated by Mn(III) atom in the Zn(II)–Mn(III) complex. The Zn(II)–Mn(III) complex can be used as a potential light-emitting material owing to the fluorescent property. In addition, density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations were performed to take insight of experimental electronic spectra. Interaction region indicator (IRI) analyses were calculated to show relative chemical bond changes before and after coordination.
ABSTRACT We present preliminary results of the quasar survey in the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) first data release (DR1), which includes the pilot survey and ...the first year of the regular survey. There are 3921 quasars reliably identified, among which 1180 are new quasars discovered in the survey. These quasars are at low to median redshifts, with a highest z of 4.83. We compile emission line measurements around the H , Hβ, Mg ii, and C iv regions for the new quasars. The continuum luminosities are inferred from SDSS photometric data with model fitting, as the spectra in DR1 are non-flux-calibrated. We also compile the virial black hole mass estimates, with flags indicating the selection methods, and broad absorption line quasars. The catalog and spectra for these quasars are also available. Of the 3921 quasars, 28% are independently selected with optical-infrared colors, indicating that the method is quite promising for the completeness of the quasar survey. LAMOST DR1 and the ongoing quasar survey will provide valuable data for studies of quasars.
Purpose
Tumoral calcinosis is a rare clinicopathological entity characterized by ectopic soft-tissue calcification, typically periarticular. Normophosphatemic tumoral calcinosis is seldom reported in ...East Asian populations, and the preoperative diagnosis is often elusive. This study was performed to characterize the clinical profile of normophosphatemic tumoral calcinosis and investigate the presence of the
SAMD9
gene mutation.
Methods
The clinical features, pathological examination findings, and outcomes of 19 subjects were retrospectively reviewed. All patients were analyzed for
SAMD9
gene mutation using paraffin-embedded tumoral calcinosis specimens.
Results
Nineteen subjects were analyzed (7 males, 12 females). Their mean age at surgery, mean age at symptom onset, and median disease duration was 51.9 ± 17.3 (range 7–75) years, 49.1 ± 17.2 (range 7–74) years, and 1.3 (interquartile range 0.5–3.0) years, respectively. Lesions were located in the hand in 8 (42.1%) subjects; wrist in 5 (26.3%); shoulder in 2 (10.5%); and hip, knee, buttock, and scrotum in 1 (5.3%) subject each. The lesions in 17 (89.5%) subjects were located around the joints small joints (hand and wrist) in 13 (68.4%) and large joints (shoulder, hip, and knee) in 4 (21.1%). Lesions occurred in the upper limbs in 15 (78.9%) subjects and in the lower limbs in 2 (10.5%). Multiple-lesion involvement (distal right index finger and middle finger) occurred in one (5.3%) subject. Symptoms included pain in 15 (78.9%) subjects, impaired mobility in 5 (26.3%), swelling in 5 (26.3%), numbness in 2 (10.5%), and an asymptomatic mass in 2 (10.5%). The serum inorganic phosphorus concentration was normal in all 19 subjects (mean 1.17 ± 0.15 mmol/L). The serum calcium concentration was normal in 18 subjects and low in 1. The serum alkaline phosphatase concentration was normal in all 19 subjects. Pathological examination indicated multiple nodules of calcified materials that manifested an amorphous or granular blue-purple crystal and were surrounded by proliferation of mononuclear or multinuclear macrophages, osteoclastic-like giant cells, fibroblasts, and chronic inflammatory cells. Notably, different phases of pathological manifestations were observed in the same microscopic field. During follow-up (0.5–65.0 months), no recurrence of tumoral calcinosis was observed in 18 (94.7%) subjects, but 1 subject developed in situ recurrence of an asymptomatic subcutaneous mass after 6 months postoperatively. Genetic analysis in all 19 subjects revealed no
SAMD9
gene mutations.
Conclusions
Most subjects were females and developed calcinosis in adulthood. Small joints (hand and wrist) and the upper limbs were frequently involved. The presence of different phases of pathological features in the same subject suggests that about half of the study participants had been misdiagnosed with another condition (such as gout, osteoarthritis, etc.). Complete surgical excision led to cure without recurrence during follow-up in majority of the study participants.
Abstract
We report on analysis of observations of the bright transient X-ray pulsar Swift J0243.6+6124 obtained during its 2017-2018 giant outburst with Insight-HXMT, NuSTAR, and Swift observatories. ...We focus on the discovery of a sharp state transition of the timing and spectral properties of the source at super-Eddington accretion rates, which we associate with the transition of the accretion disk to a radiation pressure dominated (RPD) state, the first ever directly observed for magnetized neutron star. This transition occurs at slightly higher luminosity compared to already reported transition of the source from sub- to super-critical accretion regime associate with onset of an accretion column. We argue that this scenario can only be realized for comparatively weakly magnetized neutron star, not dissimilar to other ultra-luminous X-ray pulsars (ULPs), which accrete at similar rates. Further evidence for this conclusion is provided by the non-detection of the transition to the propeller state in quiescence which strongly implies compact magnetosphere and thus rules out magnetar-like fields.
The impact of impurity ions on a pedestal has been investigated in the HL-2A Tokamak, at the Southwestern Institute of Physics, Chengdu, China. Experimental results have clearly shown that during the ...H-mode phase, an electromagnetic turbulence was excited in the edge plasma region, where the impurity ions exhibited a peaked profile. It has been found that double impurity critical gradients are responsible for triggering the turbulence. Strong stiffness of the impurity profile has been observed during cyclic transitions between the I-phase and H-mode regime. The results suggest that the underlying physics of the self-regulated edge impurity profile offers the possibility for an active control of the pedestal dynamics via pedestal turbulence.
Purpose
Though type 2 diabetes mellitus (T2DM) is an important and independent risk factor for coronary artery disease (CAD) in the general population, the impact of T2DM on CAD in patients with ...familial hypercholesterolemia (FH) is less understood. Thus, the current study aimed to examine the features of FH patients with T2DM and explore the effects of T2DM on CAD in FH.
Methods
A total of 289 clinical heterozygous FH (HeFH) patients diagnosed with Dutch Lipid Clinic Criteria were consecutively recruited and divided into a T2DM group (
n
= 58) and non-T2DM group (
n
= 231). Clinical characteristics and laboratory findings were compared between the two groups. Target exome sequencing was used for gene mutation analysis.
Results
HeFH patients with T2DM had significantly higher levels of triglycerides, body mass index and free fatty acids than did non-T2DM patients; moreover, patients with T2DM more frequently exhibited hypertension. However, the spectrum of FH-causing mutations was not significantly different (
p
= 0.061). Notably, patients with T2DM had higher prevalence of CAD (
p
= 0.012) and higher Gensini Score (
p
= 0.002). The regression analysis confirmed that HbA1c was an independent risk factor for both the presence and severity of CAD OR 2.321 (1.098–4.904),
p
= 0.027; OR 1.349 (1.032–1.762),
p
= 0.028, respectively in patients with HeFH.
Conclusions
Although there were not many differences in the clinical, lipid and genetic aspects of HeFH patients with and without T2DM, T2DM and HbA1c were associated with worse coronary lesions, suggesting that diabetes and the degree of blood glucose control are also important determinants of cardiovascular disease in these patients.
The control of sound waves by metasurfaces is an interesting research topic in the metamaterial technology field. Based on existing research about the acoustic metamaterials constructed using ...meta-molecules, we propose a theoretical model of a deep subwavelength acoustic reflection metasurface. We further verify this model via simulations and experiments. The designed broadband acoustic metasurface consists of 'meta-atoms', 'meta-molecules', 'meta-molecule clusters' and 'meta-molecule cluster sets', in the aforementioned order. The structural parameters of the two meta-atom types can be adjusted to regulate the acoustic reflection phase, and the meta-molecule are sufficient to realise the discrete phase shifts that cover the complete 2π span. Meta-molecule clusters comprise meta-molecules that can adjust certain geometric parameters of the meta-atoms to achieve abnormal and negative reflections. In addition, 'meta-molecule cluster sets' enable the metasurface to achieve a broad multi-frequency response by combining two types of meta-atoms' regulative modes. We construct a meta-molecule cluster set consist of two clusters enable the broadband metasurface achieve 800 Hz bandwidth abnormal reflection. Our ultrathin acoustic meta-molecule metasurface combines a simple and highly-integrated structure with a thickness equal to only 1/16th of the acoustic wavelength. We additionally design a subwavelength-thickness acoustic axicon by arranging meta-molecule structure. The proposed ultrathin acoustic metasurface exhibits considerable potential for applications in acoustic devices such as acoustic cloaking and absorption.
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