Abstract
Recent findings indicate that the microbiome may have significant impact on the development of lung cancer by its effects on inflammation, dysbiosis or genome damage. The aim of this study ...was to compare the sputum microbiome of lung cancer (LC) patients with the chromosomal aberration (CA) and micronuclei (MN) frequency in peripheral blood lymphocytes. In the study, the taxonomic composition of the sputum microbiome of 66 men with untreated LC were compared with 62 control subjects with respect to CA and MN frequency and centromere fluorescence in situ hybridisation analysis. Results showed a significant increase in CA (4.11 ± 2.48% versus 2.08 ± 1.18%) and MN (1.53 ± 0.67% versus 0.87 ± 0.49%) frequencies, respectively, in LC patients as compared to control subjects. The higher frequency of centromeric positive MN of LC patients was mainly due to aneuploidy. A significant increase in Streptococcus, Bacillus, Gemella and Haemophilus in LC patients was detected, in comparison to the control subjects while 18 bacterial genera were significantly reduced, which indicates a decrease in the beta diversity in the microbiome of LC patients. Although, the CA frequency in LC patients is significantly associated with an increased presence of the genera Bacteroides, Lachnoanaerobaculum, Porphyromonas, Mycoplasma and Fusobacterium in their sputum, and a decrease for the genus Granulicatella after application of false discovery rate correction, significance was not any more present. The decrease of MN frequency of LC patients is significantly associated with an increase in Megasphaera genera and Selenomonas bovis. In conclusion, a significant difference in beta diversity of microbiome between LC and control subjects and association between the sputum microbiome composition and genome damage of LC patients was detected, thus supporting previous studies suggesting an etiological connection between the airway microbiome and LC.
Here we report a pilot-sized study to compare the taxonomic composition of sputum microbiome in 17 newly-diagnosed lung cancer (LC) patients and 17 controls. Another object was to compare the ...representation of individual bacterial genera and species in sputum with the frequency of chromosomal aberrations in the blood lymphocytes of LC patients and in controls. Both groups were male; average age 56.1 ± 11.5 in patients and 55.7 ± 4.1 in controls. Differences in the species composition of bacterial communities in LC patients and controls were significant (pseudo-F = 1.94; p = 0.005). Increased prevalence in LC patients was detected for the genera Haemophilus and Bergeyella; whereas a decrease was observed for the genera Atopobium, Stomatobaculum, Treponema and Porphyromonas. Donors with high frequencies of chromosomal aberrations had a significant reduction in the microbiome of representatives of the genus Atopobium in the microbiome and a simultaneous increase in representatives of the species Alloprevotella compared to donors with a low level of chromosomal aberrations in lymphocytes. Thus, a comparison of the bacterial composition in the sputum of donors with cytogenetic damages in theirs lymphocytes, warrants further investigations on the potential role of microorganisms in the process of mutagenesis in somatic cells of the host body.
Contemporary thermoset composites using natural fibres offer a wide range of strength performance. Recently, the combination of flax and carbon fibres has received an increasing attention, mainly ...dictated by the possibility of merging in a single material high damping properties of flax fibres and the well-known high mechanical properties of carbon fibres. Evaluation of low energy impact damage defects has received a little coverage even if these composites are well known to be susceptible to impact damage. In this study, the use of ultrasonic resonance vibrometry is proposed as an effective nondestructive tool to detect the extent of impact damage in natural/synthetic fibre reinforced composites with different stacking sequences. The results for impacts at 10 and 40 J highlighted the role played by the different stacking sequences with damaged areas being twice smaller in composites with flax skins and carbon core compared to carbon-flax-carbon sandwiches.
•The use of natural/synthetic composite hybridization allows improving damage tolerance in compared to carbon laminates.•Scanning laser vibrometry is a promising technique for inspecting impact damage in natural fibre reinforced composites.•Low velocity impacts result in energy absorption through internal damages and global elastic-plastic deformation.•Single discontinuities represent independent oscillators characterized by particular resonance frequencies.•The defect size and location can be easily detected by the help of total vibration pattern.
A
bstract
The cross section of the process
e
+
e
−
→
π
+
π
−
has been measured in the Spherical Neutral Detector (SND) experiment at the VEPP-2000
e
+
e
−
collider VEPP-2000 in the energy region 525
...<
s
<
883 MeV. The measurement is based on data with an integrated luminosity of about 4.6 pb
−
1
. The systematic uncertainty of the cross section determination is 0.8% at
s
>
0
.
600 GeV. The
ρ
meson parameters are obtained as
m
ρ
= 775
.
3 ± 0
.
5 ± 0
.
6 MeV, Γ
ρ
= 145
.
6 ± 0
.
6 ± 0
.
8 MeV,
B
ρ
→
e
+
e−
×
B
ρ
→
π
+
π−
= (4
.
89 ± 0
.
02 ± 0
.
04) × 10
−
5
, and the parameters of the
e
+
e
−
→
ω
→
π
+
π
−
process, suppressed by
G
-parity, as
B
ω
→
e
+
e−
×
B
ω
→
π
+
π−
= (1
.
32 ± 0
.
06 ± 0
.
02) × 10
−
6
and and
ϕ
ρω
= 110
.
7 ± 1
.
5 ± 1
.
0 degrees.
Laser Doppler vibrometry has found application both in nondestructive testing (NDT) of polymer composite materials (PCMs) and in studies of the amplitude-frequency characteristics of acoustic ...emitters in a wide frequency range. The use of air-coupled systems for the excitation of acoustic vibrations in the tested objects makes it possible to carry out a non-contact NDT procedure. This expands testing facilities of composites, simplifies the quality control procedure, and minimizes external influences on the test objects in comparison with traditional acoustic NDT methods based on contact emitters. In this paper, we have investigated the features of NDT of composites by a non-contact method using scanning laser Doppler vibrometry. The results of NDT of impact damage to PCMs using several types of air-coupled systems for excitation of acoustic vibrations, namely, based on piezoelectric, magnetostrictive, and gas-discharge transducers are presented.
The recent precise measurements of the
e
+
e
–
→
K
S
K
L
and
e
+
e
–
→
K
+
K
–
cross sections and the hadronic spectral function of the τ
–
→
K
–
K
S
ν
τ
decay are used to extract the isoscalar and ...isovector electromagnetic kaon form factors and their relative phase in a model-independent way. The experimental results are compared with a fit based on the vector-meson-dominance model.
The process
e
+
e
-
→
n
n
¯
is studied in the experiment at the VEPP-2000
e
+
e
-
collider with the SND detector. The technique of the time measurements in the multichannel NaI(Tl) electromagnetic ...calorimeter is used to select
n
n
¯
events. The value of the measured cross section in the center-of-mass energy range from 1.894 to 2 GeV varies from 0.5 to 0.35 nb. The effective neutron timelike form factor is derived from the measured cross section and compared with the proton form factor. The ratio of the neutron electric and magnetic form factors is obtained from the analysis of the antineutron polar angle distribution and found to be consistent with unity.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This paper describes the use of laser vibrometry and thermal non-destructive testing for detecting defects in GFRP composite by applying a single test procedure. The laser vibrometry involves the ...averaging of vibration amplitudes over an entire frequency spectrum accompanied by the frequency-phase analysis. Such procedure may lead to suppression of low signals, produced by smaller and deeper defects, by higher signals conditioned by larger and shallower defects. The fusion of results obtained with both laser vibrometry and thermal NDT was used to enhance defect detectability. The corresponding experimental techniques were applied to detecting four types of defects (air gaps, foam, blank grooves, resin) in GFRP composite, as well as evaluating defect size and depth. Also, laser vibrometry was used to characterise barely visible impact damage in CFRP composite, and test data was compared with C-scan ultrasonic inspection results. It has been shown that the results supplied by three inspection techniques have been reasonably consistent in characterisation of defect lateral area and depth. When analysing the complex structure of impact damage in composites, the detection of both shallow and deep defects can also be enhanced by performing fusion of test results supplied by laser vibrometry and active thermal NDT.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The process
e
+
e
-
→
η
η
γ
is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb
-
1
collected by the SND detector at the VEPP-2000
e
+
e
-
...collider. The
e
+
e
-
→
η
η
γ
cross section is measured for the first time. It is shown that the dominant mechanism of this reaction is the transition through the
ϕ
η
intermediate state. Our result on the
e
+
e
-
→
η
η
γ
cross section is consistent with the
e
+
e
-
→
ϕ
η
measurement in the
ϕ
→
K
+
K
-
mode. The search for radiative processes contributing to the
e
+
e
-
→
η
η
γ
cross section is performed, and no significant signal is observed.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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