Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized ...mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.
Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.
The media and even the specialized literature report that the ultraviolet (UV) protection for sunglasses is critical, on the grounds that sunglasses can have a counter effect if the lenses do not ...provide adequate UV protection. They reason that the primary and natural mechanism is that the pupil of the eye contracts to attenuate radiation and protect the inner eye under sun exposure. Therefore, if dark lenses do not provide appropriate UV protection, there is an increased UV incidence in the inner eye due to pupil dilation, which enhances the adverse effects and impacts the ocular tissues more severely than in situations without UV protection. However, no existing literature properly quantified or supported this argument. In this work, the influx of solar UV throughout the pupil of the eye was calculated in two situations: when a person wear sunglasses and when he/she does not. In both situations, the pupil dilation and the field of view (squint) were considered with their dependence on the brightness of the ambient, calculated by modeling the solar irradiation. Finally, it was assessed whether sunglasses with poor UV protection actually increase the UV influx throughout the dilated pupil compared to the non-dilated pupil. A set of 214 sunglasses lenses were tested and the results show that pupil dilation does not play an important role in the UV influx throughout the pupil. It was observed that the FOV is the main player, surpassing the pupil size contribution by up to 314.3%, disproving the common explanation. Because of the major role of the FOV, our results show that sunglasses with UV-A protection below 86% may have a slight potential to increase hazards to the eye compared to not wearing sunglasses at all. These results can have direct impact on sunglasses standards regarding the UV protection linked to the category of the lenses.
This work focuses on brain stroke imaging via microwave technology. In particular, the open issue of monitoring patients after stroke onset is addressed here in order to provide clinicians with a ...tool to control the effectiveness of administered therapies during the follow-up period. In this paper, a novel prototype is presented and characterized. The device is based on a low-complexity architecture which makes use of a minimum number of properly positioned and designed antennas placed on a helmet. It exploits a differential imaging approach and provides 3D images of the stroke. Preliminary experiments involving a 3D phantom filled with brain tissue-mimicking liquid confirm the potential of the technology in imaging a spherical target mimicking a stroke of a radius equal to 1.25 cm.
The need to verify vehicle emissions in real world operation led to the implementation of Real Driving Emissions (RDE) test procedures, effective since September 2017 for new Euro 6 cars following ...the Commission Regulation (EU) 2016/427, which defines the RDE test conditions and data analysis methods to allow representative results. Main factors addressed by the regulation include the share of driving operation, ambient temperature range, altitude and elevation difference. However, RDE is still debatable since not only boundary conditions but also the evaluation methods and trip selection are being discussed together with a carbon dioxide (CO2) regulation, which is planned to be implemented in the short term.
Thus, this work focuses on analyzing the effect of different data measurement and analysis methods (i.e. cold-operation, road grade, trip selection and driving style) on CO2 and nitrogen oxides (NOx) emissions based on 13 RDE tests performed in the Lisbon Metropolitan Area, Portugal. The tests were conducted by 2 drivers using 5 vehicles. Each driver performed 2 trips per vehicle, one in normal driving and other in aggressive driving. A Portable Emissions Measurement System (PEMS) was used to collect 1 Hz data, which was compared and analyzed using the European Commission (EC) proposed method for RDE tests.
Results show the effects of each parameter such as average difference between drivers (7% in CO2 and 55% in NOx emissions) and between aggressive and normal driving. For road grade, big oscillations happen during the slope profile, which impacts emissions during all trips. Considering cold-operation, CO2 and NOx emissions are, on average, ~25% and 55% higher, respectively, than in hot-operation. These results highlight the need for deeper studies on these factors to assure that RDE tests evolve to a more established certification procedure than laboratorial certifications.
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•Evaluate current European RDE data analysis methods•Assess boundary conditions and driving behavior influence on RDE tests•Quantify the impacts of these factors in terms of CO2 and NOx emissions•Driving behavior leads to variations of up to 7% in CO2 and 55% in NOx emissions•Cold-operation increase CO2 and NOx emissions by 25% and 55% compared to hot-operation
Mycoplasma is a well-recognised pathogen that colonises mucosal surfaces of humans and animals. Mycoplasma pneumoniae infects the upper and lower respiratory tracts of children and adults, leading to ...a wide range of respiratory and non-respiratory clinical conditions. M. pneumoniae infection is frequently considered in the differential diagnosis of patients with respiratory illnesses, and is commonly managed empirically with macrolides and fluoroquinolones. This contrasts with patients who present with non-respiratory symptoms in the context of a recent or current unrecognised M. pneumoniae infection, for whom this pathogen is rarely considered in the initial differential diagnosis. This review considers the microbiological, epidemiological, pathogenic and clinical features of this frequent pathogen that need to be considered in the differential diagnosis of respiratory and non-respiratory infections.
The analysis of vehicle cold start emissions has become an issue of utmost importance since the cold phase occurs mainly in urban context, where most of the population lives. In this sense, this ...research work analyzes and quantifies the impacts of cold start in urban context using naturalistic driving data. Furthermore, an assessment of the influence of ambient temperature on the percentage of time spent on cold start was also performed.
Regarding the impacts of ambient temperature on cold start duration, a higher percentage of time spent on cold start was found for lower ambient temperatures (80% of the time for 0°C and ~50% for 29°C). Results showed that, during cold start, energy consumption is >110% higher than during hot conditions while emissions are up to 910% higher. Moreover, a higher increase on both energy consumption and emissions was found for gasoline vehicles than for diesel vehicles. When assessing the impacts on a city perspective, results revealed that the impacts of cold start increase for more local streets.
The main finding of this study is to provide evidence that a higher increase on emissions occurs on more local streets, where most of the population lives. This kind of knowledge is of particular relevance to urban planners in order to perform an informed definition of public policies and regulations to be implemented in the future, to achieve a cleaner and healthier urban environment.
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•Extensive real world data collection to evaluate vehicle cold start running.•Assess the impacts of cold start running on the city perspective.•Lower average ambient temperatures increases the cold start running duration.•Increase of 110% on energy consumption and up to 910% on emissions for cold start.•The impact of cold start is higher on more densely populated areas.
The inference of genetic ancestry plays an increasingly prominent role in clinical, population, and forensic genetics studies. Several genotyping strategies and analytical methodologies have been ...developed over the last few decades to assign individuals to specific biogeographic regions. However, despite these efforts, ancestry inference in populations with a recent history of admixture, such as those in Brazil, remains a challenge. In admixed populations, proportion and components of genetic ancestry vary on different levels: (i) between populations; (ii) between individuals of the same population, and (iii) throughout the individual's genome. The present study evaluated 1171 admixed Brazilian samples to compare the genetic ancestry inferred by tri-/tetra-hybrid admixture models and evaluated different marker sets from those with small numbers of ancestry informative markers panels (AIMs), to high-density SNPs (HDSNP) and whole-genome-sequence (WGS) data. Analyses revealed greater variation in the correlation coefficient of ancestry components within and between admixed populations, especially for minority ancestral components. We also observed positive correlation between the number of markers in the AIMs panel and HDSNP/WGS. Furthermore, the greater the number of markers, the more accurate the tri-/tetra-hybrid admixture models.
Innovative strategies have been proposed to increase drug delivery to the tumor site and avoid cytotoxicity, improving the therapeutic efficacy of well-established anti-cancer drugs. Alterations in ...normal glycosylation processes are frequently observed in cancer cells and the resulting cell surface aberrant glycans can be used as direct molecular targets for drug delivery. In the present review, we address the development of strategies, such as monoclonal antibodies, antibody-drug conjugates and nanoparticles that specific and selectively target cancer-associated glycans in tumor cells. The use of nanoparticles for drug delivery encompasses novel applications in cancer therapy, including vaccines encapsulated in synthetic nanoparticles and specific nanoparticles that target glycoproteins or glycan-binding proteins. Here, we highlight their potential to enhance targeting approaches and to optimize the delivery of clinically approved drugs to the tumor microenvironment, paving the way for improved personalized treatment approaches with major potential importance for the pharmaceutical and clinical sectors.
Although a reduced glomerular filtration rate (GFR) in old people has been attributed to physiologic aging, it may be associated with kidney disease or superimposed comorbidities. This study aims to ...assess the prevalence of decreased GFR in a geriatric population in a developing country and its prevalence in the absence of simultaneous diseases.
This is a cross-sectional study of data from the Saúde, Bem-Estar e Envelhecimento cohort study (SABE studyHealth, Well-Being and Aging), a multiple cohorts study. A multistage cluster sample composed of 1,253 individuals representative of 1,249,388 inhabitants of São Paulo city aged ≥60 years in 2010 was analyzed. The participants answered a survey on socio-demographic factors and health, had blood pressure measured and urine and blood samples collected. GFR was estimated and defined as decreased when <60 mL/min/1.73m2. Kidney damage was defined as dipstick-positive hematuria or urinary protein:creatinine > 0.20 g/g.
The prevalence of GFR <60 mL/min/1.73m2 was 19.3%. Individuals with GFR <60 mL/min/1.73m2 were older (75±1 versus 69±1 years, p<0.001), had lower schooling (18 versus 30% with complete 8-year basic cycle, p = 0.010), and higher prevalence of hypertension (82 versus 63%, p<0.001), diabetes (34 versus 26%, p = 0.021), cardiovascular disease (43 versus 24%, p<0.001) and kidney damage (35% versus 15%, p<0.001). Only 0.7% of the entire studied population had GFR <60 mL/min/1.73m2 without simultaneous diseases or kidney damage. Among the individuals with GFR <60 mL/min/1.73m2, 3.5% had neither renal damage nor associated comorbidities, whereas among those with GFR ≥60 mL/min/1.73m2, 11.0% had none of these conditions. Logistic regression showed that older age, cardiovascular disease and hypertension were associated with GFR<60 mL/min/1.73m2.
Decreased GFR was highly prevalent among the geriatric population in a megalopolis of a developing country. It was rarely present without simultaneous chronic comorbidities or kidney damage.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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