Skladateljski proces se praviloma ne konča z izdelavo avtografa. Kopije, ki so jih pripravljali profesionalni pisarji, so Beethovnu pogosto služile kot osnova za včasih tudi obsežne revizije; pogosto ...dokončni avtorjev notni zapis iz avtografa niti še ni razviden. Razveseljivo je, da imamo zdaj na voljo obsežen kopistov prepis neke celotne simfonije, ki ga je Beethoven tudi sam pregledal, in sicer kljub temu da je ohranjen tudi avtograf – tako v tiskani faksimilirani kakor v digitalizirani lahko dostopni spletni obliki – in kljub temu da prepis niti nima veliko Beethovnovih pripisov. Gre za prepis partiture Pastoralne simfonije, ki jo je kopist Joseph Klumpar izdelal kot tretjo kopijo simfonije (pred tem je prepisal že orkestrske glasove in partituro za založnika Breitkopf & Härtel) in je pri prvi javni izvedbi decembra 1808 služila kot izvajalska partitura. Danes jo hrani Narodna in univerzitetna knjižnica v Ljubljani.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The “Fachgruppe freie Forschungsinstitute” is one of the few permanent special interest groups within the “Gesellschaft für Musikforschung” (GfM). It represents research institutes in Germany which ...are not based at university departments (hence “free” institutes) and is thus concerned with institutional issues of long-term editorial projects. Furthermore, it serves as a forum for intense discussion of methodological and philological questions among its members. The group was founded in the mid-1960s, when the importance of research institutes had increased within musicology while their funding had not been secured yet. The association of the editorial projects with the German Academies of Science in the 1970s ensured their financial viability. Today the section is the central forum of exchange for musical philologists in Germany, regularly organising conferences and publishing scholarly volumes. As many of the long-term editorial projects are coming to an end and new projects are increasingly funded only short-term, the institutional function of the group has recently come back into focus.
B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been shown to be effective in AAV maintenance ...therapy, but an optimal RTX treatment schedule is unknown and the time to B cell repopulation after RTX has not been studied.
Retrospective single-center analysis of B cell repopulation in patients with AAV, RA or connective tissue disease (CTD) treated with RTX.
Beginning B cell repopulation within the first year after RTX treatment was observed in 93% of RA and 88% of CTD patients. Only 10% of patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) and no patient with eosinophilic granulomatosis with polyangiitis (EGPA) showed B cell repopulation within this time. Median time of B cell depletion was 26 months in GPA/MPA, and 21 months in EGPA compared to 9 months in RA, and 8 months in CTD (p < 0.0001). In 25 AAV-patients B cell depletion lasted for at least 44 months. There was a significant decline in serum immunoglobulin concentrations in GPA/MPA patients, but not in patients with RA or CTD. Significantly more GPA/MPA patients developed hygogammaglobulinemia (IgG <7 g/L) compared to patients with RA or CTD.
In contrast to RA and CTD, in AAV RTX induces long-lasting depletion of B cells that is associated with decreased antibody production. This observation points toward potential defects in the B cell compartment in AAV that are unmasked by immunosuppressive treatment and has important implications for the design of maintenance treatment schedules using RTX.
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