Needle-related distress is a common yet poorly recognised and managed problem among haemodialysis (HD) patients. The aim of this pilot study is to test the feasibility and acceptability of the INJECT ...Intervention-an innovative psychology-based intervention to empower patients to self-manage needle distress with the support of dialysis nurses.
This investigator-initiated, single-arm, non-randomised feasibility study will take place in a large dialysis service in Adelaide, Australia. Participants will include patients aged ≥ 18 years, commencing or already receiving maintenance HD, recruited through dialysis physicians and nursing staff as individuals believed to be at risk of needle distress. They will be screened for inclusion using the Dialysis Fear of Injection Questionnaire (DFIQ) and enrolled into the study if the score is ≥ 2. The multi-pronged intervention encompasses (i) psychologist review, (ii) patient self-management program and (iii) nursing education program. The primary aim is to evaluate feasibility and acceptability of the intervention from patient and dialysis nurse perspectives, including recruitment, retention, engagement with the intervention and completion. Secondary exploratory outcomes will assess suitability of various tools for measuring needle distress, evaluate acceptability of the nursing education program and measure cannulation-related trauma and vascular access outcomes.
The results will inform the protocol for larger trials addressing needle distress in HD patients.
Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12621000229875, approved 4 April 2021, https://www.anzctr.org.au/ .
nir1, a conditional-lethal mutation in barley causing a defect in nitrite reduction Duncanson, E. (St. Andrews Univ., Fife (United Kingdom). School of Biological and Medical Sciences. Div. of Environmental and Evolutionary Biology); Gilkes, A.F; Kirk, D.W ...
Molecular & general genetics,
(1993), 1993-Jan, Letnik:
236, Številka:
2-3
Journal Article
Recenzirano
Eleven green individuals were isolated when 95 000 M(2) plants of barley (Hordeum vulgare L.), mutagenised with azide in the M(1), were screened for nitrite accumulation in their leaves after nitrate ...treatment in the light. The selected plants were maintained in aerated liquid culture solution containing glutamine as sole nitrogen source. Not all plants survived to flowering and some others that did were not fertile. One of the selected plants, STA3999, from the cultivar Tweed could be crossed to the wild-type cultivar and analysis of the F(2) progeny showed that leaf nitrite accumulation was due to a recessive mutation in a single nuclear gene, which has been designated Nir1. The homozygous nir1 mutant could be maintained to flowering in liquid culture with either glutamine or ammonium as sole nitrogen source, but died within 14 days after transfer to compost. The nitrite reductase cross- reacting material seen in nitrate-treated wild-type plants could not be detected in either the leaf or the root of the homozygous nir1 mutant. Nitrite reductase activity, measured with dithionite-reduced methyl viologen as electron donor, of the nitrate- treated homozygous nir1 mutant was much reduced but NADH-nitrate reductase activity was elevated compared to wild-type plants. It is concluded that the Nir1 locus determines the formation of nitrite reductase apoprotein in both the leaf and root of barley and speculated that it represents either the nitrite reductase apoprotein gene locus or, less likely, a regulatory locus whose product is required for the synthesis of nitrite reductase, but not nitrate reductase. Elevation of NADH-nitrate reductase activity in the nir1 mutant suggests a regulatory perturbation in the expression of the Nar1 gene.
The dimensions of physical quantities Duncanson, W E
Proceedings (Physical Society (Great Britain) : 1926),
07/1941, Letnik:
53, Številka:
4
Journal Article
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