We present a method of calculation of the effective magnetic permeability of magnonic metamaterials containing periodically arranged magnetic inclusions of arbitrary shapes. The spectrum of spin wave ...modes confined in the inclusions is fully taken into account. Within the scope of the proposed method, we compare two approaches. The first approach is based on a simple semi-analytical theory that uses the numerically calculated susceptibility tensor of an isolated inclusion as input data. Within the second approach, micromagnetic packages with periodic boundary conditions (PBC) are used to calculate the susceptibility of a single 2D periodic array of such inclusions, with the whole 3D metamaterial consisting of a stack of such arrays. To calculate the susceptibility tensor of an isolated inclusion, we have implemented and compared two different methods: (a) a micromagnetic method, in which we have employed three different micromagnetic packages: the finite element package NMAG and the two finite differences packages OOMMF and MicroMagus; and (b) the modified dynamical matrix method. To illustrate the methodology, we have calculated the effective permeability of a metamaterial consisting of a stack of hexagonal arrays of magnetic nanodisks in a non-magnetic matrix. The range of geometrical parameters for which such a metamaterial is characterized by the negative permeability has been identified. The critical comparison of the different micromagnetic packages and the dynamical matrix method (based on the calculation of the susceptibility tensor of an isolated inclusion) has demonstrated that their results agree to within 3 %.
The relationship between dose and bioavailability of propranolol was determined in 12 healthy male subjects. The doses employed were 10, 40, 80 or 160 mg of propranolol HCl given three times daily ...for 4 days. Daily minimum plasma levels showed that there was no accumulation of the drug. In all subjects, non-linear relationships were observed between peak plasma level, or area under the plasma concentration-time curve, and dose. The between subject variation of these parameters was not dose related.
The effect of long-term administration of AY-9944, a specific inhibitor of cholesterol biosynthesis, was examined in rats maintained on diets with low and high cholesterol and fat content. Sterol and ...phospholipid levels were determined in the serum, liver, adrenals, lungs, and brain after 6 and 12 months of feeding AY-9944 at several dose levels. In all the tissues examined, the cholesterol content was lowered and the cholesterol was partly replaced by 7-dehydrocholesterol biosynthesized instead of cholesterol in the presence of AY-9944. Cholesterol levels were particularly low in the serum and adrenals, while 7-dehydrocholesterol accumulated in the lungs. The fall in cholesterol and appearance of 7-dehydrocholesterol were reversible. Alterations of this type in the brain indicated that sterol metabolism is active in the adult rat brain. Addition of cholesterol to the diet reduced the effect of the inhibitor by eliminating the liver as a site of sterol synthesis.
Introduction: This study aimed to assess whether heart fatty acid-binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) could be used for the accurate diagnosis of acute myocardial ...infarction (AMI) in acute coronary syndrome (ACS) patients.
Materials and methods: The study included 108 ACS patients admitted to a coronary unit within 3 h after chest pain onset. AMI was distinguished from unstable angina (UA) using a classical cardiac troponin I (cTnI) assay. H-FABP and GPBB were measured by ELISA on admission (0 h) and at 3, 6, 12, and 24 h after admission; their accuracy to diagnose AMI was assessed using statistical methods.
Results: From 92 patients with ACS; 71 had AMI. H-FABP and GPBB had higher peak value after 3 h from admission than cTnI (P = 0.001). Both markers normalized at 24 h. The area under the receiver operating characteristic curves was significantly greater for both markers in AMI patients than in UA patients at all time points tested, including admission (P < 0.001). At admission, the H-FABP (37%) and GPBB (40%) sensitivities were relatively low. They increased at 3 and 6 h after admission for both markers and decreased again after 24 h. It was 40% for H-FABP and approximately 2-times lower for GPBB (P < 0.01). In AMI patients, both biomarkers had similar specificities, positive- and negative-predictive values, positive and negative likelihood ratios, and risk ratios for AIM.
Conclusion: H-FABP and GPBB can contribute to early AMI diagnosis and can distinguish AMI from UA.
