Lactate biosensors: current status and outlook Rassaei, Liza; Olthuis, Wouter; Tsujimura, Seiya ...
Analytical and bioanalytical chemistry,
01/2014, Letnik:
406, Številka:
1
Journal Article
Recenzirano
Many research efforts over the last few decades have been devoted to sensing lactate as an important analytical target in clinical care, sport medicine, and food processing. Therefore, research in ...designing lactate sensors is no longer in its infancy and now is more directed toward viable sensors for direct applications. In this review, we provide an overview of the most immediate and relevant developments toward this end, and we discuss and assess common transduction approaches. Further, we critically describe the pros and cons of current commercial lactate sensors and envision how future sensing design may benefit from emerging new technologies.
Metal–organic frameworks (MOFs) are porous crystalline materials consisting of metal ions bound through coordination bonds to organic linkers. Much research over the last few decades have been ...devoted to the synthesis of these materials in view of their promising applications in, for example, catalysis, separation, gas storage, drug delivery and sensing. Among the variety of methods developed for the synthesis of MOFs are electrochemical techniques. These methods have several advantages such as mild synthesis conditions, shorter synthesis times and the possibility to control the reaction conditions directly during the synthesis process. However, the progress of electrosynthesis methods has lagged behind that of other methods such as solvothermal and microwave‐assisted synthesis. In this Review, we summarise and critically assess research on the electrosynthesis of MOFs and provide a full picture of the developments within this field. The various ways in which electrochemistry has contributed to the synthesis of MOFs are explained, their strengths and shortcomings are discussed, and an outlook for future research is provided.
MOFs in the making: Much research is devoted to the synthesis of metal–organic frameworks (MOFs) for catalysis, separation, drug delivery and other applications. Electrochemical syntheses of MOFs have many advantages including mild conditions and shorter reaction times; however, the progress of these methods lags behind that of other methods. In this Review, research efforts in this area are summarized and critically assessed.
Only relatively recently has it become clear that mammalian genomes encode tens of thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed specifically in the brain, where ...they show precisely regulated temporal and spatial expression patterns. This begs the question, what is the functional role of these many lncRNA transcripts in the brain? Here we canvass a growing number of mechanistic studies that have elucidated central roles for lncRNAs in the regulation of nervous system development and function. We also survey studies indicating that neurological and psychiatric disorders may ensue when these mechanisms break down. Finally, we synthesize these insights with evidence from comparative genomics to argue that lncRNAs may have played important roles in brain evolution, by virtue of their abundant sequence innovation in mammals and plausible mechanistic connections to the adaptive processes that occurred recently in the primate and human lineages.
Thousands of lncRNAs exhibit precise spatiotemporal expression in the nervous system. Briggs et al. canvass emerging studies showing the mechanistic importance of lncRNAs in brain development, function, and disease. They synthesize these functions with comparative genomic evidence to implicate lncRNAs in brain evolution.
For extrasolar planets discovered using the radial velocity method, the spectral characterization of the host star leads to a mass estimate of the star and subsequently of the orbiting planet. If the ...orbital velocity of the planet could be determined, the masses of both star and planet could be calculated using Newton’s law of gravity, just as in the case of stellar double-line eclipsing binaries. Here we report high-dispersion ground-based spectroscopy of a transit of the extrasolar planet HD 209458b. We see a significant wavelength shift in absorption lines from carbon monoxide in the planet’s atmosphere, which we conclude arises from a change in the radial component of the planet’s orbital velocity. The masses of the star and planet are 1.00 ± 0.22MSun and 0.64 ± 0.09MJup respectively. A blueshift of the carbon monoxide signal of approximately 2 km s−1 with respect to the systemic velocity of the host star suggests the presence of a strong wind flowing from the irradiated dayside to the non-irradiated nightside of the planet within the 0.01–0.1 mbar atmospheric pressure range probed by these observations. The strength of the carbon monoxide signal suggests a carbon monoxide mixing ratio of (1–3) × 10−3 in this planet’s upper atmosphere.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The purpose of this Clinical Practice Update Expert Review is to provide clinicians with guidance on the diagnosis and management of atrophic gastritis, a common preneoplastic condition of the ...stomach, with a primary focus on atrophic gastritis due to chronic Helicobacter pylori infection—the most common etiology—or due to autoimmunity. To date, clinical guidance for best practices related to the diagnosis and management of atrophic gastritis remains very limited in the United States, which leads to poor recognition of this preneoplastic condition and suboptimal risk stratification. In addition, there is heterogeneity in the definitions of atrophic gastritis, autoimmune gastritis, pernicious anemia, and gastric neoplasia in the literature, which has led to confusion in clinical practice and research. Accordingly, the primary objective of this Clinical Practice Update is to provide clinicians with a framework for the diagnosis and management of atrophic gastritis. By focusing on atrophic gastritis, this Clinical Practice Update is intended to complement the 2020 American Gastroenterological Association Institute guidelines on the management of gastric intestinal metaplasia. These recent guidelines did not specifically discuss the diagnosis and management of atrophic gastritis. Providers should recognize, however, that a diagnosis of intestinal metaplasia on gastric histopathology implies the diagnosis of atrophic gastritis because intestinal metaplasia occurs in underlying atrophic mucosa, although this is often not distinctly noted on histopathologic reports. Nevertheless, atrophic gastritis represents an important stage with distinct histopathologic alterations in the multistep cascade of gastric cancer pathogenesis.
The Best Practice Advice statements presented herein were developed from a combination of available evidence from published literature and consensus-based expert opinion. No formal rating of the strength or quality of the evidence was carried out. These statements are meant to provide practical advice to clinicians practicing in the United States.
Best Practice Advice Statements
Atrophic gastritis is defined as the loss of gastric glands, with or without metaplasia, in the setting of chronic inflammation mainly due to Helicobacter pylori infection or autoimmunity. Regardless of the etiology, the diagnosis of atrophic gastritis should be confirmed by histopathology.
Providers should be aware that the presence of intestinal metaplasia on gastric histology almost invariably implies the diagnosis of atrophic gastritis. There should be a coordinated effort between gastroenterologists and pathologists to improve the consistency of documenting the extent and severity of atrophic gastritis, particularly if marked atrophy is present.
Providers should recognize typical endoscopic features of atrophic gastritis, which include pale appearance of gastric mucosa, increased visibility of vasculature due to thinning of the gastric mucosa, and loss of gastric folds, and, if with concomitant intestinal metaplasia, light blue crests and white opaque fields. Because these mucosal changes are often subtle, techniques to optimize evaluation of the gastric mucosa should be performed.
When endoscopic features of atrophic gastritis are present, providers should assess the extent endoscopically. Providers should obtain biopsies from the suspected atrophic/metaplastic areas for histopathological confirmation and risk stratification; at a minimum, biopsies from the body and antrum/incisura should be obtained and placed in separately labeled jars. Targeted biopsies should additionally be obtained from any other mucosal abnormalities.
In patients with histology compatible with autoimmune gastritis, providers should consider checking antiparietal cell antibodies and anti-intrinsic factor antibodies to assist with the diagnosis. Providers should also evaluate for anemia due to vitamin B-12 and iron deficiencies.
All individuals with atrophic gastritis should be assessed for H pylori infection. If positive, treatment of H pylori should be administered and successful eradication should be confirmed using nonserological testing modalities.
The optimal endoscopic surveillance interval for patients with atrophic gastritis is not well-defined and should be decided based on individual risk assessment and shared decision making. A surveillance endoscopy every 3 years should be considered in individuals with advanced atrophic gastritis, defined based on anatomic extent and histologic grade.
The optimal surveillance interval for individuals with autoimmune gastritis is unclear. Interval endoscopic surveillance should be considered based on individualized assessment and shared decision making.
Providers should recognize pernicious anemia as a late-stage manifestation of autoimmune gastritis that is characterized by vitamin B-12 deficiency and macrocytic anemia. Patients with a new diagnosis of pernicious anemia who have not had a recent endoscopy should undergo endoscopy with topographical biopsies to confirm corpus-predominant atrophic gastritis for risk stratification and to rule out prevalent gastric neoplasia, including neuroendocrine tumors.
Individuals with autoimmune gastritis should be screened for type 1 gastric neuroendocrine tumors with upper endoscopy. Small neuroendocrine tumors should be removed endoscopically, followed by surveillance endoscopy every 1–2 years, depending on the burden of neuroendocrine tumors.
Providers should evaluate for iron and vitamin B-12 deficiencies in patients with atrophic gastritis irrespective of etiology, especially if corpus-predominant. Likewise, in patients with unexplained iron or vitamin B-12 deficiency, atrophic gastritis should be considered in the differential diagnosis and appropriate diagnostic evaluation pursued.
In patients with autoimmune gastritis, providers should recognize that concomitant autoimmune disorders, particularly autoimmune thyroid disease, are common. Screening for autoimmune thyroid disease should be performed.
ABSTRACT We present a comprehensive analysis of planetary phase variations, including possible planetary light offsets, using eighteen quarters of data from the Kepler space telescope. Our analysis ...found fourteen systems with significant detections in each of the phase curve components: planet's phase function, secondary eclipse, Doppler boosting, and ellipsoidal variations. We model the full phase curve simultaneously, including primary and secondary transits, and derive albedos, day- and night-side temperatures and planet masses. Most planets manifest low optical geometric albedos (< 0.25), with the exception of Kepler-10b, Kepler-91b, and KOI-13b. We find that KOI-13b, with a small eccentricity of 0.0006 0.0001, is the only planet for which an eccentric orbit is favored. We detect a third harmonic for HAT-P-7b for the first time, and confirm the third harmonic for KOI-13b reported in Esteves et al.: both could be due to their spin-orbit misalignments. For six planets, we report a planetary brightness peak offset from the substellar point: of those, the hottest two (Kepler-76b and HAT-P-7b) exhibit pre-eclipse shifts or on the evening-side, while the cooler four (Kepler-7b, Kepler-8b, Kepler-12b, and Kepler-41b) peak post-eclipse or on the morning-side. Our findings dramatically increase the number of Kepler planets with detected planetary light offsets, and provide the first evidence in the Kepler data for a correlation between the peak offset direction and the planet's temperature. Such a correlation could arise if thermal emission dominates light from hotter planets that harbor hot spots shifted toward the evening-side, as theoretically predicted, while reflected light dominates cooler planets with clouds on the planet's morning-side.
With the increasing demand for efficient extraction of residual oil, enhanced oil recovery (EOR) offers prospects for producing more reservoirs’ original oil in place. As one of the most promising ...methods, chemical EOR (cEOR) is the process of injecting chemicals (polymers, alkalis, and surfactants) into reservoirs. However, the main issue that influences the recovery efficiency in surfactant flooding of cEOR is surfactant losses through adsorption to the reservoir rocks. This review focuses on the key issue of surfactant adsorption in cEOR and addresses major concerns regarding surfactant adsorption processes. We first describe the adsorption behavior of surfactants with particular emphasis on adsorption mechanisms, isotherms, kinetics, thermodynamics, and adsorption structures. Factors that affect surfactant adsorption such as surfactant characteristics, solution chemistry, rock mineralogy, and temperature were discussed systematically. To minimize surfactant adsorption, the chemical additives of alkalis, polymers, nanoparticles, co-solvents, and ionic liquids are highlighted as well as implementing with salinity gradient and low salinity water flooding strategies. Finally, current trends and future challenges related to the harsh conditions in surfactant based EOR are outlined. It is expected to provide solid knowledge to understand surfactant adsorption involved in cEOR and contribute to improved flooding strategies with reduced surfactant loss.
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•Up-to-date review of surfactant adsorption on mineral surfaces in cEOR is provided.•Adsorption behavior is a key to understand the adsorption loss of surfactants.•Influencing factors play a primary role in surfactant adsorption.•Strategies to reduce surfactant adsorption is given.
Affinity layers play a crucial role in chemical sensors for the selective and sensitive detection of analytes. Here, we report the use of composite affinity layers containing Metal Organic Frameworks ...(MOFs) in a polymeric matrix for sensing purposes. Nanoparticles of NH2-MIL-53(Al) were dispersed in a Matrimid polymer matrix with different weight ratios (0–100 wt %) and drop-casted on planar capacitive transducer devices. These coated devices were electrically analyzed using impedance spectroscopy and investigated for their sensing properties toward the detection of a series of alcohols and water in the gas phase. The measurements indicated a reversible and reproducible response in all devices. Sensor devices containing 40 wt % NH2-MIL-53(Al) in Matrimid showed a maximum response for methanol and water. The sensor response time slowed down with increasing MOF concentration until 40 wt %. The half time of saturation response (τ0.5) increased by ∼1.75 times for the 40 wt % composition compared to devices coated with Matrimid only. This is attributed to polymer rigidification near the MOF/polymer interface. Higher MOF loadings (≥50 wt %) resulted in brittle coatings with a response similar to the 100 wt % MOF coating. Cross-sensitivity studies showed the ability to kinetically distinguish between the different alcohols with a faster response for methanol and water compared to ethanol and 2-propanol. The observed higher affinity of the pure Matrimid polymer toward methanol compared to water allows also for a higher uptake of methanol in the composite matrices. Also, as indicated by the sensing studies with a mixture of water and methanol, the methanol uptake is independent of the presence of water up to 6000 ppm of water. The NH2-MIL-53(Al) MOFs dispersed in the Matrimid matrix show a sensitive and reversible capacitive response, even in the presence of water. By tuning the precise compositions, the affinity kinetics and overall affinity can be tuned, showing the promise of this type of chemical sensors.
During the last decade, the synthesis and application of metal–organic framework (MOF) nanosheets has received growing interest, showing unique performances for different technological applications. ...Despite the potential of this type of nanolamellar materials, the synthetic routes developed so far are restricted to MOFs possessing layered structures, limiting further development in this field. Here, a bottom‐up surfactant‐assisted synthetic approach is presented for the fabrication of nanosheets of various nonlayered MOFs, broadening the scope of MOF nanosheets application. Surfactant‐assisted preorganization of the metallic precursor prior to MOF synthesis enables the manufacture of nonlayered Al‐containing MOF lamellae. These MOF nanosheets are shown to exhibit a superior performance over other crystal morphologies for both chemical sensing and gas separation. As revealed by electron microscopy and diffraction, this superior performance arises from the shorter diffusion pathway in the MOF nanosheets, whose 1D channels are oriented along the shortest particle dimension.
A bottom‐up surfactant‐assisted synthetic approach to synthesize nanosheets of various nonlayered metal–organic frameworks (MOFs) is reported. The surfactant‐assisted preorganization of the metallic precursor prior to MOF synthesis enables the manufacture of nonlayered Al‐containing MOF lamellae. These MOF nanosheets are shown to exhibit a superior performance over other crystal morphologies in different molecular recognition applications.
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