Inhaltsverzeichnis
Zum Geleit
Academia
Rolf Parr
Lesen als Experiment.
Kultur- und medienwissenschaftliche Perspektiven
Tanja Nusser
Das „atemlose Stocken der Zeit“.
Die Vielfalt akademischer ...Zeit(-lichkeiten) oder das Schrumpfen
der wissenschaftsgeschichtlichen Gegenwart
Guillaume van Gemert
Narrentheater, Mördergrube, Verblödungsanstalt?
Vom allmählichen Verschwinden der Alma Mater
aus dem deutschen Universitätsroman
Poetik – Ästhetik – Didaktik
Martin Schubert
Hartmann, Thomas Mann und Oulipo.
Der Gregorius-Stoff im experimentellen Roman
Simone Loleit
Der Sperling, der Schneider und die ‚dürre Moral‘.
Ein Platztausch in den „Kinder- und Hausmärchen“
der Brüder Grimm und seine poetologischen Implikationen ...
Jörg Wesche
Barockpoetik und Übersetzung.
Antwortversuch
„… so träumt sie doch letzthin Revolution“.
Zu Ernst Blochs Unterscheidung von Kitsch und Kolportage ...
Peter Ellenbruch
Rehmann, Klingler & Co. –
oder: die Gebäude der Bundesrepublik
Peter Bekes
Textgenese – Interpretation – Didaktik
Heinrich Böll
Corinna Schlicht
Hate Speech und Antifeminismus.
„Die verlorene Ehre der Katharina Blum“ revisited
Walter Delabar
Misslungene Liebe, schlechter Krieg und die Sinnfrage.
Heinrich Bölls „Wo warst du, Adam?“
Literatur des 17. bis 21. Jahrhunderts
Gaby Herchert
Wenn Vernunft sich verstecken muss.
Verschwörungstheorien in Alessandro Manzonis Roman
„Die Brautleute“
Heinz Eickmans
Flandern als völkischer Mythos im Werk rheinischer Autoren.
Zu den ‚flämischen‘ Romanen „Der Bürger von Gent“
von Theodor Seidenfaden und „Fliegt der Blaufuß?“ von Otto Brües
Erhard Schütz
Städtebund und Stahlhaus.
Erik Regers kritische Revision der Kultur im Ruhrgebiet
Walter Fähnders
Aktionskünstler, Dadaisten, Surrealisten und andere Figuren
der Avantgarde im Gegenwartsroman –
oder: „Was kann die Avantgarde heute sein?“
Elke Reinhardt-Becker
Ein sachlich-romantisches Liebesdurcheinander.
Katrin Hollands Roman „Man spricht über Jacqueline“
Jochen Vogt
Jörg und ich.
Eine Ferienerinnerung
Julia Bertschik
‚Benachbartes und Entferntes‘.
Zu Brigitte Kronauers poetologischen Lektüre –
„Favoriten“ des 19. Jahrhunderts
Hannes Krauss
Poetisches Engagement?
Handke und Jugoslawien
Liane Schüller
Das „Ende der mentalen Privatsphäre“.
Anmerkungen zu Überwachung und Künstlicher Intelligenz
in Ian McEwans „Mashines like me (and people like you)“
Beiträgerinnen und Beiträger
During the recent Ebola outbreak in West Africa several international mobile laboratories were deployed to the mainly affected countries Guinea, Sierra Leone and Liberia to provide ebolavirus ...diagnostic capacity. Additionally, imported cases and small outbreaks in other countries required global preparedness for Ebola diagnostics. Detection of viral RNA by reverse transcription polymerase chain reaction has proven effective for diagnosis of ebolavirus disease and several assays are available. However, reliability of these assays is largely unknown and requires serious evaluation. Therefore, a proficiency test panel of 11 samples was generated and distributed on a global scale. Panels were analyzed by 83 expert laboratories and 106 data sets were returned. From these 78 results were rated optimal and 3 acceptable, 25 indicated need for improvement. While performance of the laboratories deployed to West Africa was superior to the overall performance there was no significant difference between the different assays applied.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Emerging infectious diseases (EIDs) and highly infectious diseases (HIDs) have received much attention in recent years, when a number of networks and projects were funded by the European Community 1: ...ENIVD (European Network for the Diagnosis of Imported Viral Diseases), EUNID and EURONHID (European Network of Infectious Disease Physicians), ETHREAT (European Training for Health Professionals on Rapid Responses to Health Threats), ETIDE (European Training for Infectious Disease Emergencies), RIVIGENE (genomic inventory, forensic markers, and assessment of potential therapeutic and vaccine targets for viruses relevant in biological crime and terrorism), and EURONET-P4 and ENP4-Lab (European Network of Biosafety-Level-4 Laboratories). Since the 2010 conference, European BSL-4 laboratories have strengthened their programme of coordinated quality assurance exercises under the QUANDHIP project that started in 2011 9 and have become part of the larger ERINHA consortium funded under the 7th Framework Programme of the European Commission 8, the goal of which is to facilitate access to the BSL-4 research infrastructure by qualified scientists from EU countries.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background. Reliable reverse transcription polymerase chain reaction (RT-PCR)–based diagnosis of Ebola virus infection currently requires a blood sample obtained by intravenous puncture. During the ...current Ebola outbreak in Guinea, we evaluated the usability of capillary blood samples collected from fingersticks of patients suspected of having Ebola virus disease (EVD) for field diagnostics during an outbreak emergency. Methods. A total of 120 venous and capillary blood samples were collected from 53 patients admitted to the Ebola Treatment Centre in Guéckédou, Guinea, between July and August 2014. All sample specimens were analyzed by RT-PCR using the RealStar Filovirus Screen RT-PCR Kit 1.0 from altona Diagnostics (Germany). We compared samples obtained by venipuncture and those obtained by capillary blood sampling absorbed onto swab devices. Results. The resulting sensitivity and specificity of tests performed with capillary blood samples were 86.8% (95% confidence interval CI, 71.9%–95.6%; 33/38 patients) and 100% (95% CI, 84.6%–100%; 22/22 patients), respectively. Conclusions. Our data suggest that capillary blood samples could serve as an alternative to venous blood samples for the diagnosis of EVD in resource-limited settings during a crisis. This can be of particular advantage in cases when venipuncture is difficult to perform—for example, with newborns and infants or when adult patients reject venipuncture for cultural or religious reasons.
An LC–MS/MS multi-method for the simultaneous determination of the structurally different and frequently used cytostatic drugs 5-fluorouracil, gemcitabine, methotrexate, cyclophosphamide, ifosfamide, ...etoposide, docetaxel and paclitaxel was developed and validated. In order to perform repeated ambient monitoring in 130 German pharmacies all steps of the monitoring procedure such as sample collection, transport, storage, sample preparation and HPLC–MS/MS analysis have been adapted and optimised. Thus sensitivity and reliability as well as sample throughput were increased. The final method consists of wipe sampling from 900 cm² surfaces and extraction of the tissues with an aqueous pH 3 solution. The limits of quantification range from 3.7 to 37 pg cm⁻². Validation showed that sampling via the individual pharmacy personnel does not affect the overall results. Recovery rates below 70% were observed on rough surfaces for the taxanes docetaxel and paclitaxel. Likewise, neither the storage nor the shipping conditions affected the results significantly.
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