In this paper, we develop discrete models of Tuberculosis (TB). This includes SEI endogenous and exogenous models without treatment. These models are then extended to a SEIT model with treatment. We ...develop two types of net reproduction numbers, one is the traditional
which is based on the disease-free equilibrium, and a new net reproduction number
based on the endemic equilibrium. It is shown that the disease-free equilibrium is globally asymptotically stable if
and unstable if
. Moreover, the endemic equilibrium is locally asymptotically stable if
.
Dementia associated with the Alzheimer's disease is thought to be correlated with the conversion of the β - Amyloid (Aβ) peptides from soluble monomers to aggregated oligomers and insoluble fibrils. ...We present a discrete-time mathematical model for the aggregation of Aβ monomers into oligomers using concepts from chemical kinetics and population dynamics. Conditions for the stability and instability of the equilibria of the model are established. A formula for the number of monomers that is required for producing oligomers is also given. This may provide compound designers a mechanism to inhibit the Aβ aggregation.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In this paper, we apply a new approach to a special class of discrete time evolution models and establish a solid mathematical foundation to analyse them. We propose new single and multi-species ...evolutionary competition models using the evolutionary game theory that require a more advanced mathematical theory to handle effectively. A key feature of this new approach is to consider the discrete models as non-autonomous difference equations. Using the powerful tools and results developed in our recent work E. D'Aniello and S. Elaydi, The structure of ω-limit sets of asymptotically non-autonomous discrete dynamical systems, Discr. Contin. Dyn. Series B. 2019 (to appear)., we embed the non-autonomous difference equations in an autonomous discrete dynamical systems in a higher dimension space, which is the product space of the phase space and the space of the functions defining the non-autonomous system. Our current approach applies to two scenarios. In the first scenario, we assume that the trait equations are decoupled from the equations of the populations. This requires specialized biological and ecological assumptions which we clearly state. In the second scenario, we do not assume decoupling, but rather we assume that the dynamics of the trait is known, such as approaching a positive stable equilibrium point which may apply to a much broader evolutionary dynamics.
Alzheimer's disease is a degenerative disorder characterized by the loss of synapses and neurons from the brain, as well as the accumulation of amyloid-based neuritic plaques. While it remains a ...matter of contention whether β-amyloid causes the neurodegeneration, β-amyloid aggregation is associated with the disease progression. Therefore, gaining a clearer understanding of this aggregation may help to better understand the disease. We develop a continuous-time model for β-amyloid aggregation using concepts from chemical kinetics and population dynamics. We show the model conserves mass and establish conditions for the existence and stability of equilibria. We also develop two discrete-time approximations to the model that are dynamically consistent. We show numerically that the continuous-time model produces sigmoidal growth, while the discrete-time approximations may exhibit oscillatory dynamics. Finally, sensitivity analysis reveals that aggregate concentration is most sensitive to parameters involved in monomer production and nucleation, suggesting the need for good estimates of such parameters.
The association between plasma cholesterol levels and the development of dementia continues to be an important topic of discussion in the scientific community, while the results in the literature ...vary significantly. We study the effect of reducing oxidized neuronal cholesterol on the lipid raft structure of plasma membrane. The levels of plasma membrane cholesterol were reduced by treating the intact cells with methyl-ß-cyclodextrin (MßCD). The relationship between the cell viability with varying levels of MßCD was then examined. The viability curves are well described by a modified form of the empirical Gompertz law of mortality. A detailed statistical analysis is performed on the fitting results, showing that increasing MßCD concentration has a minor, rather than significant, effect on the cellular viability. In particular, the dependence of viability on MßCD concentration was found to be characterized by a ~25% increase per 1 μM of MßCD concentration.
In this paper, we develop several population models with Allee effects. We start by defining the Allee effect as a phenomenon in which individual fitness increases with increasing density. Based on ...this biological assumption, we develop several fitness functions that produce corresponding models with Allee effects. In particular, a rational fitness function yields a new mathematical model, which is the focus of our study. Then we study the dynamics of 2-periodic systems with Allee effects and show the existence of an asymptotically stable 2-periodic carrying capacity.
Integrates both classical and modern treatments of difference equations. This third edition includes proofs, graphs, and applications. It contains: a chapter on Higher Order Scalar Difference ...Equations, and also results on local and global stability of one-dimensional maps. It is useful for advanced undergraduate and beginning graduate students.
This paper is dedicated to Jim Cushing on the occasion of his 80th birthday. It is inspired by his work on evolutionary theory. We investigate the global dynamics of discrete-time phenotypic ...evolutionary models, both autonomous and periodic. We developed the theory of mixed monotone maps and applied it to show that the positive equilibrium of the autonomous evolutionary Ricker model of single and multi-species is globally asymptotically stable. Then we extend this result to the corresponding evolutionary Ricker model with periodic parameters.
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