Izhodišča: Čeprav so srčne kateterizacije v primerjavi s kardiokirurškimi posegi manj invazivne, imajo manj zapletov, bolniki pa po njih hitreje okrevajo, te niso brez zapletov. Z raziskavo smo ...želeli ugotoviti značilnosti populacije, najpogostejše patologije, vrste kateterizacij, zaplete pri kateterizacijah v našem centru ter opredeliti morebitne dejavnike tveganja.
Metode: Zbrali smo podatke o vseh pediatričnih srčnih kateterizacijah, opravljenih med junijem 2018 in avgustom 2021. Opredelili smo jih glede na vrsto kateterizacije (diagnostične in terapevtske), težo, starost, spol bolnikov in kompleksnost patologije. Zaplete smo ločili na lažje in težje ter z uporabo Pearsonovega testa hi-kvadrat in testa Mann-Whitney U ugotavljali njihovo povezanost s morebitnimi dejavniki tveganja.
Rezultati: V tem obdobju je bilo opravljenih 191 srčnih kateterizacij (54 diagnostičnih in 137 terapevtskih) pri 175 otrocih, od tega pri 95 dečkih in 80 deklicah. Otroci so bili stari od nekaj ur do 18 let, tehtali so od 2,6 kg do 85,5 kg. Zabeležili smo 9 zapletov, od tega 5 težjih in 4 lažje. Z našo raziskavo nismo dokazali statistično pomembne povezave med dejavniki tveganja (telesna teža, spol, vrsta kateterizacije, starost, kompleksnost patologije) in pojavom zapletov.
Zaključek: Največ kateterizacij je bilo opravljenih pri otrocih, starih med 1 letom in 10 let in tistih, ki so tehtali med 10 in 40 kg. Nekoliko več kateterizacij je bilo opravljenih pri dečkih. Najpogostejše so bile terapevtske kateterizacije. Pojavnost zapletov v našem centru je primerljiva z drugimi centri. Telesna teža, spol, starost otroka, vrsta kateterizacije in kompleksnost patologije v našem centru niso bili statistično značilno povezani s pojavom zapletov ob katerizaciji.
Congenitally corrected transposition of the great arteries is a rare congenital heart defect characterized by atrioventricular and ventriculoarterial discordance and can be potentially associated ...with several other concomitant anomalies, such as ventricular septal defect or congenital complete atrioventricular block. Different surgical options are used for treating the condition. Anatomic repair yields the best long-term outcomes; however, it is technically the most challenging. We present a case of a 3-year old female patient who was electively admitted for complete repair after pulmonary artery banding and pacemaker implantation soon after birth. Subsequently, an anatomic repair (double switch) was performed with an uneventful postoperative course and excellent mid-term outcomes.
In humans, early life exposure to inorganic arsenic is associated with adverse health effects. Inorganic arsenic in utero or in early postnatal life also produces adverse health effects in offspring ...of pregnant mice that consumed drinking water containing low part per billion levels of inorganic arsenic. Because aggregate exposure of pregnant mice to inorganic arsenic from both drinking water and food has not been fully evaluated in experimental studies, quantifying arsenic exposure of the developing mouse is problematic. Here, we determined levels of total arsenic and arsenic species in natural ingredient rodent diets that are composed of many plant and animal-derived foodstuffs and in a purified ingredient rodent diet that is composed of a more restricted mixture of foodstuffs. In natural ingredient diets, total arsenic levels ranged from ∼60 to ∼400 parts per billion, and in the purified ingredient diet, total arsenic level was 13 parts per billion. Inorganic arsenic was the predominant arsenic species in trifluoroacetic acid extracts of each diet. Various exposure scenarios were evaluated using information on inorganic arsenic levels in diet and drinking water and on daily food and water consumption of pregnant mice. In a scenario in which pregnant mice consumed drinking water with 10 parts per billion of inorganic arsenic and a natural ingredient diet containing 89 parts per billion of inorganic arsenic, drinking water contributed only ∼20% of inorganic arsenic intake. Quantitation of arsenic species in diets used in studies in which drinking water is the nominal source of arsenic exposure provides more accurate dosimetry and improves understanding of dose–response relations. Use of purified ingredient diets will minimize the discrepancy between the target dosage level and the actual dosage level attained in utero exposure studies designed to evaluate effects of low level exposure to inorganic arsenic.
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