The IoT paradigm holds the promise to revolutionize the way we live and work by means of a wealth of new services, based on seamless interactions between a large amount of heterogeneous devices. ...After decades of conceptual inception of the IoT, in recent years a large variety of communication technologies has gradually emerged, reflecting a large diversity of application domains and of communication requirements. Such heterogeneity and fragmentation of the connectivity landscape is currently hampering the full realization of the IoT vision, by posing several complex integration challenges. In this context, the advent of 5G cellular systems, with the availability of a connectivity technology, which is at once truly ubiquitous, reliable, scalable, and cost-efficient, is considered as a potentially key driver for the yet-to emerge global IoT. In the present paper, we analyze in detail the potential of 5G technologies for the IoT, by considering both the technological and standardization aspects. We review the present-day IoT connectivity landscape, as well as the main 5G enablers for the IoT. Last but not least, we illustrate the massive business shifts that a tight link between IoT and 5G may cause in the operator and vendors ecosystem.
The Border Gateway Protocol (BGP) is the de facto standard interdomain routing protocol. Despite its critical role on the Internet, it does not provide any security guarantees. In response to this, a ...large amount of research has proposed a wide variety BGP security extensions and detection-recovery systems in recent decades. Nevertheless, BGP remains vulnerable to many types of attack. In this work, we conduct an up-to-date review of fundamental BGP threats and present a methodology for evaluation of existing BGP security proposals. Based on this, we introduce a comprehensive and up-to-date survey of proposals intended to make BGP secure and methods for detection and mitigation of routing instabilities. Last but not least, we identify gaps in research, and pinpoint open issues and unsolved challenges.
The co-occurrence of diseases can inform the underlying network biology of shared and multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects of external ...exposures, such as diet, lifestyle and patient care. With worldwide health transaction data now often being collected electronically, disease co-occurrences are starting to be quantitatively characterized. Linking network dynamics to the real-life, non-ideal patient in whom diseases co-occur and interact provides a valuable basis for generating hypotheses on molecular disease mechanisms, and provides knowledge that can facilitate drug repurposing and the development of targeted therapeutic strategies.
End Tidal CO2 (ETCO2) is a reasonable predictor of Return of Spontaneous Circulation (ROSC) in cardiac arrest (CA), though with many limitations. Cerebral Oximetry (CerOx) non-invasively measures ...brain O2 saturation and correlates with flow.
This study compares ETCO2 and CerOx for ROSC prediction during both out of hospital (OHCA) and emergency department cardiac arrests (EDCA).
We conducted a prospective study on CA patients resuscitated in the ED. ETCO2 and CerOx simultaneously measured during ED CPR. Data was analyzed with logistic regression modeling and area under the curve (AUC).
176 patients were analyzed, 66.7% were witnessed, 52.8% had bystander CPR. EMS alert to ED arrival was 27.0 ± 10.6 min. Initial rhythm was 31.8% asystole, 27.8% PEA, 25.6% VF/VT with 26.1% achieving ROSC. AUC predictors of ROSC were: last 5 min trend CerOx = 0.82 ; ETCO2 = 0.74, delta first to last CerOx = 0.86 ; ETCO2 = 0.73, the penultimate minute CerOx = 0.81 ; ETCO2 = 0.76, and final minute CerOx = 0.89 ; ETCO2 = 0.77. AUC comparison of simultaneous measurements (n = 125) revealed: last 5 min trend CerOx = 0.80 ; ETCO2 = 0.79, delta first to last CerOx = 0.83 ; ETCO2 = 0.75, penultimate minute CerOx = 0.83 ETCO2 = 0.74, and final minute CerOx = 0.89 ; ETCO2 = 0.75.
Our data shows, both ETCO2 and rSO2 are good predictors of ROSC. We found CerOx superior to ETCO2 in predicting ROSC.
Even in the face of strong encryption, the spectacular Internet of Things (IoT) penetration across sectors such as e-health, energy, transportation, and entertainment is expanding the attack surface, ...which can seriously harm users' privacy. We demonstrate in this paper that an attacker is able to disclose sensitive information about the IoT device, such as its type, by identifying specific patterns in IoT traffic. To perform the fingerprint attack, we train machine-learning algorithms based on selected features extracted from the encrypted IoT traffic. Extensive simulations involving the baseline approach show that we achieve not only a significant mean accuracy improvement of 18.5% and but also a speedup of 18.39 times for finding the best estimators. Obtained results should spur the attention of policymakers and IoT vendors to secure the IoT devices they bring to market.
OBJECTIVE—Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages.
METHODS AND RESULTS—Human apoE receptors ...very-low-density lipoprotein receptor (VLDL-R) and apoE receptor-2 (apoER2) were stably expressed in RAW264.7 mouse macrophages. In these cells, apoE downregulated markers of the proinflammatory M1 phenotype (inducible nitric oxide synthase, interleukin IL-12, macrophage inflammatory protein-1α) but upregulated markers of the antiinflammatory M2 phenotype (arginase I, SOCS3, IL-1 receptor antagonist IL-1RA). In addition, M1 macrophage responses (migration, generation of reactive oxygen species, antibody-dependent cell cytotoxicity, phagocytosis), as well as poly(I:C)- or interferon-γ-induced production of proinflammatory cytokines; cyclooxygenase-2 expression; and activation of nuclear factor-κB, IκB, and STAT1, were suppressed in VLDL-R- or apoER2-expressing cells. Conversely, the suppression of the M2 phenotype and the enhanced response to poly(I:C) were observed in apoE-producing bone marrow macrophages derived from VLDL-R-deficient mice but not wild-type or low-density lipoprotein receptor–deficient mice. The modulatory effects of apoE on macrophage polarization were inhibited in apoE receptor-expressing RAW264.7 cells exposed to SB220025, a p38 mitogen-activated protein kinase inhibitor, and PP1, a tyrosine kinase inhibitor. Accordingly, apoE induced tyrosine kinase-dependent activation of p38 mitogen-activated protein kinase in VLDL-R- or apoER2-expressing macrophages. Under in vivo conditions, apoE mice transplanted with apoE-producing wild-type bone marrow showed increased plasma IL-1RA levels, and peritoneal macrophages of transplanted animals were shifted to the M2 phenotype (increased IL-1RA production and CD206 expression).
CONCLUSION—ApoE signaling via VLDL-R or apoER2 promotes macrophage conversion from the proinflammatory M1 to the antiinflammatory M2 phenotype. This effect may represent a novel antiinflammatory activity of apoE.
Abstract
The GEMIMEG-II project is intended to pave the way for digitalization in metrology. The central element of this digitalization initiative is the digital calibration certificate (DCC). It ...contains all calibration information in full digital form. This means, that it is machine readable and machine understandable without human interaction. This enables its utilization by being securely machine interpretable and machine actionable in the entire chain of truly digital workflows and information technology (IT) environments in Industry 4.0. Therefore, the DCC is created automatically in the calibration process in a standardized form based on a digital document schema. This systematic schema enables to safely transfer, process, and interpret all data in the DCC automatically in all subsequent IT based processes. This paper reflects the project status of GEMIMEG-II in its final phase and shares some insights on the concepts developed and solutions implemented as the results will be demonstrated in five Realbeds. Furthermore, the concept of quality of sensing and quality of data will be introduced as it is implemented in the GEMIMEG-II project to convey supplementary information on the measurement, environmental and/or surrounding modalities, and data quality. Finally, a brief outlook will be given on next steps and actions planned in the project related to other digitalization initiatives for the fab of the future.
Abstract
The field of optical 3D metrology is gaining significant interest in the past years. Optical sensors can probe the geometry of workpieces and biological samples very fast, highly accurate ...and without any tactile physical contact to the object’s surface. In this respect, optical sensors are a pre-requisite for many applications in the big trends like Industrial Internet of Things, Industry 4.0 or Medicine 4.0. The interest for optical 3D metrology is shifting from a metrology for quality assurance in industrial production to “digitize the real world” to facilitate a precise digital representation of an object or an environment for documentation or as input data for virtual applications like digital fab or augmented reality. The aspiration to digitize the world necessitates fast and efficient contact free sensing principles of appropriate accuracy for solid and even soft objects with a variety of colour, surface texture and lighting conditions. This review article tries to give a concise conceptual overview about the evolution of a broad variety of optical measurement principles that evolved and gained some importance in the field of 3D metrology for industrial 3D applications and their related technological enablers.
We evaluated the incidence of change in serial 12-lead electrocardiogram (ECG) diagnostic classifications in patients resuscitated from out-of-hospital (OH) cardiac arrest (OHCA) comparing OH to ...emergency department (ED) ECGs.
This retrospective case series included: 1) adults (≥ 18 years old), 2) resuscitated from OHCA, 3) ≥ 1 OH and 1 ED ECG/patient, and 4) emergency medical services (EMS) transport to the study hospital. OH and ED ECGs were classified as: 1) STEMI (ST-segment Elevation Myocardial Infarction), 2) Ischemic, and 3) Non-ischemic. Two ED physicians and one cardiologist independently classified all ECGs, then generated a consensus opinion classification for each ECG based on American Heart Association’s 2018 Expert Consensus criteria. The most ischemic OH ECG classification was compared with the last ED ECG classification.
From 7/27/12 to 7/18/19, 176 patients were entered with a mean age of 61.2 ± 16.6 years; 102/176 (58%) were male. Overall, 504 OH and ED 12-lead ECGs were acquired (2.9 ECGs/patient). ECG classification inter-rater reliability kappa score was 0.63 ± 0.02 (substantial agreement). Overall, 86/176 (49%) changed ECG classification from the OH to ED setting; 69/86 (80%) of these ECGs changed from more to less ischemic classifications. Of 49 OH STEMI ECG classifications, 33/49 (67%) changed to a less ischemic (non-STEMI) ED ECG classification.
Change in 12-lead ECG classification from OH to ED setting in patients resuscitated from OHCA was common (49%). The OH STEMI classification changed to a less ischemic (non-STEMI) ED classification in 67% of cases.
Deterioration of the searchability of Pareto dominance-based, many-objective evolutionary optimization algorithms is a well-known problem. Alternative solutions, such as scalarization-based and ...indicator-based approaches, have been proposed in the literature. However, Pareto dominance-based algorithms are still widely used. In this paper, we propose to redefine the calculation of Pareto-dominance. Instead of assigning solutions to non-dominated fronts, they are ranked according to the measure of dominating solutions referred to as k-Pareto optimality. In the case of probability measures, such re-definition results in an elegant and fast approximate procedure. Through experimental results on the many-objective 0/1 knapsack problem, we demonstrate the advantages of the proposed approach: (1) the approximate calculation procedure is much faster than the standard sorting by Pareto dominance; (2) it allows for achieving higher hypervolume values for both multi-objective (two objectives) and many-objective (25 objectives) optimization; (3) in the case of many-objective optimization, the increased ability to differentiate between solutions results in a better compared to NSGA-II and NSGA-III. Apart from the numerical improvements, the probabilistic procedure can be considered as a linear extension of multidimentional topological sorting. It produces almost no ties and, as opposed to other popular linear extensions, has an intuitive interpretation.
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