Control de los síntomas Martínez-Castro, Raúl; Barranco-Lampón, Gilberto; Arana-Luna, Luara L. ...
Gaceta médica de México,
03/2024, Letnik:
158, Številka:
93
Journal Article
Recenzirano
Odprti dostop
Además de la sintomatología secundaria a la esplenomegalia, a las alteraciones microvasculares y a las complicaciones trombohemorrágicas, los pacientes con neoplasias mieloproliferativas (NMP) pueden ...experimentar una importante carga sintomática atribuida a un aumento de citocinas inflamatorias circulantes. Estos síntomas pueden ser severos y limitar la calidad de vida. Por ello, además de la prevención de las complicaciones, uno de los objetivos del tratamiento de las NMP es el control de los síntomas.
Las complicaciones trombóticas mayores en las neoplasias mieloproliferativas (NMP) representan un importante problema clínico debido a su elevada morbilidad, la complejidad de su manejo y su ...mortalidad asociada. La aparición de una trombosis comporta una estratificación de alto riesgo trombótico de la NMP y determina el inicio o la optimización del tratamiento citorreductor y el uso de terapia antiplaquetaria o anticoagulante como profilaxis secundaria. La incidencia de trombosis en el momento del diagnóstico es mayor que durante la evolución de la enfermedad, localizándose en territorio arterial en el 60-70% casos. Una vez se ha producido una trombosis, hasta el 20-33% de los pacientes sufre una recurrencia trombótica en el mismo territorio vascular inicial.
Mielofibrosis: diagnóstico y tratamiento Martínez-Castro, Raúl; Barranco-Lampón, Gilberto; Arana-Luna, Luara L. ...
Gaceta médica de México,
03/2024, Letnik:
158, Številka:
93
Journal Article
Recenzirano
Odprti dostop
La mielofibrosis (MF) es una neoplasia mieloproliferativa negativa para BCR-ABL1 caracterizada por mieloproliferación clonal, señalización de cinasa desregulada y liberación de citocinas anormales. ...En los últimos años se han realizado importantes avances en el conocimiento de la biología molecular y la valoración pronóstica de la MF. El tratamiento convencional tiene un impacto limitado en la supervivencia de los pacientes; incluye un enfoque de espera para pacientes asintomáticos, agentes estimulantes de la eritropoyesis, andrógenos o agentes inmunomoduladores para la anemia, fármacos citorreductores como la hidroxiurea para la esplenomegalia y los síntomas constitucionales, y esplenectomía o radioterapia en pacientes seleccionados. El descubrimiento de la mutación Janus cinasa (JAK) 2 desencadenó el desarrollo de la terapia dirigida molecular de la MF. Los inhibidores de JAK son efectivos tanto en MF con JAK2 positivo como con JAK2 negativo; uno de ellos, el ruxolitinib, es la mejor terapia disponible actualmente para la esplenomegalia y los síntomas constitucionales de la MF. Sin embargo, aunque el ruxolitinib ha cambiado el escenario terapéutico de la MF, no hay indicios claros de un efecto modificador de la enfermedad. El alotrasplante de células madre sigue siendo la única terapia curativa de la MF, pero debido a su morbilidad y mortalidad asociadas, generalmente se restringe a pacientes elegibles con MF de riesgo alto e intermedio 2. Para mejorar los resultados terapéuticos actuales, actualmente se está probando la combinación de inhibidores de JAK con otros agentes y se están investigando fármacos más nuevos.
Objetivo: El objetivo del consenso es poner a disposición de los profesionales de las diferentes instituciones de salud pública en nuestro país, quienes se encuentran a cargo de estas enfermedades, ...la información más relevante y actualizada acerca de su diagnóstico y tratamiento en la práctica clínica. Con este consenso interinstitucional esperamos contribuir a mejorar la calidad de la atención de los pacientes con neoplasias mieloproliferativas crónicas a todo lo ancho y largo de la República Mexicana, con el fin de unificar criterios tanto en diagnóstico como en tratamiento de las diferentes enfermedades mieloproliferativas.
La trombocitemia esencial (TE) es una neoplasia mieloproliferativa crónica Filadelfia negativa que tiene su principal involucro en la línea megacariopoyética, generando trombocitosis sostenida en la ...sangre periférica y un incremento en el número de megacariocitos maduros en médula ósea. Además de una marcada trombocitosis, se caracteriza por un mayor riesgo trombótico o hemorrágico y la presencia de síntomas constitucionales. Los pacientes con TE tienen un riesgo bajo, pero conocido, de evolución de la enfermedad a mielofibrosis y/o leucemia aguda. El diagnóstico se realiza con base en los criterios de la Organización Mundial de la Salud del 2016. Los tratamientos actualmente disponibles para los pacientes con TE están dirigidos principalmente a minimizar el riesgo de trombosis y/o hemorragia.
► Our NLP bibliographical analysis shows low balance in combination methods usage. ► We experiment with eight combination methods, 13 corpora, four classifiers, and four NLP tasks. ► Scenarios with ...low quality data or base classifiers can obtain major improvements. ► Classification can also be improved combining different versions of only one classifier. ► Stacking can combine integrating heterogeneous information from multiple sources.
The paper is devoted to a comparative study of classifier combination methods, which have been successfully applied to multiple tasks including Natural Language Processing (NLP) tasks. There is variety of classifier combination techniques and the major difficulty is to choose one that is the best fit for a particular task. In our study we explored the performance of a number of combination methods such as voting, Bayesian merging, behavior knowledge space, bagging, stacking, feature sub-spacing and cascading, for the part-of-speech tagging task using nine corpora in five languages. The results show that some methods that, currently, are not very popular could demonstrate much better performance. In addition, we learned how the corpus size and quality influence the combination methods performance. We also provide the results of applying the classifier combination methods to the other NLP tasks, such as name entity recognition and chunking. We believe that our study is the most exhaustive comparison made with combination methods applied to NLP tasks so far.
Abstract
The relative growth of Calappa convexa can be used to identify dimorphism or morphological change related to sexual maturation. The carapace width (CW) against width and length of the ...propodus of the right and left cheliped were tested to obtain a coefficient of allometry. CW against total wet weight WT values were analysed for length-weight relationships (LWR). Relative growth was analysed by a multi-model approach. Five models were tested and the best was selected due to the greater weight of the Akaike criterion (
W
i
). Significant differences between sexes were found in CW (
t
=
3.33,
p
<
0.001) and WT (
U
=
14
012,
p
<
0.05). The negative or positive allometry varied according to the morphometric relationship and sex. No real winner model (
W
i
>
90
%) was observed in the LWR analysis under a multi-model approach. The average model estimated a breakpoint at 118 mm CW in males and 132 mm CW in females.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Abstract
In vivo
detection and quantification of inflammation is a major goal in molecular imaging. Furthermore, cell-specific detection of inflammation would be a tremendous advantage in the ...characterization of many diseases. Here, we show how this goal can be achieved through the synergistic combination of nanotechnology and nuclear imaging. One of the most remarkable features of this hybrid approach is the possibility to tailor the pharmacokinetics of the nanomaterial-incorporated biomolecule and radionuclide. A good example of this approach is the covalent binding of a large amount of a neutrophil-specific, hydrophobic peptide on the surface of
68
Ga core-doped nanoparticles. This new nano-radiotracer has been used for non-invasive
in vivo
detection of acute inflammation with very high
in vivo
labelling efficiency, i.e. a large percentage of labelled neutrophils. Furthermore, we demonstrate that the tracer is neutrophil-specific and yields images of neutrophil recruitment of unprecedented quality. Finally, the nano-radiotracer was successfully detected in chronic inflammation in atherosclerosis-prone ApoE
−/−
mice after several weeks on a high-fat diet.
Acid hydrolysis of wheat straw: A kinetic study GUERRA-RODRIGUEZ, Esther; PORTILLA-RIVERA, Oscar M; JARQUIN-ENRIQUEZ, Lorenzo ...
Biomass & bioenergy,
2012, 2012-1-00, 20120101, Letnik:
36
Journal Article
Recenzirano
Biotechnological xylitol production can be enhanced if the needed xylose solutions can be obtained from hydrolysis of low-cost lignocellulosic wastes. The hydrolysis of wheat straw to obtain xylose ...solutions has a double consequence, the elimination of a waste and the generation of a value-added product. The objective of this work was to study the xylose production from wheat straw by sulphuric acid hydrolysis at 130 °C. Several mass fraction of acid (1, 2, 3, 4 or 5%) were evaluated. Kinetic models were developed to explain the variation with time of xylose, glucose, arabinose, furfural, 5-(hydroxymethyl)-2-furaldehyde and acetic acid in the hydrolysates. Optimal conditions found were a H
2SO
4 mass fraction of 2% at 130 °C for 29 min, which yielded a solution with xylose, 18.9 kg m
−3; glucose, 3.5 kg m
−3; arabinose, 3.1 kg m
−3; furfural, 0.6 kg m
−3; 5-(hydroxymethyl)-2-furaldehyde, 0.3 kg m
−3 and acetic acid, 2.3 kg m
−3. In these conditions, 99% of the hemicelluloses and 11% of the glucan were hydrolysed.
► The acid hydrolysis of wheat straw eliminates a waste. ► The acid hydrolysis also generates a value-added products. ► The objective was to study the sugar production from wheat straw as a pretreatment for ethanol or xylose fermentation. ► Kinetic models were developed to explain the variation with time of sugars and growth inhibitors. ► Optimal conditions found were 2% H
2SO
4 at 130 °C for 29 min.
The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the defence against viral infection. IFITM3 gene variants have been linked to differences in expression and ...associated with the risk of severe influenza by some authors. More recently, these variants have been associated with the risk of COVID-19 after SARS-CoV-2 infection. We determined the effect of two common IFITM3 polymorphisms (rs34481144 C/T and rs12252 A/G) on the risk of hospitalization due to COVID-19 by comparing 484 patients (152 required support in thr intensive care unit, ICU) and 182 age and sex matched controls (no disease symptoms). We found significantly higher frequencies of rs34481144 T and rs12252 G carriers among the patients (OR = 2.02 and OR = 1.51, respectively). None of the two variants were associated with ICU-admission or death. We found a significantly higher frequency of rs34481144 CC + rs12252 AA genotype carriers among the controls, suggesting a protective effect (p = 0.001, OR = 0.56, 95%CI = 0.40–0.80). Moreover, haplotype rs34481144 C - rs12252 A was significantly increased in the controls (p = 0.008, OR = 0.71, 95%CI = 0.55–0.91).
Our results showed a significant effect of the IFITM3 variants in the risk for hospitalization after SARS-CoV-2 infection.
Display omitted
•IFITM3 is a key component of the innate immunity.•IFITM3 has been implicated in the defence against viral infection.•IFITM3 gene variants have been associated with influenza and COVID-19 disease.•A common IFITM3 haplotype was a susceptibility factor for severe SARS-CoV-2 disease, COVID-19 hospitalization.
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