With the aim to give an overview of the most recent discoveries in the field of socially engaging interactive systems, the present paper discusses features affecting users' acceptance of virtual ...agents, robots, and chatbots. In addition, questionnaires exploited in several investigations to assess the acceptance of virtual agents, robots, and chatbots (voice only) are discussed and reported in the
Supplementary material
to make them available to the scientific community. These questionnaires were developed by the authors as a scientific contribution to the H2020 project EMPATHIC (
http://www.empathic-project.eu/
), Menhir (
https://menhir-project.eu/
), and the Italian-funded projects SIROBOTICS (
https://www.exprivia.it/it-tile-6009-si-robotics/
) and ANDROIDS (
https://www.psicologia.unicampania.it/android-project
) to guide the design and implementation of the promised assistive interactive dialog systems. They aimed to quantitatively evaluate Virtual Agents Acceptance (VAAQ), Robot Acceptance (RAQ), and Synthetic Virtual Agent Voice Acceptance (VAVAQ).
Currently, the diagnosis of major depressive disorder (MDD) and its subtypes is mainly based on subjective assessments and self-reported measures. However, objective criteria as ...Electroencephalography (EEG) features would be helpful in detecting depressive states at early stages to prevent the worsening of the symptoms. Scientific community has widely investigated the effectiveness of EEG-based measures to discriminate between depressed and healthy subjects, with the aim to better understand the mechanisms behind the disorder and find biomarkers useful for diagnosis. This work offers a comprehensive review of the extant literature concerning the EEG-based biomarkers for MDD and its subtypes, and identify possible future directions for this line of research. Scopus, PubMed and Web of Science databases were researched following PRISMA's guidelines. The initial papers' screening was based on titles and abstracts; then full texts of the identified articles were examined, and a synthesis of findings was developed using tables and thematic analysis. After screening 1871 articles, 76 studies were identified as relevant and included in the systematic review. Reviewed markers include EEG frequency bands power, EEG asymmetry, ERP components, non-linear and functional connectivity measures. Results were discussed in relations to the different EEG measures assessed in the studies. Findings confirmed the effectiveness of those measures in discriminating between healthy and depressed subjects. However, the review highlights that the causal link between EEG measures and depressive subtypes needs to be further investigated and points out that some methodological issues need to be solved to enhance future research in this field.
In the effort to improve the antimicrobial activity of iminosugars, we report the synthesis of lipophilic iminosugars
-
and
-
based on the one-pot conjugation of both enantiomeric forms of
...-butyldeoxynojirimycin (NBDNJ) and
-nonyloxypentyldeoxynojirimycin (NPDNJ) with cholesterol and a succinic acid model linker. The conjugation reaction was tuned using the established PS-TPP/I
/ImH activating system, which provided the desired compounds in high yields (94-96%) by a one-pot procedure. The substantial increase in the lipophilicity of
-
and
-
is supposed to improve internalization within the bacterial cell, thereby potentially leading to enhanced antimicrobial properties. However, assays are currently hampered by solubility problems; therefore, alternative administration strategies will need to be devised.
Pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1 (PYED-1), a heterocyclic corticosteroid derivative of deflazacort, exhibits broad-spectrum antibacterial activity against Gram-negative and ...Gram-positive bacteria. Here, we investigated the effect of PYED-1 on the biofilms of
, an etiological agent of biofilm-based chronic infections such as osteomyelitis, indwelling medical device infections, periodontitis, chronic wound infections, and endocarditis. PYED-1 caused a strong reduction in biofilm formation in a concentration dependent manner. Furthermore, it was also able to completely remove the preformed biofilm. Transcriptional analysis performed on the established biofilm revealed that PYED-1 downregulates the expression of genes related to quorum sensing (
,
,
,
, and
), surface proteins (
and
), secreted toxins (
,
and
), and capsular polysaccharides (
). The expression of genes that encode two main global regulators,
and
, was also significantly inhibited after treatment with PYED-1. In conclusion, PYED-1 not only effectively inhibited biofilm formation, but also eradicated preformed biofilms of
, modulating the expression of genes related to quorum sensing, surface and secreted proteins, and capsular polysaccharides. These results indicated that PYED-1 may have great potential as an effective antibiofilm agent to prevent
biofilm-associated infections.
Antibiotic resistance has become more and more widespread over the recent decades, becoming a major global health problem and causing colistin to be increasingly used as an antibiotic of last resort. ...Acinetobacter baumannii, an opportunistic pathogen that has rapidly evolved into a superbug exhibiting multidrug-resistant phenotypes, is responsible for a large number of hospital infection outbreaks. With the intensive use of colistin, A. baumannii resistance to colistin has been found to increase significantly. In previous work, we identified a deflazacort derivative, PYED-1 (pregnadiene-11-hydroxy-16,17-epoxy-3,20-dione-1), which exhibits either direct-acting or synergistic activity against Gram-positive and Gram-negative species and Candida spp., including A. baumannii. The aim of this study was to evaluate the antibacterial activity of PYED-1 in combination with colistin against both A. baumannii planktonic and sessile cells. Furthermore, the cytotoxicity of PYED-1 with and without colistin was assessed. Our results show that PYED-1 and colistin can act synergistically to produce a strong antimicrobial effect against multidrug-resistant populations of A. baumannii. Interestingly, our data reveal that PYED-1 is able to restore the efficacy of colistin against all colistin-resistant A. baumannii isolates. This drug combination could achieve a much stronger antimicrobial effect than colistin while using a much smaller dosage of the drugs, additionally eliminating the toxicity and resistance issues associated with the use of colistin.
In this work we combine time, spectral and cepstral features of the signal captured in a tablet to characterize depression, anxiety, and stress emotional state recognition on the EMOTHAW database. ...EMOTHAW contains the emotional states of users represented by capturing signals from sensors on the tablet and pen when the user is performing 3 specific handwriting and 4 drawing tasks, which had been categorized into depressed, anxious, stressed, and typical, according to the Depression, Anxiety and Stress Scale (DASS). Each user was characterized with six time-domain features, and the number of spectral-domain and cepstral-domain features for the horizontal and vertical displacement of the pen, the pressure on the paper, and the time spent on-air and off-air, depended on the configuration of the filterbank. As next step, we select the best features using the Fast Correlation-Based Filtering method. Since our dataset has 129 users, then as next step, we augmented the training data by randomly selecting a percentage of the training data and adding a small random Gaussian noise to the extracted features. We then train a radial basis SVM model using the Leave-One-Out (LOO) methodology. The experimental results show an average accuracy classification improvement ranging of 15%, and an accuracy classification improvement ranging from 4% to 34% compared with baseline (state of the art) for specific emotions such as depression, anxiety, stress, and typical emotional states.
Lung cancer has the highest cancer incidence, and it is the most common cause of cancer death worldwide. Cutaneous metastases are infrequent compared to hilar nodes, adrenal glands, liver, brain, and ...bones. However, unusual skin lesions in patients at high risk of lung cancer should be regarded carefully to rule out a metastatic manifestation of an occult primary site tumor. Surgical excision, or incisional biopsy when the former is deemed unfeasible, should be performed to allow histopathological examination in case of occult primary site. In patients affected by advanced lung tumors, surgical excision could be beneficial in terms of pain control and improvement of the quality of life. We report a case of a solitary large skin lesion as an early manifestation of a lung adenocarcinoma.
Based on a previous investigation, a quantitative study aimed to identify user’ preferences towards four synthetic voices of two different quality levels (classified through the sophistication of the ...synthesizer: low vs. high) is proposed. The voices administered to participants were developed considering two main aspects: the voice quality (high/low) and their gender (male/female). 182 unpaid participants were recruited for the study, divided in four groups according to their age, and therefore classified as adolescents, young adults, middle-aged, and seniors. To collect data regarding each voice, randomly audited by participants, the shortened version of the Virtual Agent Voice Acceptance Questionnaire (VAVAQ) was exploited. Outcomes of the previous study revealed that the voices of high quality, regardless of their gender, received a higher acclaim by all participants examined rather than the corresponding two voices assessed as lower quality. Conversely, findings of the current study suggest that the four new groups of participants involved agreed in showing their strong preference towards the high-quality voice gendered as female compared to all the other considered voices. Regarding the two voices gendered as male, the high-quality one was considered as more original and capable to arouse positive emotional states than the low-quality one. Moreover, the high-quality male voice was judged as more natural than the female low-quality one. Results provide some insights for future directions in the user experience and design field.
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