We derive new empirical calibrations for strong-line diagnostics of gas-phase metallicity in local star-forming galaxies by uniformly applying the T sub( e) method over the full metallicity range ...probed by the Sloan Digital Sky Survey (SDSS). To measure electron temperatures at high metallicity, where the auroral lines needed are not detected in single galaxies, we stacked spectra of more than 110 000 galaxies from the SDSS in bins of logOii/H... and logOiii/H... This stacking scheme does not assume any dependence of metallicity on mass or star formation rate, but only that galaxies with the same line ratios have the same oxygen abundance. We provide calibrations which span more than 1 dex in metallicity and are entirely defined on a consistent absolute T sub( e) metallicity scale for galaxies. We apply our calibrations to the SDSS sample and find that they provide consistent metallicity estimates to within 0.05 dex. (ProQuest: ... denotes formulae/symbols omitted.)
Knowledge of whether and how respiratory microbiota composition can prime the immune system and provide colonisation resistance, limiting consecutive pathobiont overgrowth and infections, is ...essential to improving the prevention and therapy of respiratory disorders. Modulation of dysbiotic ecosystems or reconstitution of missing microbes might be a possible measure to reduce respiratory diseases. The aim of this review is to analyse the role of nasopharyngeal microbiota in the development of respiratory tract disease in paediatric-age subjects. PubMed was used to search for all studies published over the last 15 years using the following key words: “microbiota” or “microbioma” and “nasopharyngeal” or “respiratory” or “nasal” and “children” or “paediatric” or “infant”. Analysis of the literature showed that respiratory microbiota can regulate health and disease development in the respiratory tract. Like the gut microbiota, the respiratory microbiota is established at birth, and early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children. Protective and dangerous bacteria have been identified, and this can be considered the base for developing new approaches to diseases that respond poorly to traditional interventions. Reconstitution of missing microbes can be achieved by the administration of pre- and probiotics. Modulation of respiratory microbiota by favouring colonisation of the upper respiratory tract by beneficial commensals can interfere with the proliferation and activity of resident pathobionts and is a possible new measure to reduce the risk of disease. However, further studies are needed because a deeper understanding of these and related issues can be transferred to clinical practice.
The benefits of vaccination are clearly demonstrated by the eradication or enormous decline in the incidence of many vaccine-preventable diseases, but the coverage of many highly recommended vaccines ...is still frequently inadequate and children continue to suffer from diseases that could have been prevented. The main aim of this paper is to discuss the recognized barriers to the vaccination of children and adolescents confronting national health systems, providers and parents, and the ways in which they can be overcome. Most of the problems underlying limited vaccination coverage among children are due to a lack of understanding on the part of healthcare providers and parents, which underlines the need for educational programmes specifically addressed to each of these groups. It is also essential that all of the physicians providing immunization develop approaches that acknowledge parents’ concerns and respectfully try to correct any misinformation. Other means of extending vaccine coverage include the implementation of adequate systems for recording vaccine administration and the activation of effective reminder/recall systems, the provision of immunization services in some medical care specialties or by integrating healthcare sites, and the elimination or reduction of all the problems that currently limit access to vaccination services. However, it will take the combined efforts of healthcare systems and providers to pull down all of the barriers.
The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate ...on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.
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•Glutamatergic mesencephalic locomotor region (MLR) neurons segregate by axonal target•MLR neurons projecting to basal ganglia output nuclei are labeled by Rbp4 transgene•Spinally projecting MLR neurons encode rearing and regulate body extension•Rbp4-MLR neurons are mostly tuned to forelimb movements and modulate behavior
The functionally diverse mesencephalic locomotor region (MLR) contains distinct subpopulations of glutamatergic neurons with different axonal targets, with activity correlated to specific behaviors beyond just locomotion.
Pertussis is a highly contagious infectious disease caused by Bordetella pertussis that can be extremely serious, particularly in young infants. For many years the efforts of health authorities ...throughout the world to prevent pertussis had the main goals of reducing the morbidity of infants and children under 5 years of age, maintaining protection for several years during the school-age period and developing a significant herd immunity to directly and indirectly reduce the risk of the spread of the disease among young infants and the risk of transmission of the infection from preschool children to infants. However, the increased risk of B. pertussis infection among adolescents and adults due to the waning immunity to this bacterium induced by vaccines and natural infection seems to be the main reason for the resurgence of pertussis. We discuss the reasons for the administration of pertussis vaccines to individuals for whom they were previously not recommended, the expected results of the administration of additional pertussis vaccine doses and the differences in the administration of pertussis vaccines in different countries. An analysis of the literature revealed several reports indicating the need for the modification of immunization schedules against pertussis, with booster doses among adolescents and the need for the vaccination of pregnant women. However, to monitor the true epidemiology of pertussis, effective programmes to collect pertussis cases, adequate reporting systems and vaccination coverage monitoring should be urgently implemented.
Pertussis, a highly contagious infective disease caused by Bordetella pertussis, was in the past very common among newborns and children, causing significant medical, social and economic issues ...burden, also due to frequent need of hospitalization and high mortality. Following the introduction of vaccines against pertussis, the burden of the disease dramatically decreased, although nowadays, this disease it is still the most widespread among the vaccine preventable ones. First vaccine formulations were composed with whole cell antigen of Bordetella pertussis and were followed by formulations with acellular antigens (PT, FHA, PRN, FIM), that showed to have similar efficacy and less reactogenicity. In particular, all the acellular vaccines, regardless the number of antigenic component included, demonstrated good immunogenicity in clinical trials and high effectiveness in real world evidence studies. Nevertheless, in the recent years it has been notified an increasing number of cases of pertussis. The most recent evidence demonstrated that for an effective control and prevention of pertussis it is necessary to strengthen vaccination coverage among the whole population, providing primary vaccination to newborns and booster in infancy, adolescence and adulthood every 10 years. Finally, vaccination of women at the third trimester of every pregnancy is the most effective intervention to protect the newborn from pertussis in his first months of life, before developing a protective response after the primary vaccination.
Although the clinical relevance of antibiotic treatment in influencing the natural course of Mycoplasma pneumoniae-associated respiratory diseases is questioned by some physicians, most experts ...suggest that antibiotics should be systematically used in patients with M. pneumoniae respiratory infections, especially those involving the lower respiratory tract. Macrolides (MLs), tetracyclines (TCs) and fluoroquinolones (FQs) are the drugs of choice for M. pneumoniae infection, but only MLs are recommended for children. The main aim of this review is to analyse what is known about M. pneumoniae resistance to MLs and discuss the most reasonable approach to treating patients with M. pneumoniae infection at a time when resistant strains are being increasingly detected. The results show that no change in ML prescription is needed in countries in which the incidence of ML-resistant M. pneumoniae is low; however, in countries in which ML-resistant M. pneumoniae strains are very common, the replacement of an ML by a TC or FQ should be considered depending on the severity of the disease. A number of cases treated with ineffective antibiotics have shown similar outcomes to those observed in patients infected by susceptible strains. This seems to indicate that there is no need to change ML use systematically in the case of mild to moderate disease, but other antibiotics should be prescribed if the symptoms persist or there are signs of a clinical deterioration.
We review the non-trivial issue of the relativistic description of a quantum mechanical system that, contrary to a common belief, kept theoreticians busy from the end of 1920s to (at least) mid ...1940s. Starting by the well-known works by Klein–Gordon and Dirac, we then give an account of the main results achieved by a variety of different authors, ranging from de Broglie to Proca, Majorana, Fierz–Pauli, Kemmer, Rarita–Schwinger and many others.
A particular interest comes out for the general problem of the description of particles with arbitrary spin, introduced (and solved) by Majorana as early as 1932, and later reconsidered, within a different approach, by Dirac in 1936 and by Fierz–Pauli in 1939. The final settlement of the problem in 1945 by Bhabha, who came back to the general ideas introduced by Majorana in 1932, is discussed as well, and, by making recourse also to unpublished documents by Majorana, we are able to reconstruct the line of reasoning behind the Majorana and the Bhabha equations, as well as its evolution. Intriguingly enough, such an evolution was identical in the two authors, the difference being just the period of time required for that: probably few weeks in one case (Majorana), while more than ten years in the other one (Bhabha), with the contribution of several intermediate authors.
The important unpublished contributions by Majorana anticipated later results obtained, in a more involved way, by de Broglie (1934) and by Duffin and Kemmer (1938-9), and testify the intermediate steps in the line of reasoning that led to the paper published in 1932 by Majorana, while Bhabha took benefit of the corresponding (later) published literature. Majorana’s paper of 1932, in fact, contrary to the more complicated Dirac–Fierz–Pauli formalism, resulted to be very difficult to fully understand (probably for its pregnant meaning and latent physical and mathematical content): as is clear from his letters, even Pauli (who suggested its reading to Bhabha) took about one year in 1940-1 to understand it. This just testifies for the difficulty of the problem, and for the depth of Majorana’s reasoning and results.
The relevance for present day research of the issue here reviewed is outlined as well.
► Relativistic wave equations are reviewed since their first appearance, with particular regard to Dirac, Majorana and Bhabha equations. ► Novel material from Majorana and Fierz–Pauli is included. ► The possible relevance of Kemmer equation (besides the other equations) for describing electrons in exotic materials is pointed out.
Infections and systemic lupus erythematosus Esposito, S.; Bosis, S.; Semino, M. ...
European journal of clinical microbiology & infectious diseases,
09/2014, Letnik:
33, Številka:
9
Journal Article
Recenzirano
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that presents a protean spectrum of clinical manifestations, and may affect any organ. The typical course of SLE is insidious, slow, ...and progressive, with potential exacerbations and remissions, and even dramatically acute and rapidly fatal outcomes. Recently, infections have been shown to be highly associated with the onset and/or exacerbations of SLE, and their possible causative and/or protective role has been largely emphasized in the medical literature. However, the etiopathogenesis of SLE is still obscure and far from being completely elucidated. Among infections, particularly Epstein–Barr virus (EBV), parvovirus B19, retrovirus, and cytomegalovirus (CMV) infections might play a pivotal pathogenetic role. The multifaceted interactions between infections and autoimmunity reveal many possibilities for either causative or protective associations. Indeed, some infections, primarily protozoan infections, might confer protection from autoimmune processes, depending on the unique interaction between the microorganism and host. Further studies are needed in order to demonstrate that infectious agents might, indeed, be causative of SLE, and to address the potential clinical sequelae of infections in the field of autoimmunity.
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