Abstract
Amines, particularly primary amines (R-NH
2
), are closely related to the primordial synthesis of amino acids since they share the same structural backbone. However, only a limited number of ...amines has been identified in the interstellar medium, which prevents us from studying their chemistry as well as their relation to prebiotic species that could lead to the emergence of life. In this Letter, we report the first interstellar detection of vinylamine (C
2
H
3
NH
2
) and tentative detection of ethylamine (C
2
H
5
NH
2
) toward the Galactic center cloud G+0.693-0.027. The derived abundance with respect to H
2
is (3.3 ± 0.4) × 10
−10
and (1.9 ± 0.5) × 10
−10
, respectively. The inferred abundance ratios of C
2
H
3
NH
2
and C
2
H
5
NH
2
with respect to methylamine (CH
3
NH
2
) are ∼0.02 and ∼0.008, respectively. The derived abundance of C
2
H
3
NH
2
, C
2
H
5
NH
2
, and several other NH
2
-bearing species are compared to those obtained toward high-mass and low-mass star-forming regions. Based on recent chemical and laboratory studies, possible chemical routes for the interstellar synthesis of C
2
H
3
NH
2
and C
2
H
5
NH
2
are discussed.
Synchrotron-based total ion yield and photoelectron–photoion-coincidence spectra have been applied to investigate the electronic structure and the dissociative ionization of gaseous O,S-dimethyl ...xanthate, CH3OC(S)SCH3, in the shallow-core S 2p region. The spectral assignment and the electronic structure are interpreted in terms of the most stable synperiplanar conformer in the C s symmetry point group. The use of tunable synchrotron radiation allows for a selective excitation of sulfur atoms at different photon energy values, including resonance transitions and ionization around the S 2p level. The fragmentation patterns show that the title molecule is well suited as a laboratory precursor of ionic species found in the interstellar medium, especially formyl and thioformyl cations, HCO+ and HCS+, respectively.
Two closely related compounds, namely,
O
-methyl (4-fluorobenzoyl)carbamothioate (
I
) and
O
-methyl (4-methylbenzoyl)carbamothioate (
II
) were prepared in good yields by the reaction of the ...corresponding benzoyl isothiocyanates and methanol. The structural and conformational properties of both compounds were analyzed using a combined approach including single-crystal X-ray diffraction and quantum chemical calculations. A rich conformational landscape is envisaged for the vacuum-isolated species around the central carbamothioate group, with the pseudo-
anti
conformation (C&z.dbd;O and C&z.dbd;S double bonds pointing toward opposite orientations) being the most stable form. The X-ray molecular structure shows the presence of this form in the crystalline phase for both compounds. The occurrence of a 1,5-O O intramolecular short distance was observed, suggesting the relevance of chalcogen chalcogen interactions in the conformational preference. Natural bond orbital population analysis and quantum chemical calculations through an isodesmic reaction scheme were applied to better understand the conformational preference and the nature of the O O intramolecular interactions. The quantum theory of atoms in molecules was also used to examine the electronic densities around the S(5) pseudo-ring formed through the intramolecular interaction in the carbamothioate moiety. Furthermore, the vibrational features were analyzed by measuring the infrared and Raman spectra.
Two closely related carbamothioates were prepared by the reaction of benzoyl isothiocyanates and methanol. The crystal structures show the occurrence of 1,5-O O intramolecular short distance that determines the conformational preference.
Significance
The detection of ethanolamine (
N
H
2
C
H
2
C
H
2
OH) in a molecular cloud in the interstellar medium confirms that a precursor of phospholipids is efficiently formed by interstellar ...chemistry. Hence, ethanolamine could have been transferred from the proto-Solar nebula to planetesimals and minor bodies of the Solar System and thereafter to our planet. The prebiotic availability of ethanolamine on early Earth could have triggered the formation of efficient and permeable amphiphilic molecules such as phospholipids, thus playing a relevant role in the evolution of the first cellular membranes needed for the emergence of life.
Cell membranes are a key element of life because they keep the genetic material and metabolic machinery together. All present cell membranes are made of phospholipids, yet the nature of the first membranes and the origin of phospholipids are still under debate. We report here the presence of ethanolamine in space,
N
H
2
C
H
2
C
H
2
OH, which forms the hydrophilic head of the simplest and second-most-abundant phospholipid in membranes. The molecular column density of ethanolamine in interstellar space is
N
= (1.51
±
0.07)
×
10
13
c
m
−
2
, implying a molecular abundance with respect to
H
2
of
(
0.9
−
1.4
)
×
10
−
10
. Previous studies reported its presence in meteoritic material, but they suggested that it is synthesized in the meteorite itself by decomposition of amino acids. However, we find that the proportion of the molecule with respect to water in the interstellar medium is similar to the one found in the meteorite (
10
−
6
). These results indicate that ethanolamine forms efficiently in space and, if delivered onto early Earth, could have contributed to the assembling and early evolution of primitive membranes.
One of the proposed scenarios for the origin of life is the primordial RNA world, which considers that RNA molecules were likely responsible for the storage of genetic information and the catalysis ...of biochemical reactions in primitive cells, before the advent of proteins and DNA. In the last decade, experiments in the field of prebiotic chemistry have shown that RNA nucleotides can be synthesized from relatively simple molecular precursors, most of which have been found in space. An important exception is hydroxylamine, NH2OH, which, despite several observational attempts, it has not been detected in space yet. Here we present the first detection of NH2OH in the interstellar medium toward the quiescent molecular cloud G+0.693-0.027 located in the Galactic Center. We have targeted the three groups of transitions from the J = 2−1, 3−2, and 4−3 rotational lines, detecting five transitions that are unblended or only slightly blended. The derived molecular abundance of NH2OH is (2.1 0.9) × 10−10. From the comparison of the derived abundance of NH2OH and chemically related species, with those predicted by chemical models and measured in laboratory experiments, we favor the formation of NH2OH in the interstellar medium via hydrogenation of NO on dust grain surfaces, with possibly a contribution of ice-mantle NH3 oxidation processes. Further laboratory studies and quantum chemical calculations are needed to completely rule out the formation of NH2OH in the gas phase.
The chemical compounds carrying the thiol group (-SH) have been considered essential in recent prebiotic studies regarding the polymerization of amino acids. We have searched for this kind of ...compound toward the Galactic Center quiescent cloud G+0.693–0.027. We report the first detection in the interstellar space of the trans-isomer of monothioformic acid (t-HC(O)SH) with an abundance of ∼1 נ10−10. Additionally, we provide a solid confirmation of the gauche isomer of ethyl mercaptan (g-C2H5SH) with an abundance of ∼3 נ10−10, and we also detect methyl mercaptan (CH3SH) with an abundance of ∼5 נ10−9. Abundance ratios were calculated for the three SH-bearing species and their OH analogs, revealing similar trends between alcohols and thiols with increasing complexity. Possible chemical routes for the interstellar synthesis of t-HC(O)SH, CH3SH, and C2H5SH are discussed, as well as the relevance of these compounds in the synthesis of prebiotic proteins in the primitive Earth.
Today, recommendation algorithms are widely used by companies in multiple sectors with the aim of increasing their profits or offering a more specialized service to their customers. Moreover, there ...are countless applications in which classification algorithms are used, seeking to find patterns that are difficult for people to detect or whose detection cost is very high. Sometimes, it is necessary to use a mixture of both algorithms to give an optimal solution to a problem. This is the case of the ADAGIO, a R&D project that combines machine learning (ML) strategies from heterogeneous data sources to generate valuable knowledge based on the available open data. In order to support the ADAGIO project requirements, the main objective of this paper is to provide a clear vision of the existing classification and recommendation ML systems to help researchers and practitioners to choose the best option. To achieve this goal, this work presents a systematic review applied in two contexts: scientific and industrial. More than a thousand papers have been analyzed resulting in 80 primary studies. Conclusions show that the combination of these two algorithms (classification and recommendation) is not very used in practice. In fact, the validation presented for both cases is very scarce in the industrial environment. From the point of view of software development life cycle, this review also shows that the work being done in the ML (for classification and recommendation) research and industrial environment is far from earlier stages such as business requirements and analysis. This makes it very difficult to find efficient and effective solutions that support real business needs from an early stage. It is therefore that the article suggests the development of new ML research lines to facilitate its application in the different domains.
The electronic structure and the dissociative ionization of selenium oxychloride, OSeCl2, have been investigated in the valence region by using results from both photoelectron spectroscopy (PES) and ...synchrotron-based photoelectron photoion coincidence (PEPICO) spectra. The PES is assigned with the help of quantum chemical calculations at the outer-valence Green’s function (OVGF) and symmetry adapted cluster/configuration interaction (SAC-CI) levels. The first energy ionization is observed at 11.47 eV assigned to the ionization of electrons formally delocalized over the Se, Cl, and O lone pair orbitals. Irradiation of OSeCl2 with photons in the valence region leads to the formation of OSeCl2 •+, OSeCl+, SeCl2 •+, SeCl+, and SeO•+ ions. Furthermore, the inner shell Se 3p, Cl 2p, and Se 3s electronic regions of OSeCl2 together with S 2p, Cl 2p, and S 2s electronic regions of thionyl chloride, OSCl2, have been studied by using tunable synchrotron radiation. Thus, total ion yield spectra and the fragmentation patterns deduced from PEPICO spectra at the various excitation energies have been studied. Cl+, O•+, and Se•+ ions appear as the most intense fragments in the OSeCl2 PEPICO spectra, like in the sulfur analogue OSCl2, whose photofragmentation is dominated by the Cl+, O•+, and S•+ ions. Fragmentation processes in OSCl2 leading to the formation of the double coincidences involving atomic ions appear as the most intense in the PEPIPICO spectra.
The valence electronic properties of S-ethyl flouromethanethioate (S-ethyl fluoromethsanethioate), FC(O)SCH2CH3, were investigated by means of He(I) photoelectron spectroscopy in conjunction with the ...analysis of the photofragmentation products determined by PEPICO (phtoelectron-photoion-coincidence) by using synchrotron radiation in the 11.1–21.6 eV photon energy range. The first band observed at 10.28 eV in the HeI photoelectron spectrum can be assigned with confidence to the ionization process from the HOMO nπ(S) orbital, which is described as a lone pair formally localized on the sulfur atom, in agreement with quantum chemical calculations using the outer valence Green function method OVGF/6-311++G (d,p). One of the most important fragmentation channels also observed in the valence region corresponds to the decarbonylation process yielding the M–CO·+ ion, which is clearly observed at m/z = 80. Moreover, S 2p and S 2s absorption edges have been examined by measuring the total ion yield spectra in the 160–240 eV region using variable synchrotron radiation. The dynamic of ionic fragmentation following the Auger electronic decay has been evaluated with the help of the PEPIPICO (photoion–photoion–photoelectron–coincidence spectra) technique.