Calibration strategy of the JUNO-TAO experiment Xu, Hangkun; Abusleme, Angel; Anfimov, Nikolay V. ...
The European physical journal. C, Particles and fields,
12/2022, Letnik:
82, Številka:
12
Journal Article
Recenzirano
Odprti dostop
The Taishan Antineutrino Observatory (TAO or JUNO-TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). Located near a reactor of the Taishan Nuclear Power Plant, ...TAO will measure the reactor antineutrino energy spectrum with an unprecedented energy resolution of
<
2
%
at 1 MeV. Energy calibration is critical to achieve such a high energy resolution. Using the Automated Calibration Unit (ACU) and the Cable Loop System (CLS), multiple radioactive sources are deployed to various positions in the TAO detector for energy calibration. The residual non-uniformity can be controlled within 0.2%. The energy resolution degradation and energy bias caused by the residual non-uniformity can be controlled within 0.05% and 0.3%, respectively. The uncertainty of the non-linear energy response can be controlled within 0.6% with the radioactive sources of various energies, and could be further improved with cosmogenic
12
B
which is produced by the interaction of cosmic muon in the liquid scintillator. The stability of other detector parameters, e.g., the gain of each Silicon Photo-multiplier, will be monitored with an ultraviolet LED calibration system.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Human cytomegalovirus (HCMV) is the leading infectious cause of congenital disabilities. We designed a prospective study to investigate the rate, outcome, and risk factors of congenital CMV (cCMV) ...infection in neonates born to immune women, and the potential need and effectiveness of hygiene recommendations in this population.
The study was composed of 2 sequential parts: an epidemiology (part 1) and a prevention (part 2) study. Performance of part 2 depended upon a cCMV rate >0.4%. Women enrolled in part 1 did not receive hygiene recommendations. Newborns were screened by HCMV DNA testing in saliva and cCMV was confirmed by urine testing.
Saliva swabs were positive for HCMV DNA in 45/9661 newborns and cCMV was confirmed in 18 cases. The rate of cCMV was .19% (95% confidence interval CI: .11-.29%), and 3 out of 18 infants with cCMV had symptoms of CMV at birth. Age, nationality, occupation, and contact with children were similar between mothers of infected and noninfected newborns. Twin pregnancy (odds ratio OR: 7.2; 95% CI: 1.7-32.2; P = .037) and maternal medical conditions (OR: 3.9; 95% CI: 1.5-10.1; P = .003) appeared associated with cCMV. Given the rate of cCMV was lower than expected, the prevention part of the study was cancelled.
Newborns from women with preconception immunity have a low rate of cCMV, which appears to be mostly due to reactivation of the latent virus. Therefore, serological screening in childbearing age would be pivotal to identify HCMV-seropositive women, whose newborns have a low risk of cCMV.
www.clinicaltrials.gov (NCT03973359).
We demonstrate that highly porous ZnO nanobelts can be prepared by thermally decomposing ZnS(en)
0.5
hybrid nanobelts (NBs) synthesized through a solvothermal route using Zn layers deposited on ...alumina substrates as both the Zn substrate and source. Hybrid decomposition by thermal annealing at 400 °C gives porous ZnS NBs that are transformed by further annealing at 600 °C into wurtzite single crystal ZnO nanobelts with an axial direction of 0001. The evolution of the morphological and structural transformation ZnS(en)
0.5
→ ZnS → ZnO is investigated at the nanoscale by transmission and scanning electron microscopy analyses. Control of the ZnO NB distributions by patterning the Zn metallization on alumina is achieved as a consequence of the parent hybrid NB patterned growth. The presence of NBs on alumina in a ∼100 μm wide region between Zn stripes allows us to fabricate two contact devices where contact pads are electrically connected through a porous ZnO NB entanglement. Such devices are suitable for employment in photodetectors as well as in gas and humidity sensors.
Supported highly porous ZnO nanobelts were achieved by thermally decomposing ZnS(en)
0.5
hybrid nanobelts synthesized on Zn-metallized alumina substrates through a solvothermal route.
We addressed trastuzumab emtansine (T-DM1) efficacy in HER2+ metastatic breast cancer patients treated in real-world practice, and its activity in pertuzumab-pretreated patients. We conducted a ...retrospective, observational study involving 23 cancer centres, and 250 patients. Survival data were analyzed by Kaplan Meier curves and log rank test. Factors testing significant in univariate analysis were tested in multivariate models. Median follow-up was 15 months and median T-DM1 treatment-length 4 months. Response rate was 41.6%, clinical benefit 60.9%. Median progression-free and median overall survival were 6 and 20 months, respectively. Overall, no differences emerged by pertuzumab pretreatment, with median progression-free and median overall survival of 4 and 17 months in pertuzumab-pretreated (p=0.13), and 6 and 22 months in pertuzumab-naïve patients (p=0.27). Patients who received second-line T-DM1 had median progression-free and median overall survival of 3 and 12 months (p=0.0001) if pertuzumab-pretreated, and 8 and 26 months if pertuzumab-naïve (p=0.06). In contrast, in third-line and beyond, median progression-free and median overall survival were 16 and 18 months in pertuzumab-pretreated (p=0.05) and 6 and 17 months in pertuzumab-naïve patients (p=0.30). In multivariate analysis, lower ECOG performance status was associated with progression-free survival benefit (p<0.0001), while overall survival was positively affected by lower ECOG PS (p<0.0001), absence of brain metastases (p 0.05), and clinical benefit (p<0.0001). Our results are comparable with those from randomized trials. Further studies are warranted to confirm and interpret our data on apparently lower T-DM1 efficacy when given as second-line treatment after pertuzumab, and on the optimal sequence order.
In the past decade, lead sulfide quantum dots (PbS QDs) have been widely adopted for the fabrication of visible and infrared photodetectors, thanks to their unique properties such as a wide range of ...band gap tunability, high optical absorption, easy processability, as well as mechanical flexibility. Such characteristics may be also desirable for the realization of high-energy detectors, and the high atomic number of Pb suggests that PbS QDs could be effectively employed also at X-ray wavelengths. Here, we propose PbS QDs as a sensing material for X-ray detection. A homogeneous population of colloidal PbS QDs (3–4 nm) was synthesized with high purity and good yield (>70%) through a low-cost synthetic route. The colloidal solution of PbS QDs showed chemical and physical stabilities for over 6 months. A PbS QDs thin layer of about 2 μm thickness was obtained through a simple drop-casting deposition and slow evaporation. The device exhibited high sensitivity (2370 μC Gy–1 cm–2) and a good detection limit of 5 μGy s–1 to 23 keV hard X-rays at a 1 V bias. Such encouraging results pave the way for the use of PbS QD-based X-ray sensors for imaging applications, suggesting also future developments of low-power and high-sensitivity wearable sensors.
The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e. ...sildenafil, may increase the expression of nitric oxide synthase (NOS) proteins in the heart and cardiomyocytes. In this study we analyzed the effect of sildenafil on endothelial cells in insulin resistance conditions in vitro.
Human umbilical vein endothelial cells (HUVECs) were treated with insulin in presence of glucose 30 mM (HG) and glucosamine 10 mM (Gluc-N) with or without sildenafil. Insulin increased the expression of PDE5 and eNOS mRNA assayed by Real time-PCR. Cytofluorimetric analysis showed that sildenafil significantly increased NO production in basal condition. This effect was partially inhibited by the PI3K inhibitor LY 294002 and completely inhibited by the NOS inhibitor L-NAME. Akt-1 and eNOS activation was reduced in conditions mimicking insulin resistance and completely restored by sildenafil treatment. Conversely sildenafil treatment can counteract this noxious effect by increasing NO production through eNOS activation and reducing oxidative stress induced by hyperglycaemia and glucosamine.
These data indicate that sildenafil might improve NOS activity of endothelial cells in insulin resistance conditions and suggest the potential therapeutic use of sildenafil for improving vascular function in diabetic patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In the originally published version of this Article, the positions of the final two authors in the author list were inadvertently inverted during the production process. This error has now been ...corrected in both the PDF and HTML versions of the Article.
Purpose
The aim of this study was to assess the effectiveness of reverse total shoulder arthroplasty (RTSA) with an all-polyethylene glenosphere in patients with failed hemiarthroplasty (HH) or the ...sequelae of proximal humeral fractures.
Methods
Thirty-six patients were assessed at a mean follow-up of 36 months using clinical scores and recording shoulder range of movement (ROM).
Results
Active anterior elevation (
p
< 0.001), lateral elevation (
p
< 0.001) and internal rotation (
p
< 0.0001) improved significantly, whereas improvement in external rotation was not significant. The mean Constant score rose significantly from 8.5 ± 7.6 to 40.7 ± 15.7 (
p
< 0.001) and the Simple Shoulder Test score from 0.42 ± 0.85 to 5.5 ± 2.6 (
p
< 0.001). Pain improved significantly from 8.7 ± 0.9 to 2.3 ± 1.2 (
p
< 0.001). Implant radiographic survivorship was 84.6 %. Scapular notching was detected in 7/36 patients (17.5 %). There were five complications: one (stiffness) among patients with fracture sequelae and four among those with failed HH (instability,
n
= 2; humeral component disassembly,
n
= 1; pain,
n
= 1). The two groups did not exhibit significant differences in pain, clinical scores or ROM.
Discussion
RTSA with an all-polyethylene glenosphere may have the potential to reduce the risk of biological notching due to polyethylene osteolysis. Further long-term studies are required to assess its efficacy.
Conclusions
The good clinical performance and reasonable rate of notching of the polyethylene glenosphere support its use in primary and revision shoulder arthroplasty.
Level of evidence: Level 4, retrospective therapeutic case series.
Impaired sleep has been reported as an important nonmotor feature in dystonia, but so far, self-reported complaints have never been compared with nocturnal video-polysomnographic (PSG) recording, ...which is the gold standard to assess sleep-related disorders.
Twenty patients with idiopathic isolated cervical dystonia and 22 healthy controls (HC) underwent extensive clinical investigations, neurological examination, and questionnaire screening for excessive daytime sleepiness and sleep-related disorders. A full-night video PSG was performed in both patients and HC. An ad hoc montage, adding electromyographic leads over the muscle affected with dystonia, was used.
When compared to controls, patients showed significantly increased pathological values on the scale assessing self-reported complaints of impaired nocturnal sleep. Higher scores of impaired nocturnal sleep did not correlate with any clinical descriptors but for a weak correlation with higher scores on the scale for depression. On video-PSG, patients had significantly affected sleep architecture (with decreased sleep efficiency and increased sleep latency). Activity over cervical muscles disappears during all the sleep stages, reaching significantly decreased values when compared to controls both in nonrapid eye movements and rapid eye movements sleep.
Patients with cervical dystonia reported poor sleep quality and showed impaired sleep architecture. These features however cannot be related to the persistence of muscle activity over the cervical muscles, which disappears in all the sleep stages, reaching significantly decreased values when compared to HC.
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