This article advances a contextual approach to understanding the emotional and social outcomes of Facebook use. In doing so, we address the ambiguity of previously reported relationships between ...Facebook use and well-being. We test temporal (shorter vs longer time spans) and spatial (at home vs away from home) dimensions of Facebook activity using an innovative approach. By triggering smartphone surveys in response to users’ naturalistic Facebook posting, we captured the immediate context of both mobile and desktop activities during daily life. Findings indicated positive—yet fleeting—emotional experiences up to 10 minutes after active posting and higher arousal for 30 minutes following posting at home. Nonetheless, Facebook activities predicted no changes in aggregate mood over 2 weeks, despite showing positive relationships to bridging social capital during the same period. Our results call attention to fleeting experiences (vs enduring consequences) and encourage future research to specify temporal and spatial boundaries.
Abstract
Background and Objectives
Social distancing, while effective in slowing the spread of the coronavirus disease 2019 (COVID-19), can increase social isolation. The current preregistered study ...examined purpose in life as a psychological resource that may buffer against loneliness and increase intentions to engage in health-protective behaviors.
Research Design and Methods
During the COVID-19 pandemic, 517 adults (mean = 37.71, SD = 11.30; range = 19–73) reported their levels of purpose in life, current and prepandemic levels of loneliness, and degrees to which they intended to engage in behaviors known to prevent the spread of COVID-19.
Results
Across age, having a stronger sense of purpose in life was associated with lower loneliness, as well as greater intentions to engage in COVID-protective behaviors. Higher loneliness was associated with lower intentions to maintain social distance and engage in additional health promotion behaviors such as handwashing. However, this link was not present at higher levels of purpose in life. Older age was also associated with less loneliness, but not for individuals with lower levels of purpose in life.
Discussion and Implications
Results suggest that psychological resources such as purpose in life are associated with increased protective health behaviors. Furthermore, purpose in life may reduce loneliness and counteract the negative effects of stressors that diminish the willingness to engage in health-protective behaviors. Our data also highlight resilience among older individuals in times of isolation during a global pandemic.
•Physical activity interventions often impact loneliness as a secondary outcome.•Many physical activity interventions have social elements (e.g., group class, coach).•Social interactions may underlie ...the physical activity and loneliness relationships.•Effective interventions may create synergy between physical activity and social connections.•More research is needed to optimize social experiences during interventions.
Loneliness and physical inactivity are serious public health issues that often co-occur. However, they are often treated separately. Our systematic review aimed to identify components of interventions that most effectively improve physical inactivity and/or loneliness and whether/how these two variables are related. Specifically, we tested the following questions: 1) whether interventions focused on physical inactivity alleviate loneliness; 2) whether interventions focused on loneliness increase physical activity; 3) whether interventions that target broader levels of physical and mental well-being improve both loneliness and physical activity. We further examined 4) common intervention components that influenced loneliness and/or physical activity, with a particular focus on social components of each intervention.
We searched for peer-reviewed journal articles published before May 22nd, 2022 in PubMed Plus, Scopus, Web of Science, ScienceDirect, EBSCO, and Embase. Both quantitative and qualitative studies that investigated the effects of interventions on physical activity and/or loneliness were included for review. Risk of bias was assessed for each study.
We identified 34 papers, including 27 studies examining the effects of physical activity interventions, one study explicitly targeting loneliness, and six studies targeting broader subjective well-being. Studies showed mixed results and a high heterogeneity in intervention design and sample characteristics. Overall, we found group exercise, individualized consultation and education on physical activity, and social support-building during physical activity (vs. other social activities) as promising intervention components that were frequently associated with improvements in physical activity and loneliness.
This review highlights that interventions targeting physical activity can also alleviate loneliness. Improved social experiences from such interventions may explain this hidden benefit. Limited data were available to conclusively answer whether physical activity and loneliness bi-directionally influence each other. More research is needed to systematically test the impact of different social components built into physical activity interventions on loneliness.
During the 2007 growing season, melon (Cucumis melo) samples from the state of Guerrero in Mexico showing mosaic and other virus-like symptoms were collected for analysis. Electron microscopic ...examination of negatively stained leaf-dip extracts revealed the presence of abundant virus-like particles with features characteristic of the family Bunyaviridae. No other viral particles were observed in these preparations. However, enzyme-linked immunosorbent assays (ELISAs) specific for the most common Tospovirus spp. gave negative results. Antibodies raised against purified nucleocapsids reacted specifically with the infected leaf extracts in Western blots and double-antibody sandwich ELISA. The viral RNA was used as a template for a cDNA library, and nucleotide sequence analysis identified cloned cDNAs representing sequences corresponding to the three Tospovirus genome segments. Sequence comparisons showed that the new virus had the highest similarity to Chrysanthemum stem necrosis virus (CSNV). Phylogenetic analysis of two genome regions confirmed that this virus, provisionally named Melon severe mosaic virus (MeSMV), is a previously undescribed Tospovirus sp. belonging to the “new world” clade of Tospovirus spp. An initial survey of various cucurbit crops in various states of Mexico confirmed the widespread occurrence of this virus.
Neuroimaging measures have been used to forecast complex behaviors, including how individuals change decisions about their health in response to persuasive communications, but have rarely ...incorporated metrics of brain network dynamics. How do functional dynamics within and between brain networks relate to the processes of persuasion and behavior change? To address this question, we scanned 45 adult smokers by using functional magnetic resonance imaging while they viewed anti-smoking images. Participants reported their smoking behavior and intentions to quit smoking before the scan and 1 month later. We focused on regions within four atlas-defined networks and examined whether they formed consistent network communities during this task (measured as allegiance). Smokers who showed reduced allegiance among regions within the default mode and fronto-parietal networks also demonstrated larger increases in their intentions to quit smoking 1 month later. We further examined dynamics of the ventromedial prefrontal cortex (vmPFC), as activation in this region has been frequently related to behavior change. The degree to which vmPFC changed its community assignment over time (measured as flexibility) was positively associated with smoking reduction. These data highlight the value in considering brain network dynamics for understanding message effectiveness and social processes more broadly.
How do functional dynamics within and between brain networks relate to the processes of persuasion and behavior change? In this report, we assess brain network dynamics by using fMRI while smokers view antismoking messages, and relate these metrics to smoking behavior and intentions to quit smoking 1 month following the scan. Smokers who showed reduced allegiance (less consistent network communities) among regions within the default mode and fronto-parietal networks also demonstrated larger increases in their intentions to quit smoking. Furthermore, the degree to which the ventromedial prefrontal cortex flexibly changed its community assignment over time was positively associated with later smoking reduction. These data show that metrics of functional network dynamics can provide new information about individual differences in responsiveness to anti-smoking messaging.
► Impulsivity and inhibitory control are implicated in unhealthy eating and obesity. ► We used structural equation modeling to test these relationships in 210 subjects. ► Heightened impulsivity and ...inhibition deficits predicted greater Emotional Eating. ► Heightened impulsivity predicted more External Eating and Unhealthy Food Choices. ► Some unhealthy eating measures, but not impulse control measures, predicted BMI.
Heightened impulsivity and inefficient inhibitory control are increasingly recognized as risk factors for unhealthy eating and obesity but the underlying processes are not fully understood. We used structural equation modeling to investigate the relationships between impulsivity, inhibitory control, eating behavior, and body mass index (BMI) in 210 undergraduates who ranged from underweight to obese. We demonstrate that impulsivity and inhibitory control deficits are positively associated with several facets of unhealthy eating, including overeating in response to external food cues and in response to negative emotional states, and making food choices based on taste preferences without consideration of health value. We further show that such unhealthy eating is, for the most part, associated with increased BMI, with the exception of Restraint Eating, which is negatively associated with BMI. These results add to our understanding of the impact of individual differences in impulsivity and inhibitory control on key aspects of unhealthy eating and may have implications for the treatment and prevention of obesity.
Brain activity in medial prefrontal cortex (MPFC) during exposure to persuasive messages can predict health behavior change. This brain-behavior relationship has been linked to areas of MPFC ...previously associated with self-related processing; however, the mechanism underlying this relationship is unclear. We explore two components of self-related processing - self-reflection and subjective valuation - and examine coherent activity between relevant networks of brain regions during exposure to health messages encouraging exercise and discouraging sedentary behaviors. We find that objectively logged reductions in sedentary behavior in the following month are linked to functional connectivity within brain regions associated with positive valuation, but not within regions associated with self-reflection on personality traits. Furthermore, functional connectivity between valuation regions contributes additional information compared to average brain activation within single brain regions. These data support an account in which MPFC integrates the value of messages to the self during persuasive health messaging and speak to broader questions of how humans make decisions about how to behave.
The betaine/GABA transporter 1 (BGT1) is a member of the GABA transporter (GAT) family with still elusive function, largely due to a lack of potent and selective tool compounds. Based on modeling, we ...here present the design, synthesis and pharmacological evaluation of five novel conformationally restricted cyclic GABA analogs related to the previously reported highly potent and selective BGT1 inhibitor (1
S
,2
S
,5
R
)-5-aminobicyclo3.1.0hexane-2-carboxylic acid (bicyclo-GABA). Using
3
HGABA radioligand uptake assays at the four human GATs recombinantly expressed in mammalian cell lines, we identified bicyclo-GABA and its
N
-methylated analog (
2
) as the most potent and selective BGT1 inhibitors. Additional pharmacological characterization in a fluorescence-based membrane potential assay showed that bicyclo-GABA and
2
are competitive inhibitors, not substrates, at BGT1, which was validated by a Schild analysis for bicyclo-GABA (p
K
B
value of 6.4). To further elaborate on the selectivity profile both compounds were tested at recombinant α
1
β
2
γ
2
GABA
A
receptors. Whereas bicyclo-GABA showed low micromolar agonistic activity, the
N
-methylated
2
was completely devoid of activity at GABA
A
receptors. To further reveal the binding mode of bicyclo-GABA and
2
binding hypotheses of the compounds were obtained from
in silico
-guided mutagenesis studies followed by pharmacological evaluation at selected BGT1 mutants. This identified the non-conserved BGT1 residues Q299 and E52 as the molecular determinants driving BGT1 activity and selectivity. The binding mode of bicyclo-GABA was further validated by the introduction of activity into the corresponding GAT3 mutant L314Q (38 times potency increase cf. wildtype). Altogether, our data reveal the molecular determinants for the activity of bicyclic GABA analogs, that despite their small size act as competitive inhibitors of BGT1. These compounds may serve as valuable tools to selectively and potently target BGT1 in order to decipher its elusive pharmacological role in the brain and periphery such as the liver and kidneys.
In this study we examined changes in the salivary concentrations of immunoglobulin A (sIgA), cortisol (sC), testosterone (sT), and testosterone-to-cortisol ratio (T/C) in 21 competitive swimmers, ...11–15 years old, during a week leading to competition as compared to a control (noncompetition) week. No day-to-day changes or significant differences between weeks were observed for sIgA ( 47.9 ± 4.4 versus 54.9 ± 5.2 μg/mL for control versus competition week, resp.), sC ( 2.7 ± 0.2 versus 2.5 ± 0.2 ng/mL for control versus competition week, resp.), and T/C ratio ( 83.4 ± 7.0 versus 77.9 ± 7.7 for control versus competition week, resp.). In contrast, sT was significantly lower during the week of competition ( 154.5 ± 11.3 pg/mL) as compared to the control week ( 181.3 ± 11.5 pg/mL) suggesting that the swimmers were in a catabolic state, although this did not have a negative effect on their performance. In conclusion, salivary cortisol did not change between the two weeks, and thus competition stress was relatively low, and mucosal immunity was unaffected in these young athletes prior to competition.
We examined the population structure and genetic variation of four genomic regions within and between 30 Citrus tristeza virus (CTV) isolates from Spain and California. Our analyses showed that most ...isolates contained a population of sequence variants, with one being predominant. Four isolates showed two major sequence variants in some genomic regions. The two major variants of three of these isolates showed very low nucleotide identity to each other but were very similar to those of other isolates, suggesting the possibility of mixed infections with two divergent isolates. Incongruencies of phylogenetic relationships in the different genomic regions and statistical analyses suggested that the genomes of some CTV sequence variants originated by recombination events between diverged sequence variants. No correlation was observed between geographic origin and nucleotide distance, and thus from a genetic view, the Spanish and Californian isolates analyzed here could be considered members of the same population.
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