The global epidemic of diabetes mellitus continues to grow and affects developed and developing countries alike. Intensive glycemic control is thought to modify the risks for vascular complications, ...hence the risks for diabetes-related death. We investigated the trend of diabetic vascular complication-related deaths between 2000 and 2016 in the global diabetes landscape.
We collected 17 years of death certificates data from 108 countries in the World Health Organization mortality database between 2000 and 2016, with coding for diabetic complications. Crude and age-standardized proportions and rates were calculated. Trend analysis was done with annual average percentage change (AAPC) of rates computed by joinpoint regression.
From 2000 through 2016, 7,108,145 deaths of diabetes were reported in the 108 countries. Among them, 26.8% (1,904,787 cases) were attributed to vascular complications in damaged organs, including the kidneys (1,355,085 cases, 71.1%), peripheral circulatory (515,293 cases, 27.1%), nerves (28,697 cases, 1.5%) and eyes (5751 cases, 0.3%). Overall, the age-standardized proportion of vascular complication-related mortality was 267.8 95% confidence interval (95% CI), 267.5-268.1 cases per 1000 deaths and the rate was 53.6 (95% CI 53.5-53.7) cases per 100,000 person-years. Throughout the 17-year period, the overall age-standardized proportions of deaths attributable to vascular complications had increased 37.9%, while the overall age-standardized mortality rates related to vascular complications had increased 30.8% (AAPC = 1.9% 1.4-2.4%, p < 0.05). These increases were predominantly driven by a 159.8% increase in the rate (AAPC = 2.7% 1.2-4.3%, p < 0.05) from renal complications. Trends in the rates and AAPC of deaths varied by type of diabetes and of complications, as well as by countries, regions and domestic income.
Diabetic vascular complication-related deaths had increased substantially during 2000-2016, mainly driven by the increased mortality of renal complications.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form of cell death, is highly ...linked to mitochondrial metabolism and mediated by protein lipoylation. However, the clinical impacts of cuproptosis-related genes (CRGs) in ccRCC largely remain unclear. In the current study, we systematically evaluated the genetic alterations of cuproptosis-related genes in ccRCC. Our results revealed that CDKN2A, DLAT, DLD, FDX1, GLS, PDHA1 and PDHB exhibited differential expression between ccRCC and normal tissues (|log2(fold change)| > 2/3 and p < 0.05). Utilizing an iterative sure independence screening (SIS) method, we separately constructed the prognostic signature of CRGs for predicting the overall survival (OS) and progression-free survival (PFS) in ccRCC patients. The prognostic score of CRGs yielded an area under the curve (AUC) of 0.658 and 0.682 for the prediction of 5-year OS and PFS, respectively. In the Kaplan−Meier survival analysis of OS, a higher risk score of cuproptosis-related gene signature was significantly correlated with worse overall survival (HR = 2.72 (2.01−3.68), log-rank p = 1.76 × 10−7). Patients with a higher risk had a significantly shorter PFS (HR = 2.83 (2.08−3.85), log-rank p = 3.66 × 10−7). Two independent validation datasets (GSE40435 (N = 101), GSE53757 (N = 72)) were collected for meta-analysis, suggesting that CDKN2A (log2(fold change) = 1.46, 95%CI: 1.75−2.35) showed significantly higher expression in ccRCC tissues while DLAT (log2(fold change) = −0.54, 95%CI: −0.93−−0.15) and FDX1 (log2(fold change) = −1.01, 95%CI: −1.61−−0.42) were lowly expressed. The expression of CDKN2A and FDX1 in ccRCC was also significantly associated with immune infiltration levels and programmed cell death protein 1 (PD-1) expression (CDKN2A: r = 0.24, p = 2.14 × 10−8; FDX1: r = −0.17, p = 1.37 × 10−4). In conclusion, the cuproptosis-related gene signature could serve as a potential prognostic predictor for ccRCC patients and may offer novel insights into the cancer treatment.
The catalyst in the oxygen electrode is the core component of the aqueous metal-air battery, which plays a vital role in the determination of the open circuit potential, energy density, and cycle ...life of the battery. For rechargeable aqueous metal-air batteries, the catalyst should have both good oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic performance. Compared with precious metal catalysts, non-precious metal materials have more advantages in terms of abundant resource reserves and low prices. Over the past few years, great efforts have been made in the development of non-precious metal bifunctional catalysts. This review selectively evaluates the advantages, disadvantages and development status of recent advanced materials including pure carbon materials, carbon-based metal materials and carbon-free materials as bifunctional oxygen catalysts. Preliminary improvement strategies are formulated to make up for the deficiency of each material. The development prospects and challenges facing bifunctional catalysts in the future are also discussed.
Different types of advanced non-noble materials in bifunctional catalysts for ORR and OER.
Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance and ...age‐related cognitive decline, accompanied by peripheral inflammation. (—)‐Epigallocatechin‐3‐gallate (EGCG), the major polyphenol in green tea, possesses antioxidant, anti‐inflammatory, and cardioprotective activities; however, few reports have focused on its potential effect on cognitive disorders. In this study, our goal was to investigate the protective effects of EGCG treatment on insulin resistance and memory impairment induced by a high‐fat and high‐fructose diet (HFFD). We randomly assigned 3‐mo‐old C57BL/6J mice to 3 groups with different diets: control group, HFFD group, and HFFD plus EGCG group. Memory loss was assessed by using the Morris water maze test, during which EGCG was observed to prevent HFFD‐elicited memory impairment and neuronal loss. Consistent with these results, EGCG attenuated HFFD‐induced neuronal damage. Of note, EGCG significantly ameliorated insulin resistance and cognitive disorder by up‐regulating the insulin receptor substrate‐1 (IRS‐1)/AKT and ERK/cAMP response element binding protein (CREB)/brain‐derived neurotrophic factor (BDNF) signaling pathways. Long‐term HFFD‐triggered neuroinflammation was restored by EGCG supplementation by inhibiting the MAPK and NF‐κB pathways, as well as the expression of inflammatory mediators, such as TNF‐α. EGCG also reversed high glucose and glucosamine‐induced insulin resistance in SH‐SY5Y neuronal cells by improving the oxidized cellular status and mitochondrial function. To our knowledge, this study is the first to provide compelling evidence that the nutritional compound EGCG has the potential to ameliorate HFFD‐triggered learning and memory loss.—Mi, Y., Qi, G., Fan, R., Qiao, Q., Sun, Y., Gao, Y., Liu, X. EGCG ameliorates high‐fat– and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS. FASEB J. 31, 4998–5011 (2017). www.fasebj.org
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels ...limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. Moreover, it easily enters cells and binds to toll-like receptor 4. This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. This study highlights a direct self-assembly hydrogel from natural small molecule as a promising neuroinflammatory therapy.
A compact multiple-input-multiple-output (MIMO) antenna is presented for ultrawideband (UWB) applications. The antenna consists of two open L-shaped slot (LS) antenna elements and a narrow slot on ...the ground plane. The antenna elements are placed perpendicularly to each other to obtain high isolation, and the narrow slot is added to reduce the mutual coupling of antenna elements in the low frequency band (3-4.5 GHz). The proposed MIMO antenna has a compact size of 32 ×32 mm 2 , and the antenna prototype is fabricated and measured. The measured results show that the proposed antenna design achieves an impedance bandwidth of larger than 3.1-10.6 GHz, low mutual coupling of less than 15 dB, and a low envelope correlation coefficient of better than 0.02 across the frequency band, which are suitable for portable UWB applications.
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•A pilot BAF system built in a swine farm to treat the piggery wastewater.•Antibiotics could be efficiently removed by the BAF system.•Antibiotic dissipation in the simulated systems ...followed the first order kinetics.•The biodegradation kinetics predicted the fate of antibiotics in the BAF system.•BAF is a promising technology for treating antibiotics-containing wastewaters.
This study aimed to investigate the removal efficiency and mechanism for antibiotics in swine wastewater by a biological aerated filter system (BAF system) in combination with laboratory aerobic and anaerobic incubation experiments. Nine antibiotics including sulfamonomethoxine, sulfachloropyridazine, sulfamethazine, trimethoprim, norfloxacin, ofloxacin, lincomycin, leucomycin and oxytetracycline were detected in the wastewater with concentrations up to 192,000ng/L. The results from this pilot study showed efficient removals (>82%) of the conventional wastewater pollutants (BOD5, COD, TN and NH3-N) and the detected nine antibiotics by the BAF system. Laboratory simulation experiment showed first-order dissipation kinetics for the nine antibiotics in the wastewater under aerobic and anaerobic conditions. The biodegradation kinetic parameters successfully predicted the fate of the nine antibiotics in the BAF system. This suggests that biodegradation was the dominant process for antibiotic removal in the BAF system.
In future smart cities supported by cyber-physical social intelligence, autonomous behavioral decision for vehicular agents is going to become a general demand. Despite much progress achieved in ...autonomous behavioral decision of vehicular agents, the existing works can just be used in scenarios of short-distance behavioral decision. Naturally, they are not well suitable for long-distance behavioral decision tasks, posing much challenge in realistic cyber-physical environment. To bridge the existing gaps, this article proposes an autonomous behavioral decision framework for vehicular agents using cyber-physical social intelligence. First, it is expected to establish a dynamic planning model with multiple objectives and constraints. This can be embedded into the control unit of a vehicular agent to endow it with proper social intelligence. On this basis, an iterative search algorithm is specifically designed for it to find the optimal solutions from the whole solution space. Finally, two typical situation cases are implemented with use of simulation modeling to display the working architecture of the proposed method. In addition, a universal optimization search algorithm is selected as the baseline to be compared with the proposed method. The comparison results reveal both planning utility and running efficiency of the proposed method.
As one of the most common types of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) is highly invasive and lethal. This study aims to develop biomarkers and targets for the diagnosis and ...treatment of PDAC. Differentially expressed genes (DEGs) were screened via GEO2R, protein network was constructed through STRING and Cytoscape. Functional enrichment analysis was performed, followed by survival analysis and expression validation. A total of 115 DEGs were identified, including 108 upregulated and 7 downregulated genes. After enrichment, survival analysis, one potential gene, Cyclin B1 (CCNB1), was selected for further expression verification at the mRNA and protein level. Taker together, CCNB1 may act as a potential biomarker which provided new idea for elucidation of the pathogenesis of PDAC.
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