Aloe vera extracts are available as rubbery preparations (from the pericyclic cells of the leaf, contains various anthraquinones as aloin, aloe-emodin, ethereal oil, resins and saponins) and gel ...(from the inner parenchymal cells of the leaf, contains polysaccharides, vitamins, aminoacids, phosphatase, lipase, salicylic acid and steroids). The extract has cathartic, antibacterial, anti-inflammatory effect, hemagglutinating activity and wound healing effects. The use of Aloe herbal remedies is increasing with numerous "indications" such as addictions, AIDS, asthma, autoimmune diseases, infections, cancer, poisoning, anxiety and depression, diabetes, menopause and sexual impotency. In addition cosmetics and detergents containing Aloe vera are now highly advertised in the mass media. We present the first case-report of fatal pneumonitis after inhalation of Aloe extract.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•We investigate the peristaltic flow of a Bingham fluid.•The tube wall evolves as a travelling wave.•We consider lubrication approximation.•We consider the zero and first order approximation.•We ...perform numerical simulations.
We model the peristaltic flow of a Bingham fluid in a tube in lubrication approximation. Following the procedure developed in Fusi et al. (2015a) we derive the rigid plug equation using an integral formulation for the balance of linear momentum, modelling the unyielded domain as an evolving non-material volume. The mathematical problem is formulated for the yielded and unyielded part and appropriate boundary conditions are established at the pipe walls and at the yield surface. The zero order approximation leads to a system formed by an integral equation and an algebraic equation for the yield surface and for the plug velocity (which is uniform in space), respectively. Because of the integral approach adopted in the unyielded part of the flow, the leading order approximation does not give rise to the lubrication paradox. The problem is solved numerically and an analytical solution is found when the oscillating wall is given as a small perturbation of the uniform wall.
To assess anthropometric variables and body composition in children with moderate asthma.
Cross-sectional study of two homogeneous cohorts. Group 1 (study group): 84 children with moderate asthma ...treated with inhaled budesonide for al least 12 months; group 2 (control group): 89 healthy children. Body measurements were studied by bioelectrical impedance.
Males with moderate asthma showed lower values for fat-free mass and total body water. Data corrected for weight rendered no statistically significant differences.
Male children with moderate asthma show a lower fast-free mass.
Alzheimer’s disease (AD) is the leading cause of dementia, accounting for 70% of cases worldwide. By 2050, dementia prevalence will have tripled, with most new cases occurring in low- and ...middle-income countries. Mild cognitive impairment (MCI) is a stage between healthy aging and dementia, marked by cognitive deficits that do not impair daily living. People with MCI are at increased risk of dementia, with an average progression rate of 39% within 5 years. There is urgent need for low-cost, accessible and objective methods to facilitate early dementia detection. Electroencephalography (EEG) has potential to address this need due to its low cost and portability. Here, we collected resting state EEG, structural MRI (sMRI) and rich neuropsychological data from older adults (55+ years) with AD, amnestic MCI (aMCI) and healthy controls (~60 per group). We evaluated a range of candidate EEG markers (i.e., frequency band power and functional connectivity) for AD and aMCI classification and compared their performance with sMRI. We also tested a combined EEG and cognitive classification model (using Mini-Mental State Examination; MMSE). sMRI outperformed resting state EEG at classifying AD (AUCs = 1.00 vs 0.76, respectively). However, both EEG and sMRI were only moderately good at distinguishing aMCI from healthy aging (AUCs = 0.67–0.73), and neither method achieved sensitivity above 70%. The addition of EEG to MMSE scores had no added benefit relative to MMSE scores alone. This is the first direct comparison of EEG and sMRI for classification of AD and aMCI.
•Structural MRI out-performs resting state EEG in classifying Alzheimer’s disease.•MRI and EEG were only moderately good at classifying Mild Cognitive Impairment.•Combining EEG and cognitive measures did not improve classification accuracy.•Future research should investigate task-based EEG features for classification.
Many patients with classic congenital muscular dystrophy have been found to have partial or total deficiency of the alpha2 chain of laminin 2 (merosin). This deficiency has mostly been studied using ...only 1 antibody against a fragment of the protein.
To characterize the expression of laminin alpha2 in the skeletal muscle of patients with laminin alpha2 deficiency using antibodies against 2 different portions of the protein and to correlate the immunochemical findings with clinical phenotype.
We studied 4 patients with total lack of laminin alpha2 and 12 with partial laminin alpha2 deficiency with immunohistochemical techniques and Western blot analysis. We used antibodies recognizing an 80-kd fragment toward the C-terminus and a 300-kd fragment toward the amino-terminal. Patient characteristics examined were functional compromise, magnetic resonance imaging or computed tomography of the brain, electromyography, evoked potentials, and creatine kinase levels.
In 4 patients, immunohistochemical analysis revealed no reactivity to either antibody; in 2 patients, the 300-kd fragment alone was partially expressed; in 2 patients, the 80-kd fragment alone was partially expressed; and in 8 patients, both fragments were partially expressed. Immunoblot analysis revealed bands of reduced intensity and normal molecular weight generally corresponding to the immunohistochemical findings. Absence of both fragments or of one with reduction of the other always produced a severe clinical phenotype, while a milder clinical phenotype was observed when both fragments were partially expressed.
Extent of laminin alpha2 deficiency in most cases correlates with clinical phenotype but not with peripheral and central white matter abnormalities. Skin biopsy specimens may reveal laminin alpha2 deficiency in patients who have normal laminin alpha2 levels in muscle biopsy specimens.
Twenty male patients aged 26-79 years old, with symptomatic unilateral hydrocele, were treated by evacuation puncture and intracavitary instillation of 2 ml of a 3% polydocanol solution. In 13 cases, ...treatment was done ambulatory and only in the first few cases sperm cord anaesthetics was used. Regular follow-up of at least 6 months was made. No complications were encountered and only one third of patients complained of mild pain. In 12 cases (60%) hydrocele cure was achieved and 6 relapsed (another 2 were lost to follow-up). Testes ultrasound performed 1 month later showed that 4 patients had non-symptomatic multicystic relapse, which disappeared spontaneously within 6 months in three cases. The advantages of this substance in hydrocele non-surgical treatment versus other therapies used until now are reviewed, concluding by recommending other groups to test it clinically.
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