Ireland's Citizens' Assembly (CA) of 2016-18 was tasked with making recommendations on abortion. This paper shows that from the outset its members were in large part in favour of the liberalisation ...of abortion (though a fair proportion were undecided), that over the course of its deliberations the CA as a whole moved in a more liberal direction on the issue, but that its position was largely reflected in the subsequent referendum vote by the population as a whole.
Pseudomonas aeruginosa isolates (n = 3,902) from 75 U.S. medical centers were tested against ceftazidime-avibactam and comparator agents by the reference broth microdilution method. Overall, 96.9% of ...the strains were susceptible (MIC, ≤8 μg/ml) to ceftazidime-avibactam, while the rates of susceptibility for ceftazidime, meropenem, and piperacillin-tazobactam were 83.8, 81.9, and 78.5%, respectively. Multidrug-resistant and extensively drug-resistant phenotypes were observed in 14.9 and 8.7% of the strains, respectively, and 81.0 and 73.7% of the strains were susceptible to ceftazidime-avibactam, respectively.
The objective of this study was to evaluate the prevalence and in vitro susceptibility of enterococci and VRE among bloodstream infections in European and US hospitals over time.
Isolates recovered ...from the blood of infected patients in Europe (72 996) and the USA (67 725) between 2001 and 2014 were included in the prevalence analysis. A subset (2349) collected during 2011-13 was used for the in vitro activity analysis.
Enterococcus faecium rates increased in Europe (from 1.4% in 2001 to 4.3% in 2014). These rates also increased in the USA (from 3.0% in 2001 to 5.4% in 2010), with decreasing prevalence (4.6% in 2011 to 3.6% in 2014) in later years. Enterococcus faecalis rates remained stable in Europe, but rose in the USA from 6.9% in 2001 to 8.8% in 2009, declining later (from 7.4% to 5.0%). VRE rates among E. faecalis did not vary in either region, while VRE rates among E. faecium increased in Europe (from 4.7% to 20.3%). US VRE rates among E. faecium increased until 2010 (60.0% in 2001 to 80.7% in 2010), decreasing from 75.1% in 2011 to 68.4% in 2013. Oritavancin demonstrated activity against vancomycin-susceptible E. faecalis (MIC
, 0.015/0.06 mg/L; 99.5% susceptible) and vancomycin-resistant E. faecalis (MIC
, 0.25/0.5 mg/L). Oritavancin showed MIC
, MIC
and MIC
values of 0.03, 0.12 and 0.25 mg/L, respectively, for VanA E. faecium.
Rates of E. faecium and VRE increased in Europe. Although still elevated, VRE rates appeared to show a decreasing trend in the USA since 2010. Oritavancin demonstrated activity against enterococci, including VRE.
Delafloxacin, an investigational anionic fluoroquinolone, is active against a broad range of Gram-positive and Gram-negative bacteria. In this study, 200 Streptococcus pneumoniae (plus 30 ...levofloxacin-resistant isolates), 200 Haemophilus influenzae, and 100 Moraxella catarrhalis isolates selected primarily from the United States (2014) were tested against delafloxacin and comparator agents. Delafloxacin was the most potent agent tested. MIC50 and MIC90 values against all S. pneumoniae isolates were 0.008 and 0.015 μg/ml. Delafloxacin susceptibility was not affected by β-lactamase status against H. influenzae and M. catarrhalis.
Abstract Context We have reconceptualized advance care planning (ACP) as a multistep process focused on preparing patients with skills needed for communication and in-the-moment decision making. ...Objectives To operationalize this paradigm, we created an easy-to-use ACP website ( prepareforyourcare.org ) based on a theoretical framework of behavior change and pilot-tested its efficacy to engage older adults in ACP. Methods At baseline and 1 week after viewing the PREPARE website, we assessed behavior change in ACP by using a validated survey that includes Process Measures (knowledge, contemplation, self-efficacy, and readiness, 5-point Likert scales) and Action Measures (yes/no whether an ACP behavior was completed). We also assigned participants into behavior change stages (i.e., precontemplation, contemplation, preparation, action, maintenance) and determined the percentage of participants who moved from precontemplation at baseline to higher stages at 1 week. We also assessed PREPARE ease-of-use (10-point scale, 10 being the easiest). Changes were assessed with Wilcoxon signed rank sum tests and McNemar’s tests. Results Mean age of the participants was 68.4 years (SD 6.6), and 65% were nonwhite. Behavior Change Process Measures average Likert scores increased from 3.1 (0.9) to 3.7 (0.7), P < 0.001. Action Measures did not change significantly. However, precontemplation significantly decreased for most actions (e.g., talking to doctor about desired medical care, 61% to 35%, P < 0.003), with a mean decrease of 21% (range, 16%-33%). PREPARE was rated a nine of ten (±1.9) for ease-of-use. Conclusion A new, patient-centered ACP website that focuses on preparing patients for communication and decision making significantly improves engagement in the process of ACP and behavior change. A clinical trial of PREPARE is currently underway.
Ceftobiprole medocaril is a newly approved drug in Europe for the treatment of hospital-acquired pneumonia (HAP) (excluding patients with ventilator-associated pneumonia but including ventilated HAP ...patients) and community-acquired pneumonia in adults. The aim of this study was to evaluate the in vitro antimicrobial activity of ceftobiprole against prevalent Gram-positive and -negative pathogens isolated in Europe, Turkey, and Israel during 2005 through 2010. A total of 60,084 consecutive, nonduplicate isolates from a wide variety of infections were collected from 33 medical centers. Species identification was confirmed, and all isolates were susceptibility tested using reference broth microdilution methods. Ceftobiprole had high activity against methicillin-susceptible Staphylococcus aureus (MSSA) (100.0% susceptible), methicillin-susceptible coagulase-negative staphylococci (CoNS), beta-hemolytic streptococci, and Streptococcus pneumoniae (99.3% susceptible), with MIC90 values of 0.25, 0.12, ≤ 0.06, and 0.5 μg/ml, respectively. Ceftobiprole was active against methicillin-resistant S. aureus (MRSA) (98.3% susceptible) and methicillin-resistant CoNS, having a MIC90 of 2 μg/ml. Ceftobiprole was active against Enterococcus faecalis (MIC50/90, 0.5/4 μg/ml) but not against most Enterococcus faecium isolates. Ceftobiprole was very potent against the majority of Enterobacteriaceae (87.3% susceptible), with >80% inhibited at ≤ 0.12 μg/ml. The potency of ceftobiprole against Pseudomonas aeruginosa (MIC50/90, 2/>8 μg/ml; 64.6% at MIC values of ≤ 4 μg/ml) was similar to that of ceftazidime (MIC50/90, 2/>16 μg/ml; 75.4% susceptible), but limited activity was observed against Acinetobacter spp. and Stenotrophomonas maltophilia. High activity was also observed against all Haemophilus influenzae (MIC90, ≤ 0.06 μg/ml) and Moraxella catarrhalis (MIC50/90, ≤ 0.06/0.25 μg/ml) isolates. Ceftobiprole demonstrated a wide spectrum of antimicrobial activity against this very large longitudinal sample of contemporary pathogens.
On 22 May 2015 the marriage referendum proposal was passed by a large majority of Irish voters and the definition of marriage in the constitution was broadened to introduce marriage equality. This ...referendum is remarkable for a number of reasons: (1) it is uniquely based on an experiment in deliberative democracy; (2) the referendum campaign was unusually vigorous and active; and (3) the voting patterns at the referendum point to a significant value shift along the deep seated liberal conservative political cleavage of Irish politics. This article provides an overview of the background to the referendum initiative, the campaign prior to the referendum, and the key factors that drove voter turnout and preference. Based on a post-referendum survey, we find that while support for the government of the day, political knowledge, and social attitudes have the same effects as commonly found in other referendums, the variation among social classes was less prevalent than usual and door-to-door canvassing by the two sides of the campaign impacted through turnout rather than vote preference. The voting behaviour of the different age groups suggests strong generational effects.
The Effect of Telithromycin in Acute Exacerbations of Asthma Johnston, Sebastian L; Blasi, Francesco; Black, Peter N ...
New England journal of medicine/The New England journal of medicine,
04/2006, Letnik:
354, Številka:
15
Journal Article
Recenzirano
Odprti dostop
Antibiotics have a limited role in the treatment of acute exacerbations of asthma. In this study, a macrolide antibiotic, telithromycin, was administered for 10 days after an acute exacerbation of ...asthma and led to improvements in symptoms but not in home-measured peak expiratory flow rates. There was no relationship between bacteriologic status and the response to asthma treatment, and the mechanism of the effect is unknown.
In this study, a macrolide antibiotic, telithromycin, was administered for 10 days after an acute exacerbation of asthma and led to improvements in symptoms but not in home-measured peak expiratory flow rates.
Ketolides are a new class of antibiotics that are structurally related to macrolides
1
and have a bactericidal effect against
Chlamydophila pneumoniae
and
Mycoplasma pneumoniae
.
2
–
4
Like macrolides, the ketolide telithromycin (Ketek, Sanofi-Aventis) has immunomodulatory effects both in vitro and in vivo.
5
,
6
It is not known whether treatment with a ketolide could improve treatment of an exacerbation of asthma.
The Telithromycin, Chlamydophila, and Asthma trial (TELICAST) was designed to determine whether a 10-day course of telithromycin, as compared with placebo, in combination with standard therapy improves symptoms and peak expiratory flow rates in the morning among patients with an . . .
This paper compares the debate quality in the plenary sessions of an Irish Citizens’ Assembly and an Irish parliamentary committee to assess the epistemic effects of public deliberation on a ...contentious subject: abortion. The unusual occurrence of a similar process of detailed discussion on the same topic in different institutions at around the same time (in 2016–2017) allows us to compare the deliberative capacities of these institutions and thus contribute to discussions on the appropriateness of an increasingly debated democratic reform: assigning political offices by lot. We suggest that the epistemic effect of deliberation on abortion should facilitate nuanced multi-layered discussion that is both ‘deeper’ in being based on multi-faceted arguments and ‘wider’ in terms of a more accommodative view. We anticipate that these effects should be more pronounced in the more deliberative, less polarized, environment of a citizens’ assembly rather than in a parliamentary committee. The analysis deploys the psychological concept of ‘cognitive complexity’. We find that members of the Citizens’ Assembly demonstrate a deeper cognitively complex grasp of the subject matter. In contrast, experts and parliamentarians tend to adjust their mode of delivery at a parliamentary committee reflecting the conflictual and strategic aspects of political debates in such a forum.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, OILJ, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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