Aim
To evaluate the incidence of iron deficiency (ID) in men and women with chronic heart failure (CHF) and to compare clinical and functional indexes in patient with and without ID depending on ...the gender.
Material and methods
An additional analysis of the study “Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (ID-CHF-RF)” was performed. The study included 498 (198 women, 300 men) patients with CHF, in whom, in addition to iron metabolism, the quality of life and exercise tolerance (ET) were studied. 97 % of patients were enrolled during their stay in a hospital. ID was defined in consistency with the European Society of Cardiology (ESC) Guidelines. Also, and additional analysis was performed according to ID criteria validated by the morphological picture of the bone marrow.
Results
ID was detected in 174 (87.9 %) women and 239 (79.8 %) men (p=0.028) according to the ESC criteria, and in 154 (77.8 %) women and 217 (72.3 %) men (p=0.208) according to the criteria validated by the morphological picture of the bone marrow. Men with ID were older and had more severe CHF. They more frequently had HF functional class (FC) III and IV (63.4 % vs. 43.3 % in men without ID); higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and lower ET. HF FC III increased the probability of ID presence 3.4 times (p=0.02) and the probability of HF FC IV 13.7 times (p=0.003). This clinical picture was characteristic of men when either method of determining ID was used. In women, ID was not associated with more severe CHF.
Conclusion
Based on the presented analysis, it is possible to characterize the male and female ID phenotypes. The male ID phenotype is associated with more severe CHF, low ET, and poor quality of life. In females of the study cohort, ID was not associated with either the severity of CHF or with ET.
Aim To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).Material and methods Iron metabolism variables were studied in 498 (198 women, 300 men) ...patients with HF. Data were evaluated at admission for HF (97 %) or during an outpatient visit (3 %). ID was determined according to the European Society of Cardiology Guidelines.Results 83.1 % of patients had ID; only 43.5 % of patients with ID had anemia. Patients with ID were older: 70.0 63.0;79.0 vs. 66.0 years 57.0;75.2 (p=0.009). The number of patients with ID increased in parallel with the increase in HF functional class (FC). Among patients with ID, fewer people were past or current alcohol users (p=0.002), and a greater number of patients had atrial fibrillation (60.1 vs. 45.2 %, p=0.016). A multiple logistic regression showed that more severe HF (HF FC) was associated with a higher incidence of ID detection, whereas past alcohol use was associated with less pronounced ID. An increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) by 100 pg/ml was associated with an increased likelihood of ID (odds ratio, 1.006, 95 % confidence interval: 1.002-1.011, p=0.0152).Conclusion The incidence rate of HF patients is high in the Russian Federation (83.1 %). Only 43.5 % of these patients had anemia. The prevalence of ID in the study population increased with increases in HF FC and NT-proBNP.
Using the reactions of copper(II) acetate magnesium(II) oxide with 2-furancarboxylic acid (HFur), compounds with chemical compositions Cu
2
(Fur)
4
(MeCN)
2
(
I
) and Mg
2
(Fur)
4
(H
2
O)
5
∙ MeCN∙H
...2
O (
II
) are synthesized. According to the X-ray diffraction data (CIF files CCDC nos. 2085817 (
I
) and 2085818 (
II
)), both complexes have a binuclear structure. The metal core of
I
correspond to the tetracarboxylate bridged {Cu
2
(μ-Fur)
4
} complex, the coordination number of the copper atom in which is 5 (CuNO
4
); in
II
, the metal atoms are linked by two carboxylate groups and a water molecule, and the coordination environment of the metal centers is completed to the polyhedron (MgO
6
) by oxygen atoms of the Fur
–
anions and water molecules. According to EPR spectroscopy data, exchange-coupled copper(II) dimers with a substantial zero-field splitting are observed in
I
. For
I
and
II
, antibacterial activity against the nonpathogenic strain of
M. smegmatis
, and cytotoxicity against human ovarian adenocarcinoma cells
SCOV3
and normal human fibroblast cells of the
HDF
line have been determined.
A possibility of fast rapid temperature changing for the studied compound makes it possible to study related phenomena, such as thermally induced trapping of metastable states in magnetoactive ...compounds and thermally activated catalytic and biological processes. The Electron Paramagnetic Resonance (EPR) spectroscopy station at the Novosibirsk Free Electron Laser (NovoFEL) allows one to study effects of powerful terahertz (THz) radiation on the spin state of paramagnetic systems. A change in the sample temperature as a result of radiation absorption is an inevitable consequence of such an exposure. However, the sample heating at the NovoFEL EPR station itself is of interest due to the record power of THz radiation and small sizes of the samples used. A combination of these two factors can provide a significantly high heating rate. The magnetoactive complex Cu(hfac)
2
L
Et
was chosen as a model system for studying the heating process, since the complex has a magnetostructural transition at ∼125 K with substantially different spin states above and below the transition temperature. The heating processes with the amplitudes above 60 K were studied, the heating and cooling rates of the sample in similar experiments were estimated, and prospects for using the method to study various thermally induced effects are discussed.
As a result of the transformation of the initial ligand m-Cl-benzoyl-β-(piperidin-1-yl)propioamidoxime during complexation, a nontrivial Cu(II) ionic complex is formed, which simultaneously contains ...two different formula units {Cu(phen)2Cl}+ and {Cu(phen)2benz}+.
Display omitted
Two cationic and molecular copper(II) complexes - mixed ligand {Cu(phen)2benz}{Cu(phen)2Cl}2+·2Cl-·benz-·H3O+·4·.5H2O (1), Cu(benz)2phen (2) (benz- = m-Cl-benzoate anion; phen = 1,10-phenantroline) and Cu(phen)32+·2OTf-·2EtOH (3) (OTf = trifluoromethylsulfonate, triflate anion, CF3SO3-) were synthesized using various synthetic approaches and thoroughly characterized by spectroscopic methods and single crystal X-ray diffraction analysis. The structures of the complexes according to X-ray diffraction data are characterized by a diverse geometric environment of the complexing agent - the cationic form of 1 comprises two structurally nonequivalent moieties: the Cu (1) and Cu (2) complex-forming atoms coordinate, in chelate manner, two phen moieties each and the benz- (1)/Cl- (2) anions, respectively, thus forming different-ligand formula units, a trigonal–bipyramidal {Cu(1)N4Cl} and a pseudo octahedral one {Cu(2)N4O2}. The copper(II) ion in the complex 2 coordinates one phen ligand in a bidentate mode and two benz- anions to produce a distorted planar square environment {CuN2O2}. In complex 3, the copper(II) cation is surrounded by three phenanthroline fragments {Cu(phen)3}2+ and non-coordinated OTf- ions. The results of an EPR study 1 show that in the solid phase, intermolecular exchange interactions that cause exchange narrowing of the spectrum are efficient, whereas in solutions, resolved spectra of copper(II) ion with rhombic symmetry of the g-tensor are observed. An in vitro study of the biological properties of 1–3 toward nonpathogenic mycobacterial strain Mycolicibacterium smegmatis showed an increase in biological effectiveness depending on the structure of complexes (MIC, 1 (2 nmol/disk) > 3 (5 nmol/disk) > 2 (12.5 nmol/disk)). Complex 1 was also tested for antitumor activity against an ovarian adenocarcinoma SKOV3 demonstrated high efficiency: the IC50 value is almost 9 times higher than the activity of cisplatin.
The ATLAS (one of two general purpose detectors at the LHC) Transition Radiation Tracker (TRT) is the outermost of the three tracking subsystems of the ATLAS Inner Detector. It is a large straw-based ...detector and contains about 350,000 electronics channels. The performance of the TRT as tracking and particularly particle identification detector strongly depends on stability of the operation parameters with most important parameter being the gas gain which must be kept constant across the detector volume. The gas gain in the straws can vary significantly with atmospheric pressure, temperature, and gas mixture composition changes. This paper presents a concept of the gas gain stabilisation in the TRT and describes in detail the Gas Gain Stabilisation System (GGSS) integrated into the Detector Control System (DCS). Operation stability of the GGSS during Run-1 is demonstrated.
Breathing crystals based on polymer-chain complexes of Cu(hfac)2 with nitroxides exhibit thermally and light-induced magnetostructural anomalies in many aspects similar to a spin crossover. In the ...present work, we report the synthesis and investigation of a new family of Cu(hfac)2 complexes with tert-butylpyrazolylnitroxides and their nonradical structural analogues. The complexes with paramagnetic ligands clearly exhibit structural rearrangements in the copper(II) coordination units and accompanying magnetic phenomena characteristic for breathing crystals. Contrary to that, their structural analogues with diamagnetic ligands do not undergo rearrangements in the copper(II) coordination environments. This confirms experimentally the crucial role of paramagnetic ligands and exchange interactions between them and copper(II) ions for the origin of magnetostructural anomalies in this family of molecular magnets.
Improved mechanical properties of oxide dispersion strengthened (ODS) steels, the advanced materials for the reactor core, are due to the high density of uniformly distributed nanosized oxide ...inclusions. Transformation of the nanostructure of ODS steels under irradiation determines their stability during operation in the reactor conditions. In this work, three ODS steels are studied: Eurofer ODS, 10Cr ODS, and KP-3 ODS with different alloying systems. In these steels, the chromium content varies from 9 to 14 at %; such alloying elements as V, Ti, Al, W, and Mn are present in different proportions. The effect of irradiation with iron ions up to 3, 6, and 30 dpa at a temperature of 350°C was studied. The radiation-induced changes were analyzed by transmission electron microscopy and atom probe tomography. Although the sizes of oxide inclusions remained almost without change under irradiation, a decrease in their number density was observed in 10Cr ODS and KP-3 ODS steels, while the number density of oxides in Eurofer ODS steel did not change under the irradiation to 30 dpa. On the whole, the strengthening of the ODS steels due to inclusions during the irradiation to 30 dpa at 350°C changed insignificantly, which indicates their radiation resistance and their low propensity for low-temperature radiation strengthening and embrittlement.
The study is devoted to the methodology of simulation experiments for the analysis of radiation damage of structural materials of nuclear power plants by irradiation with heavy ions and subsequent ...analysis with use of the ultramicroscopy and nanoindentation methods. Details of the irradiation experiments in the TIPr accelerator (Institute for Theoretical and Experimental Physics) with ion energy of 101 keV/nucleon are given. Current approaches to the analysis of radiation-induced changes in the structural phase state of samples irradiated with ions with use of transmission electron microscopy and atom probe tomography are demonstrated. Models for the evaluation of radiation hardening based on microscopic changes, as well as the capabilities of the nanoindentation method for direct measurement of the hardening of a specimen layer irradiated by ions, are considered.
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