Rock burst is one of the major geological hazards in coal mines and is difficult to prevent. Faced with this problem, the low-frequency electromagnetic radiation (EMR) test experiments of coal and ...rock were conducted to explore the characteristics of low-frequency EMR (1 kHz) signals induced form fractures. The relation between EMR signals and paroxysmal fractures was analyzed theoretically. Time-series extraction method was put forward to represent coal and rock paroxysmal fractures. The research results showed that deformation and fracture of coal and rock is caused by the accumulation of paroxysmal and discrete fractures in the samples. The time series obtained by moving average method shows rather good correlation with interior coal rock fractures, which has more obvious precursory characteristics of coal rock instability and dynamic disasters. When the coal rocks are damaged under uniaxial compression, low-frequency EMR (1 kHz) signals are more sensitive to local fracture with more abundant precursor information than high-frequency EMR (500 kHz) signals. The paroxysmal and discrete low-frequency EMR (1 kHz) signal is quite sensitive to rock burst, and when the signals representing coal rock fractures show an increasing trend and the high signals last for some time, it can be regarded as the precursor of rock burst disaster in coal mine. The separation technology of EMR representing coal rock fractures provided the key scientific basis for the field monitoring and forewarning of EMR technology, and a new method to identify the precursor of dynamic disasters of coal and rock.
•An effective method is proposed to analyze the discreteness and continuity of electromagnetic radiation sequence.•Compared with high-frequency EMR, the low-frequency EMR are more sensitive to fractures with richer precursor information.•The processed EMR signals have more obvious precursory features for rock burst in coal mine.
Underground rock is often subjected to the coupled action of acid sulfate, chloride ion corrosion, and external dynamic disturbance: the degree of corrosion and dynamic load can significantly affect ...the pore structure and mechanical behavior of rock. To quantify the microscopic pore structure changes and macro-dynamic behavior characteristics of acidified corroded sandstone, first, a mixed acidic solution of NaHSO
4
and HCl with different pH values was used for immersion corrosion of sandstone; second, the pore structure of sandstone before and after corrosion was quantitatively evaluated by nuclear magnetic resonance (NMR), dynamic loading tests of corroded sandstone were conducted on an SHPB experimental system and scanning electron microscopy (SEM) was used to observe the morphology of corroded sandstone section; and finally, the mechanism of water–rock interaction and damage and fracture of acid-corroded sandstone were analyzed. The results show that, after acidizing corrosion of sandstone, the macropores increase significantly in number and volume, the boundary of the pore structure tends to be fuzzy; the effective porosity, the number of effective pores, and the total porosity increase significantly; the residual porosity, the number of residual pores, and T
2
cut-off value decrease. The proportion accounted for by the elastic stage in stress–strain curves of corroded sandstone is lowered; the proportion accounted for by the plastic yield stage is increased; and post-peak rebound is diminished. With the decrease of pH value, the peak stress on acid-corroded sandstone decreases and the peak strain increases. The peak stress on corroded sandstone is negatively correlated with effective porosity and the number of effective pores, but positively correlated with residual porosity, the number of residual pores, and the T
2
cut-off value. The reaction of acidic solution with sandstone minerals causes the free fluid space to increase, the bound fluid space decreases, and the number of pores increases, resulting in a decrease in the dynamic strength of acidified sandstone. The fracture of original sandstone after impact failure has no obvious directionality, and the failure mode of grain is the coexistence of intergranular fracture and trans-granular fracture. The fracture of sandstone after acidizing corrosion is obviously directional after impact damage, and the fracture form is single, which is intergranular fracture. The research results can provide a certain reference for the protection of rock engineering under acidic water chemical environment.
Dynamic disasters in Chinese coal mines pose a significant threat to coal productivity. Thus, a thorough understanding of the deformation and failure processes of coal is necessary. In this study, ...the energy dissipation rate is proposed as a novel indicator of coal deformation and failure under static and dynamic compressive loads. The relationship between stress-strain, uniaxial compressive strength, displacement rate, loading rate, fractal dimension, and energy dissipation rate was investigated through experiments conducted using the MTS C60 tests (static loads) and split Hopkinson pressure bar system (dynamic loads). The results show that the energy dissipation rate peaks are associated with stress drop during coal deformation, and also positively related to the uniaxial compressive strength. A higher displacement rate of quasi-static loads leads to an initial increase and then a decrease in energy dissipation rate, whereas a higher loading rate of dynamic loads results in larger energy dissipation rate. Theoretical analysis indicates that a sudden increase in energy dissipation rate suggests partial fracture occurring within coal under both quasi-static and dynamic loads. Hence, the energy dissipation rate is an essential indicator of partial fracture and final failure within coal, as well as a prospective precursor for catastrophic failure in coal mine.
A comprehensive understanding of the failure behavior and mechanism of coal is a prerequisite for dealing with dynamic problems in mining space. In this study, the failure behavior and mechanism of ...coal under uniaxial dynamic compressive loads were experimentally and numerically investigated. The experiments were conducted using a split Hopkinson pressure bar (SHPB) system. The results indicated that the typical failure of coal is lateral and axial at lower loading rates and totally smashed at higher loading rates. The further fractography analysis of lateral and axial fracture fragments indicated that the coal failure under dynamic compressive load is caused by tensile brittle fracture. In addition, the typical failure modes of coal under dynamic load were numerically reproduced. The numerical results indicated that the axial fracture is caused directly by the incident compressive stress wave and the lateral fracture is caused by the tensile stress wave reflected from the interface between coal specimen and transmitted bar. Potential application was further conducted to interpret dynamic problems in underground coal mine and it manifested that the lateral and axial fractures of coal constitute the parallel cracks in the coal mass under roof fall and blasting in mining space.
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, with high incidence and mortality rates and low survival rates. However, the detailed molecular mechanism of ...ESCC progression remains unclear. Here, we first showed significantly higher WNT5A and SNAIL expression in ESCC samples than in corresponding paracancerous samples. High WNT5A and SNAIL expression levels correlated positively with lymphatic metastasis and poor prognosis for patients with ESCC based on immunohistochemical (IHC) staining of 145 paired ESCC samples. Spearman's correlation analyses confirmed the strong positive correlation between WNT5A and SNAIL expression, and patients with ESCC presenting coexpression of WNT5A and SNAIL had the worst prognosis. Then, we verified that the upregulation of WNT5A promoted ESCC cell metastasis in vivo and in vitro, suggesting that WNT5A might be a promising therapeutic target for the prevention of ESCC. Furthermore, WNT5A overexpression induced the epithelial-mesenchymal transition via histone deacetylase 7 (HDAC7) upregulation, and HDAC7 silencing significantly reversed WNT5A-induced SNAIL upregulation and ESCC cell metastasis. In addition, we used HDAC7 inhibitors (SAHA and TMP269) to further confirm that HDAC7 participates in WNT5A-mediated carcinogenesis. Based on these results, HDAC7 is involved in WNT5A-mediated ESCC progression, and approaches targeting WNT5A and HDAC7 might be potential therapeutic strategies for ESCC.
tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon ...loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage event in mammalian cells. More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro and in vivo. These results imply that angiogenin plays an important physiological role in cell stress response, except for the known function of inducing angiogenesis.
Background Restless leg syndrome (RLS) is a type of sensorimotor disorder, and clinical workers have made some recent developments in its pathological mechanism and treatment. Epidemiological studies ...have verified that RLS is notably associated with neuro-psychological diseases, kidney disease, cerebro-cardiovascular diseases, nutritional and metabolic diseases, and pregnancy disorders. The diagnostic rate of RLS is low due to lack of specific clinical symptoms, clear genetic and biological markers, and polysomnography (PSG) diagnostic criteria. There are several sleep centers in foreign countries where the suggested immobilization test (SIT) has been applied in clinical treatment and research about RLS. Objective To evaluate the clinical significance of SIT in RLS diagnosis. Methods The study enrolled 220 patients who visited the PKU-UPenn Sleep Center, Peking University International Hospital with a main complaint of discomfort in bilateral lower limbs during daytime rest or before sleep, and 150 healthy vo
In this paper, FeCrCoW alloys with different W contents (0.4, 2.1 and 3.4 at%) are designed and studied in order to overcome the existing shortcomings of resistance materials. These resistance ...materials have high resistivity and a low temperature coefficient of resistivity. It is observed that the addition of W has a remarkable effect on the phase structure of the alloy. In particular, when the W content is 3.4 at%, the single BCC phase of the alloy can be transformed into the BCC and FCC phase. Meanwhile, when analyzed by transmission electron microscopy, there are stacking faults and martensite in FeCrCoW alloy with W content of 3.4 at%. These features are related to excessive W content. In addition, the strength of the alloy can be improved, and the ultimate tensile strength and yield strength are both very high, which are considered as grain-boundary strengthening and solid solution strengthening, caused by the addition of W. The electrical resistivity of the FeCrCoW alloys decreases when the content of W is more than 2.1 at%. The maximum resistivity of the alloy is 170 ± 1.5 μΩ·cm. Moreover, the unique properties of the transition metal allow the alloy to have a low temperature coefficient of resistivity in the temperature range of 298~393 K. The temperature coefficient of resistivity values of the W0.4, W2.1 and W3.4 alloys are -0.0073, -0.0052 and -0.0051 ppm/K. Therefore, this work provides a vision for resistance alloys, which can achieve highly stable resistivity and high strengths in a certain temperature range.
There are important theoretical and scientific benefits to identify natural mineral earthquake and blast accurately to ensure the safety of mining. In the paper, we studied the wave characteristics ...of natural mineral earthquake and blast in a coal mine based on the Hilbert–Huang transform (HHT) method. Results show that the dominant frequency of natural mineral earthquake wave is 20Hz, which is lower than the other frequency bands. The blast wave frequency is relatively complex and its dominant frequency is 140Hz, which is higher than the other frequency bands. The natural mineral earthquake wave amplitude is 50mV and the blast signal amplitude reaches up to 250mV. However, the decay rate of natural mineral earthquake wave is slower than the blast wave. Both of them could be decomposed into 9 intrinsic mode functions (IMFs) by empirical mode decomposition (EMD). c2, c3, c4 and c5 are the main part of the natural mineral earthquake wave; while c2, c3, and c4 are the main part of the blast wave. These IMFs contain most of the signal energy and belong to the advantage part of the original signal. Besides, the instantaneous energy duration of natural mineral earthquake wave is longer, its peak energy arrival time is earlier and decay rate is slower, while the value is lower. The natural mineral earthquake wave Hilbert energy distributes in the sampling points 600–1200, frequency less than 50Hz, and the energy peak 100 is at 25Hz. By contrast, the blast wave Hilbert energy is concentrated on the sampling points 600–800, frequency around 50Hz and 140Hz, and the energy peak 170 is at 140Hz.
PDF
