Abstract
We present 0.″4 resolution imaging polarimetry at 8.7, 10.3, and 12.5
μ
m, obtained with CanariCam at the Gran Telescopio Canarias, of the central 0.11 pc × 0.28 pc (4.″2 × 10.″8) region of ...W51 IRS2. The polarization, as high as ∼14%, arises from silicate particles aligned by the interstellar magnetic field (
B
-field). We separate, or unfold, the polarization of each sightline into emission and absorption components, from which we infer the morphologies of the corresponding projected
B
-fields that thread the emitting- and foreground-absorbing regions. We conclude that the projected
B
-field in the foreground material is part of the larger-scale ambient field. The morphology of the projected
B
-field in the mid-infrared (mid-IR) emitting region spanning the cometary H
ii
region W51 IRS2W is similar to that in the absorbing region. Elsewhere, the two
B
-fields differ significantly with no clear relationship between them. The
B
-field across the W51 IRS2W cometary core appears to be an integral part of a champagne outflow of gas originating in the core and dominating the energetics there. The bipolar outflow, W51north jet, that appears to originate at or near SMA1/N1 coincides almost exactly with a clearly demarcated north–south swath of lower polarization. While speculative, comparison of mid-IR and submillimeter polarimetry on two different scales may support a picture in which SMA1/N1 plays a major role in the
B
-field structure across W51 IRS2.
Abstract
We present the first mid-IR detection of the linear polarization toward the star CygOB2-12, a luminous blue hypergiant that, with
A
V
≈ 10 mag of foreground extinction, is a benchmark in the ...study of the properties of dust in the diffuse interstellar medium. The 8–13
μ
m spectropolarimetry, obtained with the CanariCam multimode camera at the Gran Telescopio CANARIAS shows clear trends with wavelength characteristic of silicate grains aligned in the interstellar magnetic field. The maximum polarization, detected with 7.8
σ
statistical significance near 10.2
μ
m, is (1.24 ± 0.28)% with position angle 126° ± 8°. We comment on these measurements in the context of recent models for the dust composition in the diffuse interstellar medium.
We present the first mid-IR detection of the linear polarization toward the star CygOB2-12, a luminous blue hypergiant that, with Av of ~10 mag of foreground extinction, is a benchmark in the study ...of the properties of dust in the diffuse interstellar medium. The 8-13 micrometer spectropolarimetry, obtained with the CanariCam multi-mode camera at the Gran Telescopio Canarias (GTC), shows clear trends with wavelength characteristic of silicate grains aligned in the interstellar magnetic field. The maximum polarization, detected with 7.8 statistical significance near 10.2 micrometers, is (1.24 +/- 0.28) % with position angle (126 +/- 8) deg. We comment on these measurements in the context of recent models for the dust composition in the diffuse interstellar medium.
We present 0.4 arcsec-resolution imaging polarimetry at 8.7, 10.3, and 12.5 microns, obtained with CanariCam at the Gran Telescopio Canarias, of the central region of W51 IRS2. The polarization, as ...high as 14 percent, arises from silicate particles aligned by the interstellar magnetic field. We separate, or unfold, the polarization of each sightline into emission and absorption components, from which we infer the morphologies of the corresponding projected magnetic fields that thread the emitting and foreground-absorbing regions. We conclude that the projected magnetic field in the foreground material is part of the larger-scale ambient field. The morphology of the projected magnetic field in the mid-IR emitting region spanning the cometary HII region W51 IRS2W is similar to that in the absorbing region. Elsewhere, the two magnetic fields differ significantly with no clear relationship between them. The magnetic field across the W51 IRS2W cometary core appears to be an integral part of a champagne outflow of gas originating in the core and dominating the energetics there. The bipolar outflow, W51north jet, that appears to originate at or near SMA1/N1 coincides almost exactly with a clearly demarcated north-south swath of lower polarization. While speculative, comparison of mid-IR and submm polarimetry on two different scales may support a picture in which SMA1/N1 plays a major role in the magnetic field structure across W51 IRS2.
Abstract
Objective
To assess the effectiveness of cervical manual therapy (MT) on patients with temporomandibular disorders (TMDs) and to compare cervico-craniomandibular MT vs cervical MT.
Design
...Systematic review and meta-analysis (MA).
Methods
A search in PubMed, EMBASE, PEDro, and Google Scholar was conducted with an end date of February 2019. Two independent reviewers performed the data analysis, assessing the relevance of the randomized clinical trials regarding the studies’ objectives. The qualitative analysis was based on classifying the results into levels of evidence according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE).
Results
Regarding cervical MT, MA included three studies and showed statistically significant differences in pain intensity reduction and an increase in masseter pressure pain thresholds (PPTs), with a large clinical effect. In addition, the results showed an increase in temporalis PPT, with a moderate clinical effect. MA included two studies on cervical MT vs cervico-craniomandibular MT interventions and showed statistically significant differences in pain intensity reduction and pain-free maximal mouth opening, with a large clinical effect.
Conclusions
Cervical MT treatment is more effective in decreasing pain intensity than placebo MT or minimal intervention, with moderate evidence. Cervico-craniomandibular interventions achieved greater short-term reductions in pain intensity and increased pain-free MMO over cervical intervention alone in TMD and headache, with low evidence.
More than 260 million surgical procedures are performed worldwide each year. Although sutures and staples are widely used to reconnect tissues, they can cause further damage and increase the risk of ...infection. Bioadhesives have been proposed as an alternative to reconnect tissues. However, clinical adhesives that combine strong adhesion with cytocompatibility have yet to be developed. In this study, we explored the production of adhesives based on protein-engineered polymers bioinspired by the sequence of elastin (i.e., elastin-like recombinamers, ELRs). We hypothesized that the combination of polyphenols (i.e., tannic acid, TA) and ELRs would produce an adhesive coacervate (ELR+TA), as reported for other protein polymers such as silk fibroin (SF). Notably, the adhesion of ELR alone surpassed that of ELR+TA. Indeed, ELR alone achieved adhesive strengths of 88.8 ± 33.2 kPa and 17.0 ± 2.0 kPa on porcine bone and skin tissues, respectively. This surprising result led us to explore a multicomponent bioadhesive to encompass the complementary roles of elastin (mimicked here by ELR) and silk fibroin (SF), and subsequently mirror more closely the multicomponent nature of the extracellular matrix. Tensile testing showed that ELR+SF achieved an adhesive strength of 123.3 ± 60.2 kPa on porcine bone and excellent cytocompatibility. To express this in a more visual and intuitive way, a small surface of only 2.5 cm
was able to lift at least 2 kg of weight. This opens the door for further studies focusing on the ability of protein-engineered polymers to adhere to biological tissues without further chemical modification for applications in tissue engineering.
The Snow Hill Island Formation (SHIF; late Campanian - early Maastrichtian) crops out in the northeast of the Antarctic Peninsula and constitutes the basal part of the late Campanian-early ...Maastrichtian sedimentary succession of the James Ross Basin (NG Sequence). Its major exposures occur at the James Ross and Vega islands. Several fossil-bearing localities have been identified in the SHIF providing a valuable fauna of invertebrates and vertebrates, and flora. Our study focuses on the vertebrate fauna recovered at Gamma and Cape Lamb members of the SHIF. The marine vertebrate assemblages include chondrichthyans, actinopterygians, and marine reptiles (elasmosaurid plesiosaurs and mosasaurs). A diverse terrestrial vertebrate assemblage has been reported being characterized by dinosaurs (sauropod, elasmarian ornithopods, nodosaurid ankylosaur, and a paravian theropod), pterosaurs and birds. Most SHIF dinosaurs share close affinities with penecontemporaneous taxa from southern South America, indicating that at least some continental vertebrates could disperse between southern South America and Antarctica during the Late Cretaceous. The Snow Hill Island Formation provides the most diverse Late Cretaceous marine and continental faunas from Antarctica. The present study summarizes previous and new vertebrate findings with the best actualized stratigraphical framework, providing a more complete fauna association and analyzing further perspectives.
Purpose
To assess the effects of aerobic exercise (AE) on patients with migraine in terms of pain intensity, frequency and duration of migraine, and quality of life.
Methods
A systematic review and ...meta‐analysis of randomized controlled trials were conducted. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for relevant outcomes and were pooled in a meta‐analysis using the random‐effects model.
Results
A total of 10 articles from 1950 to 2019 were included, involving 508 patients. The meta‐analysis showed statistically significant differences in the decrease in pain intensity (five studies, n = 166; SMD = 1.25; 95% CI 0.47‐2.04), frequency (six studies, n = 214; SMD = 0.76; 95% CI 0.32‐1.2) and duration of migraine (four studies, n = 106; SMD = 0.41; 95% CI 0.03‐0.8), in the short‐term. In addition, the meta‐analysis showed statistically significant differences in the increase in quality of life (four studies, n = 150; SMD = 2.7; 95% CI 1.17‐4.24), even though the Egger's test suggested significant evidence of publication bias for the analysis of quality of life (intercept = 5.81; t = 6.97; P = .02).
Conclusions
There is low‐ and moderate‐quality evidence that in patients with migraine AE can decrease the pain intensity, frequency and duration of migraine and can also increase quality of life.
The numerical solutions of shallow water equations are useful for applications related to geophysical flows that usually take place in large computational domains and could require real time ...calculation. Therefore, parallel versions of accurate and efficient numerical solvers for high performance platforms are needed to be able to deal with these simulation scenarios in reasonable times. In this paper we present an efficient CUDA implementation of a first and second order HLL methods and a two-waves TVD-WAF one. We propose to write all these methods under a common framework, such as, their CUDA implementations share the same structure. In particular, the reformulation of TVD-WAF numerical flux and the improved definition of the flux limiter allows us to obtain a more robust solver in situations like wet/dry fronts. Finally, some numerical tests are presented showing that the TVD-WAF method is slightly slower that the first order HLL method and two times faster than the second order HLL method, but it provides numerical results almost as accurate as the second order HLL scheme.
Painful distal symmetrical polyneuropathy (DPN) is a frequent complication of type-2 diabetes mellitus (T2DM) that commonly presents as neuropathic pain and loss of skin nerve fibers. However, there ...are limited therapies to effectively treat DPN and many of the current animal models of T2DM-induced DPN do not appear to mirror the human disease. Thus, we validated a DPN mouse model induced by a cafeteria-style diet plus low-doses of streptozotocin (STZ).
Female C57BL/6J mice were fed either standard (STD) diet or obesogenic cafeteria (CAF) diet for 32 weeks, starting at 8 weeks old. Eight weeks after starting diets, CAF or STD mice received either four low-doses of STZ or vehicle. Changes in body weight, blood glucose and insulin levels, as well as oral glucose- and insulin-tolerance tests (OGTT and ITT) were determined. The development of mechanical hypersensitivity of the hindpaws was determined using von Frey filaments. Moreover, the effect of the most common neuropathic pain drugs was evaluated on T2DM-induced mechanical allodynia. Finally, the density of PGP -9.5
(a pan-neuronal marker) axons in the
from the hindpaw glabrous skin was quantified.
At 22-24 weeks after STZ injections, CAF + STZ mice had significantly higher glucose and insulin levels compared to CAF + VEH, STD + STZ, and STD + VEH mice, and developed glucose tolerance and insulin resistance. Skin mechanical sensitivity was detected as early as 12 weeks post-STZ injections and it was significantly attenuated by intraperitoneal acute treatment with amitriptyline, gabapentin, tramadol, duloxetine, or carbamazepine but not by diclofenac. The density of PGP-9.5
nerve fibers was reduced in CAF + STZ mice compared to other groups.
This reverse translational study provides a painful DPN mouse model which may help in developing a better understanding of the factors that generate and maintain neuropathic pain and denervation of skin under T2DM and to identify mechanism-based new treatments.
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