UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants ...for brain, heart and body MRI, carotid ultrasound and low-dose bone/fat x-ray. The brain imaging component covers 6 modalities (T1, T2 FLAIR, susceptibility weighted MRI, Resting fMRI, Task fMRI and Diffusion MRI). Raw and processed data from the first 10,000 imaged subjects has recently been released for general research access. To help convert this data into useful summary information we have developed an automated processing and QC (Quality Control) pipeline that is available for use by other researchers. In this paper we describe the pipeline in detail, following a brief overview of UK Biobank brain imaging and the acquisition protocol. We also describe several quantitative investigations carried out as part of the development of both the imaging protocol and the processing pipeline.
Abstract
This article describes the main features of the Brazilian Global Atmospheric Model (BAM), analyses of its performance for tropical rainfall forecasting, and its sensitivity to convective ...scheme and horizontal resolution. BAM is the new global atmospheric model of the Center for Weather Forecasting and Climate Research Centro de Previsão de Tempo e Estudos Climáticos (CPTEC), which includes a new dynamical core and state-of-the-art parameterization schemes. BAM’s dynamical core incorporates a monotonic two-time-level semi-Lagrangian scheme, which is carried out completely on the model grid for the tridimensional transport of moisture, microphysical prognostic variables, and tracers. The performance of the quantitative precipitation forecasts (QPFs) from two convective schemes, the Grell–Dévényi (GD) scheme and its modified version (GDM), and two different horizontal resolutions are evaluated against the daily TRMM Multisatellite Precipitation Analysis over different tropical regions. Three main results are 1) the QPF skill was improved substantially with GDM in comparison to GD; 2) the increase in the horizontal resolution without any ad hoc tuning improves the variance of precipitation over continents with complex orography, such as Africa and South America, whereas over oceans there are no significant differences; and 3) the systematic errors (dry or wet biases) remain virtually unchanged for 5-day forecasts. Despite improvements in the tropical precipitation forecasts, especially over southeastern Brazil, dry biases over the Amazon and La Plata remain in BAM. Improving the precipitation forecasts over these regions remains a challenge for the future development of the model to be used not only for numerical weather prediction over South America but also for global climate simulations.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Recent models support the view that the Pyrenees were formed after the inversion of a previously highly extended continental crust that included exhumed upper mantle rocks. Mantle rocks remain near ...to the surface after compression and mountain building, covered by the latest Cretaceous to Paleogene sequences. 3‐D lithospheric‐scale gravity inversion demands the presence of a high‐density mantle body placed within the crust in order to justify the observed anomalies. Exhumed mantle, having ~50 km of maximum width, continuously extends beneath the Basque‐Cantabrian Basin and along the northern side of the Pyrenees. The association of this body with rift, postrift, and inversion structural geometries is tested in a balanced cross section across the Basque‐Cantabrian Basin that incorporates a major south‐dipping ramp‐flat‐ramp extensional detachment active between Valanginian and early Cenomanian times. Results indicate that horizontal extension progressed ~48 km at variable strain rates that increased from 1 to ~4 mm/yr in middle Albian times. Low‐strength Triassic Keuper evaporites and mudstones above the basement favor the decoupling of the cover with formation of minibasins, expulsion rollovers, and diapirs. The inversion of the extensional system is accommodated by doubly verging basement thrusts due to the reactivation of the former basin bounding faults in Eocene‐Oligocene times. Total shortening is estimated in ~34 km and produced the partial subduction of the continental lithosphere beneath the two sides of the exhumed mantle. Obtained results help to pinpoint the original architecture of the North Iberian Margin and the evolution of the hyperextended aborted intracontinental basins.
Key Points
3‐D lithospheric‐scale gravity inversion demands the presence of a high‐density mantle body placed within the crust
Exhumed mantle extends beneath the Basque‐Cantabrian Basin and along the northern side of the Pyrenees
A major south‐dipping ramp‐flat‐ramp extensional detachment active between Valanginian and early Cenomanian times controlled rifting and mantle exhumation
• Amazonian droughts are increasing in frequency and severity. However, little is known about how this may influence species-specific vulnerability to drought across different ecosystem types.
• We ...measured 16 functional traits for 16 congeneric species from six families and eight genera restricted to floodplain, swamp, white-sand or plateau forests of Central Amazonia. We investigated whether habitat distributions can be explained by species hydraulic strategies, and if habitat specialists differ in their vulnerability to embolism that would make water transport difficult during drought periods.
• We found strong functional differences among species. Nonflooded species had higher wood specific gravity and lower stomatal density, whereas flooded species had wider vessels, and higher leaf and xylem hydraulic conductivity. The P50 values (water potential at 50% loss of hydraulic conductivity) of nonflooded species were significantly more negative than flooded species. However, we found no differences in hydraulic safety margin among species, suggesting that all trees may be equally likely to experience hydraulic failure during severe droughts.
• Water availability imposes a strong selection leading to differentiation of plant hydraulic strategies among species and may underlie patterns of adaptive radiation in many tropical tree genera. Our results have important implications for modeling species distribution and resilience under future climate scenarios.
We investigate some aspects of the Maxwell–Chern–Simons electrodynamics focusing on physical effects produced by the presence of stationary sources and a perfectly conducting plate (mirror). ...Specifically, in addition to point charges, we propose two new types of point-like sources called topological source and Dirac point, and we also consider physical effects in various configurations that involve them. We show that the Dirac point is the source of the vortex field configurations. The propagator of the gauge field due to the presence of a conducting plate and the interaction forces between the plate and point-like sources are computed. It is shown that the image method is valid for the point-like charges as well as for Dirac points. For the topological source we show that the image method is not valid and the symmetry of spatial refection on the mirror is broken. In all setups considered, it is shown that the topological source leads to the emergence of torques.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Mass stranding events (MSEs) of beaked whales (BWs) were extremely rare prior to the 1960s but increased markedly after the development of naval mid-frequency active sonar (MFAS). The temporal and ...spatial associations between atypical BW MSEs and naval exercises were first observed in the Canary Islands, Spain, in the mid-1980s. Further research on BWs stranded in association with naval exercises demonstrated pathological findings consistent with decompression sickness (DCS). A 2004 ban on MFASs around the Canary Islands successfully prevented additional BW MSEs in the region, but atypical MSEs have continued in other places of the world, especially in the Mediterranean Sea, with examined individuals showing DCS. A workshop held in Fuerteventura, Canary Islands, in September 2017 reviewed current knowledge on BW atypical MSEs associated with MFAS. Our review suggests that the effects of MFAS on BWs vary among individuals or populations, and predisposing factors may contribute to individual outcomes. Spatial management specific to BW habitat, such as the MFAS ban in the Canary Islands, has proven to be an effective mitigation tool and mitigation measures should be established in other areas taking into consideration known population-level information.
The correlation length ξ, a key quantity in glassy dynamics, can now be precisely measured for spin glasses both in experiments and in simulations. However, known analysis methods lead to ...discrepancies either for large external fields or close to the glass temperature. We solve this problem by introducing a scaling law that takes into account both the magnetic field and the time-dependent spin-glass correlation length. The scaling law is successfully tested against experimental measurements in a CuMn single crystal and against large-scale simulations on the Janus II dedicated computer.
We investigate the inner regions of the Milky Way using data from APOGEE and
Gaia
EDR3. Our inner Galactic sample has more than 26 500 stars within |
X
Gal
|< 5 kpc, |
Y
Gal
|< 3.5 kpc, |
Z
Gal
|< 1 ...kpc, and we also carry out the analysis for a foreground-cleaned subsample of 8000 stars that is more representative of the bulge–bar populations. These samples allow us to build chemo-dynamical maps of the stellar populations with vastly improved detail. The inner Galaxy shows an apparent chemical bimodality in key abundance ratios
α
/Fe, C/N, and Mn/O, which probe different enrichment timescales, suggesting a star formation gap (quenching) between the high- and low-
α
populations. Using a joint analysis of the distributions of kinematics, metallicities, mean orbital radius, and chemical abundances, we can characterize the different populations coexisting in the innermost regions of the Galaxy for the first time. The chemo-kinematic data dissected on an eccentricity–|
Z
|
max
plane reveal the chemical and kinematic signatures of the bar, the thin inner disc, and an inner thick disc, and a broad metallicity population with large velocity dispersion indicative of a pressure-supported component. The interplay between these different populations is mapped onto the different metallicity distributions seen in the eccentricity–|
Z
|
max
diagram consistently with the mean orbital radius and
V
ϕ
distributions. A clear metallicity gradient as a function of |
Z
|
max
is also found, which is consistent with the spatial overlapping of different populations. Additionally, we find and chemically and kinematically characterize a group of counter-rotating stars that could be the result of a gas-rich merger event or just the result of clumpy star formation during the earliest phases of the early disc that migrated into the bulge. Finally, based on 6D information, we assign stars a probability value of being on a bar orbit and find that most of the stars with large bar orbit probabilities come from the innermost 3 kpc, with a broad dispersion of metallicity. Even stars with a high probability of belonging to the bar show chemical bimodality in the
α
/Fe versus Fe/H diagram. This suggests bar trapping to be an efficient mechanism, explaining why stars on bar orbits do not show a significant, distinct chemical abundance ratio signature.
It is now widely accepted that the early-life nutritional environment is important in determining susceptibility to metabolic diseases. In particular, intra-uterine growth restriction followed by ...accelerated postnatal growth is associated with an increased risk of obesity, type-2 diabetes and other features of the metabolic syndrome. The mechanisms underlying these observations are not fully understood.
Using a well-established maternal protein-restriction rodent model, our aim was to determine if exposure to mismatched nutrition in early-life programmes adipose tissue structure and function, and expression of key components of the insulin-signalling pathway.
Offspring of dams fed a low-protein (8%) diet during pregnancy were suckled by control (20%)-fed dams to drive catch-up growth. This 'recuperated' group was compared with offspring of dams fed a 20% protein diet during pregnancy and lactation (control group). Epididymal adipose tissue from 22-day and 3-month-old control and recuperated male rats was studied using histological analysis. Expression and phosphorylation of insulin-signalling proteins and gene expression were assessed by western blotting and reverse-transcriptase PCR, respectively.
Recuperated offspring at both ages had larger adipocytes (P<0.001). Fasting serum glucose, insulin and leptin levels were comparable between groups but increased with age. Recuperated offspring had reduced expression of IRS-1 (P<0.01) and PI3K p110β (P<0.001) in adipose tissue. In adult recuperated rats, Akt phosphorylation (P<0.01) and protein levels of Akt-2 (P<0.01) were also reduced. Messenger RNA expression levels of these proteins were not different, indicating a post-transcriptional effect.
Early-life nutrition programmes alterations in adipocyte cell size and impairs the protein expression of several insulin-signalling proteins through post-transcriptional mechanisms. These indices may represent early markers of insulin resistance and metabolic disease risk.
Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and ...reproducible in vitro 3D-assay employing the main constituents of pancreatic ductal adenocarcinoma, namely pancreatic stellate and cancer cells.
A spheroid assay, directly co-culturing human pancreatic stellate cells with human pancreatic tumour cells in 3D was established and characterized by electron microscopy, immunohistochemistry and real-time RT-PCR. In order to facilitate the cell type-specific crosstalk analysis by real-time RT-PCR, we developed a novel in vitro 3D co-culture model, where the participating cell types were from different species, human and mouse, respectively. Using species-specific PCR primers, we were able to investigate the crosstalk between stromal and cancer cells without previous cell separation and sorting.
We found clear evidence for mutual influence, such as increased proliferation and a shift towards a more mesenchymal phenotype in cancer cells and an activation of pancreatic stellate cells towards the myofibroblast phenotype. Using a heterospecies approach, which we coined virtual sorting, confirmed the findings we made initially in the human-human spheroids.
We developed and characterized different easy to set up 3D models to investigate the crosstalk between cancer and stroma cells for pancreatic cancer.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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