Ventilation in the prone position (PP) has been used for decades in patients with acute respiratory distress syndrome (ARDS) and is associated with a reduction in mortality rate. Its application has ...been extended to patients with SARS-Cov-2 pneumonia and is recommended by the main international organizations. The objective is to evaluate the effects of PP on the outcomes of patients with SARS-Cov-2 pneumonia admitted to a multipurpose intensive care unit. This is a quantitative, quasi-experimental, single-group, longitudinal and retrospective study. Data were collected based on clinical records. Data were processed using SPSS (version 26.0). PP significantly increased oxygenation in patients with SARS-Cov-2 pneumonia, with a mean increase of 21.27% between the PaO
/FiO
ratio before and after the PP. However, its effectiveness was inversely proportional to the number of cycles performed and the timing of orotracheal intubation. PP improves oxygenation in patients with SARS-Cov-2 pneumonia. However, multiple PP sessions are not beneficial, as this procedure is no longer effective after the fourth cycle. This study thus contributes to better management in the approach of critically ill patients with SARS-Cov-2 pneumonia.
Black rot caused by
Xanthomonas campestris
pv.
campestris
(Xcc) is one of the most important diseases affecting
Brassica oleracea
crops in Brazil. In the present study, 150 bacterial isolates from ...symptomatic leaf samples of broccoli, kale, Chinese cabbage, cauliflower, wild mustard, radish, and cabbage were identified and characterized phenotypically and genotypically. One isolate from a symptomatic tomato plant that grew spontaneously in a diseased cabbage field was also identified. Of these 151 isolates, 145 were confirmed as Xcc by multiplex PCR with Xcc and
X. campestris
pv.
raphani
(Xcr) specific primers and were pathogenic to cauliflower cv. Verona, including the isolate from tomato. The identity of six isolates that, although PCR positive for Xcc, were not pathogenic to cauliflower was determined by partial sequencing of the housekeeping
rpoD
gene, confirming that they were
X. campestris
. To investigate the ability of Xcc to infect tomato, 13 isolates were inoculated on tomato cv. Bonny Best, and six isolates, including the tomato isolate, induced chlorosis and small necrotic lesions on leaves and stems. Variability was assessed by BOX-PCR which resulted in 65 distinct haplotypes in the collection, with the largest number of haplotypes identified among broccoli isolates.
In vitro
copper and kasugamycin sensitivity tests showed that 143 isolates were resistant to 100 μg/mL of kasugamycin, and five isolates were resistant to 200 μg/mL of copper sulfate. From a subsample of 79 isolates, inoculated in eight differential genotypes, five races were detected (races 1, 3, 4, 6, and 9) with predominance of race 4 (54.43%,
n
= 43) and race 1 (32.91%,
n
= 26). The results provide tools for genetic breeding and the establishment of integrated black rot management programs for these important vegetables. Additionally, the newly found association between Xcc and tomato should be considered on the perspective of both brassica and tomato crop production in the country.
Social innovation projects are enablers of social wellbeing and value in communities, although such relationship has received little attention from the academia. Taking into account the social value ...for the communities, this paper aims to explore social innovation processes regarding the decision-making processes, in particular the governance and funding of innovative initiatives. This study aims to explore how governance and funding decisions impact on the process of social innovation and enhance social value creation. Through qualitative research methodologies, a multi case study of five social innovation projects named as ES+ Initiatives (innovative initiatives with high entrepreneurship potential) was used. These are Innovation and Social Entrepreneurship projects of innovative value, with a strong social, economic and environmental impact. The data was collected through semi-structured interviews, with five professionals involved in the projects undertaking coordination and management roles. Content analysis was performed using
NVivo 12
software in order to identify and better understand the effect of the analysis dimension on the projects under study. Our results suggest that new forms of governance and financing have contributed to the emergence of new social innovation projects.
Objective
To describe the clinical presentation, diagnostic imaging, management, and follow‐up of a dog that presented with sequential, bilateral, spontaneous, subcapsular and perirenal hemorrhage ...(Wunderlich syndrome) due to bilateral renal arterial malformations.
Case Summary
A 9‐year‐old intact male Field Spaniel presented for acute onset abdominal pain following a possible syncopal episode. Abdominal ultrasonography, contrast‐enhanced ultrasound, and computed tomography (CT) revealed right‐sided perirenal hemorrhage that extended into the peritoneum. The dog was discharged following stabilization with analgesia, fluid therapy, and tranexamic acid. One month later, the patient presented with identical clinical signs. A CT scan at this stage revealed bilateral kidney infarcts with new left‐sided perirenal hemorrhage. Abdominal ultrasound and contrast‐enhanced ultrasound were repeated and showed similar findings. Follow up with four‐dimensional CT angiography revealed bilateral renal arterial malformations, likely causing spontaneous renal hemorrhage and secondary subcapsular hematomas , retroperitoneal and peritoneal hemorrhage.
Unique Information Provided
This is the first reported case of both bilateral renal arterial malformations and bilateral spontaneous subcapsular and perirenal hemorrhage in the absence of neoplasia, coagulopathy, or trauma in a dog. Advanced imaging modalities, including selective angiography, were required to diagnose this condition successfully. Arterial malformations should be considered as a differential diagnosis in cases of hemoretroperitoneum. Nephrectomy due to perirenal hemorrhage should be cautiously considered, especially in the absence of angiography, because of the sequential bilateral nature of this case. Conservative management in this case resulted in a good long‐term outcome 10 months later.
This study characterises microplastics in small cetaceans on the coast of Portugal and assesses the relationship between several biological variables and the amount of detected microplastics. The ...intestines of 38 stranded dead cetaceans were processed in the laboratory, with digestion methods adapted to the amount of organic matter in each sample. The influence of several biological and health variables (e.g., species, sex, body condition) on the amount of microplastics was tested in all analysed species and particularly in common dolphins, due to the larger number of available samples. Most of the analysed individuals had microplastics in the intestine (92.11%), with harbour porpoises revealing a significantly higher median number of microplastics than common dolphins, probably due to their different diets, use of habitat and feeding strategies. None of the other tested variables significantly influenced the number of microplastics. Moreover, the microplastics found should not be enough to cause physical or chemical sublethal effects, although the correlation between microplastic ingestion and plastic additive bioaccumulation in cetacean tissues requires further investigation. Future monitoring in biota should rely on improved and standardised protocols for microplastic analyses in complex samples to allow for accurate analyses of larger samples and spatio-temporal comparisons.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Xanthomonas vesicatoria is a member of the species complex associated with tomato bacterial spot. New and specific primers for X. vesicatoria were developed and validated. The primers were highly ...specific and detection was positive using purified bacterial DNA, bacterial suspensions and foliar lesions. These primers represent an additional tool for detection and identification of one of the species involved in this important disease complex.
The Active Role of Geography: A Manifesto Bernardes, Adriana; Zerbini, Adriano; Gomes, Cilene ...
Antipode,
September 2017, 2017-09-00, 20170901, Letnik:
49, Številka:
4
Journal Article
Recenzirano
Odprti dostop
The role attributed to geography and the possibility of a valid intervention by geographers in the process of social transformation depend on one another and result from the manner in which we ...conceptualize the discipline and its object.If this conceptualization is not embracing of all forms of relation with its milieu, the interventions of geographers will only be partial or functional, and their effectiveness will be increasingly limited in time.It is true that, in common language and in the understanding of other specialists, such as politicians and administrators, geography is frequently considered to be a discipline that is preoccupied with locations. Moreover, a good many geographers work within this vision.Nevertheless, the list of relations that occur between humankind and its milieu shows that the long‐accepted position of geography as a discipline of locations is limiting and, for this reason, insufficient.But this is not the only focus that simplifies and distorts the significance of the discipline of geography.
A 6-year-old, male-neutered, domestic short-haired cat was referred for further management of a 3-month history of uncontrolled diabetes mellitus. The cat visited the hospital on 3 occasions during a ...3-week time period. Hyperglycemia was documented at all visits.
The cat initially presented with evidence of hypovolemia, cranial abdominal pain, and dehydration. Moderate hyperglycemia, mild ketonemia, and severe hypokalemia were documented. A 3 × 2 cm skin lesion with associated alopecia and erythema was first noticed at a routine follow-up examination (visit 2) 1 week later. A diagnosis of diabetic ketoacidosis was made 6 days later. The previously identified skin lesion now measured 6 × 2.5 cm. Two episodes of respiratory distress were identified at this visit, with no evidence of cardiac or pulmonary pathology. The cat developed a moderate anemia (packed cell volume 16 %, total solids 7.9 g/dL) on the fifth day of hospitalization.
Fluid therapy, electrolyte supplementation, regular insulin, anti-emetic, and analgesia medications were administered during visits 1 and 3. Due to development of anemia, suspected pulmonary thromboembolism events and progression of skin lesions, euthanasia was elected. A diagnosis of cutaneous vasculopathy with secondary ischemic necrosis was made postmortem and pulmonary thromboembolism was confirmed.
To the authors’ knowledge, this is the first report of cutaneous vasculopathy and pulmonary thromboembolism in a cat with confirmed diabetes mellitus, warranting further research to assess if hypercoagulability is common in this patient population, as routine thromboprophylaxis and anticoagulation may be potentially indicated.
Caloric restriction has been shown to robustly ameliorate age-related diseases and to prolong lifespan in several model organisms, and these beneficial effects are dependent on the stimulation of ...autophagy. Autophagy dysfunction contributes to the accumulation of altered macromolecules, and is a key mechanism of promoting aging and age-related disorders, as neurodegenerative ones. We have previously shown that caloric restriction (CR), and CR mimetics Neuropeptide Y (NPY) and ghrelin, stimulate autophagy in rat cortical neurons, however by unknown molecular mechanisms. Overall, we show that CR, NPY, and ghrelin stimulate autophagy through PI3K/AKT/MTOR inhibition and ERK1/2-MAPK activation. The knowledge of these kinases in autophagy regulation and the contribution to the understanding of molecular mechanism facilitates the discovery of more targeted therapeutic strategies to stimulate autophagy, which is relevant in the context of age-related disorders.
PDF
