In this paper we present results from dynamic simulations of the Northern California Current ecosystem, based on historical estimates of fishing mortality, relative fishing effort, and climate ...forcing. Climate can affect ecosystem productivity and dynamics both from the bottom-up (through short- and long-term variability in primary and secondary production) as well as from the top-down (through variability in the abundance and spatial distribution of key predators). We have explored how the simplistic application of climate forcing through both bottom-up and top-down mechanisms improves the fit of the model dynamics to observed population trends and reported catches for exploited components of the ecosystem. We find that using climate as either a bottom-up or a top-down forcing mechanism results in substantial improvements in model performance, such that much of the variability observed in single species models and dynamics can be replicated in a multi-species approach. Using multiple climate variables (both bottom-up and top-down) simultaneously did not provide significant improvement over a model with only one forcing. In general, results suggest that there do not appear to be strong trophic interactions among many of the longer-lived, slower-growing rockfish, roundfish and flatfish in this ecosystem, although strong interactions were observed in shrimp, salmon and small flatfish populations where high turnover and predation rates have been coupled with substantial changes in many predator populations over the last 40 years.
A recent analysis showed that the excess odds ratio (EOR) for lung cancer due to smoking can be modeled by a function which is linear in total pack-years and exponential in the logarithm of smoking ...intensity and its square. Below 15–20 cigarettes per day, the EOR/pack-year increased with intensity (direct exposure rate or enhanced potency effect), suggesting greater risk for a total exposure delivered at higher intensity (for a shorter duration) than for an equivalent exposure delivered at lower intensity. Above 20 cigarettes per day, the EOR/pack-year decreased with increasing intensity (inverse exposure rate or reduced potency effect), suggesting greater risk for a total exposure delivered at lower intensity (for a longer duration) than for an equivalent exposure delivered at higher intensity. The authors applied this model to data from 10 case-control studies of cancer, including cancers of the lung, bladder, oral cavity, pancreas, and esophagus. At lower intensities, there was enhanced potency for several cancer sites, but narrow ranges for pack-years increased uncertainty, precluding definitive conclusions. At higher intensities, there was a consistent reduced potency effect across studies. The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites.
Radar scattering by aggregate snowflakes Westbrook, C. D.; Ball, R. C.; Field, P. R.
Quarterly journal of the Royal Meteorological Society,
April 2006 Part A, Letnik:
132, Številka:
616
Journal Article
To survey soccer practitioners' recovery strategy: (1) use, (2) perceived effectiveness, and (3) factors influencing their implementation in professional soccer.
A cross-sectional convenience sample ...of professional soccer club/confederation practitioners completed a web-based survey (April to July 2020). Pearson chi-square and Fisher exact tests with Cramer V (φ - c) assessed relationships and their strength, respectively, between the perceived effectiveness and frequency of strategy use.
A total of 80 soccer practitioners (13 countries) completed the survey. The 3 most important recovery objectives were "alleviating muscle damage/fatigue," "minimizing injury risk," and "performance optimization." The most frequently used strategies were active recovery, structured recovery day, extra rest day, massage, cold-water therapy, and carbohydrate provision (predominantly on match day and match day + 1). Relationships were identified between perceived effectiveness and frequency of strategy use for sleep medication (P < .001, φ - c = 0.48), carbohydrate provision (P = .007, φ - c = 0.60), protein provision (P = .007, φ - c = 0.63), an extra rest day (P < .001, φ - c = 0.56), and a structured recovery day (P = .049, φ - c = 0.50).
The study demonstrates that professional soccer practitioners have a range of objectives geared toward enhancing player recovery. A disconnect is apparent between the perceived effectiveness of many recovery strategies and their frequency of use in an applied setting. Novel data indicate that strategies are most frequently employed around match day. Challenges to strategy adoption are mainly competing disciplinary interests and resource limitations. Researchers and practitioners should liaise to ensure that the complexities involved with operating in an applied environment are elucidated and apposite study designs are adopted, in turn, facilitating the use of practically effective and compatible recovery modalities.
The combination of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) has been proposed as a potential treatment for diabetes and obesity. However, the combined effects of these hormones, PYY(3-36) ...and GLP-1(7-36 amide), on glucose homeostasis are unknown.
This study sought to investigate the acute effects of PYY(3-36) and GLP-1(7-36) amide, individually and in combination, on insulin secretion and sensitivity.
Using a frequently sampled iv glucose tolerance test (FSIVGTT) and minimal modeling, this study measured the effects of PYY(3-36) alone, GLP-1(7-36) amide alone, and a combination of PYY(3-36) and GLP-1(7-36) amide on acute insulin response to glucose (AIRg) and insulin sensitivity index (SI) in 14 overweight human volunteers, studied in a clinical research facility.
PYY(3-36) alone caused a small but nonsignificant increase in AIRg. GLP-1(7-36) amide alone and the combination of PYY(3-36) and GLP-1(7-36) amide did increase AIRg significantly. No significant differences in SI were observed with any intervention.
PYY(3-36) lacks any significant acute effects on first-phase insulin secretion or SI when tested using an FSIVGTT. Both GLP-1(7-36) amide alone and the combination of PYY3-36 and GLP-1(7-36) amide increase first-phase insulin secretion. There does not seem to be any additive or synergistic effect between PYY(3-36) and GLP-1(7-36) amide on first-phase insulin secretion. Neither hormone alone nor the combination had any significant effects on SI.
In response to our article, Davidson and Dahl offer commentary and advice regarding additional topics crucial to a comprehensive prescriptive agenda for future research on mindfulness and meditation. ...Their commentary raises further challenges and provides an important complement to our article. More consideration of these issues is especially welcome because limited space precluded us from addressing all relevant topics. While we agree with many of Davidson and Dahl’s suggestions, the present reply (a) highlights reasons why the concerns we expressed are still especially germane to mindfulness and meditation research (even though those concerns may not be entirely unique) and (b) gives more context to other issues posed by them. We discuss special characteristics of individuals who participate in mindfulness and meditation research and focus on the vulnerability of this field inherent in its relative youthfulness compared to other more mature scientific disciplines. Moreover, our reply highlights the serious consequences of adverse experiences suffered by a significant subset of individuals during mindfulness and other contemplative practices. We also scrutinize common contemporary applications of mindfulness and meditation to illness, and some caveats are introduced regarding mobile technologies for guidance of contemplative practices.
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