The synthesis of a quantum computer remains an ongoing challenge in modern physics. Whereas decoherence stymies most approaches, topological quantum computation schemes evade decoherence at the ...hardware level by storing quantum information non-locally. Here we establish that a key operation--braiding of non-Abelian anyons--can be implemented using one-dimensional semiconducting wires. Such wires can be driven into a topological phase supporting long-sought particles known as Majorana fermions that can encode topological qubits. We show that in wire networks, Majorana fermions can be meaningfully braided by simply adjusting gate voltages, and that they exhibit non-Abelian statistics like vortices in a p+ip superconductor. We propose experimental set-ups that enable probing of the Majorana fusion rules and the efficient exchange of arbitrary numbers of Majorana fermions. This work should open a new direction in topological quantum computation that benefits from physical transparency and experimental feasibility. PUBLICATION ABSTRACT
We study stabilizer quantum error correcting codes (QECC) generated under hybrid dynamics of local Clifford unitaries and local Pauli measurements in one dimension. Building upon (1) a general ...formula relating the error susceptibility of a subregion to its entanglement properties, and (2) a previously established mapping between entanglement entropies and domain wall free energies of an underlying spin model, we propose a statistical mechanical description of the QECC in terms of "entanglement domain walls." Free energies of such domain walls generically feature a leading volume law term coming from its "surface energy," and a subvolume law correction coming from thermodynamic entropies of its transverse fluctuations. These are most easily accounted for by capillary-wave theory of liquid-gas interfaces, which we use as an illustrative tool. We show that the information-theoretic decoupling criterion corresponds to a geometric decoupling of domain walls, which further leads to the identification of the "contiguous code distance" of the QECC as the crossover length scale at which the energy and entropy of the domain wall are comparable. The contiguous code distance thus diverges with the system size as the subleading entropic term of the free energy, protecting a finite code rate against local undetectable errors. We support these correspondences with numerical evidence, where we find capillary-wave theory describes many qualitative features of the QECC; we also discuss when and why it fails to do so.
We introduce and explore a one-dimensional “hybrid” quantum circuit model consisting of both unitary gates and projective measurements. While the unitary gates are drawn from a random distribution ...and act uniformly in the circuit, the measurements are made at random positions and times throughout the system. By varying the measurement rate we can tune between the volume law entangled phase for the random unitary circuit model (no measurements) and a “quantum Zeno phase” where strong measurements suppress the entanglement growth to saturate in an area law. Extensive numerical simulations of the quantum trajectories of the many-particle wave functions (exploiting Clifford circuitry to access systems up to 512 qubits) provide evidence for a stable “weak measurement phase” that exhibits volume-law entanglement entropy, with a coefficient decreasing with increasing measurement rate. We also present evidence for a continuous quantum dynamical phase transition between the “weak measurement phase” and the “quantum Zeno phase,” driven by a competition between the entangling tendencies of unitary evolution and the disentangling tendencies of projective measurements. Detailed steady-state and dynamic critical properties of this quantum entanglement transition are accessed.
Classically closo-carborane anions, particularly HCB11H11− and HCB9H9−, and their derivatives have primarily been used as weakly coordinating anions to isolate reactive intermediates, platforms for ...stoichiometric and catalytic functionalization, counteranions for simple Lewis acid catalysis, and components of materials like liquid crystals. The aim of this article is to educate the reader on the contemporary nonclassical applications of these anions. Specifically, this review will cover new directions in main group catalysis utilized to achieve some of the most challenging catalytic reactions such as C–F, C–H, and C–C functionalizations that are difficult or impossible to realize with transition metals. In addition, the review will cover the utilization of the clusters as dianionic C σ-bound ligands for coordination chemistry, ligand substituents for coordination chemistry and advanced catalyst design, and covalently bound spectator substituents to stabilize radicals. Furthermore, their applications as solution-based and solid-state electrolytes for Li, Na, and Mg batteries will be discussed.
3D Bioprinting for Organ Regeneration Cui, Haitao; Nowicki, Margaret; Fisher, John P. ...
Advanced healthcare materials,
01/2017, Letnik:
6, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage ...and transplantation needs. Three‐dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high‐integration potential for patient‐specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.
3D bioprinting offers an exciting prospect for engineering 3D artificial tissue, as it precisely recapitulates complex compositions, architectures, and biological functions of the living organs. This review presents the cutting‐edge techniques of 3D bioprinting and the bioink design concept as well as highlights its applications in engineering living organs.
Introduction
This article provides a meta‐analysis of a new, cognitive approach to (non‐)verbal lie detection. This cognitive lie detection approach consists of three techniques: (1) imposing ...cognitive load, (2) encouraging interviewees to say more, and (3) asking unexpected questions.
Method
A meta‐analysis was carried out on studies using the cognitive approach, 14 of which directly compared the cognitive approach to a standard approach.
Results
The cognitive lie detection approach produced superior accuracy results in truth detection (67%), lie detection (67%), and total detection (truth and lie detection combined, 71%) compared to a traditional standard approach (truth detection: 57%; lie detection: 47%; total detection: 56%).
Conclusions
Practitioners may find it useful to use a cognitive lie detection approach in their daily practice.
This unique collection of chapters from world experts on person-centered outcome (PCO) measures addresses the following critical questions: Can individual experiences be represented in measurements ...that do not reduce unique differences to meaningless uniformity? How person-centric are PCO measures? Are PCO measurements capable of delivering the kind of quality assured quantification required for high-stakes decision making? Are PCO measures likely to support improved health care delivery? Have pivotal clinical studies failed to deliver treatments for diseases because of shortcomings in the PCO measures used? Are these shortcomings primarily matters of precision and meaningfulness? Or is the lack of common languages for communicating outcomes also debilitating to quality improvement, research, and the health care economy? Three key issues form an urgent basis for further investigation. First, the numbers generated by PCO measures are increasingly used as the central dependent variables upon which high stakes decisions are made. The rising profile of PCO measures places new demands for higher quality information from scale and test construction, evaluation, selection, and interpretation. Second, PCO measurement science has well-established lessons to be learned from those who have built and established the science over many decades. Finally, the goal in making a PCO measurement is to inform outcome management. As such, it is vitally important that key stakeholders understand that, over the last half century, developments in psychometrics have refocused measurement on illuminating clinically important individual differences in the context of widely reproduced patterns of variation in health and functioning, comparable scale values for quality improvement, and practical explanatory models. This book’s audience includes anyone interested in person-centered care, including healthcare researchers and practitioners, policy makers, pharmaceutical industry representatives, clinicians, patient advocates, and metrologists. This is an open access book.
The standard of care (SOC) for high-grade gliomas (HGG) is maximally safe surgical resection, followed by concurrent radiation therapy (RT) and temozolomide (TMZ) for 6 weeks, then adjuvant TMZ for 6 ...months. Before this SOC was established, glioblastoma (GBM) patients typically lived for less than one year after diagnosis, and no adjuvant chemotherapy had demonstrated significant survival benefits compared with radiation alone. In 2005, the Stupp et al. randomized controlled trial (RCT) on newly diagnosed GBM patients concluded that RT plus TMZ compared to RT alone significantly improved overall survival (OS) (14.6 vs. 12.1 months) and progression-free survival (PFS) at 6 months (PFS6) (53.9% vs. 36.4%). Outside of TMZ, there are four drugs and one device FDA-approved for the treatment of HGGs: lomustine, intravenous carmustine, carmustine wafer implants, bevacizumab (BVZ), and tumor treatment fields (TTFields). These treatments are now mainly used to treat recurrent HGGs and symptoms. TTFields is the only treatment that has been shown to improve OS (20.5 vs. 15.6 months) and PFS6 (56% vs. 37%) in comparison to the current SOC. TTFields is the newest addition to this list of FDA-approved treatments, but has not been universally accepted yet as part of SOC.
Over the last 30 years deception researchers have changed their attention from observing nonverbal behaviour to analysing speech content. However, many practitioners we speak to are reluctant to make ...the change from nonverbal to verbal lie detection. In this article we present what practitioners believe is problematic about verbal lie detection: the interview style typically used is not suited for verbal lie detection; the most diagnostic verbal cue to deceit (total details) is not suited for lie detection purposes; practitioners are looking for signs of deception but verbal deception researchers are mainly examining cues that indicate truthfulness; cut-off points (decision rules to decide when someone is lying) do not exist; different verbal indicators are required for different types of lie; and verbal veracity indicators may be culturally defined. We discuss how researchers could address these problems.
Increases in muscular strength may increase sports performance, reduce injury risk, are associated with a plethora of health markers, as well as exerting positive psychological effects. Due to their ...efficiency and effectiveness in increasing total body muscular strength, multi-joint exercises like the powerlifts, i.e.: the squat (SQ), bench-press (BP) and deadlift (DL), are widely used by active individuals as well as athletes in the pursuit of increasing strength. To date, the concept of a minimum dose, i.e. "what is the minimum one needs to do to increase 1-repetition maximum (1RM) strength?" has not been directly examined in the literature, especially in the context of the powerlifts. This review aims to explore the current available evidence around the minimum effective training dose required to increase 1RM strength in trained individuals in an attempt to enhance the practical guidelines around resistance-training as well as provide active individuals, athletes and coaches with more flexibility when designing a training protocol.
One reviewer independently conducted the search in a PRISMA systematic approach using PubMed, SportDiscus and Google Scholar databases. The databases were searched with the following search terms/phrases and Boolean operators: "training volume" AND "powerlifting" OR "1RM strength" OR "powerlifters", "low volume" AND "powerlifting" OR "powerlifting" OR "1RM strength", "high vs low volume" AND "powerlifting" OR "1RM strength", "minimum effective training dose 1RM". Meta-analyses were performed to estimate the change in 1RM strength for the lowest dose group in the included studies.
From the initial 2629 studies, 6 studies met our inclusion criteria. All identified studies showed that a single set performed minimum 1 time and maximum 3 times per week was sufficient to induce significant 1RM strength gains. Meta-analysis of 5 studies showed an estimated increase for overall 1RM of 12.09 kg 95% CIs 8.16 kg-16.03 kg, an increase of 17.48 kg 95% CIs 8.51 kg-26.46 kg for the SQ, and 8.25 kg 95% CIs 0.68 kg-15.83 kg for the BP. All of the included studies contained details on most of the variables comprising "training dose", such as: weekly and per session sets and repetitions as well as intensity of effort. Specific information regarding load (%1RM) was not provided by all studies.
The results of the present systematic review suggest that performing a single set of 6-12 repetitions with loads ranging from approximately 70-85% 1RM 2-3 times per week with high intensity of effort (reaching volitional or momentary failure) for 8-12 weeks can produce suboptimal, yet significant increases in SQ and BP 1RM strength in resistance-trained men. However, because of the lack of research, it is less clear as to whether these improvements may also be achievable in DL 1RM strength or in trained women and highly trained strength athletes.
This systematic review was registered with PROSPERO (CRD42018108911).
PDF
