Abstract
The geology, tectonic history and landscape evolution of ice-covered East Antarctica are the least known of any continent. Lithic boulders eroded from the continental interior and deposited ...in glacial moraines flanking the Transantarctic Mountains provide rare constraints on the geological history of central interior East Antarctica. Crystallization ages and ice velocities indicate these glacial erratics are not sourced locally from the Transantarctic Mountains but rather originate from the continental interior, possibly as far inland as the enigmatic Gamburtsev Subglacial Mountains. We apply low-temperature thermochronology to these boulders, including multi-kinetic inverse thermal modeling, to constrain a multi-stage episodic exhumation history. Cambro-Ordovician and Jurassic rapid-cooling episodes correlate with significant exhumation events accompanying Pan-African convergence and Gondwanan supercontinent rifting, respectively. Here we show that while Cretaceous rapid cooling overlaps temporally with Transantarctic Mountains formation, a lack of discrete younger rapid-cooling pulses precludes significant Cenozoic tectonic or glacial exhumation of central interior East Antarctica.
Highlights ► Anodal tDCS improves speed of accuracy of WM performance on the 2-back task. ► tRNS does not affect WM performance. ► Anodal tDCS may have significant implications for WM remediation in ...psychiatric conditions, particularly schizophrenia.
Since the first discovery of ultrahigh pressure (UHP) rocks 30 years ago in the Western Alps, the mechanisms for exhumation of (U)HP terranes worldwide are still debated. In the western ...Mediterranean, the presently accepted model of synconvergent exhumation (e.g., the channel‐flow model) is in conflict with parts of the geologic record. We synthesize regional geologic data and present alternative exhumation mechanisms that consider the role of divergence within subduction zones. These mechanisms, i.e., (i) the motion of the upper plate away from the trench and (ii) the rollback of the lower plate, are discussed in detail with particular reference to the Cenozoic Adria‐Europe plate boundary, and along three different transects (Western Alps, Calabria‐Sardinia, and Corsica‐Northern Apennines). In the Western Alps, (U)HP rocks were exhumed from the greatest depth at the rear of the accretionary wedge during motion of the upper plate away from the trench. Exhumation was extremely fast, and associated with very low geothermal gradients. In Calabria, HP rocks were exhumed from shallower depths and at lower rates during rollback of the Adriatic plate, with repeated exhumation pulses progressively younging toward the foreland. Both mechanisms were active to create boundary divergence along the Corsica‐Northern Apennines transect, where European southeastward subduction was progressively replaced along strike by Adriatic northwestward subduction. The tectonic scenario depicted for the Western Alps trench during Eocene exhumation of (U)HP rocks correlates well with present‐day eastern Papua New Guinea, which is presented as a modern analog of the Paleogene Adria‐Europe plate boundary.
Key Points:
A specific geologic record for each different exhumation mechanism
An integrated tectonic reconstruction for the Alpine and Apenninic subductions
Synconvergent exhumation models are not consistent with Mediterranean geology
Gout is a common type of inflammatory arthritis in patients seen by primary care physicians.
To review evidence about treatment of acute gout attacks, management of hyperuricemia to prevent attacks, ...and discontinuation of medications for chronic gout in adults.
Multiple electronic databases from January 2010 to March 2016, reference mining, and pharmaceutical manufacturers.
Studies of drugs approved by the U.S. Food and Drug Administration and commonly prescribed by primary care physicians, randomized trials for effectiveness, and trials and observational studies for adverse events.
Data extraction was performed by one reviewer and checked by a second reviewer. Study quality was assessed by 2 independent reviewers. Strength-of-evidence assessment was done by group discussion.
High-strength evidence from 28 trials (only 3 of which were placebo-controlled) shows that colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids reduce pain in patients with acute gout. Moderate-strength evidence suggests that low-dose colchicine is as effective as high-dose colchicine and causes fewer gastrointestinal adverse events. Moderate-strength evidence suggests that urate-lowering therapy (allopurinol or febuxostat) reduces long-term risk for acute gout attacks after 1 year or more. High-strength evidence shows that prophylaxis with daily colchicine or NSAIDs reduces the risk for acute gout attacks by at least half in patients starting urate-lowering therapy, and moderate-strength evidence indicates that duration of prophylaxis should be longer than 8 weeks. Although lower urate levels reduce risk for recurrent acute attacks, treatment to a specific target level has not been tested.
Few studies of acute gout treatments, no placebo-controlled trials of management of hyperuricemia lasting longer than 6 months, and few studies in primary care populations.
Colchicine, NSAIDs, and corticosteroids relieve pain in adults with acute gout. Urate-lowering therapy decreases serum urate levels and reduces risk for acute gout attacks.
Agency for Healthcare Research and Quality. (Protocol registration: http://effectivehealth-care.ahrq.gov/ehc/products/564/1992/Gout-managment-protocol-141103.pdf).
The current theoretical framework suggests that tripartite positive feedback relationships between soil biodiversity, fertility and plant productivity are universal. However, empirical evidence for ...these relationships at the continental scale and across different soil depths is lacking.
We investigate the continental-scale relationships between the diversity of microbial and invertebrate-based soil food webs, fertility and above-ground plant productivity at 289 sites and two soil depths, that is 0–10 and 20–30 cm, across Australia.
Soil biodiversity, fertility and plant productivity are strongly positively related in surface soils. Conversely, in the deeper soil layer, the relationships between soil biodiversity, fertility and plant productivity weaken considerably, probably as a result of a reduction in biodiversity and fertility with depth. Further modeling suggested that strong positive associations among soil biodiversity–fertility and fertility–plant productivity are limited to the upper soil layer (0–10 cm), after accounting for key factors, such as distance from the equator, altitude, climate and physicochemical soil properties.
These findings highlight the importance of surface soil biodiversity for soil fertility, and suggest that any loss of surface soil could potentially break the links between soil biodiversity–fertility and/or fertility–plant productivity, which can negatively impact nutrient cycling and food production, upon which future generations depend.
Accurate segmentation of the coronary arteries with intravascular ultrasound (IVUS) is important to optimize coronary stent implantation. Recently, deep learning (DL) methods have been proposed to ...develop automatic IVUS segmentation. However, most of those have been limited to segmenting the lumen and vessel (i.e. lumen-intima and media-adventitia borders), not applied to segmenting stent dimension. Hence, this study aimed to develop a DL method for automatic IVUS segmentation of stent area in addition to lumen and vessel area.
This study included a total of 45,449 images from 1576 IVUS pullback runs. The datasets were randomly split into training, validation, and test datasets (0.7:0.15:0.15). After developing the DL-based system to segment IVUS images using the training and validation datasets, we evaluated the performance through the independent test dataset.
The DL-based segmentation correlated well with the expert-analyzed segmentation with a mean intersection over union (± standard deviation) of 0.80 ± 0.20, correlation coefficient of 0.98 (95% confidence intervals: 0.98 to 0.98), 0.96 (0.95 to 0.96), and 0.96 (0.96 to 0.96) for lumen, vessel, and stent area, and the mean difference (± standard deviation) of 0.02 ± 0.57, −0.44 ± 1.56 and − 0.17 ± 0.74 mm2 for lumen, vessel and stent area, respectively.
This automated DL-based IVUS segmentation of lumen, vessel and stent area showed an excellent agreement with manual segmentation by experts, supporting the feasibility of artificial intelligence-assisted IVUS assessment in patients undergoing coronary stent implantation.
•We developed a deep learning-based intravascular ultrasound segmentation model.•It provided excellent segmentation performance compared with human experts.•This automated segmentation method can be wildly applicable.
Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C-terminally end-deleted ...AQP0-expressing transgenic mouse model AQP0ΔC/ΔC developed abnormal optical aberrations in the lens. This investigation was undertaken to find out whether the total loss of the BF structural proteins alter the optical properties of the lens and cause optical aberrations similar to those in AQP0ΔC/ΔC lenses; also, to map the changes in the optical quality as a function of age in the single or double BF protein knockouts as well as to assess whether there is any significant change in the water channel function of AQP0 in these knockouts. A double knockout mouse (2xKO) model for CP49 and filensin was developed by crossing CP49-KO and filensin-KO mice. Wild type, CP49-KO, filensin-KO, and 2xKO lenses at different ages, and AQP0ΔC/ΔC lenses at postnatal day-17 were imaged through the optical axis and compared for optical quality and focusing property. All three knockout models showed loss of transparency, and development of abnormal optical distortion aberration similar to that in AQP0ΔC/ΔC. Copper grid focusing by the lenses at 6, 9 and 12 months of age showed an increase in aberrations as age advanced. With progression in age, the grid images produced by the lenses of all KO models showed a transition from a positive barrel distortion aberration to a pincushion distortion aberration with the formation of three distinct aberration zones similar to those produced by AQP0ΔC/ΔC lenses. Water permeability of fiber cell membrane vesicles prepared from CP49-KO, filensin-KO and 2xKO models, measured using the osmotic shrinking method, remained similar to that of the wild type without any statistically significant alteration (P > 0.05). Western blotting and quantification revealed the expression of comparable quantities of AQP0 in all three BF protein KOs. Our study reveals that loss of single or both beaded filament proteins significantly affect lens refractive index gradient, transparency and focusing ability in an age-dependent manner and the interaction of BF proteins with AQP0 is critical for the proper functioning of the lens. The presence of BF proteins is necessary to prevent abnormal optical aberrations and maintain homeostasis in the aging lens.
•Beaded filaments are critical for establishing lens refractive index gradient.•Loss of CP49 or filensin or both causes age-related lens abnormal aberration.•Loss of the C-terminal end of AQP0 causes lens abnormal aberration.
Age-related cataracts affect the majority of older adults and are a leading cause of blindness worldwide. Treatments that delay cataract onset or severity have the potential to delay cataract ...surgery, but require relevant animal models that recapitulate the major types of cataracts for their development. Unfortunately, few such models are available. Here, we report the lens phenotypes of aged mice lacking the critical antioxidant transcription factor Nfe2l2 (designated as Nrf2 -/-).
Three independent cohorts of Nrf2 -/- and wild-type C57BL/6J mice were evaluated for cataracts using combinations of slit lamp imaging, photography of freshly dissected lenses, and histology. Mice were fed high glycemic diets, low glycemic diets, regular chow ad libitum, or regular chow with 30% caloric restriction.
Nrf2 -/- mice developed significant opacities between 11 and 15 months and developed advanced cortical, posterior subcapsular, anterior subcapsular, and nuclear cataracts. Cataracts occurred similarly in male mice fed high or low glycemic diets, and were also observed in 21-month male and female Nrf2 -/- mice fed ad libitum or 30% caloric restriction. Histological observation of 18-month cataractous lenses revealed significant disruption to fiber cell architecture and the retention of nuclei throughout the cortical region of the lens. However, fiber cell denucleation and initiation of lens differentiation was normal at birth, with the first abnormalities observed at 3 months.
Nrf2 -/- mice offer a tool to understand how defective antioxidant signaling causes multiple forms of cataract and may be useful for screening drugs to prevent or delay cataractogenesis in susceptible adults.
We present the first results from the polarimetry mode of the Gemini Planet Imager (GPI), which uses a new integral field polarimetry architecture to provide high contrast linear polarimetry with ...minimal systematic biases between the orthogonal polarizations. We describe the design, data reduction methods, and performance of polarimetry with GPI. Point-spread function (PSF) subtraction via differential polarimetry suppresses unpolarized starlight by a factor of over 100, and provides sensitivity to circumstellar dust reaching the photon noise limit for these observations. In the case of the circumstellar disk around HR 4796A, GPI's advanced adaptive optics system reveals the disk clearly even prior to PSF subtraction. In polarized light, the disk is seen all the way in to its semi-minor axis for the first time. The disk exhibits surprisingly strong asymmetry in polarized intensity, with the west side > ~9 times brighter than the east side despite the fact that the east side is slightly brighter in total intensity. Based on a synthesis of the total and polarized intensities, we now believe that the west side is closer to us, contrary to most prior interpretations. Forward scattering by relatively large silicate dust particles leads to the strong polarized intensity on the west side, and the ring must be slightly optically thick in order to explain the lower brightness in total intensity there. These findings suggest that the ring is geometrically narrow and dynamically cold, perhaps shepherded by larger bodies in the same manner as Saturn's F ring.
Abstract Objectives To determine the effectiveness of exercise therapy (ET) compared with ET with adjunctive manual therapy (MT) for people with hip osteoarthritis (OA); and to identify if immediate ...commencement of treatment (ET or ET+MT) was more beneficial than a 9-week waiting period for either intervention. Design Assessor-blind randomized controlled trial with a 9-week and 18-week follow-up. Setting Four academic teaching hospitals in Dublin, Ireland. Participants Patients (N=131) with hip OA recruited from general practitioners, rheumatologists, orthopedic surgeons, and other hospital consultants were randomized to 1 of 3 groups: ET (n=45), ET+MT (n=43), and waitlist controls (n=43). Interventions Participants in both the ET and ET+MT groups received up to 8 treatments over 8 weeks. Control group participants were rerandomized into either ET or ET+MT groups after 9 week follow-up. Their data were pooled with original treatment group data: ET (n=66) and ET+MT (n=65). Main Outcome Measures The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function (PF) subscale. Secondary outcomes included physical performance, pain severity, hip range of motion (ROM), anxiety/depression, quality of life, medication usage, patient-perceived change, and patient satisfaction. Results There was no significant difference in WOMAC PF between the ET (n=66) and ET+MT (n=65) groups at 9 weeks (mean difference, .09; 95% confidence interval CI −2.93 to 3.11) or 18 weeks (mean difference, .42; 95% CI, −4.41 to 5.25), or between other outcomes, except patient satisfaction with outcomes, which was higher in the ET+MT group ( P =.02). Improvements in WOMAC, hip ROM, and patient-perceived change occurred in both treatment groups compared with the control group. Conclusions Self-reported function, hip ROM, and patient-perceived improvement occurred after an 8-week program of ET for patients with OA of the hip. MT as an adjunct to exercise provided no further benefit, except for higher patient satisfaction with outcome.
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