The detection of five new fast radio bursts (FRBs) found in the 1.4-GHz High Time Resolution Universe high-latitude survey at Parkes, is presented. The rate implied is 7
$^{+5}_{-3}\times 10^3$
...(95 per cent) FRBs sky−1 d−1 above a fluence of 0.13 Jy ms for an FRB of 0.128 ms duration to 1.5 Jy ms for 16 ms duration. One of these FRBs has a two-component profile, in which each component is similar to the known population of single component FRBs and the two components are separated by 2.4 ± 0.4 ms. All the FRB components appear to be unresolved following deconvolution with a scattering tail and accounting for intrachannel smearing. The two-component burst, FRB 121002, also has the highest dispersion measure (1629 pc cm−3) of any FRB to-date. Many of the proposed models to explain FRBs use a single high-energy event involving compact objects (such as neutron-star mergers) and therefore cannot easily explain a two-component FRB. Models that are based on extreme versions of flaring, pulsing, or orbital events, however, could produce multiple component profiles. The compatibility of these models and the FRB rate implied by these detections is discussed.
Abstract
We report the discovery of PSR J1757−1854, a 21.5-ms pulsar in a highly-eccentric, 4.4-h orbit with a neutron star (NS) companion. PSR J1757−1854 exhibits some of the most extreme ...relativistic parameters of any known pulsar, including the strongest relativistic effects due to gravitational-wave damping, with a merger time of 76 Myr. Following a 1.6-yr timing campaign, we have measured five post-Keplerian parameters, yielding the two component masses (mp = 1.3384(9) M⊙ and mc = 1.3946(9) M⊙) plus three tests of general relativity, which the theory passes. The larger mass of the NS companion provides important clues regarding the binary formation of PSR J1757−1854. With simulations suggesting 3-σ measurements of both the contribution of Lense–Thirring precession to the rate of change of the semimajor axis and the relativistic deformation of the orbit within ∼7–9 yr, PSR J1757−1854 stands out as a unique laboratory for new tests of gravitational theories.
We present initial results from the low-latitude Galactic plane region of the High Time Resolution Universe pulsar survey conducted at the Parkes 64-m radio telescope. We discuss the computational ...challenges arising from the processing of the terabyte-sized survey data. Two new radio interference mitigation techniques are introduced, as well as a partially coherent segmented acceleration search algorithm which aims to increase our chances of discovering highly relativistic short-orbit binary systems, covering a parameter space including potential pulsar–black hole binaries. We show that under a constant acceleration approximation, a ratio of data length over orbital period of ≈0.1 results in the highest effectiveness for this search algorithm. From the 50 per cent of data processed thus far, we have redetected 435 previously known pulsars and discovered a further 60 pulsars, two of which are fast-spinning pulsars with periods less than 30 ms. PSR J1101−6424 is a millisecond pulsar whose heavy white dwarf (WD) companion and short spin period of 5.1 ms indicate a rare example of full-recycling via Case A Roche lobe overflow. PSR J1757−27 appears to be an isolated recycled pulsar with a relatively long spin period of 17 ms. In addition, PSR J1244−6359 is a mildly recycled binary system with a heavy WD companion, PSR J1755−25 has a significant orbital eccentricity of 0.09 and PSR J1759−24 is likely to be a long-orbit eclipsing binary with orbital period of the order of tens of years. Comparison of our newly discovered pulsar sample to the known population suggests that they belong to an older population. Furthermore, we demonstrate that our current pulsar detection yield is as expected from population synthesis.
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of ...pathologies such as interstitial lung disease, cancer and coronavirus disease 2019 (COVID-19) pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we describe the development of a long-term feeder-free, chemically defined culture system for distal lung progenitors as organoids derived from single adult human alveolar epithelial type II (AT2) or KRT5
basal cells. AT2 organoids were able to differentiate into AT1 cells, and basal cell organoids developed lumens lined with differentiated club and ciliated cells. Single-cell analysis of KRT5
cells in basal organoids revealed a distinct population of ITGA6
ITGB4
mitotic cells, whose offspring further segregated into a TNFRSF12A
subfraction that comprised about ten per cent of KRT5
basal cells. This subpopulation formed clusters within terminal bronchioles and exhibited enriched clonogenic organoid growth activity. We created distal lung organoids with apical-out polarity to present ACE2 on the exposed external surface, facilitating infection of AT2 and basal cultures with SARS-CoV-2 and identifying club cells as a target population. This long-term, feeder-free culture of human distal lung organoids, coupled with single-cell analysis, identifies functional heterogeneity among basal cells and establishes a facile in vitro organoid model of human distal lung infections, including COVID-19-associated pneumonia.
Accurately accounting for new particle formation (NPF) is crucial to our ability to predict aerosol number concentrations in many environments and thus cloud properties, which is in turn vital in ...simulating radiative transfer and climate. Here we present an analysis of NPF events observed in the Greenland Sea during the summertime as part of the Aerosol-Cloud Coupling And Climate Interactions in the Arctic (ACCACIA) project. While NPF events have been reported in the Arctic before, we were able, for the first time, to detect iodine in the growing particles using an Aerosol Mass Spectrometer (AMS) during a persistent event in the region of the coastal sea-ice near Greenland. Given the potency of iodine as a nucleation precursor, the results imply that iodine was responsible for the initial NPF, a phenomenon that has been reported at lower latitudes and associated with molecular iodine emissions from coastal macroalgae. The initial source of iodine in this instance is not clear, but it was associated with air originating approximately 1 day previously over melting coastal sea-ice. These results show that atmospheric models must consider iodine as a source of new particles in addition to established precursors such as sulfur compounds.
A
bstract
We propose a model-independent framework for fitting hadronic form-factor data, which is often only available at discrete kinematical points, using parameterisations based on to unitarity ...and analyticity. In this novel approach the latter two properties of quantum-field theory regulate the ill-posed fitting problem and allow model-independent predictions over the entire physical range. Kinematical constraints, for example for the vector and scalar form factors in semileptonic meson decays, can be imposed exactly. The core formulae are straight-forward to implement with standard math libraries. We take account of a generalisation of the original Boyd Grinstein Lebed (BGL) unitarity constraint for form factors and demonstrate our method for the exclusive semileptonic decay
B
s
→ Kℓν
, for which we make a number of phenomenologically relevant predictions, including the CKM matrix element
|V
ub
|
.
We present microphysical observations of cumulus clouds measured over the southwest peninsula of the UK during the COnvective Precipitation Experiment (COPE) in August 2013, which are framed into a ...wider context using ground-based and airborne radar measurements. Two lines of cumulus clouds formed in the early afternoon along convergence lines aligned with the peninsula. The lines became longer and broader during the afternoon due to new cell formation and stratiform regions forming downwind of the convective cells. Ice concentrations up to 350 L−1, well in excess of the expected ice nuclei (IN) concentrations, were measured in the mature stratiform regions, suggesting that secondary ice production was active. Detailed sampling focused on an isolated liquid cloud that glaciated as it matured to merge with a band of cloud downwind. In the initial cell, drizzle concentrations increased from ∼ 0.5 to ∼ 20 L−1 in around 20 min. Ice concentrations developed up to a few per litre, which is around the level expected of primary IN. The ice images were most consistent with freezing drizzle, rather than smaller cloud drops or interstitial IN forming the first ice. As new cells emerged in and around the cloud, ice concentrations up to 2 orders of magnitude higher than the predicted IN concentrations developed, and the cloud glaciated over a period of 12–15 min. Almost all of the first ice particles to be observed were frozen drops, while vapour-grown ice crystals were dominant in the latter stages. Our observations are consistent with the production of large numbers of small secondary ice crystals/fragments, by a mechanism such as Hallett–Mossop or droplets shattering upon freezing. Some of the small ice froze drizzle drops on contact, while others grew more slowly by vapour deposition. Graupel and columns were seen in cloud penetrations up to the −12 °C level, though many ice particles were mixed habit due to riming and growth by vapour deposition at multiple temperatures. Our observations demonstrate that the freezing of drizzle/raindrops is an important process that dominates the formation of large ice in the intermediate stages of cloud development. As these frozen drops were the first precipitation observed, interactions between the warm-rain and secondary ice production processes appear to be key to determining the timing and location of precipitation.
BackgroundA vaccine is needed to prevent human immunodeficiency virus type 1 (HIV-1) infection MethodsA double-blind, randomized trial of a recombinant HIV-1 envelope glycoprotein subunit (rgp120) ...vaccine was conducted among men who have sex with men and among women at high risk for heterosexual transmission of HIV-1. Volunteers received 7 injections of either vaccine or placebo (ratio, 2:1) over 30 months. The primary end point was HIV-1 seroconversion over 36 months ResultsA total of 5403 volunteers (5095 men and 308 women) were evaluated. The vaccine did not prevent HIV-1 acquisition: infection rates were 6.7% in 3598 vaccinees and 7.0% in 1805 placebo recipients; vaccine efficacy (VE) was estimated as 6% (95% confidence interval, −17% to 24%). There were no significant differences in viral loads, rates of antiretroviral-therapy initiation, or the genetic characteristics of the infecting HIV-1 strains between treatment arms. Exploratory subgroup analyses showed nonsignificant trends toward efficacy in preventing infection in the highest risk (VE, 43%; n=247) and nonwhite (VE, 47%; n=914) volunteers (P=.10, adjusted for multiple subgroup comparisons) ConclusionsThere was no overall protective effect. The efficacy trends in subgroups may provide clues for the development of effective immunization approaches
Black carbon aerosols (BC) at a London urban site were characterised in both winter- and summertime 2012 during the Clean Air for London (ClearfLo) project. Positive matrix factorisation (PMF) ...factors of organic aerosol mass spectra measured by a high-resolution aerosol mass spectrometer (HR-AMS) showed traffic-dominant sources in summer but in winter the influence of additional non-traffic sources became more important, mainly from solid fuel sources (SF). Measurements using a single particle soot photometer (SP2, DMT), showed the traffic-dominant BC exhibited an almost uniform BC core size (Dc) distribution with very thin coating thickness throughout the detectable range of Dc. However, the size distribution of Dc (project average mass median Dc = 149 ± 22 nm in winter, and 120 ± 6 nm in summer) and BC coating thickness varied significantly in winter. A novel methodology was developed to attribute the BC number concentrations and mass abundances from traffic (BCtr) and from SF (BCsf), by using a 2-D histogram of the particle optical properties as a function of BC core size, as measured by the SP2. The BCtr and BCsf showed distinctly different Dc distributions and coating thicknesses, with BCsf displaying larger Dc and larger coating thickness compared to BCtr. BC particles from different sources were also apportioned by applying a multiple linear regression between the total BC mass and each AMS-PMF factor (BC–AMS–PMF method), and also attributed by applying the absorption spectral dependence of carbonaceous aerosols to 7-wavelength Aethalometer measurements (Aethalometer method). Air masses that originated from westerly (W), southeasterly (SE), and easterly (E) sectors showed BCsf fractions that ranged from low to high, and whose mass median Dc values were 137 ± 10 nm, 143 ± 11 nm and 169 ± 29 nm, respectively. The corresponding bulk relative coating thickness of BC (coated particle size/BC core – Dp/Dc) for these same sectors was 1.28 ± 0.07, 1.45 ± 0.16 and 1.65 ± 0.19. For W, SE and E air masses, the number fraction of BCsf ranged from 6 ± 2% to 11 ± 5% to 18 ± 10%, respectively, but importantly the larger BC core sizes lead to an increased fraction of BCsf in terms of mass than number (for W, SE and E air masses, the BCsf mass fractions ranged from 16 ± 6%, 24 ± 10% and 39 ± 14%, respectively). An increased fraction of non-BC particles (particles that did not contain a BC core) was also observed when SF sources were more significant. The BC mass attribution by the SP2 method agreed well with the BC–AMS–PMF multiple linear regression method (BC–AMS–PMF : SP2 ratio = 1.05, r2 = 0.80) over the entire experimental period. Good agreement was found between BCsf attributed with the Aethalometer model and the SP2. However, the assumed absorption Ångström exponent (αwb) had to be changed according to the different air mass sectors to yield the best comparison with the SP2. This could be due to influences of fuel type or burn phase.
Computer system design Flynn, Michael J; Luk, Wayne
2011., 2011, 2011-06-15, 2011-08-08
eBook
The next generation of computer system designers will be less concerned about details of processors and memories, and more concerned about the elements of a system tailored to particular ...applications. These designers will have a fundamental knowledge of processors and other elements in the system, but the success of their design will depend on the skills in making system-level tradeoffs that optimize the cost, performance and other attributes to meet application requirements. This book provides a new treatment of computer system design, particularly for System-on-Chip (SOC), which addresses the issues mentioned above. It begins with a global introduction, from the high-level view to the lowest common denominator (the chip itself), then moves on to the three main building blocks of an SOC (processor, memory, and interconnect). Next is an overview of what makes SOC unique (its customization ability and the applications that drive it). The final chapter presents future challenges for system design and SOC possibilities.