Abstract
Detections and non-detections of Lyman alpha (Lyα) emission from z > 6 galaxies (<1 Gyr after the big bang) can be used to measure the timeline of cosmic reionization. Of key interest to ...measuring reionization’s mid-stages, but also increasing observational challenge, are observations at z > 7, where Lyα redshifts to near infra-red wavelengths. Here we present a search for z > 7.2 Lyα emission in 53 intrinsically faint Lyman Break Galaxy candidates, gravitationally lensed by massive galaxy clusters, in the KMOS Lens-Amplified Spectroscopic Survey (KLASS). With integration times of ∼7–10 h, we detect no Lyα emission with signal-to-noise ratio (S/N) > 5 in our sample. We determine our observations to be 80 per cent complete for 5σ spatially and spectrally unresolved emission lines with integrated line flux >5.7 × 10−18 erg s−1 cm−2. We define a photometrically selected sub-sample of 29 targets at z = 7.9 ± 0.6, with a median 5σ Lyα EW limit of 58 Å. We perform a Bayesian inference of the average intergalactic medium (IGM) neutral hydrogen fraction using their spectra. Our inference accounts for the wavelength sensitivity and incomplete redshift coverage of our observations, and the photometric redshift probability distribution of each target. These observations, combined with samples from the literature, enable us to place a lower limit on the average IGM neutral hydrogen fraction of $\gt 0.76 \,\, (68{{\ \rm per\ cent}}), \,\, \gt 0.46 \,\, (95{{\ \rm per\ cent}})$ at z ∼ 8, providing further evidence of rapid reionization at z ∼ 6–8. We show that this is consistent with reionization history models extending the galaxy luminosity function to $M_ \rm {\small UV}\lesssim -12$, with low ionizing photon escape fractions, $f_\textrm{esc} \lesssim 15{{\ \rm per\ cent}}$.
Abstract
We present the results of a first search for galaxy candidates at
z
∼ 9–15 on deep seven-band NIRCam imaging acquired as part of the GLASS-James Webb Space Telescope (JWST) Early Release ...Science Program on a flanking field of the Frontier Fields cluster A2744. Candidates are selected via two different renditions of the Lyman-break technique, isolating objects at
z
∼ 9–11, and
z
∼ 9–15, respectively, supplemented by photometric redshifts obtained with two independent codes. We find five color-selected candidates at
z
> 9, plus one additional candidate with photometric redshift
z
phot
≥ 9. In particular, we identify two bright candidates at
M
UV
≃ −21 that are unambiguously placed at
z
≃ 10.6 and
z
≃ 12.2, respectively. The total number of galaxies discovered at
z
> 9 is in line with the predictions of a nonevolving luminosity function. The two bright ones at
z
> 10 are unexpected given the survey volume, although cosmic variance and small number statistics limits general conclusions. This first search demonstrates the unique power of JWST to discover galaxies at the high-redshift frontier. The candidates are ideal targets for spectroscopic follow-up in Cycle-2.
We investigate the relation between star formation rate (SFR) and stellar mass (M), i.e., the main sequence (MS) relation of star-forming galaxies, at in the first four Hubble Space Telescope (HST) ...Frontier Fields, on the basis of rest-frame UV observations. Gravitational lensing combined with deep HST observations allows us to extend the analysis of the MS down to at and at higher redshifts, a factor of ∼10 below most previous results. We perform an accurate simulation to take into account the effect of observational uncertainties and correct for the Eddington bias. This step allows us to reliably measure the MS and in particular its slope. While the normalization increases with redshift, we fit an unevolving and approximately linear slope. We nicely extend to lower masses the results of brighter surveys. Thanks to the large dynamic range in mass and by making use of the simulation, we analyzed any possible mass dependence of the dispersion around the MS. We find tentative evidence that the scatter decreases with increasing mass, suggesting a larger variety of star formation histories in low-mass galaxies. This trend agrees with theoretical predictions and is explained as either a consequence of the smaller number of progenitors of low-mass galaxies in a hierarchical scenario and/or of the efficient but intermittent stellar feedback processes in low-mass halos. Finally, we observe an increase in the SFR per unit stellar mass with redshift milder than predicted by theoretical models, implying a still incomplete understanding of the processes responsible for galaxy growth.
ABSTRACT We present a robust measurement and analysis of the rest-frame ultraviolet (UV) luminosity functions at z = 4-8. We use deep Hubble Space Telescope imaging over the Cosmic Assembly ...Near-infrared Deep Extragalactic Legacy Survey/GOODS fields, the Hubble Ultra Deep Field, and the Hubble Frontier Field deep parallel observations near the Abell 2744 and MACS J0416.1-2403 clusters. The combination of these surveys provides an effective volume of 0.6-1.2 × 106 Mpc3 over this epoch, allowing us to perform a robust search for faint 18) and bright (M 21) high-redshift galaxies. We select candidate galaxies using a well-tested photometric redshift technique with careful screening of contaminants, finding a sample of 7446 candidate galaxies at 3.5 8.5, with >1000 galaxies at 6-8. We measure both a stepwise luminosity function for candidate galaxies in our redshift samples, and a Schechter function, using a Markov Chain Monte Carlo analysis to measure robust uncertainties. At the faint end, our UV luminosity functions agree with previous studies, yet we find a higher abundance of UV-bright candidate galaxies at 6. Our best-fit value of the characteristic magnitude is consistent with −21 at 5, which is different than that inferred based on previous trends at lower redshift, and brighter at ∼2 significance than previous measures at z = 6 and 7. At z = 8, a single power law provides an equally good fit to the UV luminosity function, while at z = 6 and 7 an exponential cutoff at the bright end is moderately preferred. We compare our luminosity functions to semi-analytical models, and find that the lack of evolution in is consistent with models where the impact of dust attenuation on the bright end of the luminosity function decreases at higher redshift, although a decreasing impact of feedback may also be possible. We measure the evolution of the cosmic star-formation rate (SFR) density by integrating our observed luminosity functions to , correcting for dust attenuation, and find that the SFR density declines proportionally to (1 ) at 4, which is consistent with observations at 9. Our observed luminosity functions are consistent with a reionization history that starts at 10, completes at 6, and reaches a midpoint (x 0.5) at 6.7 9.4. Finally, using a constant cumulative number density selection and an empirically derived rising star-formation history, our observations predict that the abundance of bright z = 9 galaxies is likely higher than previous constraints, although consistent with recent estimates of bright 10 galaxies.
ABSTRACT
We measure the size–luminosity relation of photometrically selected galaxies within the redshift range z ∼ 6–9, using galaxies lensed by six foreground Hubble Frontier Fields (HFF) clusters. ...The power afforded by strong gravitational lensing allows us to observe fainter and smaller galaxies than in blank fields. We select our sample of galaxies and obtain their properties, e.g. redshift, magnitude, from the photometrically derived ASTRODEEP catalogues. The intrinsic size is measured with the Lenstruction software, and completeness maps are created as a function of size and luminosity via the GLACiAR2 software. We perform a Bayesian analysis to estimate the intrinsic and incompleteness-corrected size–luminosity distribution, with parametrization re ∝ Lβ. We find slopes of $\beta =0.50^{+0.07}_{-0.07}$ at z ∼ 6 − 7 and $\beta =0.67^{+0.14}_{-0.15}$ at z ∼ 8.5, adopting the Bradac lens model. Our inferred slopes are consistent with other independent determinations of the size–luminosity relation from the HFF data set and steeper than that obtained from the bright galaxies in blank fields. We also investigate the systematic uncertainties associated with the choice of lens models, finding that the slopes of size–luminosity relations derived from different models are mutually consistent, i.e. modelling errors are not a significant source of discrepancy between the size–luminosity relation of blank and lensed fields.
Production of TNF-α and IL-1 in infectious and autoimmune diseases is associated with fever, fatigue, and sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice ...TNF-α and IL-1 increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm and thereby locomotor activity and may alter sleep architecture we assessed the influence of TNF-α on the circadian timing system. TNF-α is shown here to suppress the expression of the PAR bZip clock-controlled genes Dbp, Tef, and Hlf and of the period genes Per1, Per2, and Per3 in fibroblasts in vitro and in vivo in the liver of mice infused with the cytokine. The effect of TNF-α on clock genes is shared by IL-1β, but not by IFN-α, and IL-6. Furthermore, TNF-α interferes with the expression of Dbp in the suprachiasmatic nucleus and causes prolonged rest periods in the dark when mice show spontaneous locomotor activity. Using clock reporter genes TNF-α is found here to inhibit CLOCK-BMAL1-induced activation of E-box regulatory elements-dependent clock gene promoters. We suggest that the increase of TNF-α and IL-1β, as seen in infectious and autoimmune diseases, impairs clock gene functions and causes fatigue.
ABSTRACT
The JWST has discovered a surprising abundance of bright galaxy candidates in the very early universe (≤500 Myr after the Big Bang), calling into question current galaxy formation models. ...Spectroscopy is needed to confirm the primeval nature of these candidates, as well as to understand how the first galaxies form stars and grow. Here we present deep spectroscopic and continuum ALMA observations towards GHZ2/GLASS-z12, one of the brightest and most robust candidates at z > 10, identified in the GLASS-JWST Early Release Science Program. We detect a 5.8σ line, offset 0${_{.}^{\prime\prime}}$5 from the JWST position of GHZ2/GLASS-z12, that associating it with the O iii 88 $\mu {\rm m}$ transition, implies a spectroscopic redshift of z = 12.117 ± 0.001. We verify the detection using extensive statistical tests. The oxygen line luminosity places GHZ2/GLASS-z12 above the O iii-SFR relation for metal-poor galaxies, implying an enhancement of O iii emission in this system while the JWST-observed emission is likely a lower-metallicity region. The lack of dust emission seen by these observations is consistent with the blue UV slope observed by JWST, which suggest little dust attenuation in galaxies at this early epoch. Further observations will unambiguously confirm the redshift and shed light on the origins of the wide and offset line and physical properties of this early galaxy. This work illustrates the synergy between JWST and ALMA, and paves the way for future spectroscopic surveys of z > 10 galaxy candidates.
System xc-, encoded by Slc7a11, is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as ...glutathione. Glutathione acts as a co-factor for enzymes responsible for scavenging reactive oxygen species. Upon exposure to bacterial products, macrophages exhibit a rapid upregulation of system xc-. This study investigates the impact of Slc7a11 deficiency on the functionality of peritoneal and bone marrow-derived macrophages. Our findings reveal that the absence of Slc7a11 results in significantly reduced glutathione levels, compromised mitochondrial flexibility, and hindered cytokine production in bone marrow-derived macrophages. Conversely, system xc- has a lesser impact on peritoneal macrophages in vivo. These results indicate that system xc- is essential for maintaining glutathione levels, mitochondrial functionality, and cytokine production, with a heightened importance under atmospheric oxygen tension.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
ABSTRACT Although there has been much progress in understanding how galaxies evolve, we still do not understand how and when they stop forming stars and become quiescent. We address this by applying ...our galaxy spectral energy distribution models, which incorporate physically motivated star formation histories (SFHs) from cosmological simulations, to a sample of quiescent galaxies at . A total of 845 quiescent galaxies with multi-band photometry spanning rest-frame ultraviolet through near-infrared wavelengths are selected from the Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS) data set. We compute median SFHs of these galaxies in bins of stellar mass and redshift. At all redshifts and stellar masses, the median SFHs rise, reach a peak, and then decline to reach quiescence. At high redshift, we find that the rise and decline are fast, as expected, because the universe is young. At low redshift, the duration of these phases depends strongly on stellar mass. Low-mass galaxies ( ) grow on average slowly, take a long time to reach their peak of star formation ( Gyr), and then the declining phase is fast ( Gyr). Conversely, high-mass galaxies ( ) grow on average fast ( Gyr), and, after reaching their peak, decrease the star formation slowly ( ). These findings are consistent with galaxy stellar mass being a driving factor in determining how evolved galaxies are, with high-mass galaxies being the most evolved at any time (i.e., downsizing). The different durations we observe in the declining phases also suggest that low- and high-mass galaxies experience different quenching mechanisms, which operate on different timescales.
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