: Although thousands of clinical isolates of
are being sequenced and analysed by short read technology, the data do not resolve the highly variable subtelomeric regions of the genomes that contain ...polymorphic gene families involved in immune evasion and pathogenesis. There is also no current standard definition of the boundaries of these variable subtelomeric regions.
: Using long-read sequence data (Pacific Biosciences SMRT technology), we assembled and annotated the genomes of 15
isolates, ten of which are newly cultured clinical isolates. We performed comparative analysis of the entire genome with particular emphasis on the subtelomeric regions and the internal
genes clusters.
: The nearly complete sequence of these 15 isolates has enabled us to define a highly conserved core genome, to delineate the boundaries of the subtelomeric regions, and to compare these across isolates. We found highly structured variable regions in the genome. Some exported gene families purportedly involved in release of merozoites show copy number variation. As an example of ongoing genome evolution, we found a novel CLAG gene in six isolates. We also found a novel gene that was relatively enriched in the South East Asian isolates compared to those from Africa.
: These 15 manually curated new reference genome sequences with their nearly complete subtelomeric regions and fully assembled genes are an important new resource for the malaria research community. We report the overall conserved structure and pattern of important gene families and the more clearly defined subtelomeric regions.
Schlüsselseiten aus dem Exemplar der BSB München: 4 Diss. 1095.
Vorlageform des Erscheinungsvermerks: Altdorfii, Literis Henrici Meyeri, Univ. Typogr.
BERNH. MATTHIAE FRANCKII, Med. D. et Profess. P. De SUMMA THEORIAE, quam vocant, MEDICAE AD MORBORUM CURATIONEM RECTE INSTITUENDAM NECESSITATE DISSERTATIO, in alma Holsatorum Academia ...CHRISTIAN-ALBERTINA, cum Professionem Medicinae Extraordinariam auspicaretur, publice solenniterque recitata
De Summa Theoriae, quam vocant, Medicae Ad Morborum Curationem recte Instituendam Necessitate Dissertatio, in alma Holsatorum Academia Christian-Albertina, cum Professionem Medicinae Extraordinariam auspicaretur, publice solenniterque recitata
Údaje o knihkupci a nakladateli dle CERLu
The emergence of low-cost, user-friendly and very compact air pollution platforms enable observations at high spatial resolution in near-real-time and provide new opportunities to simultaneously ...enhance existing monitoring systems, as well as engage citizens in active environmental monitoring. This provides a whole new set of capabilities in the assessment of human exposure to air pollution. However, the data generated by these platforms are often of questionable quality.
We have conducted an exhaustive evaluation of 24 identical units of a commercial low-cost sensor platform against CEN (European Standardization Organization) reference analyzers, evaluating their measurement capability over time and a range of environmental conditions. Our results show that their performance varies spatially and temporally, as it depends on the atmospheric composition and the meteorological conditions. Our results show that the performance varies from unit to unit, which makes it necessary to examine the data quality of each node before its use.
In general, guidance is lacking on how to test such sensor nodes and ensure adequate performance prior to marketing these platforms. We have implemented and tested diverse metrics in order to assess if the sensor can be employed for applications that require high accuracy (i.e., to meet the Data Quality Objectives defined in air quality legislation, epidemiological studies) or lower accuracy (i.e., to represent the pollution level on a coarse scale, for purposes such as awareness raising).
Data quality is a pertinent concern, especially in citizen science applications, where citizens are collecting and interpreting the data. In general, while low-cost platforms present low accuracy for regulatory or health purposes they can provide relative and aggregated information about the observed air quality.
•We find challenges associated with sensor robustness and measurement repeatability.•Field performance evaluation under diverse environmental conditions is necessary.•We show low-cost sensors are not ready for applications that require high accuracy.•Low-cost sensors can provide coarse information about the observed air quality.
In a multiterminal HVDC network, dc circuit breakers (CBs) are required at each end of a line to selectively isolate a fault. Several CB concepts have been implemented in PSCAD, which differ ...significantly in their structure and performance. This paper describes the interaction of the different HVDC CB topologies with a meshed four-terminal network and assesses their performance in terms of maximum currents and voltages. The tradeoff between network parameters and CB requirements is analyzed.
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