The dehydration of bacteria by vacuum exposure results in damage to the cell membrane. This membrane damage does not necessarily lead to cell death. A part of the dehydrated bacteria is capable of ...eliminating the membrane damage by repair processes. Repair can proceed rapidly under conditions that permit synthesizing activities. The kinetics of this repair process were studied by means of the membrane-mediated biosynthesis of the cell wall as well as by the recovery of resistance to small concentrations of lysozyme. Repair is a precondition for cell proliferation. At low temperature cells can conserve their membrane damage and the repair process can be initiated when conditions become favourable.
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The uptake of various labeled compounds by tumors was studied by double-tracer whole-body autoradiography (DTWBA) in rats. Each animal carried two types of tumors: mammary carcinomas and the Walker ...256 carcinosarcomas. The markers used were 18F- and 3Hfluorodeoxyglucose (glucose utilization), 3Hthymidine (cell proliferation), 11Cmethionine (amino acid metabolism) and 11C- and 3Htoremifene (estrogen-receptor-avid agents). In each experiment, the distribution of a substance labeled with short-lived radionuclide (11C or 18F) was compared with that of another substance labeled with a long-lived nuclide (3H). Quantification was done by combining computerized image analysis of the autoradiograms with liquid scintillation counting of punched tissue pieces obtained from the cryosections. The relationships between the uptakes of the various radiopharmaceuticals were recorded in tumors and normal tissues. The dynamics of 18Ffluorodeoxyglucose and 11Cmethionine were determined in tumors and some selected tissues by positron emission tomography (PET). The uptake rate between fluorodeoxyglucose and thymidine in the mammary tumor was five times higher than the ratio in the Walker tumor. The corresponding figure for FDG/methionine was four times. Thymidine, compared with methionine, was twice as efficient. Thus, the mammary tumors were best imaged with FDG or thymidine. The non-steroid antiestrogen toremifene was taken up in very low amounts by these tumors. By DTWBA, experimental tumors may serve as their own control.
The PS 185 experiment at LEAR/CERN studies strangeness production in antiproton-proton collisions in flight. Exclusive final states containing pairs of antihyperons and hyperons have been analysed. ...The data have been used to investigate strange quark production dynamics. New data at the highest energies available at LEAR extend the existing data set for the Λ¯Λ channel. Preliminary data from a new threshold scan are available. For the Σ¯
0Λ+cc channel first spin correlation data have been extracted. First preliminary differential cross section data from the Σ¯
−Σ
− channel are also presented.