Regulation of lipid absorption by enterocytes can influence metabolic status in humans and contribute to obesity and related complications. The intracellular steps of chylomicron biogenesis and ...transport from the Endoplasmic Reticulum (ER) to the Golgi complex have been described, but the mechanisms for post-Golgi transport and secretion of chylomicrons have not been identified. Using a newly generated Dennd5b
mouse, we demonstrate an essential role for this gene in Golgi to plasma membrane transport of chylomicron secretory vesicles. In mice, loss of Dennd5b results in resistance to western diet induced obesity, changes in plasma lipids, and reduced aortic atherosclerosis. In humans, two independent exome sequencing studies reveal that a common DENND5B variant, p.(R52K), is correlated with body mass index. These studies establish an important role for DENND5B in post-Golgi chylomicron secretion and a subsequent influence on body composition and peripheral lipoprotein metabolism.
L.G. Freeman is a major scholar of Old World Paleolithic prehistory and a self-described "behavioral paleoanthropologist." Anthropology without Informants is a collection of previously published ...papers by this preeminent archaeologist, representing a cross section of his contributions to Old Work Paleolithic prehistory and archaeological theory. A socio-cultural anthropologist who became a behavioral paleoanthropologist late in his career, Freeman took a unique approach, employing statistical or mathematical techniques in his analysis of archaeological data. All the papers in this collection blend theoretical statements with the archeological facts they are intended to help the reader understand.Although he taught at the University of Chicago for the span of his 40-year career, Freeman is not well-known among Anglophone scholars, because his primary fieldwork and publishing occurred in Cantabrian, Spain. However, he has been a major player in Paleolithic prehistory, and this volume will introduce his work to more American Archaeologists.This collection brings the work of an expert scholar, to a broad audience, and will be of interest to archaeologists, their students, and lay readers interested in the Paleolithic era.
"It is my sincere hope that this volume will be much read and reflected upon by new generations of American students of prehistoric archaeologists. Freeman's career is a model for long-term ...international collaboration, theoretical eclecticism, the centrality of field research, and the ability to 'dream big,' but with a commonsense approach to the record and its limitations." Lawrence Guy Straus, Journal of Anthropological Research
While still a graduate student, Howell began the study that would lead to his influential paper on Neanderthal evolution (1957), in which he ascribed Neanderthals' exaggerated features to adaptations ...to periglacial environments. In his research and teaching, he blended the study of hominid physical remains with their artifactual, faunal, and paleoenvironmental contexts, considering them in light of our understanding of the behavior of hunter-gatherers and communities of living primates.
F. Clark Howell: An Appreciation Freeman, Leslie G.; Freeman, Susan Tax
Journal of Anthropological Research,
06/2007, Letnik:
63, Številka:
2
Journal Article, Web Resource
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